JP2009511548A - 新規ピリミジン−２，４−ジアミン誘導体及び小コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしてのこれらの使用 - Google Patents
新規ピリミジン−２，４−ジアミン誘導体及び小コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしてのこれらの使用 Download PDFInfo
- Publication number
- JP2009511548A JP2009511548A JP2008535039A JP2008535039A JP2009511548A JP 2009511548 A JP2009511548 A JP 2009511548A JP 2008535039 A JP2008535039 A JP 2008535039A JP 2008535039 A JP2008535039 A JP 2008535039A JP 2009511548 A JP2009511548 A JP 2009511548A
- Authority
- JP
- Japan
- Prior art keywords
- pyrimidine
- diamine
- alkyl
- amino
- cyano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 102000005702 Calcium-Activated Potassium Channels Human genes 0.000 title abstract description 4
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- 239000001257 hydrogen Substances 0.000 claims description 63
- 125000000217 alkyl group Chemical group 0.000 claims description 51
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 37
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 35
- -1 cyano, amino Chemical group 0.000 claims description 33
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- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 29
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72650805P | 2005-10-14 | 2005-10-14 | |
| DKPA200501439 | 2005-10-14 | ||
| PCT/EP2006/067387 WO2007042571A1 (en) | 2005-10-14 | 2006-10-13 | Novel pyrimidine-2,4-diamine derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009511548A true JP2009511548A (ja) | 2009-03-19 |
| JP2009511548A5 JP2009511548A5 (enExample) | 2009-10-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008535039A Abandoned JP2009511548A (ja) | 2005-10-14 | 2006-10-13 | 新規ピリミジン−２，４−ジアミン誘導体及び小コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしてのこれらの使用 |
Country Status (4)
| Country | Link |
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| US (1) | US20090124645A1 (enExample) |
| EP (1) | EP1940804A2 (enExample) |
| JP (1) | JP2009511548A (enExample) |
| WO (1) | WO2007042571A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010505794A (ja) | 2006-10-03 | 2010-02-25 | ノイロサーチ アクティーゼルスカブ | カリウムチャネル調節剤として有用なインダゾリル誘導体 |
| JP2010111702A (ja) | 2009-02-16 | 2010-05-20 | Tetsuya Nishio | 複素環化合物、その製造法および用途 |
| BR112012029647A2 (pt) | 2010-05-21 | 2016-08-02 | Chemilia Ab | novos derivados de pirimidinas |
| MX2013010898A (es) | 2011-03-24 | 2013-12-06 | Chemilia Ab | Novedoso derivados de la pirimidina. |
| EP2760843B1 (en) * | 2011-09-26 | 2016-03-02 | Bristol-Myers Squibb Company | Selective nr2b antagonists |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| IN188411B (enExample) * | 1997-03-27 | 2002-09-21 | Yuhan Corp | |
| TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| WO2004043936A1 (ja) | 2002-11-14 | 2004-05-27 | Kyowa Hakko Kogyo Co., Ltd. | Ｐｌｋ阻害剤 |
| KR20060052806A (ko) | 2003-07-25 | 2006-05-19 | 시바 스폐셜티 케미칼스 홀딩 인코포레이티드 | 항균제로서 치환된 2,4-비스(알킬아미노)피리미딘 또는-퀴나졸린의 용도 |
| US7642354B2 (en) * | 2004-04-13 | 2010-01-05 | Icagen, Inc. | Polycyclic pyrazines as potassium ion channel modulators |
| EP2319512A1 (en) * | 2005-01-11 | 2011-05-11 | NeuroSearch AS | Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels. |
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2006
- 2006-10-13 JP JP2008535039A patent/JP2009511548A/ja not_active Abandoned
- 2006-10-13 EP EP06807251A patent/EP1940804A2/en not_active Withdrawn
- 2006-10-13 WO PCT/EP2006/067387 patent/WO2007042571A1/en not_active Ceased
- 2006-10-13 US US12/083,433 patent/US20090124645A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1940804A2 (en) | 2008-07-09 |
| WO2007042571A8 (en) | 2008-04-17 |
| US20090124645A1 (en) | 2009-05-14 |
| WO2007042571A1 (en) | 2007-04-19 |
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