JP2009517814A5 - - Google Patents
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- Publication number
- JP2009517814A5 JP2009517814A5 JP2008542497A JP2008542497A JP2009517814A5 JP 2009517814 A5 JP2009517814 A5 JP 2009517814A5 JP 2008542497 A JP2008542497 A JP 2008542497A JP 2008542497 A JP2008542497 A JP 2008542497A JP 2009517814 A5 JP2009517814 A5 JP 2009517814A5
- Authority
- JP
- Japan
- Prior art keywords
- ion
- ions
- drift tube
- region
- mobility spectrometer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002500 ions Chemical class 0.000 claims description 329
- 230000004913 activation Effects 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 22
- 230000005684 electric field Effects 0.000 claims description 21
- 230000001939 inductive effect Effects 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 8
- 238000000926 separation method Methods 0.000 claims description 2
- 238000001228 spectrum Methods 0.000 claims description 2
- 239000007789 gas Substances 0.000 claims 47
- 238000013467 fragmentation Methods 0.000 claims 13
- 238000006062 fragmentation reaction Methods 0.000 claims 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 6
- 239000001307 helium Substances 0.000 claims 4
- 229910052734 helium Inorganic materials 0.000 claims 4
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 3
- 229910001873 dinitrogen Inorganic materials 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 239000012460 protein solution Substances 0.000 claims 2
- 230000003595 spectral effect Effects 0.000 claims 2
- 230000003213 activating effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000010884 ion-beam technique Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000009825 accumulation Methods 0.000 description 3
- 238000000951 ion mobility spectrometry-mass spectrometry Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/286,608 | 2005-11-23 | ||
| US11/286,608 US20070114382A1 (en) | 2005-11-23 | 2005-11-23 | Ion mobility spectrometer |
| PCT/US2006/060902 WO2007062303A2 (en) | 2005-11-23 | 2006-11-15 | Ion mobility spectrometer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009517814A JP2009517814A (ja) | 2009-04-30 |
| JP2009517814A5 true JP2009517814A5 (enExample) | 2013-10-31 |
| JP5449777B2 JP5449777B2 (ja) | 2014-03-19 |
Family
ID=38052531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008542497A Active JP5449777B2 (ja) | 2005-11-23 | 2006-11-15 | イオン移動度スペクトロメータ |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20070114382A1 (enExample) |
| EP (1) | EP1952421B1 (enExample) |
| JP (1) | JP5449777B2 (enExample) |
| CA (1) | CA2629373C (enExample) |
| WO (1) | WO2007062303A2 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070114382A1 (en) | 2005-11-23 | 2007-05-24 | Clemmer David E | Ion mobility spectrometer |
| US8884221B2 (en) * | 2006-01-05 | 2014-11-11 | Excellims Corporation | High performance ion mobility spectrometer apparatus and methods |
| US9859105B2 (en) * | 2006-02-14 | 2018-01-02 | Excellims Corporation | Multiple ion gate method and apparatus |
| US7997119B2 (en) | 2006-04-18 | 2011-08-16 | Excellims Corporation | Chemical sampling and multi-function detection methods and apparatus |
| GB0613900D0 (en) * | 2006-07-13 | 2006-08-23 | Micromass Ltd | Mass spectrometer |
| GB0622780D0 (en) * | 2006-11-15 | 2006-12-27 | Micromass Ltd | Mass spectrometer |
| JP4862738B2 (ja) * | 2007-05-08 | 2012-01-25 | 株式会社日立製作所 | イオン移動度分析装置およびイオン移動度分離／質量分析複合装置 |
| US7671344B2 (en) * | 2007-08-31 | 2010-03-02 | Battelle Memorial Institute | Low pressure electrospray ionization system and process for effective transmission of ions |
| US8173960B2 (en) * | 2007-08-31 | 2012-05-08 | Battelle Memorial Institute | Low pressure electrospray ionization system and process for effective transmission of ions |
| CN104849342B (zh) * | 2007-12-27 | 2019-07-30 | 同方威视技术股份有限公司 | 离子迁移谱仪及其方法 |
| US8026475B2 (en) * | 2008-08-19 | 2011-09-27 | Thermo Finnigan Llc | Method and apparatus for a dual gate for a mass spectrometer |
| CN102315076B (zh) * | 2010-07-05 | 2014-08-27 | 同方威视技术股份有限公司 | 离子迁移管 |
| EP2643845B1 (en) * | 2010-11-26 | 2022-03-30 | Analytik Jena GmbH | Improvements in or relating to mass spectrometry |
| US8581177B2 (en) * | 2011-04-11 | 2013-11-12 | Thermo Finnigan Llc | High duty cycle ion storage/ion mobility separation mass spectrometer |
| GB201205009D0 (en) * | 2012-03-22 | 2012-05-09 | Micromass Ltd | Multi-dimensional survey scans for improved data dependent acquisitions (DDA) |
| US9281173B2 (en) * | 2013-05-30 | 2016-03-08 | Agilent Technologies, Inc. | Ion processing utilizing segmented vacuum manifold |
| US10234423B2 (en) | 2013-09-26 | 2019-03-19 | Indiana University Research And Technology Corporation | Hybrid ion mobility spectrometer |
| US9683965B2 (en) | 2013-09-26 | 2017-06-20 | Indiana University Research And Technology Corporation | Hybrid ion mobility spectrometer |
| WO2015136274A1 (en) | 2014-03-10 | 2015-09-17 | Micromass Uk Limited | Theoretical collision cross section ("ccs") in experimental design |
| GB201404195D0 (en) * | 2014-03-10 | 2014-04-23 | Micromass Ltd | Confirmation using multiple CCS measurements |
| US9324548B1 (en) * | 2014-05-08 | 2016-04-26 | Bruker Daltonik Gmbh | Method and device to increase the internal energy of ions in mass spectrometers |
| GB201410258D0 (en) * | 2014-06-10 | 2014-07-23 | Micromass Ltd | Segmented linear ion mobility spectrometer driver |
| US9995712B2 (en) | 2014-06-10 | 2018-06-12 | Micromass Uk Limited | Segmented linear ion mobility spectrometer driver |
| GB2531292B (en) * | 2014-10-14 | 2019-06-12 | Smiths Detection Watford Ltd | Method and apparatus |
| US10551348B2 (en) * | 2014-11-17 | 2020-02-04 | Shimadzu Corporation | Ion mobility spectrometer |
| WO2017042918A1 (ja) * | 2015-09-09 | 2017-03-16 | 株式会社島津製作所 | イオン移動度分析装置 |
| US11480178B2 (en) | 2016-04-27 | 2022-10-25 | Mark W. Wood | Multistage compressor system with intercooler |
| WO2018084868A1 (en) | 2016-11-07 | 2018-05-11 | Wood Mark W | Scroll compressor with circular surface terminations |
| US10030658B2 (en) | 2016-04-27 | 2018-07-24 | Mark W. Wood | Concentric vane compressor |
| CN109416343B (zh) * | 2016-06-30 | 2022-10-28 | 沃特世科技公司 | 碰撞截面碎片离子的化学类组合物 |
| US10801992B2 (en) | 2016-10-19 | 2020-10-13 | Indiana University Research And Technology Corporation | Drift tubes, ion mobility spectrometers systems, and methods of classifying charged particles |
| US11686309B2 (en) | 2016-11-07 | 2023-06-27 | Mark W. Wood | Scroll compressor with circular surface terminations |
| US10049868B2 (en) * | 2016-12-06 | 2018-08-14 | Rapiscan Systems, Inc. | Apparatus for detecting constituents in a sample and method of using the same |
| US10241079B2 (en) * | 2017-05-24 | 2019-03-26 | Bruker Daltonik Gmbh | Mass spectrometer with tandem ion mobility analyzers |
| US10794861B2 (en) | 2018-02-23 | 2020-10-06 | Bruker Scientific Llc | Tandem ion mobility spectrometer |
| GB201810273D0 (en) * | 2018-06-22 | 2018-08-08 | Thermo Fisher Scient Bremen Gmbh | Structural analysis of ionised molecules |
| GB201904425D0 (en) * | 2019-03-29 | 2019-05-15 | Micromass Ltd | Method of selecting ions |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3668383A (en) * | 1969-01-09 | 1972-06-06 | Franklin Gno Corp | Apparatus and methods for separating, detecting, and measuring trace gases |
| US4744043A (en) | 1985-03-25 | 1988-05-10 | Motorola, Inc. | Data processor execution unit which receives data with reduced instruction overhead |
| GB2217103B (en) * | 1988-04-06 | 1992-09-23 | Graseby Ionics Ltd | Ion mobility detector |
| US5095206A (en) * | 1990-06-01 | 1992-03-10 | Environmental Technologies Group, Inc. | Method and apparatus for improving the specificity of an ion mobility spectrometer utillizing sulfur dioxide dopant chemistry |
| US5096206A (en) * | 1990-06-01 | 1992-03-17 | W. E. Hall Company | Pipe joint sealer |
| US6323482B1 (en) * | 1997-06-02 | 2001-11-27 | Advanced Research And Technology Institute, Inc. | Ion mobility and mass spectrometer |
| US6960761B2 (en) * | 1997-06-02 | 2005-11-01 | Advanced Research & Technology Institute | Instrument for separating ions in time as functions of preselected ion mobility and ion mass |
| US6744043B2 (en) * | 2000-12-08 | 2004-06-01 | Mds Inc. | Ion mobilty spectrometer incorporating an ion guide in combination with an MS device |
| US6583408B2 (en) * | 2001-05-18 | 2003-06-24 | Battelle Memorial Institute | Ionization source utilizing a jet disturber in combination with an ion funnel and method of operation |
| US6630662B1 (en) * | 2002-04-24 | 2003-10-07 | Mds Inc. | Setup for mobility separation of ions implementing an ion guide with an axial field and counterflow of gas |
| EP1676291B1 (en) * | 2003-10-20 | 2013-04-24 | Ionwerks, Inc. | Ion mobility tof/maldi/ms using drift cell alternating high and low electric field regions |
| US6967325B2 (en) * | 2003-10-30 | 2005-11-22 | Battelle Memorial Institute | High performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel |
| US6818890B1 (en) * | 2003-10-30 | 2004-11-16 | Battelle Memorial Institute | High performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel |
| EP1690074A2 (en) * | 2003-11-25 | 2006-08-16 | Sionex Corporation | Mobility based apparatus and methods using dispersion characteristics, sample fragmentation, and/or pressure control to improve analysis of a sample |
| US7388195B2 (en) * | 2004-09-30 | 2008-06-17 | Charles Stark Draper Laboratory, Inc. | Apparatus and systems for processing samples for analysis via ion mobility spectrometry |
| JP4513488B2 (ja) * | 2004-10-06 | 2010-07-28 | 株式会社日立製作所 | イオンモビリティー分析装置及びイオンモビリティー分析方法 |
| US7170053B2 (en) * | 2005-03-31 | 2007-01-30 | Battelle Memorial Institute | Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD) |
| US20070114382A1 (en) | 2005-11-23 | 2007-05-24 | Clemmer David E | Ion mobility spectrometer |
-
2005
- 2005-11-23 US US11/286,608 patent/US20070114382A1/en not_active Abandoned
-
2006
- 2006-11-15 CA CA2629373A patent/CA2629373C/en active Active
- 2006-11-15 JP JP2008542497A patent/JP5449777B2/ja active Active
- 2006-11-15 EP EP06839885.8A patent/EP1952421B1/en active Active
- 2006-11-15 WO PCT/US2006/060902 patent/WO2007062303A2/en not_active Ceased
-
2011
- 2011-03-02 US US13/038,544 patent/US8618475B2/en active Active
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