JP2009519825A - 化学プロセスを制御するための装置及び方法 - Google Patents

化学プロセスを制御するための装置及び方法 Download PDF

Info

Publication number
JP2009519825A
JP2009519825A JP2008546608A JP2008546608A JP2009519825A JP 2009519825 A JP2009519825 A JP 2009519825A JP 2008546608 A JP2008546608 A JP 2008546608A JP 2008546608 A JP2008546608 A JP 2008546608A JP 2009519825 A JP2009519825 A JP 2009519825A
Authority
JP
Japan
Prior art keywords
fluid
reagent
barrier
conduit
precursors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008546608A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009519825A5 (enExample
Inventor
ワークマン，ヴィクトリア，ルイス
デイビス，ロバート，ヒュー
パルマー，ダニエル，デイビット
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Midatech Pharma Wales Ltd
Original Assignee
Q Chip Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Q Chip Ltd filed Critical Q Chip Ltd
Publication of JP2009519825A publication Critical patent/JP2009519825A/ja
Publication of JP2009519825A5 publication Critical patent/JP2009519825A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00833—Plastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00858—Aspects relating to the size of the reactor
    • B01J2219/0086—Dimensions of the flow channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/0095—Control aspects
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
    • Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
JP2008546608A 2005-12-20 2006-12-20 化学プロセスを制御するための装置及び方法 Pending JP2009519825A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0525951A GB2433448B (en) 2005-12-20 2005-12-20 Method for the control of chemical processes
PCT/GB2006/004830 WO2007072002A1 (en) 2005-12-20 2006-12-20 Device and method for the control of chemical processes

Publications (2)

Publication Number Publication Date
JP2009519825A true JP2009519825A (ja) 2009-05-21
JP2009519825A5 JP2009519825A5 (enExample) 2010-01-28

Family

ID=35840822

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008546608A Pending JP2009519825A (ja) 2005-12-20 2006-12-20 化学プロセスを制御するための装置及び方法

Country Status (8)

Country Link
US (1) US8722414B2 (enExample)
EP (1) EP1979085B1 (enExample)
JP (1) JP2009519825A (enExample)
AU (1) AU2006328123B2 (enExample)
CA (1) CA2671562C (enExample)
ES (1) ES2438566T3 (enExample)
GB (1) GB2433448B (enExample)
WO (1) WO2007072002A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010216984A (ja) * 2009-03-17 2010-09-30 Seiko Epson Corp 生体試料反応容器、生体試料充填装置、生体試料定量装置、及び生体試料反応方法

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006096571A2 (en) 2005-03-04 2006-09-14 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
US7776927B2 (en) 2007-03-28 2010-08-17 President And Fellows Of Harvard College Emulsions and techniques for formation
GB0722092D0 (en) * 2007-11-09 2007-12-19 Q Chip Ltd Microfluidic device and method for producing sheathed flow
JP5419251B2 (ja) * 2008-02-20 2014-02-19 富士フイルム株式会社 微粒子製造方法及び微粒子製造装置
EP2095872A1 (en) * 2008-02-29 2009-09-02 Corning Incorporated Injector assemblies and microreactors incorporating the same
WO2009119578A1 (ja) * 2008-03-25 2009-10-01 国立大学法人岡山大学 微小液滴調製装置
JP4661942B2 (ja) 2008-05-13 2011-03-30 ソニー株式会社 マイクロチップとその流路構造
GB0810990D0 (en) 2008-06-16 2008-07-23 Q Chip Ltd Device and method of making solid beads
US8435387B2 (en) 2008-11-14 2013-05-07 Massachusetts Institute Of Technology Small-scale method and apparatus for separating mixtures
US8192703B2 (en) * 2009-01-13 2012-06-05 Kobe Steel, Ltd. Reactor and reacting method
BR112012004719A2 (pt) 2009-09-02 2016-04-05 Harvard College emulsões múltiplas criadas por uso de jateamento e outras técnicas
BR112013029729A2 (pt) 2011-05-23 2017-01-24 Basf Se controle de emulsões, incluindo emulsões múltiplas
CN103764265A (zh) 2011-07-06 2014-04-30 哈佛学院院长等 多重乳剂和用于配制多重乳剂的技术
GB201113007D0 (en) 2011-07-28 2011-09-14 Q Chip Ltd Bead collection device and method
WO2015160919A1 (en) * 2014-04-16 2015-10-22 President And Fellows Of Harvard College Systems and methods for producing droplet emulsions with relatively thin shells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005046650A (ja) * 2003-05-30 2005-02-24 Fuji Photo Film Co Ltd マイクロデバイス
WO2005103106A1 (en) * 2004-04-23 2005-11-03 Eugenia Kumacheva Method of producing polymeric particles with selected size, shape, morphology and composition

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH563807A5 (en) 1973-02-14 1975-07-15 Battelle Memorial Institute Fine granules and microcapsules mfrd. from liquid droplets - partic. of high viscosity requiring forced sepn. of droplets
AU2002365284A1 (en) * 2001-11-19 2003-06-10 Mir-Chem Gmbh Device and method for producing foam
US7718099B2 (en) * 2002-04-25 2010-05-18 Tosoh Corporation Fine channel device, fine particle producing method and solvent extraction method
US7129091B2 (en) * 2002-05-09 2006-10-31 University Of Chicago Device and method for pressure-driven plug transport and reaction
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
GB2395196B (en) * 2002-11-14 2006-12-27 Univ Cardiff Microfluidic device and methods for construction and application
US7595195B2 (en) * 2003-02-11 2009-09-29 The Regents Of The University Of California Microfluidic devices for controlled viscous shearing and formation of amphiphilic vesicles
CA2521862C (en) * 2003-04-10 2012-10-16 President And Fellows Of Harvard College Formation and control of fluidic species
GB0502398D0 (en) * 2005-02-04 2005-03-16 Q Chip Ltd Device and method for producing spherical segmented flow

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005046650A (ja) * 2003-05-30 2005-02-24 Fuji Photo Film Co Ltd マイクロデバイス
WO2005103106A1 (en) * 2004-04-23 2005-11-03 Eugenia Kumacheva Method of producing polymeric particles with selected size, shape, morphology and composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010216984A (ja) * 2009-03-17 2010-09-30 Seiko Epson Corp 生体試料反応容器、生体試料充填装置、生体試料定量装置、及び生体試料反応方法

Also Published As

Publication number Publication date
AU2006328123B2 (en) 2011-03-31
CA2671562A1 (en) 2007-06-28
WO2007072002A1 (en) 2007-06-28
US8722414B2 (en) 2014-05-13
ES2438566T3 (es) 2014-01-17
AU2006328123A1 (en) 2007-06-28
GB0525951D0 (en) 2006-02-01
GB2433448B (en) 2011-03-02
EP1979085A1 (en) 2008-10-15
GB2433448A (en) 2007-06-27
CA2671562C (en) 2015-02-24
US20090054640A1 (en) 2009-02-26
EP1979085B1 (en) 2013-09-18

Similar Documents

Publication Publication Date Title
JP2009519825A (ja) 化学プロセスを制御するための装置及び方法
Su et al. Intensification of liquid–liquid two‐phase mass transfer by gas agitation in a microchannel
Li et al. Intensification of liquid–liquid two‐phase mass transfer in a capillary microreactor system
Li et al. Characterization of liquid–liquid mass transfer performance in a capillary microreactor system
JP4193561B2 (ja) 微小流路構造体、これを用いた微小粒子製造方法及び微小流路構造体による溶媒抽出方法
Jafari et al. Liquid–liquid extraction in twisted micromixers
TWI499552B (zh) 液滴產生方法及裝置
Wang et al. Gas/liquid/liquid three‐phase flow patterns and bubble/droplet size laws in a double T‐junction microchannel
US20210370303A1 (en) Pressure insensitive microfluidic circuit for droplet generation and uses thereof
JP2011508657A (ja) プロセス強化マイクロ流体装置
Asano et al. Chaotic-flow-driven mixing in T-and V-shaped micromixers
Boskovic et al. Synthesis of polymer particles and capsules employing microfluidic techniques
Zhou et al. Microreaction system combining chaotic micromixing with fast mixing and particle growth in liquid-segmented flow for the synthesis of hazardous ionic materials
JP2004358453A (ja) 微小流路構造体及びそれを用いた流体の化学操作方法
JP5146562B2 (ja) 微小流路構造体及び微小流路構造体による溶媒抽出方法
Asano et al. Design protocol of microjet mixers for achieving desirable mixing times with arbitrary flow rate ratios
Tan et al. Surfactant‐free microdispersion process of gas in organic solvents in microfluidic devices
JP2008528284A (ja) 球状体にセグメント化したフローを形成するための装置及び方法
Aoki et al. Design and operation of gas–liquid slug flow in miniaturized channels for rapid mass transfer
Vir et al. Phase transfer catalysis in a microchannel: Paradoxical effect of transition from kinetic control to mass transfer control
Kölbl et al. On the use of the Iodide Iodate Reaction Method for assessing mixing times in continuous flow mixers
JP4460944B2 (ja) マイクロ化学デバイス
JP4743165B2 (ja) 微小流路構造体
Hereijgers et al. Chromatography as an inspiration for microreactors
CN205188308U (zh) 一种制造组织工程微模块的微流控芯片

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091120

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20091120

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20101220

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110126

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110426

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110509

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110520

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120404

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120626

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120703

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120824

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120831

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20121212