JP2009519950A5 - - Google Patents
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- JP2009519950A5 JP2009519950A5 JP2008545854A JP2008545854A JP2009519950A5 JP 2009519950 A5 JP2009519950 A5 JP 2009519950A5 JP 2008545854 A JP2008545854 A JP 2008545854A JP 2008545854 A JP2008545854 A JP 2008545854A JP 2009519950 A5 JP2009519950 A5 JP 2009519950A5
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- Japan
- Prior art keywords
- composition
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- enzymes
- Prior art date
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- 239000000203 mixture Substances 0.000 claims 50
- 102000004190 Enzymes Human genes 0.000 claims 24
- 108090000790 Enzymes Proteins 0.000 claims 24
- 229940088598 enzyme Drugs 0.000 claims 24
- 239000000463 material Substances 0.000 claims 18
- 230000000694 effects Effects 0.000 claims 14
- 102000057297 Pepsin A Human genes 0.000 claims 12
- 108090000284 Pepsin A Proteins 0.000 claims 12
- 229940111202 pepsin Drugs 0.000 claims 12
- 238000011534 incubation Methods 0.000 claims 10
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 9
- 230000000977 initiatory effect Effects 0.000 claims 7
- 230000000593 degrading effect Effects 0.000 claims 6
- 239000004971 Cross linker Substances 0.000 claims 3
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical group N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims 3
- 239000003638 chemical reducing agent Substances 0.000 claims 3
- 230000007423 decrease Effects 0.000 claims 3
- 239000002245 particle Substances 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims 2
- 108010068005 Oxalate decarboxylase Proteins 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- 239000012062 aqueous buffer Substances 0.000 claims 2
- 230000015556 catabolic process Effects 0.000 claims 2
- 238000006731 degradation reaction Methods 0.000 claims 2
- ZWIBGKZDAWNIFC-UHFFFAOYSA-N disuccinimidyl suberate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCCC(=O)ON1C(=O)CCC1=O ZWIBGKZDAWNIFC-UHFFFAOYSA-N 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- LEQAOMBKQFMDFZ-UHFFFAOYSA-N glyoxal Chemical compound O=CC=O LEQAOMBKQFMDFZ-UHFFFAOYSA-N 0.000 claims 2
- 239000002861 polymer material Substances 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- OJQSISYVGFJJBY-UHFFFAOYSA-N 1-(4-isocyanatophenyl)pyrrole-2,5-dione Chemical compound C1=CC(N=C=O)=CC=C1N1C(=O)C=CC1=O OJQSISYVGFJJBY-UHFFFAOYSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 101001099381 Homo sapiens Peroxisomal biogenesis factor 19 Proteins 0.000 claims 1
- 108010063734 Oxalate oxidase Proteins 0.000 claims 1
- 102100038883 Peroxisomal biogenesis factor 19 Human genes 0.000 claims 1
- 241000219315 Spinacia Species 0.000 claims 1
- 235000009337 Spinacia oleracea Nutrition 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229940045110 chitosan Drugs 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 108010028610 formyl-coenzyme A transferase Proteins 0.000 claims 1
- 210000004051 gastric juice Anatomy 0.000 claims 1
- 229940015043 glyoxal Drugs 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 108010032737 oxalyl CoA decarboxylase Proteins 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 229960000292 pectin Drugs 0.000 claims 1
- 229920003175 pectinic acid Polymers 0.000 claims 1
- 229920000889 poly(m-phenylene isophthalamide) Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75089605P | 2005-12-16 | 2005-12-16 | |
| US60/750,896 | 2005-12-16 | ||
| PCT/US2006/047967 WO2007075447A2 (en) | 2005-12-16 | 2006-12-15 | Compositions and methods for oxalate reduction |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009519950A JP2009519950A (ja) | 2009-05-21 |
| JP2009519950A5 true JP2009519950A5 (https=) | 2010-01-21 |
| JP5558002B2 JP5558002B2 (ja) | 2014-07-23 |
Family
ID=38218470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008545854A Expired - Fee Related JP5558002B2 (ja) | 2005-12-16 | 2006-12-15 | シュウ酸塩低減化のための組成物および方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8900575B2 (https=) |
| EP (2) | EP2366402A1 (https=) |
| JP (1) | JP5558002B2 (https=) |
| CN (3) | CN101405022A (https=) |
| AT (1) | ATE499111T1 (https=) |
| AU (1) | AU2006329844B2 (https=) |
| CA (1) | CA2633238A1 (https=) |
| DE (1) | DE602006020347D1 (https=) |
| ES (1) | ES2362897T3 (https=) |
| HK (1) | HK1201151A1 (https=) |
| WO (1) | WO2007075447A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8486389B2 (en) | 1997-05-23 | 2013-07-16 | Oxthera, Inc. | Compositions and methods for treating or preventing oxalate-related disease |
| ES2362897T3 (es) | 2005-12-16 | 2011-07-14 | Oxthera, Inc. | Composiciones y métodos para reducción del oxalato. |
| PT2046373E (pt) | 2006-08-02 | 2013-05-06 | Althea Technologies Inc | Oxalato descarboxilase cristalizada e métodos de utilização |
| CN101554237B (zh) * | 2009-03-16 | 2013-11-06 | 武汉康复得生物科技有限公司 | 植物纤维或微生物不溶组分中的草酸降解酶的制备方法 |
| US8431122B2 (en) * | 2009-07-02 | 2013-04-30 | Oxthera Intellectual Property Ab | Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes |
| JP2012531186A (ja) * | 2009-07-02 | 2012-12-10 | オクステラ インテレクチュアル プロパティ エービー | 組換えオキサレート分解酵素の精製及び単離並びにオキサレート分解酵素を含む噴霧乾燥粒子 |
| DK2270138T3 (en) * | 2009-07-02 | 2018-06-25 | Oxthera Intellectual Property Ab | Purification and isolation of recombinant oxalate-degrading enzymes |
| EP2504428A4 (en) * | 2009-11-25 | 2013-09-25 | Captozyme Llc | METHODS AND COMPOSITIONS FOR TREATING OXALATE RELATED DISEASES |
| ES2703513T3 (es) * | 2011-04-07 | 2019-03-11 | Histapharm Inc | Composiciones enzimáticas orales para administración intestinal |
| WO2014113648A1 (en) | 2013-01-18 | 2014-07-24 | Allena Pharmaceuticals, Inc. | Crystallized oxalate decarboxylase and methods of use |
| DK3003358T3 (da) | 2013-06-07 | 2021-06-21 | Allena Pharmaceuticals Inc | Sammensætninger og anordninger til dialyse |
| EP3277099B9 (en) * | 2015-04-02 | 2024-05-29 | Oxidien Pharmaceuticals, Llc | High efficiency oxalate-degrading enzymes for degradation of insoluble and soluble oxalate |
| CA3023042A1 (en) | 2016-06-13 | 2017-12-21 | Oxthera Intellectual Property Ab | Compositions and methods for the treatment or prevention of oxalate-related disorders |
| WO2019092608A1 (en) * | 2017-11-08 | 2019-05-16 | Materias S.R.L. | In situ gelifying powder |
| CN114903985A (zh) * | 2021-02-10 | 2022-08-16 | 宁波倍益嘉生物科技有限公司 | 一种组合物及其在防治高草酸尿症方面的应用 |
| GB2625234A (en) * | 2021-09-09 | 2024-06-12 | Unlocked Labs Inc | Therapeutic engineered microbial cell systems and methods for treating conditions in which oxalate is detrimental |
| CN116444636B (zh) * | 2023-04-17 | 2024-02-20 | 西南大学 | 抑制核盘菌的水稻OsGLP3-6及其应用 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4205132A (en) | 1978-07-17 | 1980-05-27 | Microlife Technics, Inc. | Lyophilization of bacteria |
| DE3030185A1 (de) | 1980-08-07 | 1982-04-08 | Kohlbecker, Günther, 3000 Hannover | Verfahren zur enzymatischen entfernung von oxalat mittels oxalat-oxidase |
| DE3204284A1 (de) | 1982-02-06 | 1983-08-18 | Kohlbecker, Günther, 3000 Hannover | Verfahren zur enzymatischen entfernung von sauerstoff |
| JPS5968344A (ja) | 1982-10-12 | 1984-04-18 | Agency Of Ind Science & Technol | 非対称機能膜及びその製法 |
| US4539118A (en) | 1984-03-23 | 1985-09-03 | Sigma Chemical Company | Rapid, accurate method of separation of oxalate from urine and other biological fluids |
| US5263992A (en) | 1986-10-17 | 1993-11-23 | Bio-Metric Systems, Inc. | Biocompatible device with covalently bonded biocompatible agent |
| US5427935A (en) * | 1987-07-24 | 1995-06-27 | The Regents Of The University Of Michigan | Hybrid membrane bead and process for encapsulating materials in semi-permeable hybrid membranes |
| US5206219A (en) | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
| US5286495A (en) | 1992-05-11 | 1994-02-15 | University Of Florida | Process for microencapsulating cells |
| EP0673416A1 (en) | 1992-11-30 | 1995-09-27 | Zeneca Limited | Oxalate decarboxylase |
| EP0693884A4 (en) | 1993-04-16 | 1996-03-27 | Mccormick & Co Inc | ENCLOSURE COMPOSITIONS |
| US5554147A (en) | 1994-02-01 | 1996-09-10 | Caphco, Inc. | Compositions and devices for controlled release of active ingredients |
| US5788687A (en) | 1994-02-01 | 1998-08-04 | Caphco, Inc | Compositions and devices for controlled release of active ingredients |
| US5505713A (en) | 1994-04-01 | 1996-04-09 | Minimed Inc. | Indwelling catheter with stable enzyme coating |
| EP0764204B1 (en) | 1994-05-18 | 2001-08-22 | Human Genome Sciences, Inc. | HUMAN OXALYL-CoA DECARBOXYLASE |
| US6214980B1 (en) | 1994-06-20 | 2001-04-10 | University Of Florida | Materials and methods for detection of Oxalobacte formigenes |
| US6090628A (en) | 1994-06-20 | 2000-07-18 | University Of Florida | Materials and methods for detection of Oxalobactor formigenes |
| US5604111A (en) | 1994-06-20 | 1997-02-18 | University Of Florida Research Foundation | Method and kit for detection of oxalate |
| US5912125A (en) | 1994-06-20 | 1999-06-15 | University Of Florida | Materials and methods for detection of oxalobacter |
| US5916790A (en) * | 1995-03-03 | 1999-06-29 | Metabolex, Inc. | Encapsulation compositions, and methods |
| US6033719A (en) | 1996-04-25 | 2000-03-07 | Medtronic, Inc. | Method for covalent attachment of biomolecules to surfaces of medical devices |
| SE9603029D0 (sv) | 1996-08-20 | 1996-08-20 | Svenska Traeforskningsinst | Method for lowering the level of oxalic acid |
| US7435425B2 (en) * | 2001-07-17 | 2008-10-14 | Baxter International, Inc. | Dry hemostatic compositions and methods for their preparation |
| CA2266581C (en) * | 1996-09-19 | 2007-03-13 | The Regents Of The University Of Michigan | Polymers containing polysaccharides such as alginates or modified alginates |
| US6297425B1 (en) | 1997-03-21 | 2001-10-02 | Pioneer Hi-Bred International, Inc. | Gene encoding oxalate decarboxylase from aspergillus phoenices |
| US8486389B2 (en) * | 1997-05-23 | 2013-07-16 | Oxthera, Inc. | Compositions and methods for treating or preventing oxalate-related disease |
| US6355242B1 (en) | 1997-05-23 | 2002-03-12 | Ixion Biotechnology, Inc. | Materials and methods for treating or preventing oxalate-related disease |
| PT983076E (pt) * | 1997-05-23 | 2010-01-05 | Oxthera Inc | Microrganismos de degradação de oxalato ou enzimas de degradação de oxalato para prevenir doenças relacionadas com oxalato |
| US20040120941A1 (en) * | 1997-05-23 | 2004-06-24 | Allison Milton J. | Materials and methods for treating or preventing oxalate-related disease |
| US6161499A (en) * | 1997-07-07 | 2000-12-19 | Cvd Diamond Corporation | Apparatus and method for nucleation and deposition of diamond using hot-filament DC plasma |
| US6080404A (en) | 1997-09-05 | 2000-06-27 | University Of Florida | Materials and methods for removal of substances from fluids |
| US6566407B2 (en) | 1997-11-05 | 2003-05-20 | Geltex Pharmaceuticals, Inc. | Method for reducing oxalate |
| US5985938A (en) | 1997-11-05 | 1999-11-16 | Geltex Pharmaceuticals, Inc. | Method for reducing oxalate |
| US6203797B1 (en) | 1998-01-06 | 2001-03-20 | Stephen C. Perry | Dietary supplement and method for use as a probiotic, for alleviating the symptons associated with irritable bowel syndrome |
| AU3743099A (en) * | 1998-04-24 | 1999-11-16 | Onyx Pharmaceuticals, Inc. | Novel nucleic acids and polypeptides related to a farnesyl-directed cysteine carboxymethyltransferase |
| JP5068401B2 (ja) | 1998-09-28 | 2012-11-07 | カプスゲル・ベルギウム・ナムローゼ・フェンノートシャップ | Ｈｐｍｃカプセルを使用する腸及び結腸への送達 |
| DE69940821D1 (de) | 1998-10-09 | 2009-06-10 | Gen Mills Inc | Verkapselung empfindlicher flüssiger komponenten in eine matrix zur gewinnung diskreter lagerbeständiger partikel |
| IT1309427B1 (it) | 1999-05-28 | 2002-01-23 | Mendes S U R L | Composizione dietetica o farmaceutica utile per la prevenzione o iltrattamento dell'iperossaluria e suo uso |
| TR200103540T2 (tr) | 1999-06-07 | 2002-04-22 | Nanosphere Inc. | Partikül kaplama yöntemleri ve bu şekilde üretilen partiküller. |
| NZ526443A (en) | 2000-12-18 | 2005-03-24 | Probiohealth Llc | Probiotic compounds derived from lactobacillus casei strain KE01 |
| US7407668B2 (en) | 2002-01-24 | 2008-08-05 | Boston Scimed, Inc. | Medical articles having enzymatic surfaces for localized therapy |
| US6929940B1 (en) | 2002-08-20 | 2005-08-16 | University Of Florida Research Foundation, Inc. | Polynucleotides encoding oxalate decarboxylase from Aspergillus niger and methods of use |
| NL1021879C2 (nl) * | 2002-11-08 | 2004-05-11 | Univ Delft Tech | Werkwijze voor het bereiden van vernette enzymdeeltjes. |
| WO2005060937A1 (en) | 2003-12-23 | 2005-07-07 | Chr. Hansen A/S | Compressed tablets comprising viable probiotic microorganisms |
| EP1755655A4 (en) * | 2004-05-07 | 2011-03-30 | Oxthera Inc | METHOD AND COMPOSITIONS FOR REDUCING OXALATE CONCENTRATIONS |
| PT1962873E (pt) | 2005-12-14 | 2013-08-29 | Oxthera Inc | Composições farmacêuticas compreendendo bactérias redutoras de oxalato |
| ES2362897T3 (es) | 2005-12-16 | 2011-07-14 | Oxthera, Inc. | Composiciones y métodos para reducción del oxalato. |
| PT2046373E (pt) | 2006-08-02 | 2013-05-06 | Althea Technologies Inc | Oxalato descarboxilase cristalizada e métodos de utilização |
| US8431122B2 (en) | 2009-07-02 | 2013-04-30 | Oxthera Intellectual Property Ab | Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes |
-
2006
- 2006-12-15 ES ES06845574T patent/ES2362897T3/es active Active
- 2006-12-15 CN CNA2006800529042A patent/CN101405022A/zh active Pending
- 2006-12-15 CN CN201410277774.9A patent/CN104013581A/zh active Pending
- 2006-12-15 JP JP2008545854A patent/JP5558002B2/ja not_active Expired - Fee Related
- 2006-12-15 AU AU2006329844A patent/AU2006329844B2/en not_active Ceased
- 2006-12-15 CA CA 2633238 patent/CA2633238A1/en not_active Abandoned
- 2006-12-15 DE DE200660020347 patent/DE602006020347D1/de active Active
- 2006-12-15 EP EP20110155417 patent/EP2366402A1/en not_active Withdrawn
- 2006-12-15 EP EP20060845574 patent/EP1976553B1/en not_active Not-in-force
- 2006-12-15 WO PCT/US2006/047967 patent/WO2007075447A2/en not_active Ceased
- 2006-12-15 AT AT06845574T patent/ATE499111T1/de not_active IP Right Cessation
- 2006-12-15 US US11/640,126 patent/US8900575B2/en not_active Expired - Fee Related
- 2006-12-15 CN CN201710864034.9A patent/CN107638563A/zh active Pending
-
2014
- 2014-10-27 US US14/524,361 patent/US10272043B2/en not_active Expired - Fee Related
-
2015
- 2015-01-23 HK HK15100813.8A patent/HK1201151A1/xx unknown
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