JP2009515927A5 - - Google Patents
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- Publication number
- JP2009515927A5 JP2009515927A5 JP2008540580A JP2008540580A JP2009515927A5 JP 2009515927 A5 JP2009515927 A5 JP 2009515927A5 JP 2008540580 A JP2008540580 A JP 2008540580A JP 2008540580 A JP2008540580 A JP 2008540580A JP 2009515927 A5 JP2009515927 A5 JP 2009515927A5
- Authority
- JP
- Japan
- Prior art keywords
- asymptomatic
- latent
- heart failure
- use according
- pde iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010019280 Heart failures Diseases 0.000 claims 7
- 239000011575 calcium Substances 0.000 claims 7
- 230000035945 sensitivity Effects 0.000 claims 6
- 239000003623 enhancer Substances 0.000 claims 5
- 239000002570 phosphodiesterase III inhibitor Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 3
- 102000010861 Type 3 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 claims 2
- 108010037543 Type 3 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000005022 packaging material Substances 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 241000282472 Canis lupus familiaris Species 0.000 claims 1
- 241000283086 Equidae Species 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000288906 Primates Species 0.000 claims 1
- 229960002105 amrinone Drugs 0.000 claims 1
- RNLQIBCLLYYYFJ-UHFFFAOYSA-N amrinone Chemical compound N1C(=O)C(N)=CC(C=2C=CN=CC=2)=C1 RNLQIBCLLYYYFJ-UHFFFAOYSA-N 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 229960000972 enoximone Drugs 0.000 claims 1
- ZJKNESGOIKRXQY-UHFFFAOYSA-N enoximone Chemical compound C1=CC(SC)=CC=C1C(=O)C1=C(C)NC(=O)N1 ZJKNESGOIKRXQY-UHFFFAOYSA-N 0.000 claims 1
- WHXMKTBCFHIYNQ-SECBINFHSA-N levosimendan Chemical compound C[C@@H]1CC(=O)NN=C1C1=CC=C(NN=C(C#N)C#N)C=C1 WHXMKTBCFHIYNQ-SECBINFHSA-N 0.000 claims 1
- 229960000692 levosimendan Drugs 0.000 claims 1
- 229960003574 milrinone Drugs 0.000 claims 1
- PZRHRDRVRGEVNW-UHFFFAOYSA-N milrinone Chemical compound N1C(=O)C(C#N)=CC(C=2C=CN=CC=2)=C1C PZRHRDRVRGEVNW-UHFFFAOYSA-N 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 239000006201 parenteral dosage form Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229960002164 pimobendan Drugs 0.000 claims 1
- GLBJJMFZWDBELO-UHFFFAOYSA-N pimobendane Chemical group C1=CC(OC)=CC=C1C1=NC2=CC=C(C=3C(CC(=O)NN=3)C)C=C2N1 GLBJJMFZWDBELO-UHFFFAOYSA-N 0.000 claims 1
- 230000002035 prolonged effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05110689 | 2005-11-14 | ||
| EP05110689.6 | 2005-11-14 | ||
| PCT/EP2006/068231 WO2007054514A2 (en) | 2005-11-14 | 2006-11-08 | Use of pde iii inhibitors or calcium sensitizers for the treatment of asymptomatic (occult) heart failure |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009515927A JP2009515927A (ja) | 2009-04-16 |
| JP2009515927A5 true JP2009515927A5 (enExample) | 2010-01-07 |
| JP5312034B2 JP5312034B2 (ja) | 2013-10-09 |
Family
ID=37744668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008540580A Active JP5312034B2 (ja) | 2005-11-14 | 2006-11-08 | 無症候性（潜在性）心不全の治療のためのｐｄｅｉｉｉ阻害剤の使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20070112010A1 (enExample) |
| EP (2) | EP1951227B1 (enExample) |
| JP (1) | JP5312034B2 (enExample) |
| CN (2) | CN101309685A (enExample) |
| AR (1) | AR056800A1 (enExample) |
| AU (1) | AU2006310997B2 (enExample) |
| CA (1) | CA2629367C (enExample) |
| DK (1) | DK1951227T3 (enExample) |
| ES (1) | ES2631879T3 (enExample) |
| HU (1) | HUE033546T2 (enExample) |
| PL (1) | PL1951227T3 (enExample) |
| TW (1) | TW200735874A (enExample) |
| WO (1) | WO2007054514A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004011512B4 (de) | 2004-03-08 | 2022-01-13 | Boehringer Ingelheim Vetmedica Gmbh | Pharmazeutische Zubereitung enthaltend Pimobendan |
| US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
| FI20040674A0 (fi) | 2004-05-12 | 2004-05-12 | Orion Corp | Menetelmä tromboembolisten sairauksien estoon |
| EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| CA2723372A1 (en) * | 2008-05-05 | 2009-11-12 | University Of Rochester | Methods and compositions for the treatment or prevention of pathological cardiac remodeling and heart failure |
| EP2702987A1 (en) | 2008-11-25 | 2014-03-05 | Boehringer Ingelheim Vetmedica GmbH | Phosphodiesterase type III (PDE III) inhibitors or Ca2+-sensitizing agents for the treatment of hypertrophic cardiomyopathy |
| NL1037569C2 (en) * | 2009-12-18 | 2011-06-21 | Eurovet Animal Health B V | Crystalline pimobendan, process for the preparation thereof, pharmaceutical composition and use. |
| EP2825159B1 (en) * | 2012-03-15 | 2022-06-22 | Boehringer Ingelheim Vetmedica GmbH | Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof |
| EP3865120B1 (en) | 2013-07-19 | 2025-06-25 | Boehringer Ingelheim Vetmedica GmbH | Preserved etherified cyclodextrin derivatives containing liquid aqueous pharmaceutical composition |
| WO2015082389A1 (en) | 2013-12-04 | 2015-06-11 | Boehringer Ingelheim Vetmedica Gmbh | Improved pharmaceutical compositions of pimobendan |
| US10537570B2 (en) * | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
| PT3439660T (pt) * | 2016-06-01 | 2024-07-18 | Boehringer Ingelheim Vetmedica Gmbh | Utilização de pimobendan para a redução do tamanho do coração e o retardamento do início de sintomas clínicos em doentes com insuficiência cardíaca assintomática devido a doença da válvula mitral |
| WO2022073954A1 (en) | 2020-10-08 | 2022-04-14 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan in the anaesthesia of non-human mammals |
| AU2024276892A1 (en) | 2023-05-24 | 2025-10-16 | Boehringer Ingelheim Vetmedica Gmbh | Combination treatment and/or prevention of cardiac diseases in non-human mammals comprising one or more sglt-2 inhibitors and pimobendan and/or telmisartan |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES482789A0 (es) | 1978-08-25 | 1980-12-01 | Thomae Gmbh Dr K | Procedimiento para la preparacion de nuevos bencimidazoles sustituidos en posicion 5 o 6 con un anillo de piridazinona |
| GB8400863D0 (en) * | 1984-01-13 | 1984-02-15 | Smith Kline French Lab | Chemical compounds |
| ES2031821T3 (es) * | 1985-10-17 | 1993-01-01 | Smith Kline & French Laboratories Limited | Procedimiento para preparar derivados de 4(4-oxo-1,4-dihidropiridin-1-il)fenilo. |
| US4868182A (en) | 1986-11-05 | 1989-09-19 | Merrell Dow Pharmaceuticals Inc. | Enhancement of prazosin |
| DE3804490A1 (de) * | 1988-02-12 | 1989-08-24 | Heumann Pharma Gmbh & Co | Substituierte 6-phenyldihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| GB8824458D0 (en) | 1988-10-19 | 1988-11-23 | Orion Yhtymae Oy | Substituted pyridazinones |
| GB8903130D0 (en) | 1989-02-11 | 1989-03-30 | Orion Yhtymae Oy | Substituted pyridazinones |
| GB2251615B (en) | 1991-01-03 | 1995-02-08 | Orion Yhtymae Oy | (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile |
| DE60237696D1 (de) * | 2001-08-01 | 2010-10-28 | Univ Utah | Am n-terminus trunkierte isoformen von zyklischen phosphodiesterasen pde3a |
| EP1579862A1 (en) * | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
-
2006
- 2006-11-08 CN CNA2006800424125A patent/CN101309685A/zh active Pending
- 2006-11-08 JP JP2008540580A patent/JP5312034B2/ja active Active
- 2006-11-08 ES ES06829958.5T patent/ES2631879T3/es active Active
- 2006-11-08 AU AU2006310997A patent/AU2006310997B2/en active Active
- 2006-11-08 EP EP06829958.5A patent/EP1951227B1/en active Active
- 2006-11-08 PL PL06829958T patent/PL1951227T3/pl unknown
- 2006-11-08 HU HUE06829958A patent/HUE033546T2/hu unknown
- 2006-11-08 EP EP17165100.3A patent/EP3210605A1/en not_active Withdrawn
- 2006-11-08 CA CA2629367A patent/CA2629367C/en active Active
- 2006-11-08 DK DK06829958.5T patent/DK1951227T3/en active
- 2006-11-08 CN CN201210144177XA patent/CN102784394A/zh active Pending
- 2006-11-08 WO PCT/EP2006/068231 patent/WO2007054514A2/en not_active Ceased
- 2006-11-10 AR ARP060104928A patent/AR056800A1/es not_active Application Discontinuation
- 2006-11-13 TW TW095141963A patent/TW200735874A/zh unknown
- 2006-11-14 US US11/559,467 patent/US20070112010A1/en not_active Abandoned
-
2010
- 2010-07-07 US US12/831,657 patent/US20100273807A1/en not_active Abandoned
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