JP2009509956A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009509956A5 JP2009509956A5 JP2008532243A JP2008532243A JP2009509956A5 JP 2009509956 A5 JP2009509956 A5 JP 2009509956A5 JP 2008532243 A JP2008532243 A JP 2008532243A JP 2008532243 A JP2008532243 A JP 2008532243A JP 2009509956 A5 JP2009509956 A5 JP 2009509956A5
- Authority
- JP
- Japan
- Prior art keywords
- antibiotic
- middle ear
- ear infection
- administered
- treat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000003115 biocidal effect Effects 0.000 claims 12
- 206010033078 Otitis media Diseases 0.000 claims 7
- 208000022760 infectious otitis media Diseases 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000004721 Polyphenylene oxide Substances 0.000 claims 2
- 125000002877 alkyl aryl group Chemical group 0.000 claims 2
- 239000003443 antiviral agent Substances 0.000 claims 2
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims 2
- 229920000570 polyether Polymers 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 210000003454 tympanic membrane Anatomy 0.000 claims 2
- GSDSWSVVBLHKDQ-UHFFFAOYSA-N 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Chemical compound FC1=CC(C(C(C(O)=O)=C2)=O)=C3N2C(C)COC3=C1N1CCN(C)CC1 GSDSWSVVBLHKDQ-UHFFFAOYSA-N 0.000 claims 1
- 229930186147 Cephalosporin Natural products 0.000 claims 1
- KYGZCKSPAKDVKC-UHFFFAOYSA-N Oxolinic acid Chemical compound C1=C2N(CC)C=C(C(O)=O)C(=O)C2=CC2=C1OCO2 KYGZCKSPAKDVKC-UHFFFAOYSA-N 0.000 claims 1
- 229930182555 Penicillin Natural products 0.000 claims 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
- NHUHCSRWZMLRLA-UHFFFAOYSA-N Sulfisoxazole Chemical compound CC1=NOC(NS(=O)(=O)C=2C=CC(N)=CC=2)=C1C NHUHCSRWZMLRLA-UHFFFAOYSA-N 0.000 claims 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical group N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims 1
- 229960004150 aciclovir Drugs 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims 1
- 229960003022 amoxicillin Drugs 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 239000003781 beta lactamase inhibitor Substances 0.000 claims 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 claims 1
- 229940124587 cephalosporin Drugs 0.000 claims 1
- 150000001780 cephalosporins Chemical class 0.000 claims 1
- 229960003405 ciprofloxacin Drugs 0.000 claims 1
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 1
- 229960001699 ofloxacin Drugs 0.000 claims 1
- LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims 1
- 229940049954 penicillin Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000003306 quinoline derived antiinfective agent Substances 0.000 claims 1
- 229960000654 sulfafurazole Drugs 0.000 claims 1
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 claims 1
- 229960004224 tyloxapol Drugs 0.000 claims 1
- 229920001664 tyloxapol Polymers 0.000 claims 1
- 229940126085 β‑Lactamase Inhibitor Drugs 0.000 claims 1
Claims (17)
- 以下の段階を含む、医薬の経膜的投与によって中耳感染症およびその後遺症を処置または予防するための方法：
無傷の鼓膜(tympanic membrane)の外部表面に、中耳感染症およびその後遺症の処置または予防に有用な医薬を含む経膜的担体組成物を適用する段階。 - 経膜的担体が非イオン性ポリマー界面活性剤である、請求項1記載の方法。
- 非イオン性ポリマー界面活性剤がアルキルアリールポリエーテルアルコールである、請求項2記載の方法。
- 医薬が抗生物質である、請求項1記載の方法。
- 抗生物質が、キノロン系抗生物質、ペニシリン系抗生物質、マクロライド系抗生物質、セファロスポリン系抗生物質、サルファ系抗生物質、およびベータラクタマーゼ阻害剤からなる群より選択される、請求項4記載の方法。
- 抗生物質がシプロフロキサシンを含み、かつ中耳感染症を処置または予防するために投与される、請求項4記載の方法。
- 抗生物質がオフロキサシンを含み、かつ中耳感染症を処置または予防するために投与される、請求項4記載の方法。
- 抗生物質がスルフィソキサゾールを含み、かつ中耳感染症を処置または予防するために投与される、請求項4記載の方法。
- 抗生物質がアモキシシリンを含み、かつ中耳感染症を処置または予防するために投与される、請求項4記載の方法。
- 抗生物質が0.1％から10％ w/wの組成物濃度で提供される、請求項4記載の方法。
- 抗生物質が組成物の0.3％ w/wの濃度で提供される、請求項4記載の方法。
- 非イオン性ポリマー界面活性剤が約0.01から10％ w/wの濃度で提供される、請求項2記載の方法。
- 非イオン性ポリマー界面活性剤が約0.05％から約0.2％ v/vの濃度で提供される、請求項2記載の方法。
- 医薬が抗ウイルス剤である、請求項1記載の方法。
- 抗ウイルス剤がアシクロビルである、請求項14記載の方法。
- アルキルアリールポリエーテルアルコールがチロキサポールである、請求項2記載の方法。
- 経膜的担体組成物が、中耳感染症の急性期の間に鼓膜(tympanic membrane)に適用される、請求項1記載の方法。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72053605P | 2005-09-26 | 2005-09-26 | |
| PCT/US2006/033598 WO2007037886A2 (en) | 2005-09-26 | 2006-08-25 | Methods for treatment and prevention of otitis media using nonionic surfactants to facilitate transmembrane drug delivery into the middle ear |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009509956A JP2009509956A (ja) | 2009-03-12 |
| JP2009509956A5 true JP2009509956A5 (ja) | 2009-09-03 |
Family
ID=37900209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008532243A Withdrawn JP2009509956A (ja) | 2005-09-26 | 2006-08-25 | 非イオン性界面活性剤を使用して中耳内への経膜的薬物送達を促進する、中耳炎の処置および予防のための方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20080318918A1 (ja) |
| EP (1) | EP1931388A4 (ja) |
| JP (1) | JP2009509956A (ja) |
| CN (1) | CN101272807A (ja) |
| AU (1) | AU2006295248A1 (ja) |
| BR (1) | BRPI0616415A2 (ja) |
| CA (1) | CA2622002A1 (ja) |
| EA (1) | EA200800950A1 (ja) |
| IL (1) | IL190079A0 (ja) |
| WO (1) | WO2007037886A2 (ja) |
| ZA (1) | ZA200803370B (ja) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8271101B2 (en) * | 2007-08-29 | 2012-09-18 | Advanced Bionics | Modular drug delivery system for minimizing trauma during and after insertion of a cochlear lead |
| US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
| CA2721927C (en) | 2008-04-21 | 2014-01-28 | Otonomy, Inc. | Auris formulations for treating otic diseases and conditions |
| CN102026623B (zh) | 2008-05-14 | 2013-08-14 | 奥德纳米有限公司 | 用于治疗耳部病症的控制释放皮质类固醇组合物和方法 |
| US8648119B2 (en) | 2008-05-23 | 2014-02-11 | Otonomy, Inc. | Controlled release immunomodulator compositions and methods for the treatment of otic disorders |
| US8846770B2 (en) | 2008-06-18 | 2014-09-30 | Otonomy, Inc. | Controlled release aural pressure modulator compositions and methods for the treatment of OTIC disorders |
| US8349353B2 (en) | 2008-06-27 | 2013-01-08 | Otonomy, Inc. | Controlled release cytotoxic agent compositions and methods for the treatment of otic disorders |
| WO2010011466A2 (en) | 2008-06-27 | 2010-01-28 | Otonomy, Inc. | Controlled-release cns modulating compositions and methods for the treatment of otic disorders |
| US20100016450A1 (en) * | 2008-07-21 | 2010-01-21 | Otonomy, Inc. | Controlled release delivery devices for the treatment of otic disorders |
| US8496957B2 (en) | 2008-07-21 | 2013-07-30 | Otonomy, Inc | Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders |
| US8399018B2 (en) | 2008-07-21 | 2013-03-19 | Otonomy, Inc. | Controlled release ion channel modulator compositions and methods for the treatment of otic disorders |
| US8318817B2 (en) | 2008-07-21 | 2012-11-27 | Otonomy, Inc. | Controlled release antimicrobial compositions and methods for the treatment of otic disorders |
| US10092580B2 (en) | 2008-07-21 | 2018-10-09 | Otonomy, Inc. | Controlled-release otic structure modulating and innate immune system modulating compositions and methods for the treatment of otic disorders |
| US8784870B2 (en) | 2008-07-21 | 2014-07-22 | Otonomy, Inc. | Controlled release compositions for modulating free-radical induced damage and methods of use thereof |
| US11033624B2 (en) | 2010-06-02 | 2021-06-15 | Novaflux Inc. | Medical item for prevention and treatment of ear infection |
| MD674Z (ro) * | 2013-03-07 | 2014-04-30 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Metodă de tratament al otitei medii exudative la copii |
| US10166146B2 (en) | 2013-03-08 | 2019-01-01 | Mark Mitchnick | Ear medication dispenser with sensor |
| CA2921816A1 (en) | 2013-08-27 | 2015-03-05 | Otonomy, Inc. | Treatment of pediatric otic disorders |
| WO2015168642A1 (en) | 2014-05-02 | 2015-11-05 | Labib Mohamed E | Drug-releasing device usable in mucosal body cavities |
| WO2018053173A1 (en) | 2016-09-16 | 2018-03-22 | Otonomy, Inc. | Otic gel formulations for treating otitis externa |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3549770A (en) * | 1963-12-09 | 1970-12-22 | Crown Zellerbach Corp | Therapeutic administration of effective amounts of dimethyl sulfoxide to human and animal subjects |
| US5231112A (en) * | 1984-04-12 | 1993-07-27 | The Liposome Company, Inc. | Compositions containing tris salt of cholesterol hemisuccinate and antifungal |
| US4761288A (en) * | 1984-09-24 | 1988-08-02 | Mezei Associates Limited | Multiphase liposomal drug delivery system |
| US4897269A (en) * | 1984-09-24 | 1990-01-30 | Mezei Associates Limited | Administration of drugs with multiphase liposomal delivery system |
| DE3936328A1 (de) * | 1989-10-27 | 1991-05-02 | Schering Ag | Pharmazeutische praeparate |
| US5542935A (en) * | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
| US5540930A (en) * | 1993-10-25 | 1996-07-30 | Pharmos Corporation | Suspension of loteprednol etabonate for ear, eye, or nose treatment |
| US5843930A (en) * | 1995-06-06 | 1998-12-01 | Bayer Corporation | Method of treating otitis with ciprofloxacin-hydrocortisone suspension |
| US6716830B2 (en) * | 1998-09-30 | 2004-04-06 | Alcon, Inc. | Ophthalmic antibiotic compositions containing moxifloxacin |
| US6093417A (en) * | 1999-01-11 | 2000-07-25 | Advanced Medical Instruments | Composition to treat ear disorders |
| US6723714B2 (en) * | 1999-07-06 | 2004-04-20 | Blansett Pharmacal Co., Inc. | Aqueous solvent for corticosteroids |
| WO2001015677A2 (en) * | 1999-08-31 | 2001-03-08 | Alcon Laboratories, Inc. | Use of 5-ht1b/1d agonists to treat otic pain |
| CA2425749A1 (en) * | 2000-09-25 | 2002-04-04 | Daniel Ciszewski | Otic microbial combinations for treatment of animals with ruptured tympanic membrane |
| US6716813B2 (en) * | 2000-11-28 | 2004-04-06 | House Ear Institute | Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis |
| US7220431B2 (en) * | 2002-11-27 | 2007-05-22 | Regents Of The University Of Minnesota | Methods and compositions for applying pharmacologic agents to the ear |
| JP2006510657A (ja) * | 2002-12-06 | 2006-03-30 | アライバ ファーマシューティカルズ，インコーポレイティド | 中耳炎の処置のための方法および組成物 |
| MXPA05010659A (es) * | 2003-04-04 | 2005-12-12 | Merial Ltd | Formulaciones veterinarias antihelminticas topicas. |
| US20050058673A1 (en) * | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
| EP1784164A4 (en) * | 2004-09-03 | 2008-07-09 | Piedmont Pharmaceuticals Llc | PROCESS FOR TRANSMEMBRANE TREATMENT AND PREVENTION OF OTITIS MEDIA |
| US20060051384A1 (en) * | 2004-09-07 | 2006-03-09 | 3M Innovative Properties Company | Antiseptic compositions and methods of use |
-
2006
- 2006-08-25 EA EA200800950A patent/EA200800950A1/ru unknown
- 2006-08-25 WO PCT/US2006/033598 patent/WO2007037886A2/en active Application Filing
- 2006-08-25 ZA ZA200803370A patent/ZA200803370B/xx unknown
- 2006-08-25 BR BRPI0616415-3A patent/BRPI0616415A2/pt not_active IP Right Cessation
- 2006-08-25 JP JP2008532243A patent/JP2009509956A/ja not_active Withdrawn
- 2006-08-25 US US12/066,488 patent/US20080318918A1/en not_active Abandoned
- 2006-08-25 CN CNA2006800353863A patent/CN101272807A/zh active Pending
- 2006-08-25 EP EP06813877A patent/EP1931388A4/en not_active Withdrawn
- 2006-08-25 AU AU2006295248A patent/AU2006295248A1/en not_active Abandoned
- 2006-08-25 CA CA002622002A patent/CA2622002A1/en not_active Abandoned
-
2008
- 2008-03-11 IL IL190079A patent/IL190079A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009509956A5 (ja) | ||
| WO2007037886B1 (en) | Methods for treatment and prevention of otitis media using nonionic surfactants to facilitate transmembrane drug delivery into the middle ear | |
| WO2007037874B1 (en) | Methods for treatment and prevention of otitis media using chemical penetration enhancers to facilitate transmembrane drug delivery into the middle ear | |
| CN1184968C (zh) | 治疗眼、耳和鼻的抗生素组合物 | |
| WO2004062601A3 (en) | Antibacterial agents | |
| WO2005020929A3 (en) | Sustained release dosage forms of ziprasidone | |
| ATE304006T1 (de) | Aminopiperidinderivate als antibakterielles arzneimittel | |
| WO2008154642A3 (en) | Antibacterial agents | |
| FI3625233T5 (fi) | 3-(((((2s,5r)-2-karbamoyyli-7-okso-1,6-diatsabisyklo[3.2.1]oktan-6-yyli)oksi)sulfonyyli)oksi)-2,2-dimetyylipropanoaattijohdannaisia ja niihin liittyviä yhdisteitä beetalaktamaasiestäjien suun kautta otettavina aihiolääkkeinä bakteeri-infektioiden hoitamiseksi | |
| WO2008063727A3 (en) | Combination therapy for treatment of viral infections | |
| BRPI0517128A (pt) | composições de combate à resistência a antibióticos, métodos de tratamento e processos de preparação de composição | |
| WO2008020229A3 (en) | Antibacterial pyrrolecarboxamides | |
| WO2008020227A3 (en) | Antibacterial pyrrolecarboxamides | |
| JP2012532115A5 (ja) | ||
| DE602006019754D1 (de) | Verfahren und zusammensetzung, die immunomodulatorische verbindungen zur behandlung von mit niedrigen plasmaleptin-spiegeln in zusammenhang stehenden störungen verwenden | |
| WO2006029074A3 (en) | Methods for transmembrane treatment and prevention of otitis media | |
| KR20100045513A (ko) | 감염의 치료 또는 제어를 위한, 퀴놀론을 포함하는 조성물 및 방법 | |
| JP2013510861A5 (ja) | ||
| ES2324794T3 (es) | Imidazo(4,5-c)pyridine componente y metodo de tratamiento antiviral. | |
| WO2008071961A8 (en) | 2-quinolinone and 2-quinoxalinone- derivatives and their use as antibacterial agents | |
| RS51615B (en) | PHOTOSTABLE PHARMACEUTICAL COMPOSITION CONTAINING BRIVUDINE FOR THE TREATMENT OF HERPETIC KERATITIS | |
| WO2008080398A1 (en) | Anti - infective agents such as phenothiazine and thioxanthene derivates to treat infectious diseases | |
| AU2010240999A1 (en) | Thioxanthene derivatives for the treatment of infectious diseases | |
| JP2006528190A5 (ja) | ||
| JP2006528185A5 (ja) |