JP2009516903A5 - - Google Patents

Info

Publication number

JP2009516903A5

JP2009516903A5 JP2008541818A JP2008541818A JP2009516903A5 JP 2009516903 A5 JP2009516903 A5 JP 2009516903A5 JP 2008541818 A JP2008541818 A JP 2008541818A JP 2008541818 A JP2008541818 A JP 2008541818A JP 2009516903 A5 JP2009516903 A5 JP 2009516903A5

Authority

JP

Japan

Prior art keywords

ion

ions

mode

fragmentation

fragmentation device

Prior art date

2006-11-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000002500 ions Chemical class 0.000 claims 123
• 238000013467 fragmentation Methods 0.000 claims 74
• 238000006062 fragmentation reaction Methods 0.000 claims 74
• 238000006243 chemical reaction Methods 0.000 claims 45
• 239000002243 precursor Substances 0.000 claims 26
• 238000001819 mass spectrum Methods 0.000 claims 24
• 238000010494 dissociation reaction Methods 0.000 claims 17
• 230000005593 dissociations Effects 0.000 claims 17
• 239000012634 fragment Substances 0.000 claims 16
• 238000000034 method Methods 0.000 claims 12
• 238000005040 ion trap Methods 0.000 claims 10
• 238000001211 electron capture detection Methods 0.000 claims 7
• 238000001077 electron transfer detection Methods 0.000 claims 7
• 238000004949 mass spectrometry Methods 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 102000004169 proteins and genes Human genes 0.000 claims 4
• 230000005855 radiation Effects 0.000 claims 4
• -1 daughters Substances 0.000 claims 3
• 238000003795 desorption Methods 0.000 claims 3
• 230000001133 acceleration Effects 0.000 claims 2
• 239000003153 chemical reaction reagent Substances 0.000 claims 2
• 238000001360 collision-induced dissociation Methods 0.000 claims 2
• 238000000688 desorption electrospray ionisation Methods 0.000 claims 2
• 230000005684 electric field Effects 0.000 claims 2
• 239000003480 eluent Substances 0.000 claims 2
• 230000007515 enzymatic degradation Effects 0.000 claims 2
• 230000006862 enzymatic digestion Effects 0.000 claims 2
• 238000010265 fast atom bombardment Methods 0.000 claims 2
• 238000004992 fast atom bombardment mass spectroscopy Methods 0.000 claims 2
• 238000009616 inductively coupled plasma Methods 0.000 claims 2
• 238000001698 laser desorption ionisation Methods 0.000 claims 2
• 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims 2
• 230000005405 multipole Effects 0.000 claims 2
• 238000011144 upstream manufacturing Methods 0.000 claims 2
• 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims 1
• 208000035699 Distal ileal obstruction syndrome Diseases 0.000 claims 1
• 238000004252 FT/ICR mass spectrometry Methods 0.000 claims 1
• 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 claims 1
• 108010033276 Peptide Fragments Proteins 0.000 claims 1
• 102000007079 Peptide Fragments Human genes 0.000 claims 1
• XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 1
• 239000008186 active pharmaceutical agent Substances 0.000 claims 1
• DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 1
• 238000003491 array Methods 0.000 claims 1
• 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims 1
• 238000005251 capillar electrophoresis Methods 0.000 claims 1
• 238000000451 chemical ionisation Methods 0.000 claims 1
• 238000000132 electrospray ionisation Methods 0.000 claims 1
• 238000004817 gas chromatography Methods 0.000 claims 1
• 238000004811 liquid chromatography Methods 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000011159 matrix material Substances 0.000 claims 1
• PXHVJJICTQNCMI-RNFDNDRNSA-N nickel-63 Chemical compound [63Ni] PXHVJJICTQNCMI-RNFDNDRNSA-N 0.000 claims 1
• 238000004150 penning trap Methods 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 230000002285 radioactive effect Effects 0.000 claims 1
• 229910052710 silicon Inorganic materials 0.000 claims 1
• 239000010703 silicon Substances 0.000 claims 1
• 239000007921 spray Substances 0.000 claims 1