AU2006318428A1 - Method of modulating stress-activated protein kinase system - Google Patents

Method of modulating stress-activated protein kinase system Download PDF

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Publication number
AU2006318428A1
AU2006318428A1 AU2006318428A AU2006318428A AU2006318428A1 AU 2006318428 A1 AU2006318428 A1 AU 2006318428A1 AU 2006318428 A AU2006318428 A AU 2006318428A AU 2006318428 A AU2006318428 A AU 2006318428A AU 2006318428 A1 AU2006318428 A1 AU 2006318428A1
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Australia
Prior art keywords
optionally substituted
mapk
inhibition
compound
range
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AU2006318428A
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English (en)
Inventor
Karl Kossen
Scott D. Seiwert
Vladimir Serebryany
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Intermune Inc
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Intermune Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
AU2006318428A 2005-11-23 2006-11-22 Method of modulating stress-activated protein kinase system Abandoned AU2006318428A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US73931505P 2005-11-23 2005-11-23
US60/739,315 2005-11-23
US77582306P 2006-02-21 2006-02-21
US60/775,823 2006-02-21
US79352606P 2006-04-20 2006-04-20
US60/793,526 2006-04-20
PCT/US2006/045287 WO2007062167A2 (en) 2005-11-23 2006-11-22 Method of modulating stress-activated protein kinase system

Publications (1)

Publication Number Publication Date
AU2006318428A1 true AU2006318428A1 (en) 2007-05-31

Family

ID=38067929

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006318428A Abandoned AU2006318428A1 (en) 2005-11-23 2006-11-22 Method of modulating stress-activated protein kinase system

Country Status (8)

Country Link
US (1) US20110034495A1 (https=)
EP (2) EP1960405A2 (https=)
JP (1) JP2009517390A (https=)
KR (1) KR20080076968A (https=)
AU (1) AU2006318428A1 (https=)
BR (1) BRPI0618939A2 (https=)
CA (1) CA2630752A1 (https=)
WO (1) WO2007062167A2 (https=)

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ES2524922T3 (es) 2005-05-10 2014-12-15 Intermune, Inc. Derivados de piridona para modular el sistema de proteína cinasa activada por estrés
MX2007009796A (es) 2007-08-14 2009-02-25 Cell Therapy And Technology S Gel conteniendo pirfenidona.
CA2726588C (en) 2008-06-03 2019-04-16 Karl Kossen Compounds and methods for treating inflammatory and fibrotic disorders
US7635707B1 (en) 2008-11-10 2009-12-22 Intermune, Inc. Pirfenidone treatment for patients with atypical liver function
WO2010132864A1 (en) * 2009-05-15 2010-11-18 Intermune, Inc. Methods of treating hiv patients with anti-fibrotics
EP2474533B1 (en) 2009-05-25 2015-02-25 Central South University Preparation of 1-(substituted benzyl)-5-trifluoromethyl-2-(1h)pyridone compounds and salts thereof and their applications
WO2010135972A1 (zh) 2009-05-25 2010-12-02 中南大学 1-(取代芳基)-5-三氟甲基-2-（1h）吡啶酮化合物及其盐的制备方法及其用途
GB0921730D0 (en) * 2009-12-11 2010-01-27 Respivert Ltd Method of treatment
US10105356B2 (en) 2011-01-31 2018-10-23 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
JP6021117B2 (ja) 2011-01-31 2016-11-02 ジェノア ファーマシューティカルズ，インク． エアロゾルのピルフェニドンおよびピリドンアナログの化合物、および、その使用
MX2011007675A (es) 2011-07-19 2012-07-11 Cell Therapy And Technology S A De C V Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas.
MX346763B (es) 2012-03-28 2017-03-31 Cell Therapy And Tech S A De C V Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné.
MX356551B (es) 2012-08-23 2018-06-04 Grupo Medifarma S A De C V Star Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné.
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
EP3842424B1 (en) 2013-03-15 2024-12-11 The Trustees of Columbia University in the City of New York Map kinase modulators and uses thereof in the tretament of tauopathies
NZ760541A (en) 2014-01-10 2022-08-26 Avalyn Pharma Inc Aerosol pirfenidone and pyridone analog compounds and uses thereof
MX382781B (es) 2014-04-02 2025-03-13 Intermune Inc Piridinonas anti-fibroticas.
AU2017225907B2 (en) * 2016-03-01 2023-11-23 Celosia Therapeutics Pty Ltd Use of phosphorylated tau and p38gamma to treat a neurological condition
PT3724196T (pt) 2017-12-15 2023-01-13 Union Therapeutics As Azetidina di-hidrotienopiridinas substituídas e a sua utilização como inibidores de fosfodiesterase

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Publication number Priority date Publication date Assignee Title
EP0906307B1 (en) * 1996-06-10 2005-04-27 Merck & Co., Inc. Substituted imidazoles having cytokine inhibitory activity
GB0124848D0 (en) * 2001-10-16 2001-12-05 Celltech R&D Ltd Chemical compounds
GB0214268D0 (en) * 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
EP1641804A1 (en) * 2003-06-20 2006-04-05 Celltech R & D Limited Thienopyridone derivatives as kinase inhibitors

Also Published As

Publication number Publication date
CA2630752A1 (en) 2007-05-31
BRPI0618939A2 (pt) 2011-09-13
EP1960405A2 (en) 2008-08-27
KR20080076968A (ko) 2008-08-20
WO2007062167A2 (en) 2007-05-31
WO2007062167A3 (en) 2007-11-15
EP2426134A3 (en) 2012-07-04
EP2426134A2 (en) 2012-03-07
US20110034495A1 (en) 2011-02-10
JP2009517390A (ja) 2009-04-30
WO2007062167A9 (en) 2007-07-26

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