JP2009523438A - 細胞の富化 - Google Patents

細胞の富化 Download PDF

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JP2009523438A
JP2009523438A JP2008550832A JP2008550832A JP2009523438A JP 2009523438 A JP2009523438 A JP 2009523438A JP 2008550832 A JP2008550832 A JP 2008550832A JP 2008550832 A JP2008550832 A JP 2008550832A JP 2009523438 A JP2009523438 A JP 2009523438A
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cells
mscs
msc
cell
mesenchymal stem
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JP2009523438A5 (enExample
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マクゴナガル,デニス
ジョーンズ,エレナ
イングリッシュ,アン
エメリー,ポール
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University of Leeds
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University of Leeds
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0667Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0668Mesenchymal stem cells from other natural sources
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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    • C12N2509/00Methods for the dissociation of cells, e.g. specific use of enzymes

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  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
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  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2008550832A 2006-01-18 2007-01-17 細胞の富化 Pending JP2009523438A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0600972.4A GB0600972D0 (en) 2006-01-18 2006-01-18 Enrichment of cells
PCT/GB2007/000107 WO2007083093A1 (en) 2006-01-18 2007-01-17 Enrichment of cells

Publications (2)

Publication Number Publication Date
JP2009523438A true JP2009523438A (ja) 2009-06-25
JP2009523438A5 JP2009523438A5 (enExample) 2010-03-04

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JP2008550832A Pending JP2009523438A (ja) 2006-01-18 2007-01-17 細胞の富化

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US (1) US20100260721A1 (enExample)
EP (1) EP1979471A1 (enExample)
JP (1) JP2009523438A (enExample)
CN (1) CN101400786A (enExample)
AU (1) AU2007206750A1 (enExample)
GB (1) GB0600972D0 (enExample)
WO (1) WO2007083093A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016074648A (ja) * 2014-10-06 2016-05-12 佛教慈濟醫療財團法人 関節疾患を治療するための組成物及び方法
KR102858598B1 (ko) 2025-01-16 2025-09-10 신종인 콜라게나제를 이용한 지방세포 이식용 조성물의 제조방법

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2010109698A (ru) * 2007-09-19 2011-09-27 Плуристем Лтд. (Il) Адгезивные клетки жировой ткани или плаценты и их использование в лечебных целях
JP5645197B2 (ja) * 2009-06-23 2014-12-24 学校法人日本大学 幹細胞の未分化状態を維持する新規方法
US9169464B2 (en) 2009-10-16 2015-10-27 Rutgers, The State University Of New Jersey Closed system separation of adherent bone marrow stem cells for regenerative medicine applications
SG10201408187XA (en) * 2009-12-22 2015-01-29 Agency Science Tech & Res Treatment of Bone Fracture
EP2751256A4 (en) * 2011-08-29 2015-01-28 Safeguard Cell Technology Inc ISOLATION AND THERAPEUTIC USE OF PERIVASCULAR MEDICINAL CELLS
AU2012307086B2 (en) * 2011-09-09 2016-05-26 Mesoblast, Inc. Methods for increasing osteoblastic function
CN103266081B (zh) * 2012-01-21 2015-05-13 中国人民解放军军事医学科学院附属医院 从脐带中分离培养间充质干细胞的高效方法
EP3030279B1 (en) * 2013-08-06 2020-11-04 Regenexx, LLC Bone marrow adipose portion isolation device and methods
EP2998392A1 (en) * 2014-09-16 2016-03-23 The Provost, Fellows, Foundation Scholars, & the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin A population of cells for use in single-stage cell-based cartilage regeneration
US10342830B2 (en) 2015-01-05 2019-07-09 Gary M. Petrucci Methods and materials for treating lung disorders
US20160193254A1 (en) * 2015-01-05 2016-07-07 Gary M. Petrucci Methods and materials for treating arthritis
WO2017136557A1 (en) 2016-02-05 2017-08-10 Petrucci Gary M Methods and materials for treating nerve injuries and neurological disorders
US20180059109A1 (en) * 2016-08-31 2018-03-01 Meridigen Biotech Co., Ltd. Method of distinguishing mesenchymal stem cells and method of determining purity of mesenchymal stem cells
US11613733B2 (en) 2017-05-12 2023-03-28 Medical & Biological Laboratories Co., Ltd. Method for purifying mesenchymal stem cells to improve transplantation efficiency
US10478531B2 (en) 2017-06-22 2019-11-19 Gary M. Petrucci Methods and materials for treating blood vessels
US10251917B1 (en) 2017-09-19 2019-04-09 Gary M. Petrucci Methods and materials for treating tumors
US11285177B2 (en) 2018-01-03 2022-03-29 Globus Medical, Inc. Allografts containing viable cells and methods thereof
US12391924B2 (en) 2019-02-08 2025-08-19 Regrow Biosciences Private Limited Method for mesenchymal stem cell isolation and osteoblast differentiation
US11697799B2 (en) 2019-04-15 2023-07-11 Ossium Health, Inc. System and method for extraction and cryopreservation of bone marrow
EP4181675A4 (en) 2020-07-18 2024-04-24 Ossium Health, Inc. PERMEATION OF WHOLE VERTEBRATE BODIES WITH A CRYOPRETECTIVE AGENT USING VACUUM-ASSISTED DIFFUSION
CN116583594B (zh) 2020-10-14 2025-05-23 奥瑟姆健康公司 用于骨髓的提取和低温保藏的系统和方法
WO2022133282A1 (en) 2020-12-18 2022-06-23 Ossium Health, Inc. Methods of cell therapies

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002504503A (ja) * 1998-02-24 2002-02-12 エムシーピー・ハーネマン・ユニバーシテイ 中枢神経系の疾病の処置における使用のための単離されたストロマ細胞
US20030103947A1 (en) * 2001-02-23 2003-06-05 Urlich Noth In vitro engineered cartilage constructs produced by coating biodegradable polymer with human mesenchymal stem cells
US20040033217A1 (en) * 2002-05-31 2004-02-19 Padmavathy Vanguri Intraperitoneal delivery of genetically engineered mesenchymal stem cells
WO2005001076A2 (en) * 2003-06-27 2005-01-06 Ethicon, Incorporated Postpartum cells derived from placental tissue, and methods of making and using the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5226914A (en) * 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
US5811094A (en) * 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US6482231B1 (en) * 1995-11-20 2002-11-19 Giovanni Abatangelo Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative
CA2251983C (en) * 1996-04-19 2003-12-16 Sudhakar Kadiyala Regeneration and augmentation of bone using mesenchymal stem cells
US6835377B2 (en) * 1998-05-13 2004-12-28 Osiris Therapeutics, Inc. Osteoarthritis cartilage regeneration
US6893900B1 (en) * 1998-06-24 2005-05-17 Amkor Technology, Inc. Method of making an integrated circuit package
US7670628B2 (en) * 1999-07-07 2010-03-02 Angioblast Systems, Inc. Mesenchymal precursor cell
AU5723601A (en) * 2000-04-25 2001-11-07 Osiris Therapeutics Inc Joint repair using mesenchymal stem cells
US20030211602A1 (en) * 2000-04-28 2003-11-13 Anthony Atala Isolation of mesenchymal stem cells and use thereof

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002504503A (ja) * 1998-02-24 2002-02-12 エムシーピー・ハーネマン・ユニバーシテイ 中枢神経系の疾病の処置における使用のための単離されたストロマ細胞
US20030103947A1 (en) * 2001-02-23 2003-06-05 Urlich Noth In vitro engineered cartilage constructs produced by coating biodegradable polymer with human mesenchymal stem cells
US20040033217A1 (en) * 2002-05-31 2004-02-19 Padmavathy Vanguri Intraperitoneal delivery of genetically engineered mesenchymal stem cells
WO2005001076A2 (en) * 2003-06-27 2005-01-06 Ethicon, Incorporated Postpartum cells derived from placental tissue, and methods of making and using the same
WO2005001079A2 (en) * 2003-06-27 2005-01-06 Ethicon, Incorporated Soft tissue repair and regeneration using postpartum-derived cells
WO2005001078A2 (en) * 2003-06-27 2005-01-06 Ethicon, Incorporated Regeneration and repair of neural tissue using postpartum-derived cells
WO2005003334A2 (en) * 2003-06-27 2005-01-13 Ethicon, Incorporated Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
WO2005038012A2 (en) * 2003-06-27 2005-04-28 Ethicon Incorporated Cartilage and bone repair and regeneration using postpartum-derived cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6012038749; Mol Biotechnol. 2003 Jan;23(1):37-49. *
JPN6012038750; Transplant Proc. 2005 Nov;37(9):4080-3. *
JPN6012038751; Arthritis Rheum. 2002 Dec;46(12):3349-60. *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016074648A (ja) * 2014-10-06 2016-05-12 佛教慈濟醫療財團法人 関節疾患を治療するための組成物及び方法
US10624928B2 (en) 2014-10-06 2020-04-21 Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation Composition for treatment of joint disease and method thereof
KR102858598B1 (ko) 2025-01-16 2025-09-10 신종인 콜라게나제를 이용한 지방세포 이식용 조성물의 제조방법

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US20100260721A1 (en) 2010-10-14
AU2007206750A1 (en) 2007-07-26
GB0600972D0 (en) 2006-03-01
WO2007083093A1 (en) 2007-07-26
EP1979471A1 (en) 2008-10-15
CN101400786A (zh) 2009-04-01

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