JP2009525046A5 - - Google Patents
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- Publication number
- JP2009525046A5 JP2009525046A5 JP2008553336A JP2008553336A JP2009525046A5 JP 2009525046 A5 JP2009525046 A5 JP 2009525046A5 JP 2008553336 A JP2008553336 A JP 2008553336A JP 2008553336 A JP2008553336 A JP 2008553336A JP 2009525046 A5 JP2009525046 A5 JP 2009525046A5
- Authority
- JP
- Japan
- Prior art keywords
- factor
- kinase
- synuclein
- activity
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76400006P | 2006-01-31 | 2006-01-31 | |
| PCT/US2007/002685 WO2007089862A2 (en) | 2006-01-31 | 2007-01-30 | Alpha-synuclein kinase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009525046A JP2009525046A (ja) | 2009-07-09 |
| JP2009525046A5 true JP2009525046A5 (https=) | 2010-04-08 |
Family
ID=38328036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008553336A Pending JP2009525046A (ja) | 2006-01-31 | 2007-01-30 | アルファ−シヌクレインキナーゼ |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US7553639B2 (https=) |
| EP (1) | EP1989330A4 (https=) |
| JP (1) | JP2009525046A (https=) |
| CA (1) | CA2641219A1 (https=) |
| WO (1) | WO2007089862A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7553639B2 (en) | 2006-01-31 | 2009-06-30 | Elan Pharma International Limited | Alpha-synuclein kinase |
| EP2247748A2 (en) * | 2008-02-13 | 2010-11-10 | Elan Pharma International Limited | Alpha-synuclein kinase |
| PT2282758T (pt) * | 2008-04-29 | 2019-02-12 | Bioarctic Ab | Anticorpos e vacinas para uso em métodos terapêuticos e diagnósticos para perturbações relacionadas com a alfa-sinucleína |
| MX2011009807A (es) * | 2009-03-19 | 2011-09-29 | Medical Res Council Technology | Compuestos. |
| CA2789963C (en) | 2010-02-26 | 2019-09-03 | Bioarctic Neuroscience Ab | Protofibril-binding antibodies and their use in therapeutic and diagnostic methods for parkinson's disease, dementia with lewy bodies and other alpha-synucleinopathies |
| EP2426202A1 (en) * | 2010-09-03 | 2012-03-07 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Kinases as targets for anti-diabetic therapy |
| US9458463B2 (en) | 2010-09-03 | 2016-10-04 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for treatment of diabetes by a small molecule inhibitor for GRK5 |
| WO2014132249A1 (en) | 2013-02-26 | 2014-09-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Method for the assay of synucleins |
| WO2018057782A1 (en) * | 2016-09-23 | 2018-03-29 | University Of Utah Research Foundation | Methods of preventing stem cell differentiation using a pask inhibitor |
| CN110506057B (zh) | 2017-02-17 | 2023-09-29 | 百时美施贵宝公司 | Alpha突触核蛋白抗体及其应用 |
| EP3765855A1 (en) | 2018-03-14 | 2021-01-20 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Detection of phospho-serine 129 alpha-synuclein in blood cells as a biomarker for synucleinopathies |
| RS66984B1 (sr) | 2020-06-26 | 2025-07-31 | Bioarctic Ab | Antitela koja vezuju alfa-sinuklein protofibril |
| CN114601928B (zh) * | 2022-04-02 | 2023-03-17 | 首都医科大学 | 一种钙超载介导神经元死亡的标志物及应用 |
| CN115569202A (zh) * | 2022-10-19 | 2023-01-06 | 苏州捷乐思生物科技有限公司 | 一种帕金森综合征动物模型、药物筛选方法及治疗药物 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001238612A1 (en) * | 2000-02-18 | 2001-08-27 | The Regents Of The University Of California | Method for screening for anti-amyloidogenic properties and method for treatment of neurodegenerative disease |
| JP2004502781A (ja) * | 2000-07-07 | 2004-01-29 | パナシア ファーマシューティカルズ インコーポレーテッド | 神経組織の損傷を予防するため、およびα−シヌクレイン疾患を処置するための方法 |
| JP2005538048A (ja) * | 2002-05-03 | 2005-12-15 | シエーリング アクチエンゲゼルシャフト | チアゾリジノン類、それらの生成及び医薬剤としての使用 |
| WO2004069175A2 (en) * | 2003-02-02 | 2004-08-19 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PARKINSON’S DISEASE AND OTHER α-SYNUCLEINOPATHIES |
| US6861422B2 (en) * | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
| DE10351744A1 (de) * | 2003-10-31 | 2005-06-16 | Schering Ag | Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel |
| US7566548B2 (en) * | 2004-08-13 | 2009-07-28 | University Of Massachusetts | Methods for identifying therapeutic agents and for treating disease |
| US20060074088A1 (en) * | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
| EP1827473A4 (en) | 2004-12-01 | 2009-08-19 | Whitehead Biomedical Inst | MODULATOR OF ALPHA SYNNUCLEINE TOXICITY |
| MX2007007245A (es) * | 2004-12-15 | 2008-02-25 | Bayer Schering Pharma Ag | Tiazolidinonas metasustituidas, su preparacion y su uso como medicamento. |
| DE102005005395A1 (de) * | 2005-02-03 | 2006-08-10 | Schering Aktiengesellschaft | Thiazolidinone, deren Herstellung und Verwendung als Arzneimittel |
| US20070010565A1 (en) * | 2005-04-25 | 2007-01-11 | Olaf Prien | New thiazolidinones without basic nitrogen, their production and use as pharmaceutical agents |
| DE102005020104A1 (de) * | 2005-04-25 | 2006-10-26 | Schering Ag | Neue Thiazolidinone ohne basischen Stickstoff, deren Herstellung und Verwendung als Arzneimittel |
| US9018003B2 (en) * | 2005-05-13 | 2015-04-28 | Whitehead Institute For Biomedical Research | Modulators of alpha-synuclein toxicity |
| US8017781B2 (en) * | 2005-11-15 | 2011-09-13 | Vertex Pharmaceuticals Incorporated | Azaindazoles useful as inhibitors of kinases |
| CN101336244B (zh) * | 2005-12-08 | 2011-11-30 | 雅培制药有限公司 | 用作蛋白激酶抑制剂的9元杂二环化合物 |
| TW200801008A (en) * | 2005-12-29 | 2008-01-01 | Abbott Lab | Protein kinase inhibitors |
| US7553639B2 (en) | 2006-01-31 | 2009-06-30 | Elan Pharma International Limited | Alpha-synuclein kinase |
| EP2247748A2 (en) * | 2008-02-13 | 2010-11-10 | Elan Pharma International Limited | Alpha-synuclein kinase |
-
2007
- 2007-01-30 US US11/669,093 patent/US7553639B2/en not_active Expired - Fee Related
- 2007-01-30 EP EP07762749A patent/EP1989330A4/en not_active Withdrawn
- 2007-01-30 CA CA002641219A patent/CA2641219A1/en not_active Abandoned
- 2007-01-30 JP JP2008553336A patent/JP2009525046A/ja active Pending
- 2007-01-30 WO PCT/US2007/002685 patent/WO2007089862A2/en not_active Ceased
-
2008
- 2008-02-13 US US12/030,849 patent/US20080300206A1/en not_active Abandoned
-
2010
- 2010-02-08 US US12/702,201 patent/US8148089B2/en not_active Expired - Fee Related
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