JP2009515892A5 - - Google Patents
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- Publication number
- JP2009515892A5 JP2009515892A5 JP2008540234A JP2008540234A JP2009515892A5 JP 2009515892 A5 JP2009515892 A5 JP 2009515892A5 JP 2008540234 A JP2008540234 A JP 2008540234A JP 2008540234 A JP2008540234 A JP 2008540234A JP 2009515892 A5 JP2009515892 A5 JP 2009515892A5
- Authority
- JP
- Japan
- Prior art keywords
- pain
- compound
- alkyl
- aliphatic
- hydroxyphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- LNFFVBHSOAWVOO-UHFFFAOYSA-N CCOC(NC(CC1)CN1c1nc(-c2ccccc2O)nc2c1ccc(C)c2)=O Chemical compound CCOC(NC(CC1)CN1c1nc(-c2ccccc2O)nc2c1ccc(C)c2)=O LNFFVBHSOAWVOO-UHFFFAOYSA-N 0.000 description 2
- 0 Cc(cccc1)c1-c1nc(cccc2)c2c(N(CC2)C[C@@]2N(*)C(O*)=O)n1 Chemical compound Cc(cccc1)c1-c1nc(cccc2)c2c(N(CC2)C[C@@]2N(*)C(O*)=O)n1 0.000 description 2
- VWGQUJQSUCIDIJ-UHFFFAOYSA-N CC(C)(C)COC(NC(CC1)CN1c1nc(-c2ccccc2O)nc(cc2)c1cc2F)=O Chemical compound CC(C)(C)COC(NC(CC1)CN1c1nc(-c2ccccc2O)nc(cc2)c1cc2F)=O VWGQUJQSUCIDIJ-UHFFFAOYSA-N 0.000 description 1
- KUYKJFRAHWUFDM-CYBMUJFWSA-N CC(C)(C)COC(N[C@H](CC1)CN1c1c(ccc(C)c2)c2nc(Cl)n1)=O Chemical compound CC(C)(C)COC(N[C@H](CC1)CN1c1c(ccc(C)c2)c2nc(Cl)n1)=O KUYKJFRAHWUFDM-CYBMUJFWSA-N 0.000 description 1
- OZIGFTPWHPIHTR-UHFFFAOYSA-N CC(C)(C)OC(NC(CC1)CN1c1nc(-c2ccccc2O)nc2c1ccc(C)c2)=O Chemical compound CC(C)(C)OC(NC(CC1)CN1c1nc(-c2ccccc2O)nc2c1ccc(C)c2)=O OZIGFTPWHPIHTR-UHFFFAOYSA-N 0.000 description 1
- ILTGLYYBMFZIJH-CYBMUJFWSA-N CC(C)COC(N[C@H](CC1)CN1c1nc(Cl)nc2c1ccc(C)c2)=O Chemical compound CC(C)COC(N[C@H](CC1)CN1c1nc(Cl)nc2c1ccc(C)c2)=O ILTGLYYBMFZIJH-CYBMUJFWSA-N 0.000 description 1
- RLDSJJICRQBYCU-UHFFFAOYSA-N CC(C)OC(NCC(CC1)CN1c1nc(-c2ccccc2O)nc2c1ccc(C)c2)=O Chemical compound CC(C)OC(NCC(CC1)CN1c1nc(-c2ccccc2O)nc2c1ccc(C)c2)=O RLDSJJICRQBYCU-UHFFFAOYSA-N 0.000 description 1
- HRBKGMYCDLPKCF-UHFFFAOYSA-N CCCOC(NC(CC1)CN1c1nc(-c(c(O)ccc2)c2F)nc2c1ccc(C)c2)=O Chemical compound CCCOC(NC(CC1)CN1c1nc(-c(c(O)ccc2)c2F)nc2c1ccc(C)c2)=O HRBKGMYCDLPKCF-UHFFFAOYSA-N 0.000 description 1
- FJRCPLLZSWCNPI-UHFFFAOYSA-N Cc(cc1)cc(N=C(c(c(OC)ccc2)c2F)N2)c1C2=O Chemical compound Cc(cc1)cc(N=C(c(c(OC)ccc2)c2F)N2)c1C2=O FJRCPLLZSWCNPI-UHFFFAOYSA-N 0.000 description 1
- PXZNYMFSHIXAHH-UHFFFAOYSA-N Cc(cc1)cc2c1c(Cl)nc(-c(c(OC)ccc1)c1F)n2 Chemical compound Cc(cc1)cc2c1c(Cl)nc(-c(c(OC)ccc1)c1F)n2 PXZNYMFSHIXAHH-UHFFFAOYSA-N 0.000 description 1
- HKDMUKMZLPWEEV-CYBMUJFWSA-N Cc(cc1)cc2c1c(N(CC1)C[C@@H]1N)nc(-c1ccccc1O)n2 Chemical compound Cc(cc1)cc2c1c(N(CC1)C[C@@H]1N)nc(-c1ccccc1O)n2 HKDMUKMZLPWEEV-CYBMUJFWSA-N 0.000 description 1
- FMYIPXIPSVPQQI-UHFFFAOYSA-N Cc1cc2nc(Cl)nc(N(CC3)CC3N)c2cc1 Chemical compound Cc1cc2nc(Cl)nc(N(CC3)CC3N)c2cc1 FMYIPXIPSVPQQI-UHFFFAOYSA-N 0.000 description 1
- FMYIPXIPSVPQQI-SECBINFHSA-N Cc1cc2nc(Cl)nc(N(CC3)C[C@@H]3N)c2cc1 Chemical compound Cc1cc2nc(Cl)nc(N(CC3)C[C@@H]3N)c2cc1 FMYIPXIPSVPQQI-SECBINFHSA-N 0.000 description 1
- LVVGWSRWHQDNMX-UHFFFAOYSA-N NC(c(cc(cc1)F)c1N)O Chemical compound NC(c(cc(cc1)F)c1N)O LVVGWSRWHQDNMX-UHFFFAOYSA-N 0.000 description 1
- KRZCOLNOCZKSDF-UHFFFAOYSA-N Nc(cc1)ccc1F Chemical compound Nc(cc1)ccc1F KRZCOLNOCZKSDF-UHFFFAOYSA-N 0.000 description 1
- DXSBFTGUEOWLSD-BJMVGYQFSA-N O/N=C/C(Nc(cc1)ccc1F)=O Chemical compound O/N=C/C(Nc(cc1)ccc1F)=O DXSBFTGUEOWLSD-BJMVGYQFSA-N 0.000 description 1
- GKODDAXOSGGARJ-UHFFFAOYSA-N O=C(c(cc(cc1)F)c1N1)C1=O Chemical compound O=C(c(cc(cc1)F)c1N1)C1=O GKODDAXOSGGARJ-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73733005P | 2005-11-14 | 2005-11-14 | |
| PCT/US2006/043895 WO2007058989A2 (en) | 2005-11-14 | 2006-11-13 | Quinazolines useful as modulators of voltage gated ion channels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009515892A JP2009515892A (ja) | 2009-04-16 |
| JP2009515892A5 true JP2009515892A5 (enExample) | 2012-10-04 |
Family
ID=38049182
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008540234A Pending JP2009515892A (ja) | 2005-11-14 | 2006-11-13 | 電位型イオンチャネルモジュレータとして有用なキナゾリン |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US8158637B2 (enExample) |
| EP (1) | EP1957482B1 (enExample) |
| JP (1) | JP2009515892A (enExample) |
| KR (1) | KR20080073749A (enExample) |
| CN (1) | CN101356168A (enExample) |
| AR (1) | AR057576A1 (enExample) |
| AT (1) | ATE540033T1 (enExample) |
| AU (1) | AU2006315675B2 (enExample) |
| CA (1) | CA2628650A1 (enExample) |
| ES (1) | ES2377988T3 (enExample) |
| MX (1) | MX2008006303A (enExample) |
| NO (1) | NO20082746L (enExample) |
| NZ (1) | NZ568393A (enExample) |
| RU (1) | RU2008123811A (enExample) |
| TW (1) | TW200804348A (enExample) |
| WO (1) | WO2007058989A2 (enExample) |
| ZA (1) | ZA200804043B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2004000409A1 (es) | 2003-03-03 | 2005-01-07 | Vertex Pharma | Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu |
| US7713983B2 (en) * | 2003-03-03 | 2010-05-11 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| US7718658B2 (en) * | 2004-09-02 | 2010-05-18 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| US8283354B2 (en) * | 2004-09-02 | 2012-10-09 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| US7928107B2 (en) | 2004-09-02 | 2011-04-19 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| EP1828150B1 (en) * | 2004-12-17 | 2012-03-14 | Vertex Pharmaceuticals Incorporated | Processes for producing 4-aminoquinazolines |
| MX2008006303A (es) * | 2005-11-14 | 2009-02-26 | Vertex Pharma | Quinazolinas de utilidad como moduladores de canales ionicos regulados por voltaje. |
| WO2012046132A1 (en) | 2010-10-05 | 2012-04-12 | Purdue Pharma L.P. | Quinazoline compounds as sodium channel blockers |
| KR101657616B1 (ko) * | 2013-05-24 | 2016-09-19 | 주식회사유한양행 | 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법 |
| EP3551188B1 (en) | 2017-10-31 | 2023-10-18 | Southern Research Institute | Substituted quinazoline sulfonamides as thioredoxin interacting protein (txnip) inhibitors |
| MA56398A (fr) * | 2019-06-27 | 2022-05-04 | Glaxosmithkline Ip Dev Ltd | Composés 2,3-dihydroquinazoline en tant qu'inhibiteurs de nav1.8 |
| TWI813493B (zh) * | 2021-07-20 | 2023-08-21 | 友達光電股份有限公司 | 顯示裝置 |
| CA3256486A1 (en) * | 2022-04-25 | 2023-11-02 | Siteone Therapeutics Inc | Bicyclic Na V1.8 Heterocyclic Amide Inhibitors for Pain Management |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI20021314A0 (fi) * | 2002-07-03 | 2002-07-03 | Nokia Corp | Tiedonsiirtomenetelmä ja järjestely |
| CL2004000409A1 (es) | 2003-03-03 | 2005-01-07 | Vertex Pharma | Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu |
| US7713983B2 (en) | 2003-03-03 | 2010-05-11 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| US7718658B2 (en) | 2004-09-02 | 2010-05-18 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| US7928107B2 (en) | 2004-09-02 | 2011-04-19 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| WO2006028904A1 (en) * | 2004-09-02 | 2006-03-16 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| US8283354B2 (en) | 2004-09-02 | 2012-10-09 | Vertex Pharmaceuticals Incorporated | Quinazolines useful as modulators of ion channels |
| EP1828150B1 (en) | 2004-12-17 | 2012-03-14 | Vertex Pharmaceuticals Incorporated | Processes for producing 4-aminoquinazolines |
| MX2008006303A (es) * | 2005-11-14 | 2009-02-26 | Vertex Pharma | Quinazolinas de utilidad como moduladores de canales ionicos regulados por voltaje. |
-
2006
- 2006-11-13 MX MX2008006303A patent/MX2008006303A/es not_active Application Discontinuation
- 2006-11-13 AT AT06837387T patent/ATE540033T1/de active
- 2006-11-13 JP JP2008540234A patent/JP2009515892A/ja active Pending
- 2006-11-13 CA CA002628650A patent/CA2628650A1/en not_active Abandoned
- 2006-11-13 WO PCT/US2006/043895 patent/WO2007058989A2/en not_active Ceased
- 2006-11-13 US US11/598,576 patent/US8158637B2/en not_active Expired - Fee Related
- 2006-11-13 CN CNA2006800507452A patent/CN101356168A/zh active Pending
- 2006-11-13 KR KR1020087014446A patent/KR20080073749A/ko not_active Withdrawn
- 2006-11-13 AU AU2006315675A patent/AU2006315675B2/en not_active Ceased
- 2006-11-13 ZA ZA200804043A patent/ZA200804043B/xx unknown
- 2006-11-13 NZ NZ568393A patent/NZ568393A/en not_active IP Right Cessation
- 2006-11-13 EP EP06837387A patent/EP1957482B1/en not_active Not-in-force
- 2006-11-13 ES ES06837387T patent/ES2377988T3/es active Active
- 2006-11-13 RU RU2008123811/04A patent/RU2008123811A/ru not_active Application Discontinuation
- 2006-11-14 AR ARP060104980A patent/AR057576A1/es unknown
- 2006-11-14 TW TW095142123A patent/TW200804348A/zh unknown
-
2008
- 2008-03-18 US US12/050,289 patent/US8809353B2/en active Active
- 2008-06-13 NO NO20082746A patent/NO20082746L/no not_active Application Discontinuation
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