CA2629373C - Ion mobility spectrometer - Google Patents

Ion mobility spectrometer Download PDF

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Publication number
CA2629373C
CA2629373C CA2629373A CA2629373A CA2629373C CA 2629373 C CA2629373 C CA 2629373C CA 2629373 A CA2629373 A CA 2629373A CA 2629373 A CA2629373 A CA 2629373A CA 2629373 C CA2629373 C CA 2629373C
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Canada
Prior art keywords
ion
ions
drift tube
funnel
region
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CA2629373A
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English (en)
French (fr)
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CA2629373A1 (en
Inventor
David E. Clemmer
Stormy L. Koeniger
Stephen J. Valentine
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Indiana University Research and Technology Corp
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Indiana University Research and Technology Corp
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Publication of CA2629373A1 publication Critical patent/CA2629373A1/en
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/623—Ion mobility spectrometry combined with mass spectrometry

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CA2629373A 2005-11-23 2006-11-15 Ion mobility spectrometer Active CA2629373C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/286,608 2005-11-23
US11/286,608 US20070114382A1 (en) 2005-11-23 2005-11-23 Ion mobility spectrometer
PCT/US2006/060902 WO2007062303A2 (en) 2005-11-23 2006-11-15 Ion mobility spectrometer

Publications (2)

Publication Number Publication Date
CA2629373A1 CA2629373A1 (en) 2007-05-31
CA2629373C true CA2629373C (en) 2014-09-23

Family

ID=38052531

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2629373A Active CA2629373C (en) 2005-11-23 2006-11-15 Ion mobility spectrometer

Country Status (5)

Country Link
US (2) US20070114382A1 (enExample)
EP (1) EP1952421B1 (enExample)
JP (1) JP5449777B2 (enExample)
CA (1) CA2629373C (enExample)
WO (1) WO2007062303A2 (enExample)

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US20070114382A1 (en) 2005-11-23 2007-05-24 Clemmer David E Ion mobility spectrometer
US8884221B2 (en) * 2006-01-05 2014-11-11 Excellims Corporation High performance ion mobility spectrometer apparatus and methods
US9859105B2 (en) * 2006-02-14 2018-01-02 Excellims Corporation Multiple ion gate method and apparatus
CA2649186A1 (en) 2006-04-18 2008-05-22 Excellims Corporation Chemical sampling and multi-function detection methods and apparatus
GB0613900D0 (en) * 2006-07-13 2006-08-23 Micromass Ltd Mass spectrometer
GB0622780D0 (en) 2006-11-15 2006-12-27 Micromass Ltd Mass spectrometer
JP4862738B2 (ja) * 2007-05-08 2012-01-25 株式会社日立製作所 イオン移動度分析装置およびイオン移動度分離／質量分析複合装置
US8173960B2 (en) * 2007-08-31 2012-05-08 Battelle Memorial Institute Low pressure electrospray ionization system and process for effective transmission of ions
US7671344B2 (en) * 2007-08-31 2010-03-02 Battelle Memorial Institute Low pressure electrospray ionization system and process for effective transmission of ions
CN104849342B (zh) * 2007-12-27 2019-07-30 同方威视技术股份有限公司 离子迁移谱仪及其方法
US8026475B2 (en) * 2008-08-19 2011-09-27 Thermo Finnigan Llc Method and apparatus for a dual gate for a mass spectrometer
CN102315076B (zh) * 2010-07-05 2014-08-27 同方威视技术股份有限公司 离子迁移管
CA2818001A1 (en) * 2010-11-26 2012-05-31 Bruker Biosciences Pty Ltd Improvements in or relating to mass spectrometry
US8581177B2 (en) * 2011-04-11 2013-11-12 Thermo Finnigan Llc High duty cycle ion storage/ion mobility separation mass spectrometer
GB201205009D0 (en) * 2012-03-22 2012-05-09 Micromass Ltd Multi-dimensional survey scans for improved data dependent acquisitions (DDA)
US9281173B2 (en) * 2013-05-30 2016-03-08 Agilent Technologies, Inc. Ion processing utilizing segmented vacuum manifold
WO2015048014A1 (en) * 2013-09-26 2015-04-02 Indiana University Research And Technology Corporation Hybrid ion mobility spectrometer
US10234423B2 (en) 2013-09-26 2019-03-19 Indiana University Research And Technology Corporation Hybrid ion mobility spectrometer
GB201404195D0 (en) * 2014-03-10 2014-04-23 Micromass Ltd Confirmation using multiple CCS measurements
US10438783B2 (en) 2014-03-10 2019-10-08 Micromass Uk Limited Theoretical collision cross section (“CCS”) in experimental design
US9324548B1 (en) * 2014-05-08 2016-04-26 Bruker Daltonik Gmbh Method and device to increase the internal energy of ions in mass spectrometers
GB201410258D0 (en) * 2014-06-10 2014-07-23 Micromass Ltd Segmented linear ion mobility spectrometer driver
US9995712B2 (en) 2014-06-10 2018-06-12 Micromass Uk Limited Segmented linear ion mobility spectrometer driver
GB2531292B (en) * 2014-10-14 2019-06-12 Smiths Detection Watford Ltd Method and apparatus
US10551348B2 (en) * 2014-11-17 2020-02-04 Shimadzu Corporation Ion mobility spectrometer
JP6460248B2 (ja) * 2015-09-09 2019-01-30 株式会社島津製作所 イオン移動度分析装置
WO2018084868A1 (en) 2016-11-07 2018-05-11 Wood Mark W Scroll compressor with circular surface terminations
US11480178B2 (en) 2016-04-27 2022-10-25 Mark W. Wood Multistage compressor system with intercooler
US10030658B2 (en) 2016-04-27 2018-07-24 Mark W. Wood Concentric vane compressor
WO2018005948A1 (en) * 2016-06-30 2018-01-04 Waters Technologies Corporation Chemical class compositions from collision cross-section fragment ions
WO2018075821A1 (en) * 2016-10-19 2018-04-26 Indiana University Research And Technology Corporation Drift tubes, ion mobility spectrometers systems, and methods of classifying charged particles
US11686309B2 (en) 2016-11-07 2023-06-27 Mark W. Wood Scroll compressor with circular surface terminations
US10049868B2 (en) * 2016-12-06 2018-08-14 Rapiscan Systems, Inc. Apparatus for detecting constituents in a sample and method of using the same
US10241079B2 (en) * 2017-05-24 2019-03-26 Bruker Daltonik Gmbh Mass spectrometer with tandem ion mobility analyzers
US10794861B2 (en) 2018-02-23 2020-10-06 Bruker Scientific Llc Tandem ion mobility spectrometer
GB201810273D0 (en) * 2018-06-22 2018-08-08 Thermo Fisher Scient Bremen Gmbh Structural analysis of ionised molecules
GB201904425D0 (en) * 2019-03-29 2019-05-15 Micromass Ltd Method of selecting ions

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Publication number Priority date Publication date Assignee Title
US3668383A (en) * 1969-01-09 1972-06-06 Franklin Gno Corp Apparatus and methods for separating, detecting, and measuring trace gases
US4744043A (en) 1985-03-25 1988-05-10 Motorola, Inc. Data processor execution unit which receives data with reduced instruction overhead
GB2217103B (en) * 1988-04-06 1992-09-23 Graseby Ionics Ltd Ion mobility detector
US5096206A (en) * 1990-06-01 1992-03-17 W. E. Hall Company Pipe joint sealer
US5095206A (en) * 1990-06-01 1992-03-10 Environmental Technologies Group, Inc. Method and apparatus for improving the specificity of an ion mobility spectrometer utillizing sulfur dioxide dopant chemistry
US6960761B2 (en) * 1997-06-02 2005-11-01 Advanced Research & Technology Institute Instrument for separating ions in time as functions of preselected ion mobility and ion mass
US6323482B1 (en) * 1997-06-02 2001-11-27 Advanced Research And Technology Institute, Inc. Ion mobility and mass spectrometer
CA2364676C (en) * 2000-12-08 2010-07-27 Mds Inc., Doing Business As Mds Sciex Ion mobility spectrometer incorporating an ion guide in combination with an ms device
US6583408B2 (en) * 2001-05-18 2003-06-24 Battelle Memorial Institute Ionization source utilizing a jet disturber in combination with an ion funnel and method of operation
US6630662B1 (en) * 2002-04-24 2003-10-07 Mds Inc. Setup for mobility separation of ions implementing an ion guide with an axial field and counterflow of gas
CA2542869A1 (en) * 2003-10-20 2005-05-12 Ionwerks, Inc. Ion mobility tof/maldi/ms using drift cell alternating high and low electrical field regions
US6967325B2 (en) * 2003-10-30 2005-11-22 Battelle Memorial Institute High performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel
US6818890B1 (en) * 2003-10-30 2004-11-16 Battelle Memorial Institute High performance ion mobility spectrometry using hourglass electrodynamic funnel and internal ion funnel
CA2547389A1 (en) * 2003-11-25 2005-06-09 Sionex Corporation Mobility based apparatus and methods using dispersion characteristics, sample fragmentation, and/or pressure control to improve analysis of a sample
US7388195B2 (en) * 2004-09-30 2008-06-17 Charles Stark Draper Laboratory, Inc. Apparatus and systems for processing samples for analysis via ion mobility spectrometry
JP4513488B2 (ja) * 2004-10-06 2010-07-28 株式会社日立製作所 イオンモビリティー分析装置及びイオンモビリティー分析方法
US7170053B2 (en) * 2005-03-31 2007-01-30 Battelle Memorial Institute Method and apparatus for ion mobility spectrometry with alignment of dipole direction (IMS-ADD)
US20070114382A1 (en) 2005-11-23 2007-05-24 Clemmer David E Ion mobility spectrometer

Also Published As

Publication number Publication date
US20070114382A1 (en) 2007-05-24
JP2009517814A (ja) 2009-04-30
US20110198493A1 (en) 2011-08-18
EP1952421B1 (en) 2021-03-17
WO2007062303A3 (en) 2008-07-03
CA2629373A1 (en) 2007-05-31
WO2007062303A2 (en) 2007-05-31
JP5449777B2 (ja) 2014-03-19
US8618475B2 (en) 2013-12-31
EP1952421A4 (en) 2010-10-27
EP1952421A2 (en) 2008-08-06

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