JP2009515934A5 - - Google Patents
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- Publication number
- JP2009515934A5 JP2009515934A5 JP2008540620A JP2008540620A JP2009515934A5 JP 2009515934 A5 JP2009515934 A5 JP 2009515934A5 JP 2008540620 A JP2008540620 A JP 2008540620A JP 2008540620 A JP2008540620 A JP 2008540620A JP 2009515934 A5 JP2009515934 A5 JP 2009515934A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- quinazolin
- oxo
- isopropyl
- propionamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000003246 quinazolines Chemical class 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 208000002193 Pain Diseases 0.000 claims 9
- 230000036407 pain Effects 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 125000001188 haloalkyl group Chemical group 0.000 claims 6
- 125000005843 halogen group Chemical group 0.000 claims 6
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- 208000035475 disorder Diseases 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000004438 haloalkoxy group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 208000004296 neuralgia Diseases 0.000 claims 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 206010010904 Convulsion Diseases 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 206010015037 epilepsy Diseases 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- -1 methylenedioxy group Chemical group 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 208000021722 neuropathic pain Diseases 0.000 claims 2
- 125000003884 phenylalkyl group Chemical group 0.000 claims 2
- DQRAAFQFDCESKC-HXUWFJFHSA-N (2r)-2-fluoro-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)-2-phenylpropanamide Chemical compound C1([C@@](C)(F)C(=O)NN2C(=O)C3=CC=CC=C3N=C2C(C)C)=CC=CC=C1 DQRAAFQFDCESKC-HXUWFJFHSA-N 0.000 claims 1
- BHOLSJRZWUBCQE-HXUWFJFHSA-N (2r)-2-fluoro-n-[4-oxo-2-propan-2-yl-7-(trifluoromethyl)quinazolin-3-yl]-2-phenylpropanamide Chemical compound C1([C@@](C)(F)C(=O)NN2C(=O)C3=CC=C(C=C3N=C2C(C)C)C(F)(F)F)=CC=CC=C1 BHOLSJRZWUBCQE-HXUWFJFHSA-N 0.000 claims 1
- OROKJPUPTSURJR-CQSZACIVSA-N (2r)-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)-2-phenylpropanamide Chemical compound C1([C@@H](C)C(=O)NN2C(=O)C3=CC=CC=C3N=C2C(C)C)=CC=CC=C1 OROKJPUPTSURJR-CQSZACIVSA-N 0.000 claims 1
- DQRAAFQFDCESKC-FQEVSTJZSA-N (2s)-2-fluoro-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)-2-phenylpropanamide Chemical compound C1([C@](C)(F)C(=O)NN2C(=O)C3=CC=CC=C3N=C2C(C)C)=CC=CC=C1 DQRAAFQFDCESKC-FQEVSTJZSA-N 0.000 claims 1
- OROKJPUPTSURJR-AWEZNQCLSA-N (2s)-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)-2-phenylpropanamide Chemical compound C1([C@H](C)C(=O)NN2C(=O)C3=CC=CC=C3N=C2C(C)C)=CC=CC=C1 OROKJPUPTSURJR-AWEZNQCLSA-N 0.000 claims 1
- IYDDSFBOKZHXOS-UHFFFAOYSA-N 2-(3,4-dichlorophenyl)-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)propanamide Chemical compound CC(C)C1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C)C1=CC=C(Cl)C(Cl)=C1 IYDDSFBOKZHXOS-UHFFFAOYSA-N 0.000 claims 1
- SLGHXWDJZTVARG-UHFFFAOYSA-N 2-(3,4-dichlorophenyl)-n-[4-oxo-2-propan-2-yl-7-(trifluoromethyl)quinazolin-3-yl]propanamide Chemical compound CC(C)C1=NC2=CC(C(F)(F)F)=CC=C2C(=O)N1NC(=O)C(C)C1=CC=C(Cl)C(Cl)=C1 SLGHXWDJZTVARG-UHFFFAOYSA-N 0.000 claims 1
- QQTMXYFMWZRMFQ-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)propanamide Chemical compound C1=C(OC)C(OC)=CC=C1C(C)C(=O)NN1C(=O)C2=CC=CC=C2N=C1C(C)C QQTMXYFMWZRMFQ-UHFFFAOYSA-N 0.000 claims 1
- JPNTWYHCJJZYGR-UHFFFAOYSA-N 2-(3,5-difluorophenyl)-n-[2-methylsulfanyl-4-oxo-7-(trifluoromethyl)quinazolin-3-yl]propanamide Chemical compound CSC1=NC2=CC(C(F)(F)F)=CC=C2C(=O)N1NC(=O)C(C)C1=CC(F)=CC(F)=C1 JPNTWYHCJJZYGR-UHFFFAOYSA-N 0.000 claims 1
- LIWSBFYOGRKDGX-UHFFFAOYSA-N 2-(3,5-difluorophenyl)-n-[4-oxo-2-propan-2-ylsulfanyl-7-(trifluoromethyl)quinazolin-3-yl]propanamide Chemical compound CC(C)SC1=NC2=CC(C(F)(F)F)=CC=C2C(=O)N1NC(=O)C(C)C1=CC(F)=CC(F)=C1 LIWSBFYOGRKDGX-UHFFFAOYSA-N 0.000 claims 1
- LTRXRADCHHPVOT-UHFFFAOYSA-N 2-(3-benzoylphenyl)-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)propanamide Chemical compound CC(C)C1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C)C(C=1)=CC=CC=1C(=O)C1=CC=CC=C1 LTRXRADCHHPVOT-UHFFFAOYSA-N 0.000 claims 1
- DSULTIFNKXJRMQ-UHFFFAOYSA-N 2-(3-fluoro-4-methylphenyl)-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)propanamide Chemical compound CC(C)C1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C)C1=CC=C(C)C(F)=C1 DSULTIFNKXJRMQ-UHFFFAOYSA-N 0.000 claims 1
- LHRUVJUUAYKQAQ-UHFFFAOYSA-N 2-(3-fluoro-4-methylphenyl)-n-[4-oxo-2-propan-2-yl-7-(trifluoromethyl)quinazolin-3-yl]propanamide Chemical compound CC(C)C1=NC2=CC(C(F)(F)F)=CC=C2C(=O)N1NC(=O)C(C)C1=CC=C(C)C(F)=C1 LHRUVJUUAYKQAQ-UHFFFAOYSA-N 0.000 claims 1
- VDFDVUDOCJHWBF-UHFFFAOYSA-N 2-(3-fluorophenyl)-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)propanamide Chemical compound CC(C)C1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C)C1=CC=CC(F)=C1 VDFDVUDOCJHWBF-UHFFFAOYSA-N 0.000 claims 1
- OYYHCWMEVPLFAQ-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-(2-ethoxy-4-oxoquinazolin-3-yl)propanamide Chemical compound CCOC1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C)C1=CC=C(Cl)C=C1 OYYHCWMEVPLFAQ-UHFFFAOYSA-N 0.000 claims 1
- QTEPLGQIXQVCJD-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)propanamide Chemical compound CC(C)C1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C)C1=CC=C(Cl)C=C1 QTEPLGQIXQVCJD-UHFFFAOYSA-N 0.000 claims 1
- YENKQCUEYRPDSN-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-(4-oxo-2-propan-2-ylsulfanylquinazolin-3-yl)butanamide Chemical compound CC(C)SC1=NC2=CC=CC=C2C(=O)N1NC(=O)C(CC)C1=CC=C(Cl)C=C1 YENKQCUEYRPDSN-UHFFFAOYSA-N 0.000 claims 1
- SHRPCXBUVIVMBW-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-(4-oxo-2-propan-2-ylsulfanylquinazolin-3-yl)propanamide Chemical compound CC(C)SC1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C)C1=CC=C(Cl)C=C1 SHRPCXBUVIVMBW-UHFFFAOYSA-N 0.000 claims 1
- MZSUQEHOSBHNAI-UHFFFAOYSA-N 2-(4-chlorophenyl)-n-[4-oxo-2-propan-2-yl-7-(trifluoromethyl)quinazolin-3-yl]propanamide Chemical compound CC(C)C1=NC2=CC(C(F)(F)F)=CC=C2C(=O)N1NC(=O)C(C)C1=CC=C(Cl)C=C1 MZSUQEHOSBHNAI-UHFFFAOYSA-N 0.000 claims 1
- JHWKDTCARDPIBT-UHFFFAOYSA-N 2-(4-fluorophenyl)-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)propanamide Chemical compound CC(C)C1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C)C1=CC=C(F)C=C1 JHWKDTCARDPIBT-UHFFFAOYSA-N 0.000 claims 1
- JGIVXIKKKFSDBO-UHFFFAOYSA-N 2-(4-methoxyphenyl)-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)propanamide Chemical compound C1=CC(OC)=CC=C1C(C)C(=O)NN1C(=O)C2=CC=CC=C2N=C1C(C)C JGIVXIKKKFSDBO-UHFFFAOYSA-N 0.000 claims 1
- WROKVAVWVKCBMB-UHFFFAOYSA-N 2-(4-methoxyphenyl)-n-[4-oxo-2-propan-2-yl-7-(trifluoromethyl)quinazolin-3-yl]propanamide Chemical compound C1=CC(OC)=CC=C1C(C)C(=O)NN1C(=O)C2=CC=C(C(F)(F)F)C=C2N=C1C(C)C WROKVAVWVKCBMB-UHFFFAOYSA-N 0.000 claims 1
- VVQBIJHEWYLAHP-UHFFFAOYSA-N 2-(4-methylphenyl)-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)propanamide Chemical compound CC(C)C1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C)C1=CC=C(C)C=C1 VVQBIJHEWYLAHP-UHFFFAOYSA-N 0.000 claims 1
- YSOKBJGHLWPKCH-UHFFFAOYSA-N 2-[4-(2-methylpropyl)phenyl]-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)propanamide Chemical compound C1=CC(CC(C)C)=CC=C1C(C)C(=O)NN1C(=O)C2=CC=CC=C2N=C1C(C)C YSOKBJGHLWPKCH-UHFFFAOYSA-N 0.000 claims 1
- HWGRLKLVQSJHNN-UHFFFAOYSA-N 2-cyclohexyl-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)-2-phenylacetamide Chemical compound CC(C)C1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C=1C=CC=CC=1)C1CCCCC1 HWGRLKLVQSJHNN-UHFFFAOYSA-N 0.000 claims 1
- DQRAAFQFDCESKC-UHFFFAOYSA-N 2-fluoro-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)-2-phenylpropanamide Chemical compound CC(C)C1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C)(F)C1=CC=CC=C1 DQRAAFQFDCESKC-UHFFFAOYSA-N 0.000 claims 1
- YUVPFAXNQPQPIE-UHFFFAOYSA-N 2-methyl-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)-2-phenylpropanamide Chemical compound CC(C)C1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C)(C)C1=CC=CC=C1 YUVPFAXNQPQPIE-UHFFFAOYSA-N 0.000 claims 1
- LCQQIOWBOMPHSJ-UHFFFAOYSA-N 3-amino-2-propan-2-ylquinazolin-4-one Chemical compound C1=CC=C2C(=O)N(N)C(C(C)C)=NC2=C1 LCQQIOWBOMPHSJ-UHFFFAOYSA-N 0.000 claims 1
- IBLFSPRQBREHQR-UHFFFAOYSA-N 3-methyl-n-(4-oxo-2-propan-2-ylquinazolin-3-yl)-2-phenylbutanamide Chemical compound CC(C)C1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C(C)C)C1=CC=CC=C1 IBLFSPRQBREHQR-UHFFFAOYSA-N 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010026749 Mania Diseases 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- 208000010886 Peripheral nerve injury Diseases 0.000 claims 1
- 208000004983 Phantom Limb Diseases 0.000 claims 1
- 206010056238 Phantom pain Diseases 0.000 claims 1
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
- 206010043269 Tension headache Diseases 0.000 claims 1
- 208000008548 Tension-Type Headache Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000036461 convulsion Effects 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- FQMNEVSAJNBGFK-UHFFFAOYSA-N n-(2-ethyl-7-fluoro-4-oxoquinazolin-3-yl)-2-phenylpropanamide Chemical compound CCC1=NC2=CC(F)=CC=C2C(=O)N1NC(=O)C(C)C1=CC=CC=C1 FQMNEVSAJNBGFK-UHFFFAOYSA-N 0.000 claims 1
- AKCULFMCPLLACI-UHFFFAOYSA-N n-(4-oxo-2-propan-2-ylquinazolin-3-yl)-1-phenylcyclopropane-1-carboxamide Chemical compound CC(C)C1=NC2=CC=CC=C2C(=O)N1NC(=O)C1(C=2C=CC=CC=2)CC1 AKCULFMCPLLACI-UHFFFAOYSA-N 0.000 claims 1
- ZPRCFGNQMRHXSV-UHFFFAOYSA-N n-(4-oxo-2-propan-2-ylquinazolin-3-yl)-2,3-diphenylpropanamide Chemical compound CC(C)C1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C=1C=CC=CC=1)CC1=CC=CC=C1 ZPRCFGNQMRHXSV-UHFFFAOYSA-N 0.000 claims 1
- ZGPWTRZXTXCIDB-UHFFFAOYSA-N n-(4-oxo-2-propan-2-ylquinazolin-3-yl)-2-[4-(trifluoromethyl)phenyl]propanamide Chemical compound CC(C)C1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C)C1=CC=C(C(F)(F)F)C=C1 ZGPWTRZXTXCIDB-UHFFFAOYSA-N 0.000 claims 1
- INXPJWXTYAZHMK-UHFFFAOYSA-N n-(4-oxo-2-propan-2-ylquinazolin-3-yl)bicyclo[4.2.0]octa-1,3,5-triene-7-carboxamide Chemical compound C1C2=CC=CC=C2C1C(=O)NN1C(=O)C2=CC=CC=C2N=C1C(C)C INXPJWXTYAZHMK-UHFFFAOYSA-N 0.000 claims 1
- SWBPZAFTEYYZHJ-UHFFFAOYSA-N n-(4-oxo-2-propan-2-ylsulfanylquinazolin-3-yl)-2-phenylpropanamide Chemical compound CC(C)SC1=NC2=CC=CC=C2C(=O)N1NC(=O)C(C)C1=CC=CC=C1 SWBPZAFTEYYZHJ-UHFFFAOYSA-N 0.000 claims 1
- HIIGMSLJGDTXIZ-UHFFFAOYSA-N n-(5-chloro-4-oxo-2-propan-2-ylquinazolin-3-yl)-2-(3-fluorophenyl)propanamide Chemical compound CC(C)C1=NC2=CC=CC(Cl)=C2C(=O)N1NC(=O)C(C)C1=CC=CC(F)=C1 HIIGMSLJGDTXIZ-UHFFFAOYSA-N 0.000 claims 1
- RKVSJHPISADAQD-UHFFFAOYSA-N n-(6-chloro-4-oxo-2-propan-2-ylquinazolin-3-yl)-2-(3-fluorophenyl)propanamide Chemical compound CC(C)C1=NC2=CC=C(Cl)C=C2C(=O)N1NC(=O)C(C)C1=CC=CC(F)=C1 RKVSJHPISADAQD-UHFFFAOYSA-N 0.000 claims 1
- FTDNWMMTXFGLQN-UHFFFAOYSA-N n-(7-chloro-4-oxo-2-propan-2-ylquinazolin-3-yl)-2-(3-fluorophenyl)propanamide Chemical compound CC(C)C1=NC2=CC(Cl)=CC=C2C(=O)N1NC(=O)C(C)C1=CC=CC(F)=C1 FTDNWMMTXFGLQN-UHFFFAOYSA-N 0.000 claims 1
- KAYRCGCWXJUESM-UHFFFAOYSA-N n-(8-chloro-4-oxo-2-propan-2-ylquinazolin-3-yl)-2-(3-fluorophenyl)propanamide Chemical compound CC(C)C1=NC2=C(Cl)C=CC=C2C(=O)N1NC(=O)C(C)C1=CC=CC(F)=C1 KAYRCGCWXJUESM-UHFFFAOYSA-N 0.000 claims 1
- CTISVHDDKMUBMT-UHFFFAOYSA-N n-(8-cyano-4-oxo-2-propan-2-ylquinazolin-3-yl)-2-(3-fluorophenyl)propanamide Chemical compound CC(C)C1=NC2=C(C#N)C=CC=C2C(=O)N1NC(=O)C(C)C1=CC=CC(F)=C1 CTISVHDDKMUBMT-UHFFFAOYSA-N 0.000 claims 1
- ZKKOSDMSQHRYIQ-UHFFFAOYSA-N n-[4-oxo-2-propan-2-yl-7-(trifluoromethyl)quinazolin-3-yl]-2-[4-(trifluoromethyl)phenyl]propanamide Chemical compound CC(C)C1=NC2=CC(C(F)(F)F)=CC=C2C(=O)N1NC(=O)C(C)C1=CC=C(C(F)(F)F)C=C1 ZKKOSDMSQHRYIQ-UHFFFAOYSA-N 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200501615 | 2005-11-18 | ||
| US73805205P | 2005-11-21 | 2005-11-21 | |
| PCT/EP2006/068627 WO2007057447A1 (en) | 2005-11-18 | 2006-11-17 | Novel quinazoline derivatives and their medical use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009515934A JP2009515934A (ja) | 2009-04-16 |
| JP2009515934A5 true JP2009515934A5 (https=) | 2009-11-26 |
Family
ID=37685593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008540620A Abandoned JP2009515934A (ja) | 2005-11-18 | 2006-11-17 | 新規なキナゾリン誘導体及びこれらの医学的使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20090291973A1 (https=) |
| EP (1) | EP1951685A1 (https=) |
| JP (1) | JP2009515934A (https=) |
| WO (1) | WO2007057447A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008142140A2 (en) * | 2007-05-23 | 2008-11-27 | Neurosearch A/S | Novel 2,3-diamino-quinazolinone derivatives and their medical use |
| JP5937353B2 (ja) * | 2008-08-19 | 2016-06-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ | 冷感−メントール受容体拮抗剤 |
| WO2010026104A1 (en) * | 2008-09-03 | 2010-03-11 | Neurosearch A/S | 4-tetrahydropyran-aminopyridine derivatives and their medical use |
| TWI504395B (zh) * | 2009-03-10 | 2015-10-21 | Substituted 3-amino-2-mercaptoquinoline as a KCNQ2 / 3 modifier | |
| TW201038565A (en) | 2009-03-12 | 2010-11-01 | Gruenenthal Gmbh | Substituted 2-mercapto-3-aminopyridines as KCNQ2/3 modulators |
| TWI461197B (zh) | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
| TWI475020B (zh) | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
| RU2595894C2 (ru) | 2010-08-27 | 2016-08-27 | Грюненталь Гмбх | Замещенные 2-окси-хинолин-3-карбоксамиды в качестве модуляторов kcnq2/3 |
| MX342459B (es) | 2010-08-27 | 2016-09-29 | Grünenthal Gmbh * | 2-oxo- y 2-tioxo-dihidroquinolin-3-carboxamidas sustituidas, como moduladores de kcnq2/3. |
| CA2805932A1 (en) | 2010-08-27 | 2012-03-01 | Gruenenthal Gmbh | Substituted 2-amino-quinoline-3-carboxamides as kcnq2/3 modulators |
| CA2807886A1 (en) | 2010-09-01 | 2012-03-08 | Gruenenthal Gmbh | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as kcnq2/3 modulators |
| US8609674B2 (en) | 2010-11-16 | 2013-12-17 | Abbvie Inc. | Potassium channel modulators |
| CN114206328B (zh) | 2019-08-02 | 2024-09-17 | H.隆德贝克有限公司 | 用于在癫痫或癫痫发作中使用的作为Kv7钾通道开放剂的醇衍生物 |
| CN114605305A (zh) * | 2020-12-04 | 2022-06-10 | 杭州中美华东制药有限公司 | 一种吲哚布芬乙酯化物的合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE488231T1 (de) * | 2002-12-23 | 2010-12-15 | Icagen Inc | Quinazolinone als kaliumkanalmodulatoren |
| AU2004272104B2 (en) * | 2003-09-10 | 2011-09-08 | Icagen, Inc | Fused ring heterocycles as potassium channel modulators |
-
2006
- 2006-11-17 WO PCT/EP2006/068627 patent/WO2007057447A1/en not_active Ceased
- 2006-11-17 JP JP2008540620A patent/JP2009515934A/ja not_active Abandoned
- 2006-11-17 US US12/085,188 patent/US20090291973A1/en not_active Abandoned
- 2006-11-17 EP EP06830034A patent/EP1951685A1/en not_active Withdrawn
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