JP2009517390A5 - - Google Patents
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- Publication number
- JP2009517390A5 JP2009517390A5 JP2008542451A JP2008542451A JP2009517390A5 JP 2009517390 A5 JP2009517390 A5 JP 2009517390A5 JP 2008542451 A JP2008542451 A JP 2008542451A JP 2008542451 A JP2008542451 A JP 2008542451A JP 2009517390 A5 JP2009517390 A5 JP 2009517390A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- mapk
- inhibition
- compound
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 COc(cc1)ccc1N(C=C(*)C=C1)C1=O Chemical compound COc(cc1)ccc1N(C=C(*)C=C1)C1=O 0.000 description 2
- CVSLRGSGSRWNHX-UHFFFAOYSA-N O=C(C=Cc1c2)N(c3ccccc3)c1ccc2Br Chemical compound O=C(C=Cc1c2)N(c3ccccc3)c1ccc2Br CVSLRGSGSRWNHX-UHFFFAOYSA-N 0.000 description 1
- YWURBGXZPRESCI-UHFFFAOYSA-N Oc(cc1)ccc1N(C=C(C=C1)Br)C1=O Chemical compound Oc(cc1)ccc1N(C=C(C=C1)Br)C1=O YWURBGXZPRESCI-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73931505P | 2005-11-23 | 2005-11-23 | |
| US77582306P | 2006-02-21 | 2006-02-21 | |
| US79352606P | 2006-04-20 | 2006-04-20 | |
| PCT/US2006/045287 WO2007062167A2 (en) | 2005-11-23 | 2006-11-22 | Method of modulating stress-activated protein kinase system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009517390A JP2009517390A (ja) | 2009-04-30 |
| JP2009517390A5 true JP2009517390A5 (https=) | 2009-11-26 |
Family
ID=38067929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008542451A Withdrawn JP2009517390A (ja) | 2005-11-23 | 2006-11-22 | ストレス活性化プロテインキナーゼ系を調節する方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20110034495A1 (https=) |
| EP (2) | EP1960405A2 (https=) |
| JP (1) | JP2009517390A (https=) |
| KR (1) | KR20080076968A (https=) |
| AU (1) | AU2006318428A1 (https=) |
| BR (1) | BRPI0618939A2 (https=) |
| CA (1) | CA2630752A1 (https=) |
| WO (1) | WO2007062167A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2524922T3 (es) | 2005-05-10 | 2014-12-15 | Intermune, Inc. | Derivados de piridona para modular el sistema de proteína cinasa activada por estrés |
| MX2007009796A (es) | 2007-08-14 | 2009-02-25 | Cell Therapy And Technology S | Gel conteniendo pirfenidona. |
| CA2726588C (en) | 2008-06-03 | 2019-04-16 | Karl Kossen | Compounds and methods for treating inflammatory and fibrotic disorders |
| US7635707B1 (en) | 2008-11-10 | 2009-12-22 | Intermune, Inc. | Pirfenidone treatment for patients with atypical liver function |
| WO2010132864A1 (en) * | 2009-05-15 | 2010-11-18 | Intermune, Inc. | Methods of treating hiv patients with anti-fibrotics |
| EP2474533B1 (en) | 2009-05-25 | 2015-02-25 | Central South University | Preparation of 1-(substituted benzyl)-5-trifluoromethyl-2-(1h)pyridone compounds and salts thereof and their applications |
| WO2010135972A1 (zh) | 2009-05-25 | 2010-12-02 | 中南大学 | 1-(取代芳基)-5-三氟甲基-2-（1h）吡啶酮化合物及其盐的制备方法及其用途 |
| GB0921730D0 (en) * | 2009-12-11 | 2010-01-27 | Respivert Ltd | Method of treatment |
| US10105356B2 (en) | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| JP6021117B2 (ja) | 2011-01-31 | 2016-11-02 | ジェノア ファーマシューティカルズ，インク． | エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用 |
| MX2011007675A (es) | 2011-07-19 | 2012-07-11 | Cell Therapy And Technology S A De C V | Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas. |
| MX346763B (es) | 2012-03-28 | 2017-03-31 | Cell Therapy And Tech S A De C V | Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné. |
| MX356551B (es) | 2012-08-23 | 2018-06-04 | Grupo Medifarma S A De C V Star | Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné. |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| EP3842424B1 (en) | 2013-03-15 | 2024-12-11 | The Trustees of Columbia University in the City of New York | Map kinase modulators and uses thereof in the tretament of tauopathies |
| NZ760541A (en) | 2014-01-10 | 2022-08-26 | Avalyn Pharma Inc | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| AU2017225907B2 (en) * | 2016-03-01 | 2023-11-23 | Celosia Therapeutics Pty Ltd | Use of phosphorylated tau and p38gamma to treat a neurological condition |
| PT3724196T (pt) | 2017-12-15 | 2023-01-13 | Union Therapeutics As | Azetidina di-hidrotienopiridinas substituídas e a sua utilização como inibidores de fosfodiesterase |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0906307B1 (en) * | 1996-06-10 | 2005-04-27 | Merck & Co., Inc. | Substituted imidazoles having cytokine inhibitory activity |
| GB0124848D0 (en) * | 2001-10-16 | 2001-12-05 | Celltech R&D Ltd | Chemical compounds |
| GB0214268D0 (en) * | 2002-06-20 | 2002-07-31 | Celltech R&D Ltd | Chemical compounds |
| EP1641804A1 (en) * | 2003-06-20 | 2006-04-05 | Celltech R & D Limited | Thienopyridone derivatives as kinase inhibitors |
-
2006
- 2006-11-22 JP JP2008542451A patent/JP2009517390A/ja not_active Withdrawn
- 2006-11-22 BR BRPI0618939-3A patent/BRPI0618939A2/pt not_active IP Right Cessation
- 2006-11-22 EP EP06844534A patent/EP1960405A2/en not_active Withdrawn
- 2006-11-22 AU AU2006318428A patent/AU2006318428A1/en not_active Abandoned
- 2006-11-22 KR KR1020087015085A patent/KR20080076968A/ko not_active Ceased
- 2006-11-22 WO PCT/US2006/045287 patent/WO2007062167A2/en not_active Ceased
- 2006-11-22 US US12/094,230 patent/US20110034495A1/en not_active Abandoned
- 2006-11-22 EP EP11006568A patent/EP2426134A3/en not_active Withdrawn
- 2006-11-22 CA CA002630752A patent/CA2630752A1/en not_active Abandoned
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