JP2009521504A - Akt活性阻害剤 - Google Patents
Akt活性阻害剤 Download PDFInfo
- Publication number
- JP2009521504A JP2009521504A JP2008547763A JP2008547763A JP2009521504A JP 2009521504 A JP2009521504 A JP 2009521504A JP 2008547763 A JP2008547763 A JP 2008547763A JP 2008547763 A JP2008547763 A JP 2008547763A JP 2009521504 A JP2009521504 A JP 2009521504A
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolo
- pyridin
- amino
- thiophenecarboxamide
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 C*(C)(C=C1)c2c1ccc*2O Chemical compound C*(C)(C=C1)c2c1ccc*2O 0.000 description 5
- VUGDUTVSPJZIQK-XNTDXEJSSA-N C=[Br]c1c(-c2ccnc3c2cc[nH]3)[s]c(C(N/C(/CN)=C/c(cc2)ccc2F)=O)c1 Chemical compound C=[Br]c1c(-c2ccnc3c2cc[nH]3)[s]c(C(N/C(/CN)=C/c(cc2)ccc2F)=O)c1 VUGDUTVSPJZIQK-XNTDXEJSSA-N 0.000 description 1
- HGHBJBRZZWBDPK-PTNGSMBKSA-N C=[Br]c1c(-c2ccnc3c2cc[nH]3)[s]c(C(NC/C(/N)=C/c2ccccc2)=O)c1 Chemical compound C=[Br]c1c(-c2ccnc3c2cc[nH]3)[s]c(C(NC/C(/N)=C/c2ccccc2)=O)c1 HGHBJBRZZWBDPK-PTNGSMBKSA-N 0.000 description 1
- ZYAACRHAEQCEST-UHFFFAOYSA-N CC(C)(C)OC(NCC(C(Nc1cc(-c2c(-c3c[o]cc3)[nH]c3ncccc23)c[s]1)=O)c1ccccc1)=O Chemical compound CC(C)(C)OC(NCC(C(Nc1cc(-c2c(-c3c[o]cc3)[nH]c3ncccc23)c[s]1)=O)c1ccccc1)=O ZYAACRHAEQCEST-UHFFFAOYSA-N 0.000 description 1
- IHOLNALVXKMADD-UHFFFAOYSA-N CC(C)(C)OC(NCC(C(Nc1cc(-c2c(cc[n]3S(c4ccccc4)(=O)=O)c3ncc2)c[s]1)=O)c1ccccc1)=O Chemical compound CC(C)(C)OC(NCC(C(Nc1cc(-c2c(cc[n]3S(c4ccccc4)(=O)=O)c3ncc2)c[s]1)=O)c1ccccc1)=O IHOLNALVXKMADD-UHFFFAOYSA-N 0.000 description 1
- LWNZQIUZNRHYFG-UHFFFAOYSA-N CC(C)(C)OC(NCC(CCc1ccccc1)N)=O Chemical compound CC(C)(C)OC(NCC(CCc1ccccc1)N)=O LWNZQIUZNRHYFG-UHFFFAOYSA-N 0.000 description 1
- UXGBCEOFPAHMAT-UHFFFAOYSA-N CC(C)(C)OC(NCC(Cc1ccccc1)C(Nc1cc(-c(c2cccnc22)c[n]2S(c2ccccc2)(=O)=O)c(-c2ccccc2)[s]1)=O)=O Chemical compound CC(C)(C)OC(NCC(Cc1ccccc1)C(Nc1cc(-c(c2cccnc22)c[n]2S(c2ccccc2)(=O)=O)c(-c2ccccc2)[s]1)=O)=O UXGBCEOFPAHMAT-UHFFFAOYSA-N 0.000 description 1
- AXWJGVHHIMHWJM-UHFFFAOYSA-N CC(C)(C)OC(NCC(c1ccccc1)NC(c1ccc(-c2c(cc[nH]3)c3ncc2)[s]1)=O)=O Chemical compound CC(C)(C)OC(NCC(c1ccccc1)NC(c1ccc(-c2c(cc[nH]3)c3ncc2)[s]1)=O)=O AXWJGVHHIMHWJM-UHFFFAOYSA-N 0.000 description 1
- XRBIXDGVQKMCJG-UHFFFAOYSA-N CC1(C)OB(c(c2c3nccc2)c(C)[n]3S(c2ccccc2)(=O)=O)OC1(C)C Chemical compound CC1(C)OB(c(c2c3nccc2)c(C)[n]3S(c2ccccc2)(=O)=O)OC1(C)C XRBIXDGVQKMCJG-UHFFFAOYSA-N 0.000 description 1
- KZANVIJXSQABKR-UHFFFAOYSA-N CC1(C)OB(c(c2c3nccc2)c[n]3S(c2ccccc2)(=O)=O)OC1(C)C Chemical compound CC1(C)OB(c(c2c3nccc2)c[n]3S(c2ccccc2)(=O)=O)OC1(C)C KZANVIJXSQABKR-UHFFFAOYSA-N 0.000 description 1
- CSOSSWYCEXOYNK-UHFFFAOYSA-N CC1C(S([n](cc2)c3c2c(-c([s]c(C(NC(CNC(OC(C)(C)C)=O)c2ccccc2)=O)c2)c2-c2cccnc2)ccn3)(OC)=O)=CC=CC1 Chemical compound CC1C(S([n](cc2)c3c2c(-c([s]c(C(NC(CNC(OC(C)(C)C)=O)c2ccccc2)=O)c2)c2-c2cccnc2)ccn3)(OC)=O)=CC=CC1 CSOSSWYCEXOYNK-UHFFFAOYSA-N 0.000 description 1
- YGTDSYGYZFQKOY-UHFFFAOYSA-N CCNCC(Cc1ccccc1)NC(c1cc(Br)c(-c2ccnc3c2cc[nH]3)[s]1)=O Chemical compound CCNCC(Cc1ccccc1)NC(c1cc(Br)c(-c2ccnc3c2cc[nH]3)[s]1)=O YGTDSYGYZFQKOY-UHFFFAOYSA-N 0.000 description 1
- VLZWUULVFAASBC-UHFFFAOYSA-N CCOC(c([nH]c1ncc2)cc1c2Br)=O Chemical compound CCOC(c([nH]c1ncc2)cc1c2Br)=O VLZWUULVFAASBC-UHFFFAOYSA-N 0.000 description 1
- ILFKFOKAPPGUOP-UHFFFAOYSA-N COc1c(C(CN)O)cccc1 Chemical compound COc1c(C(CN)O)cccc1 ILFKFOKAPPGUOP-UHFFFAOYSA-N 0.000 description 1
- LNJZBUJHZUZDGC-HNNXBMFYSA-N COc1c(C(N[C@@H](Cc2cc(C(F)(F)F)ccc2)CN)=O)[s]c(-c2ccnc3c2cc[nH]3)c1 Chemical compound COc1c(C(N[C@@H](Cc2cc(C(F)(F)F)ccc2)CN)=O)[s]c(-c2ccnc3c2cc[nH]3)c1 LNJZBUJHZUZDGC-HNNXBMFYSA-N 0.000 description 1
- RTDBRWRSLPCCJJ-AWEZNQCLSA-N COc1c(C(N[C@@H](Cc2cc(C(F)(F)F)ccc2)CN)=O)[s]c(-c2ccnc3c2cc[nH]3)c1Br Chemical compound COc1c(C(N[C@@H](Cc2cc(C(F)(F)F)ccc2)CN)=O)[s]c(-c2ccnc3c2cc[nH]3)c1Br RTDBRWRSLPCCJJ-AWEZNQCLSA-N 0.000 description 1
- UVUQHMYMYRKQDM-UHFFFAOYSA-N COc1cccc(C(CN)NC(c2ccc(-c3ccnc4c3cc[nH]4)[s]2)=O)c1 Chemical compound COc1cccc(C(CN)NC(c2ccc(-c3ccnc4c3cc[nH]4)[s]2)=O)c1 UVUQHMYMYRKQDM-UHFFFAOYSA-N 0.000 description 1
- CEMNRPURMKREKG-UHFFFAOYSA-N Cc1c(C(CN)NC(c2ccc(-c3ccnc4c3cc[nH]4)[s]2)=O)cccc1 Chemical compound Cc1c(C(CN)NC(c2ccc(-c3ccnc4c3cc[nH]4)[s]2)=O)cccc1 CEMNRPURMKREKG-UHFFFAOYSA-N 0.000 description 1
- PSYNSCKJFPHWPW-UHFFFAOYSA-N NC(CCC(Nc1ccc(-c2ccnc3c2cc[nH]3)[s]1)=O)c1ccccc1 Chemical compound NC(CCC(Nc1ccc(-c2ccnc3c2cc[nH]3)[s]1)=O)c1ccccc1 PSYNSCKJFPHWPW-UHFFFAOYSA-N 0.000 description 1
- VUUIRFBHSQQBFK-UHFFFAOYSA-N NCC(Cc1ccccc1)C(Nc1cc(Br)c(-c2ccnc3c2cc[nH]3)[s]1)=O Chemical compound NCC(Cc1ccccc1)C(Nc1cc(Br)c(-c2ccnc3c2cc[nH]3)[s]1)=O VUUIRFBHSQQBFK-UHFFFAOYSA-N 0.000 description 1
- SDLUNQVFMKEUPX-UHFFFAOYSA-N NCC(Cc1ccccc1)NC(c1c[o]c(-c2c[nH]c3c2cccn3)c1)=O Chemical compound NCC(Cc1ccccc1)NC(c1c[o]c(-c2c[nH]c3c2cccn3)c1)=O SDLUNQVFMKEUPX-UHFFFAOYSA-N 0.000 description 1
- GDKITTFVFZJQID-UHFFFAOYSA-N NCC(c1ccccc1)NC(c1c[s]c(-c2c[nH]c3c2cccn3)c1)=O Chemical compound NCC(c1ccccc1)NC(c1c[s]c(-c2c[nH]c3c2cccn3)c1)=O GDKITTFVFZJQID-UHFFFAOYSA-N 0.000 description 1
- FRSCXNVIGBMZPG-UHFFFAOYSA-N NCC(c1ccccc1)NC(c1cc(-c2c(cc[nH]3)c3ncc2)c[s]1)=O Chemical compound NCC(c1ccccc1)NC(c1cc(-c2c(cc[nH]3)c3ncc2)c[s]1)=O FRSCXNVIGBMZPG-UHFFFAOYSA-N 0.000 description 1
- YFDNOSFIXVRVDM-UHFFFAOYSA-N NCC(c1ccccc1)NC(c1cc(Br)c(-c2ccnc3c2cc[nH]3)[s]1)=O Chemical compound NCC(c1ccccc1)NC(c1cc(Br)c(-c2ccnc3c2cc[nH]3)[s]1)=O YFDNOSFIXVRVDM-UHFFFAOYSA-N 0.000 description 1
- ZXAIWDLCJKVDIG-UHFFFAOYSA-N NCC(c1ccccc1)NC(c1cc(C2CC2)c(-c2ccnc3c2cc[nH]3)[s]1)=O Chemical compound NCC(c1ccccc1)NC(c1cc(C2CC2)c(-c2ccnc3c2cc[nH]3)[s]1)=O ZXAIWDLCJKVDIG-UHFFFAOYSA-N 0.000 description 1
- WUGQYNFKUQRGRA-UHFFFAOYSA-N NCCCC(c1ccccc1)NC(c1cc(-c2c(cc[nH]3)c3ncc2)c[s]1)=O Chemical compound NCCCC(c1ccccc1)NC(c1cc(-c2c(cc[nH]3)c3ncc2)c[s]1)=O WUGQYNFKUQRGRA-UHFFFAOYSA-N 0.000 description 1
- WURGOIXNFGPAMJ-UHFFFAOYSA-N NCCCC(c1ccccc1)NC(c1cc(Br)c(-c2c(cc[nH]3)c3ncc2)[s]1)=O Chemical compound NCCCC(c1ccccc1)NC(c1cc(Br)c(-c2c(cc[nH]3)c3ncc2)[s]1)=O WURGOIXNFGPAMJ-UHFFFAOYSA-N 0.000 description 1
- RJIFRZYJIHGIPA-UHFFFAOYSA-N NCCOc1c(C(NCCc2ccccc2)=O)[s]c(-c2ccnc3c2cc[nH]3)c1Br Chemical compound NCCOc1c(C(NCCc2ccccc2)=O)[s]c(-c2ccnc3c2cc[nH]3)c1Br RJIFRZYJIHGIPA-UHFFFAOYSA-N 0.000 description 1
- OTNSEYVEXMHIMV-OAHLLOKOSA-N NC[C@@H](Cc1cc(F)ccc1)NC(c1ccc(-c2ccnc3c2cc[nH]3)[s]1)=O Chemical compound NC[C@@H](Cc1cc(F)ccc1)NC(c1ccc(-c2ccnc3c2cc[nH]3)[s]1)=O OTNSEYVEXMHIMV-OAHLLOKOSA-N 0.000 description 1
- FLJNUPIJNHQZPV-CQSZACIVSA-N NC[C@@H](Cc1ccccc1)NC(c1cc(Br)c(-c2ccnc3c2cc[nH]3)[s]1)=O Chemical compound NC[C@@H](Cc1ccccc1)NC(c1cc(Br)c(-c2ccnc3c2cc[nH]3)[s]1)=O FLJNUPIJNHQZPV-CQSZACIVSA-N 0.000 description 1
- WLACIZOIMWNLLB-HNNXBMFYSA-N NC[C@H](CC1CCCCC1)NC(c1ccc(-c2ccnc3c2cc[nH]3)[s]1)=O Chemical compound NC[C@H](CC1CCCCC1)NC(c1ccc(-c2ccnc3c2cc[nH]3)[s]1)=O WLACIZOIMWNLLB-HNNXBMFYSA-N 0.000 description 1
- MGOYMEQGRDQCME-UHFFFAOYSA-N Nc1nc([nH]cc2)c2c(Br)c1 Chemical compound Nc1nc([nH]cc2)c2c(Br)c1 MGOYMEQGRDQCME-UHFFFAOYSA-N 0.000 description 1
- BEPFGDZUAZYOHN-UHFFFAOYSA-N [O-][N+](c1c[nH]c2c1c(Br)ccn2)=O Chemical compound [O-][N+](c1c[nH]c2c1c(Br)ccn2)=O BEPFGDZUAZYOHN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75303305P | 2005-12-22 | 2005-12-22 | |
US79319806P | 2006-04-19 | 2006-04-19 | |
PCT/US2006/062453 WO2007076423A2 (fr) | 2005-12-22 | 2006-12-21 | INHIBITEURS D’ACTIVITE Akt |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2009521504A true JP2009521504A (ja) | 2009-06-04 |
Family
ID=38218824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008547763A Withdrawn JP2009521504A (ja) | 2005-12-22 | 2006-12-21 | Akt活性阻害剤 |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1968568A4 (fr) |
JP (1) | JP2009521504A (fr) |
WO (1) | WO2007076423A2 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015530980A (ja) * | 2012-08-02 | 2015-10-29 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | キナーゼ阻害剤として活性な置換ピロール類 |
JP2021500339A (ja) * | 2017-10-18 | 2021-01-07 | エイチケー イノ.エヌ コーポレーション | タンパク質キナーゼ阻害剤としての複素環化合物 |
JP2021520415A (ja) * | 2018-04-04 | 2021-08-19 | エピオダイン,インク. | オピオイド受容体モジュレーター、およびそれに関連する生成物ならびに方法 |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2621261C (fr) | 2005-09-22 | 2014-05-20 | Incyte Corporation | Inhibiteurs tetracycliques de janus kinases |
US7625890B2 (en) | 2005-11-10 | 2009-12-01 | Smithkline Beecham Corp. | Substituted imidazo[4,5-c]pyridine compounds as Akt inhibitors |
PT3184526T (pt) | 2005-12-13 | 2018-12-19 | Incyte Holdings Corp | Derivados de pirrolo[2,3-d]pirimidina como inibidores da cinase janus |
CN101389324A (zh) | 2005-12-23 | 2009-03-18 | 史密丝克莱恩比彻姆公司 | Aurora激酶的氮杂吲哚抑制剂 |
GB0617161D0 (en) * | 2006-08-31 | 2006-10-11 | Vernalis R&D Ltd | Enzyme inhibitors |
EP2121692B1 (fr) | 2006-12-22 | 2013-04-10 | Incyte Corporation | Hétérocycles substitués servant d'inhibiteurs de janus kinases |
UY30892A1 (es) * | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
ES2543325T3 (es) * | 2007-02-07 | 2015-08-18 | Glaxosmithkline Llc | Inhibidores de la actividad de Akt |
US20080312259A1 (en) | 2007-06-13 | 2008-12-18 | Incyte Corporation | SALTS OF THE JANUS KINASE INHIBITOR (R)-3-(4-(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE |
CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
ES2389992T3 (es) | 2007-11-02 | 2012-11-05 | Vertex Pharmaceuticals Incorporated | Derivados de [1H-pirazolo[3,4-b]piridin-4-il]-fenilo o -piridin-2-ilo como proteína cinasa c-theta |
EA201070700A1 (ru) * | 2007-12-07 | 2011-06-30 | Вертекс Фармасьютикалз Инкорпорейтед | Способы получения циклоалкилкарбоксамидопиридинбензойных кислот |
US8329709B2 (en) * | 2008-01-09 | 2012-12-11 | Genentech, Inc. | 5H-cyclopenta[D]pyrimidines as AKT protein kinase inhibitors |
TWI444382B (zh) | 2008-03-11 | 2014-07-11 | Incyte Corp | 作為jak抑制劑之氮雜環丁烷及環丁烷衍生物 |
JP2011525929A (ja) * | 2008-06-26 | 2011-09-29 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Akt活性の阻害剤 |
US20110288142A1 (en) | 2009-01-30 | 2011-11-24 | Chen Pingyun Y | CRYSTALLINE N--5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride |
WO2010093885A1 (fr) * | 2009-02-12 | 2010-08-19 | Glaxosmithkline Llc | Inhibiteurs de l'activité d'akt |
EP2426117A4 (fr) * | 2009-04-30 | 2012-09-19 | Sumitomo Chemical Co | Dérivé de thiophène |
ES2487542T3 (es) | 2009-05-22 | 2014-08-21 | Incyte Corporation | Derivados de N-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2,3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de cinasas Janus |
CN106967070A (zh) | 2009-05-22 | 2017-07-21 | 因塞特控股公司 | 作为jak抑制剂的化合物 |
AR078012A1 (es) | 2009-09-01 | 2011-10-05 | Incyte Corp | Derivados heterociclicos de las pirazol-4-il- pirrolo (2,3-d) pirimidinas como inhibidores de la quinasa janus |
BR112012008267B1 (pt) | 2009-10-09 | 2022-10-04 | Incyte Holdings Corporation | Derivados hidroxila, ceto e glucuronida de 3-(4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1- il)-3-ciclopentilpropanonitrila |
TWI766281B (zh) | 2010-03-10 | 2022-06-01 | 美商英塞特控股公司 | 作為jak1抑制劑之哌啶-4-基三亞甲亞胺衍生物 |
PE20130216A1 (es) | 2010-05-21 | 2013-02-27 | Incyte Corp | Formulacion topica para un inhibidor de jak |
AR083933A1 (es) | 2010-11-19 | 2013-04-10 | Incyte Corp | Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak |
JP5917544B2 (ja) | 2010-11-19 | 2016-05-18 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Jak阻害剤としての複素環置換ピロロピリジンおよびピロロピリミジン |
US9993480B2 (en) | 2011-02-18 | 2018-06-12 | Novartis Pharma Ag | mTOR/JAK inhibitor combination therapy |
EA201490042A1 (ru) | 2011-06-20 | 2014-10-30 | Инсайт Корпорейшн | Азетидинил-фенил-, пиридил- или пиразинилкарбоксамидные производные как ингибиторы jak |
WO2013023119A1 (fr) | 2011-08-10 | 2013-02-14 | Novartis Pharma Ag | Polythérapie par jak p13k/mtor |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
AR091079A1 (es) | 2012-05-18 | 2014-12-30 | Incyte Corp | Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak |
CN105732639A (zh) | 2012-06-29 | 2016-07-06 | 辉瑞大药厂 | 作为LRRK2抑制剂的4-(取代的氨基)-7H-吡咯并〔2,3-d〕嘧啶类 |
DE102012019369A1 (de) | 2012-10-02 | 2014-04-03 | Merck Patent Gmbh | 7-Azaindolderivat |
SG11201503695XA (en) | 2012-11-15 | 2015-06-29 | Incyte Corp | Sustained-release dosage forms of ruxolitinib |
HUE057262T2 (hu) | 2013-03-06 | 2022-04-28 | Incyte Holdings Corp | Eljárás és köztitermékek JAK inhibitor elõállítására |
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KR101223914B1 (ko) * | 2003-11-21 | 2013-01-18 | 어레이 바이오파마 인크. | Akt 단백질 키나제 억제제 |
AU2005236002A1 (en) * | 2004-04-02 | 2005-11-03 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of rock and other protein kinases |
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WO2006058120A1 (fr) * | 2004-11-22 | 2006-06-01 | Vertex Pharmaceuticals Incorporated | Inhibiteurs bicycliques de rho kinase |
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- 2006-12-21 WO PCT/US2006/062453 patent/WO2007076423A2/fr active Application Filing
- 2006-12-21 JP JP2008547763A patent/JP2009521504A/ja not_active Withdrawn
- 2006-12-21 EP EP06846739A patent/EP1968568A4/fr not_active Withdrawn
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JP2021500339A (ja) * | 2017-10-18 | 2021-01-07 | エイチケー イノ.エヌ コーポレーション | タンパク質キナーゼ阻害剤としての複素環化合物 |
JP7112488B2 (ja) | 2017-10-18 | 2022-08-03 | エイチケー イノ.エヌ コーポレーション | タンパク質キナーゼ阻害剤としての複素環化合物 |
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JP2021520415A (ja) * | 2018-04-04 | 2021-08-19 | エピオダイン,インク. | オピオイド受容体モジュレーター、およびそれに関連する生成物ならびに方法 |
JP7402857B2 (ja) | 2018-04-04 | 2023-12-21 | エピオダイン,インク. | オピオイド受容体モジュレーター、およびそれに関連する生成物ならびに方法 |
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EP1968568A2 (fr) | 2008-09-17 |
WO2007076423A2 (fr) | 2007-07-05 |
WO2007076423A3 (fr) | 2007-11-29 |
EP1968568A4 (fr) | 2011-04-13 |
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