JP2009520463A - Ｔｎｎのための亜鉛フィンガー結合ドメイン - Google Patents

Ｔｎｎのための亜鉛フィンガー結合ドメイン Download PDF

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JP2009520463A
JP2009520463A JP2008542539A JP2008542539A JP2009520463A JP 2009520463 A JP2009520463 A JP 2009520463A JP 2008542539 A JP2008542539 A JP 2008542539A JP 2008542539 A JP2008542539 A JP 2008542539A JP 2009520463 A JP2009520463 A JP 2009520463A
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seq
amino acid
polypeptide
domain
heptapeptide
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JP2009520463A5 (cg-RX-API-DMAC7.html
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カルロス エフ． ザ サード バーバス，
バーギット ドライア，
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ザ スクリプス リサーチ インスティテュート
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2008542539A 2005-11-28 2006-11-28 Ｔｎｎのための亜鉛フィンガー結合ドメイン Pending JP2009520463A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74052505P 2005-11-28 2005-11-28
PCT/US2006/061289 WO2007062422A2 (en) 2005-11-28 2006-11-28 Zinc finger binding domains for tnn

Publications (2)

Publication Number Publication Date
JP2009520463A true JP2009520463A (ja) 2009-05-28
JP2009520463A5 JP2009520463A5 (cg-RX-API-DMAC7.html) 2010-01-14

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JP2008542539A Pending JP2009520463A (ja) 2005-11-28 2006-11-28 Ｔｎｎのための亜鉛フィンガー結合ドメイン

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Country Link
US (1) US7833784B2 (cg-RX-API-DMAC7.html)
EP (1) EP1963499A4 (cg-RX-API-DMAC7.html)
JP (1) JP2009520463A (cg-RX-API-DMAC7.html)
CA (1) CA2631422A1 (cg-RX-API-DMAC7.html)
WO (1) WO2007062422A2 (cg-RX-API-DMAC7.html)

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US8168181B2 (en) 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
US20090081786A1 (en) * 2006-06-30 2009-03-26 Viktoria Kheifets Peptide sequences for modulation of protein kinase C
WO2009042164A1 (en) * 2007-09-27 2009-04-02 Dow Agrosciences Llc Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
CN102027118B (zh) 2008-04-30 2014-07-30 桑比欧公司 含有dna甲基化状态改变的神经再生细胞
WO2010056808A2 (en) * 2008-11-12 2010-05-20 The Regents Of The University Of California Compositions and methods for re-programming and re-differentiating cells
WO2011017315A2 (en) 2009-08-03 2011-02-10 Recombinetics, Inc. Methods and compositions for targeted gene modification
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
EP2694554A1 (en) 2011-04-08 2014-02-12 Gilead Biologics, Inc. Methods and compositions for normalization of tumor vasculature by inhibition of loxl2
JP6023218B2 (ja) 2012-01-27 2016-11-09 サンバイオ，インコーポレイティド 血管新生及び血管発生を調節するための方法及び組成物
US11120889B2 (en) 2012-05-09 2021-09-14 Georgia Tech Research Corporation Method for synthesizing a nuclease with reduced off-site cleavage
MX2015000863A (es) 2012-07-19 2016-05-05 Alethia Biotherapeutics Inc Anticuerpos anti-siglec-15.
KR102271292B1 (ko) 2013-03-15 2021-07-02 더 제너럴 하스피탈 코포레이션 Rna-안내 게놈 편집의 특이성을 증가시키기 위한 rna-안내 foki 뉴클레아제(rfn)의 용도
WO2014186435A2 (en) 2013-05-14 2014-11-20 University Of Georgia Research Foundation, Inc. Compositions and methods for reducing neointima formation
US11918695B2 (en) 2014-05-09 2024-03-05 Yale University Topical formulation of hyperbranched polymer-coated particles
EP3721875B1 (en) 2014-05-09 2023-11-08 Yale University Particles coated with hyperbranched polyglycerol and methods for their preparation
AU2017221424A1 (en) 2016-02-16 2018-09-20 Yale University Compositions and methods for treatment of cystic fibrosis
US11136597B2 (en) 2016-02-16 2021-10-05 Yale University Compositions for enhancing targeted gene editing and methods of use thereof
WO2017173453A1 (en) 2016-04-01 2017-10-05 The Brigham And Women's Hospital, Inc. Stimuli-responsive nanoparticles for biomedical applications
EP3448997B1 (en) 2016-04-27 2020-10-14 Massachusetts Institute of Technology Stable nanoscale nucleic acid assemblies and methods thereof
WO2017189914A1 (en) 2016-04-27 2017-11-02 Massachusetts Institute Of Technology Sequence-controlled polymer random access memory storage
WO2018081138A1 (en) 2016-10-24 2018-05-03 Yale University Biodegradable contraceptive implants
US11371023B2 (en) * 2016-11-22 2022-06-28 Wisconsin Alumni Research Foundation Artificial transcription factors and uses thereof
US20200085758A1 (en) 2016-12-16 2020-03-19 The Brigham And Women's Hospital, Inc. Co-delivery of nucleic acids for simultaneous suppression and expression of target genes
WO2018187493A1 (en) 2017-04-04 2018-10-11 Yale University Compositions and methods for in utero delivery
EP3612204A4 (en) 2017-04-21 2021-01-27 The General Hospital Corporation INDUCTIBLE, TUNING AND MULTIPLEX HUMAN GENE REGULATION USING CRISPR-CPF1
US10940171B2 (en) 2017-11-10 2021-03-09 Massachusetts Institute Of Technology Microbial production of pure single stranded nucleic acids
EP3713644B1 (en) 2017-11-20 2024-08-07 University of Georgia Research Foundation, Inc. Compositions and methods for modulating hif-2a to improve muscle generation and repair
AU2019269692A1 (en) * 2018-05-17 2020-11-19 The General Hospital Corporation CCCTC-binding factor variants
US11939593B2 (en) 2018-08-01 2024-03-26 University Of Georgia Research Foundation, Inc. Compositions and methods for improving embryo development
CA3111186A1 (en) 2018-08-31 2020-03-05 Yale University Compositions and methods for enhancing triplex and nuclease-based gene editing
JP7570107B2 (ja) 2018-08-31 2024-10-21 イェール ユニバーシティー ドナーオリゴヌクレオチドベースの遺伝子編集を亢進するための組成物および方法
WO2020112195A1 (en) 2018-11-30 2020-06-04 Yale University Compositions, technologies and methods of using plerixafor to enhance gene editing
US11419932B2 (en) 2019-01-24 2022-08-23 Massachusetts Institute Of Technology Nucleic acid nanostructure platform for antigen presentation and vaccine formulations formed therefrom
US11905532B2 (en) 2019-06-25 2024-02-20 Massachusetts Institute Of Technology Compositions and methods for molecular memory storage and retrieval
US12485180B2 (en) 2019-08-30 2025-12-02 Yale University Compositions and methods for delivery of nucleic acids to cells
MX2023002480A (es) 2020-08-31 2023-05-18 Univ Yale "composiciones y métodos para el suministro de ácidos nucleicos a las células.
CN117321197A (zh) 2021-01-12 2023-12-29 马奇疗法公司 背景依赖性、双链dna特异性脱氨酶及其用途
WO2022170117A1 (en) * 2021-02-04 2022-08-11 New York University Seamless integration of engineered zinc fingers into endogenous transcription factors to commandeer their natural functions
WO2023070043A1 (en) 2021-10-20 2023-04-27 Yale University Compositions and methods for targeted editing and evolution of repetitive genetic elements
US20230302423A1 (en) 2022-03-28 2023-09-28 Massachusetts Institute Of Technology Rna scaffolded wireframe origami and methods thereof
CN119584991A (zh) 2022-07-22 2025-03-07 约翰霍普金斯大学 树枝状大分子介导的靶向细胞内crispr/cas系统递送和基因编辑
WO2024081736A2 (en) 2022-10-11 2024-04-18 Yale University Compositions and methods of using cell-penetrating antibodies
JP2025540052A (ja) 2022-12-01 2025-12-11 イェール ユニバーシティー 細胞内ペイロード送達用刺激応答性トレースレス操作プラットフォーム
WO2025224715A1 (en) 2024-04-26 2025-10-30 King Abdullah Univeristy Of Science And Technology Methods for improving precise genome modification and reducing unwanted mutations by crispr-cas editing

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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2003066828A2 (en) * 2002-02-07 2003-08-14 The Scripps Research Institute Zinc finger libraries

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Publication number Publication date
EP1963499A2 (en) 2008-09-03
CA2631422A1 (en) 2007-05-31
WO2007062422A3 (en) 2008-10-23
US7833784B2 (en) 2010-11-16
WO2007062422A2 (en) 2007-05-31
US20070213269A1 (en) 2007-09-13
EP1963499A4 (en) 2009-04-08

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