EA200800950A1 - Способы лечения и профилактики среднего отита с применением неионных поверхностно-активных веществ для облегчения трансмембранного введения лекарственного средства в среднее ухо - Google Patents

Способы лечения и профилактики среднего отита с применением неионных поверхностно-активных веществ для облегчения трансмембранного введения лекарственного средства в среднее ухо

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Publication number
EA200800950A1
EA200800950A1 EA200800950A EA200800950A EA200800950A1 EA 200800950 A1 EA200800950 A1 EA 200800950A1 EA 200800950 A EA200800950 A EA 200800950A EA 200800950 A EA200800950 A EA 200800950A EA 200800950 A1 EA200800950 A1 EA 200800950A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
otitis
ears
medicinal
introduction
Prior art date
Application number
EA200800950A
Other languages
English (en)
Inventor
Уилльям Р. Кэмпбелл
Нил Э. Полсен
Роланд Х. Джонсон
Original Assignee
ПЬЕДМОН ФАРМАСЬЮТИКАЛЗ ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ПЬЕДМОН ФАРМАСЬЮТИКАЛЗ ЭлЭлСи filed Critical ПЬЕДМОН ФАРМАСЬЮТИКАЛЗ ЭлЭлСи
Publication of EA200800950A1 publication Critical patent/EA200800950A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Abstract

Способы лечения и профилактики инфекций среднего уха посредством трансмембранного введения содержащих лекарственное средство композиций для трансмембранного переноса, включающих неионное полимерное поверхностно-активное вещество, такое как алкиларилполиэфирный спирт (например, тилоксапол), в барабанную перепонку. Лекарственные средства, доставляемые методами по настоящему изобретению, включают антибиотики, противовирусные, противогрибковые и противовоспалительные средства, которые применимы для лечения и/или профилактики инфекций среднего уха и их осложнений.
EA200800950A 2005-09-26 2006-08-25 Способы лечения и профилактики среднего отита с применением неионных поверхностно-активных веществ для облегчения трансмембранного введения лекарственного средства в среднее ухо EA200800950A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72053605P 2005-09-26 2005-09-26
PCT/US2006/033598 WO2007037886A2 (en) 2005-09-26 2006-08-25 Methods for treatment and prevention of otitis media using nonionic surfactants to facilitate transmembrane drug delivery into the middle ear

Publications (1)

Publication Number Publication Date
EA200800950A1 true EA200800950A1 (ru) 2008-08-29

Family

ID=37900209

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800950A EA200800950A1 (ru) 2005-09-26 2006-08-25 Способы лечения и профилактики среднего отита с применением неионных поверхностно-активных веществ для облегчения трансмембранного введения лекарственного средства в среднее ухо

Country Status (11)

Country Link
US (1) US20080318918A1 (ru)
EP (1) EP1931388A4 (ru)
JP (1) JP2009509956A (ru)
CN (1) CN101272807A (ru)
AU (1) AU2006295248A1 (ru)
BR (1) BRPI0616415A2 (ru)
CA (1) CA2622002A1 (ru)
EA (1) EA200800950A1 (ru)
IL (1) IL190079A0 (ru)
WO (1) WO2007037886A2 (ru)
ZA (1) ZA200803370B (ru)

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MD674Z (ru) * 2013-03-07 2014-04-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Метод лечения экссудативного среднего отита у детей

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CN102014957B (zh) 2008-04-21 2014-12-10 奥德纳米有限公司 用于治疗耳部疾病和病况的耳用调配物
MX2010012397A (es) 2008-05-14 2011-03-15 Otonomy Inc Star Composiciones de corticosteroides de liberacion controlada y metodos para el tratamiento de transtornos oticos.
US8648119B2 (en) 2008-05-23 2014-02-11 Otonomy, Inc. Controlled release immunomodulator compositions and methods for the treatment of otic disorders
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US8399018B2 (en) 2008-07-21 2013-03-19 Otonomy, Inc. Controlled release ion channel modulator compositions and methods for the treatment of otic disorders
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US8496957B2 (en) 2008-07-21 2013-07-30 Otonomy, Inc Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
US8784870B2 (en) 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
US11033624B2 (en) 2010-06-02 2021-06-15 Novaflux Inc. Medical item for prevention and treatment of ear infection
US10166146B2 (en) 2013-03-08 2019-01-01 Mark Mitchnick Ear medication dispenser with sensor
MX2016002408A (es) 2013-08-27 2016-10-28 Otonomy Inc Metodos para el tratamiento de trastornos oticos pediatricos.
WO2015168642A1 (en) 2014-05-02 2015-11-05 Labib Mohamed E Drug-releasing device usable in mucosal body cavities
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MD674Z (ru) * 2013-03-07 2014-04-30 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Метод лечения экссудативного среднего отита у детей

Also Published As

Publication number Publication date
WO2007037886B1 (en) 2008-01-10
US20080318918A1 (en) 2008-12-25
ZA200803370B (en) 2009-09-30
EP1931388A4 (en) 2010-12-15
CN101272807A (zh) 2008-09-24
CA2622002A1 (en) 2007-04-05
BRPI0616415A2 (pt) 2011-06-21
JP2009509956A (ja) 2009-03-12
WO2007037886A2 (en) 2007-04-05
EP1931388A2 (en) 2008-06-18
AU2006295248A1 (en) 2007-04-05
WO2007037886A3 (en) 2007-10-25
IL190079A0 (en) 2008-08-07

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