JP2009512844A5 - - Google Patents
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- Publication number
- JP2009512844A5 JP2009512844A5 JP2008536049A JP2008536049A JP2009512844A5 JP 2009512844 A5 JP2009512844 A5 JP 2009512844A5 JP 2008536049 A JP2008536049 A JP 2008536049A JP 2008536049 A JP2008536049 A JP 2008536049A JP 2009512844 A5 JP2009512844 A5 JP 2009512844A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- binding partner
- sample
- immune
- aggrecan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000027455 binding Effects 0.000 claims 20
- 238000000034 method Methods 0.000 claims 14
- 230000009870 specific binding Effects 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 102000016284 Aggrecans Human genes 0.000 claims 6
- 108010067219 Aggrecans Proteins 0.000 claims 6
- 238000001514 detection method Methods 0.000 claims 5
- 238000003018 immunoassay Methods 0.000 claims 5
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical group CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 claims 5
- 210000000845 cartilage Anatomy 0.000 claims 4
- 230000001900 immune effect Effects 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 210000001612 chondrocyte Anatomy 0.000 claims 2
- 238000002967 competitive immunoassay Methods 0.000 claims 2
- 239000003636 conditioned culture medium Substances 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 210000004408 hybridoma Anatomy 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 210000001179 synovial fluid Anatomy 0.000 claims 2
- 101000823100 Homo sapiens Putative alpha-1-antitrypsin-related protein Proteins 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 102100022709 Putative alpha-1-antitrypsin-related protein Human genes 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 230000007306 turnover Effects 0.000 claims 1
- 239000006226 wash reagent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0521392A GB0521392D0 (en) | 2005-10-20 | 2005-10-20 | Detection or quantification of aggrecan and its fragments |
| GB0608947A GB0608947D0 (en) | 2006-05-05 | 2006-05-05 | Detection or quantification of aggrecan and its fragments |
| PCT/EP2006/067520 WO2007045661A1 (en) | 2005-10-20 | 2006-10-17 | Detection or quantification of aggrecan and its fragments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009512844A JP2009512844A (ja) | 2009-03-26 |
| JP2009512844A5 true JP2009512844A5 (https=) | 2009-12-03 |
Family
ID=37622298
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008536049A Withdrawn JP2009512844A (ja) | 2005-10-20 | 2006-10-17 | アグリカンおよびそのフラグメントの検出または定量 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20090291462A1 (https=) |
| EP (1) | EP1938106A1 (https=) |
| JP (1) | JP2009512844A (https=) |
| WO (1) | WO2007045661A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110084254A (ko) * | 2008-10-16 | 2011-07-21 | 사이토닉스 코포레이션 | 척추 및 관절 통증을 탐지하고 치료하는 생체표식 및 방법 |
| CN102203617A (zh) * | 2008-10-22 | 2011-09-28 | 生物标记设计研究有限责任公司 | 用于检测和诊断骨或软骨障碍的方法 |
| AU2012367247B2 (en) * | 2012-01-24 | 2018-04-05 | Cd Diagnostics, Inc. | System for detecting infection in synovial fluid |
| BR112019008727A2 (pt) | 2016-11-28 | 2019-07-16 | Chugai Seiyaku Kabushiki Kaisha | domínio de ligação ao antígeno, e polipeptídeo incluindo seção de transporte |
| NZ759601A (en) * | 2017-06-02 | 2023-06-30 | Merck Patent Gmbh | Aggrecan binding immunoglobulins |
| JP7482630B2 (ja) | 2017-11-28 | 2024-05-14 | 中外製薬株式会社 | 抗原結合ドメインおよび運搬部分を含むポリペプチド |
| JP7414736B2 (ja) * | 2018-05-30 | 2024-01-16 | 中外製薬株式会社 | アグリカン結合ドメインおよび運搬部分を含むポリペプチド |
| CN114217078A (zh) * | 2021-12-23 | 2022-03-22 | 西安依朵生物科技有限公司 | 一种检测聚集蛋白聚糖的试纸条、试剂盒及检测方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8304836D0 (sv) * | 1983-09-09 | 1983-09-09 | Pharmacia Ab | Sett att bestemma forendringar i ledbrosk |
| US4704356A (en) * | 1984-03-27 | 1987-11-03 | Rush-Presbyterian-St. Luke's Medical Center | Method of diagnosing cartilage tissue abnormalities |
| US5185245A (en) * | 1989-02-24 | 1993-02-09 | Thomas Jefferson University | Immumoassays and kit for detection of proteoglycans |
| US5217903A (en) * | 1990-05-15 | 1993-06-08 | Trustees Of Boston University | Measuring connective tissue breakdown products in body fluids |
| US5427954A (en) * | 1992-04-29 | 1995-06-27 | Shriner's Hospitals For Crippled Children | Compositions and methods for detection and treatment of human osteoarthritis |
| US5387504A (en) * | 1992-09-30 | 1995-02-07 | Merck & Co., Inc. | Monospecific antibodies and assay system for detecting stromelysin cleavage products |
| JP3694894B2 (ja) * | 1994-02-19 | 2005-09-14 | 生化学工業株式会社 | 正常アグリカンの測定法および測定用キット |
| US5935796A (en) * | 1995-06-30 | 1999-08-10 | The University Of Melbourne | Diagnostic methods and compositions relating to the proteoglycan proteins of cartilage breakdown |
| US6207672B1 (en) * | 1995-11-13 | 2001-03-27 | Aventis Pharma Deutschland Gmbh | Cyclic and heterocyclic N-substituted α-iminohydroxamic and carboxyclic acids |
-
2006
- 2006-10-17 JP JP2008536049A patent/JP2009512844A/ja not_active Withdrawn
- 2006-10-17 WO PCT/EP2006/067520 patent/WO2007045661A1/en not_active Ceased
- 2006-10-17 EP EP06807362A patent/EP1938106A1/en not_active Withdrawn
- 2006-10-17 US US12/083,900 patent/US20090291462A1/en not_active Abandoned
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