JP2009514835A5 - - Google Patents
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- JP2009514835A5 JP2009514835A5 JP2008538364A JP2008538364A JP2009514835A5 JP 2009514835 A5 JP2009514835 A5 JP 2009514835A5 JP 2008538364 A JP2008538364 A JP 2008538364A JP 2008538364 A JP2008538364 A JP 2008538364A JP 2009514835 A5 JP2009514835 A5 JP 2009514835A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- acceptable salt
- group
- pharmacologically acceptable
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 5-methylpyrazin-2-yl Chemical group 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 12
- 201000001421 hyperglycemia Diseases 0.000 claims 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 2
- 239000003472 antidiabetic agent Substances 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 1
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 claims 1
- MBKBWYYDNUJGGY-UHFFFAOYSA-N [N].C=1C=NOC=1 Chemical compound [N].C=1C=NOC=1 MBKBWYYDNUJGGY-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000002058 anti-hyperglycaemic effect Effects 0.000 claims 1
- 229940125708 antidiabetic agent Drugs 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 230000005494 condensation Effects 0.000 claims 1
- 238000009833 condensation Methods 0.000 claims 1
- VILAVOFMIJHSJA-UHFFFAOYSA-N dicarbon monoxide Chemical compound [C]=C=O VILAVOFMIJHSJA-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000004284 isoxazol-3-yl group Chemical group [H]C1=C([H])C(*)=NO1 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 claims 1
- IMDSBCGXPMSCCM-UHFFFAOYSA-N OC(C(CC1CCOCC1)c(cc1)ccc1S(C1CC1)(=O)=O)=O Chemical compound OC(C(CC1CCOCC1)c(cc1)ccc1S(C1CC1)(=O)=O)=O IMDSBCGXPMSCCM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0522455A GB0522455D0 (en) | 2005-11-03 | 2005-11-03 | Compounds |
| GB0603129A GB0603129D0 (en) | 2006-02-16 | 2006-02-16 | Compounds |
| PCT/EP2006/068087 WO2007051845A1 (en) | 2005-11-03 | 2006-11-03 | Tricyclo substituted amides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009514835A JP2009514835A (ja) | 2009-04-09 |
| JP2009514835A5 true JP2009514835A5 (cg-RX-API-DMAC7.html) | 2009-07-23 |
Family
ID=37763784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538364A Withdrawn JP2009514835A (ja) | 2005-11-03 | 2006-11-03 | トリシクロ置換型アミド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20090005391A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1948644A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2009514835A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2006310474A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0618062A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2626475A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007051845A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101035767A (zh) * | 2004-08-12 | 2007-09-12 | 普洛希典有限公司 | 被取代的苯乙酰胺及其作为葡糖激酶激活剂的用途 |
| CA2628486A1 (en) * | 2005-11-03 | 2007-05-10 | Prosidion Ltd. | Tricyclo substituted amides |
| EP2261216A3 (en) * | 2006-07-24 | 2011-12-14 | F. Hoffmann-La Roche AG | Pyrazoles as glucokinase activators |
| MX2009001043A (es) | 2006-08-08 | 2009-02-06 | Sanofi Aventis | Imidazolidina-2,4-dionas sustituidas con arilaminoarilalquilo, procedimiento para preparalas, medicamentos que comprenden estos compuestos y su uso. |
| TW200831081A (en) * | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
| EP2116533B1 (en) * | 2007-03-07 | 2013-07-10 | Kyorin Pharmaceutical Co., Ltd. | Glucokinase activator |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| CL2009000004A1 (es) * | 2008-01-15 | 2010-02-19 | Lilly Co Eli | Forma cristalina de r-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida; composicion farmaceutica que comprende a dicha forma cristalina; y uso para el tratamiento de diabetes o hiperglicemia. |
| KR20100113518A (ko) | 2008-01-18 | 2010-10-21 | 아스텔라스세이야쿠 가부시키가이샤 | 페닐아세트아미드 유도체 |
| US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
| US8258134B2 (en) | 2008-04-16 | 2012-09-04 | Hoffmann-La Roche Inc. | Pyridazinone glucokinase activators |
| NZ588462A (en) | 2008-04-28 | 2012-07-27 | Kyorin Seiyaku Kk | Cyclopentylacrylic acid amide derivative |
| EP2310372B1 (en) | 2008-07-09 | 2012-05-23 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| UA104742C2 (uk) | 2008-12-19 | 2014-03-11 | Эли Лилли Энд Компани | Похідні арилциклопропілацетаміду, застосовні як активатори глюкокінази |
| US8785608B2 (en) | 2009-08-26 | 2014-07-22 | Sanofi | Crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
| US8222416B2 (en) | 2009-12-14 | 2012-07-17 | Hoffmann-La Roche Inc. | Azaindole glucokinase activators |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| BR112015005631A2 (pt) * | 2012-09-26 | 2017-07-04 | Kowa Co | composto, composição farmacêutica, agente de ativação de glucoquinase, agente hipoglicêmico, agente para prevenir e/ou tratar pelo menos uma doença, métodos para ativar glucoquinase, para diminuir o nível de glicose no sangue e para prevenir e/ou tratar pelo menos uma doença, e, uso de um composto |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4046768A (en) * | 1976-06-17 | 1977-09-06 | Velsicol Chemical Corporation | 1-Thiazolyl-5-pyridylcarbonyloxyimidazolidinones |
| US5418212A (en) * | 1990-11-30 | 1995-05-23 | Kumiai Chemical Industry Co., Ltd. | Alkanoic acid amide derivative or its salt, and herbicidal composition |
| US6610846B1 (en) * | 1999-03-29 | 2003-08-26 | Hoffman-La Roche Inc. | Heteroaromatic glucokinase activators |
| US6320050B1 (en) * | 1999-03-29 | 2001-11-20 | Hoffmann-La Roche Inc. | Heteroaromatic glucokinase activators |
| RU2242469C2 (ru) * | 1999-03-29 | 2004-12-20 | Ф.Хоффманн-Ля Рош Аг | Активаторы глюкокиназы |
| US6353111B1 (en) * | 1999-12-15 | 2002-03-05 | Hoffmann-La Roche Inc. | Trans olefinic glucokinase activators |
| WO2001083465A2 (en) * | 2000-05-03 | 2001-11-08 | F. Hoffmann-La Roche Ag | Alkynyl phenyl heteroaromatic glucokinase activators |
| KR100548901B1 (ko) * | 2000-05-08 | 2006-02-02 | 에프. 호프만-라 로슈 아게 | 치환된 페닐아세트아미드 및 그의 글루코키나제활성화제로서의 용도 |
| US6489485B2 (en) * | 2000-05-08 | 2002-12-03 | Hoffmann-La Roche Inc. | Para-amine substituted phenylamide glucokinase activators |
| ATE297907T1 (de) * | 2000-07-20 | 2005-07-15 | Hoffmann La Roche | Alpha-acyl- und alpha-heteroatom-substituierte benzenacetamide verwendbar als glucokinase- aktivatoren |
| US6369232B1 (en) * | 2000-08-15 | 2002-04-09 | Hoffmann-La Roche Inc. | Tetrazolyl-phenyl acetamide glucokinase activators |
| WO2002046173A1 (en) * | 2000-12-06 | 2002-06-13 | F. Hoffmann-La Roche Ag | Fused heteroaromatic glucokinase activators |
| US6433188B1 (en) * | 2000-12-06 | 2002-08-13 | Wendy Lea Corbett | Fused heteroaromatic glucokinase activators |
| US6482951B2 (en) * | 2000-12-13 | 2002-11-19 | Hoffmann-La Roche Inc. | Isoindolin-1-one glucokinase activators |
| US6911545B2 (en) * | 2001-12-19 | 2005-06-28 | Hoffman-La Roche Inc. | Crystals of glucokinase and methods of growing them |
| WO2003097824A1 (en) * | 2002-05-16 | 2003-11-27 | Banyu Pharmaceutical Co., Ltd. | Crystal of glucokinase protein, and method for drug design using the crystal |
| CN101805358A (zh) * | 2002-10-03 | 2010-08-18 | 诺瓦提斯公司 | 作为葡糖激酶激活剂、可用于治疗ⅱ型糖尿病的取代的(噻唑-2-基)酰胺或磺酰胺 |
| EP1585739B1 (en) * | 2003-01-06 | 2011-04-20 | Eli Lilly And Company | Substituted arylcyclopropylacetamides as glucokinase activators |
| US7262196B2 (en) * | 2003-02-11 | 2007-08-28 | Prosidion Limited | Tri(cyclo) substituted amide glucokinase activator compounds |
| PL378117A1 (pl) * | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
| CN101137631A (zh) * | 2004-12-03 | 2008-03-05 | 转化技术制药公司 | 杂芳族葡糖激酶激活剂 |
| CA2628486A1 (en) * | 2005-11-03 | 2007-05-10 | Prosidion Ltd. | Tricyclo substituted amides |
-
2006
- 2006-11-03 JP JP2008538364A patent/JP2009514835A/ja not_active Withdrawn
- 2006-11-03 CA CA002626475A patent/CA2626475A1/en not_active Abandoned
- 2006-11-03 WO PCT/EP2006/068087 patent/WO2007051845A1/en not_active Ceased
- 2006-11-03 EP EP06819250A patent/EP1948644A1/en not_active Withdrawn
- 2006-11-03 BR BRPI0618062-0A patent/BRPI0618062A2/pt not_active IP Right Cessation
- 2006-11-03 AU AU2006310474A patent/AU2006310474A1/en not_active Abandoned
- 2006-11-03 US US12/091,947 patent/US20090005391A1/en not_active Abandoned