JP2009509533A5 - - Google Patents
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- JP2009509533A5 JP2009509533A5 JP2008533553A JP2008533553A JP2009509533A5 JP 2009509533 A5 JP2009509533 A5 JP 2009509533A5 JP 2008533553 A JP2008533553 A JP 2008533553A JP 2008533553 A JP2008533553 A JP 2008533553A JP 2009509533 A5 JP2009509533 A5 JP 2009509533A5
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- 210000004027 cell Anatomy 0.000 claims 68
- 108090000623 proteins and genes Proteins 0.000 claims 48
- 238000013518 transcription Methods 0.000 claims 46
- 230000035897 transcription Effects 0.000 claims 46
- 102000039446 nucleic acids Human genes 0.000 claims 45
- 108020004707 nucleic acids Proteins 0.000 claims 45
- 150000007523 nucleic acids Chemical class 0.000 claims 45
- 230000014509 gene expression Effects 0.000 claims 16
- 238000000034 method Methods 0.000 claims 15
- 230000035772 mutation Effects 0.000 claims 15
- 239000002207 metabolite Substances 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 8
- 241000894007 species Species 0.000 claims 7
- 239000013604 expression vector Substances 0.000 claims 6
- 210000003463 organelle Anatomy 0.000 claims 5
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 4
- 241000196324 Embryophyta Species 0.000 claims 4
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims 4
- 102000017143 RNA Polymerase I Human genes 0.000 claims 4
- 108010013845 RNA Polymerase I Proteins 0.000 claims 4
- 102000009572 RNA Polymerase II Human genes 0.000 claims 4
- 108010009460 RNA Polymerase II Proteins 0.000 claims 4
- 102000014450 RNA Polymerase III Human genes 0.000 claims 4
- 108010078067 RNA Polymerase III Proteins 0.000 claims 4
- 102000018068 TATA-Binding Protein Associated Factors Human genes 0.000 claims 4
- 108010091120 TATA-Binding Protein Associated Factors Proteins 0.000 claims 4
- 102000006467 TATA-Box Binding Protein Human genes 0.000 claims 4
- 108010044281 TATA-Box Binding Protein Proteins 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 4
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- 239000002699 waste material Substances 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 108050007599 Anti-sigma factor Proteins 0.000 claims 3
- 241000238631 Hexapoda Species 0.000 claims 3
- 102000003964 Histone deacetylase Human genes 0.000 claims 3
- 108090000353 Histone deacetylase Proteins 0.000 claims 3
- 230000001580 bacterial effect Effects 0.000 claims 3
- 238000012217 deletion Methods 0.000 claims 3
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- 210000003527 eukaryotic cell Anatomy 0.000 claims 3
- 230000002538 fungal effect Effects 0.000 claims 3
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
- 210000001236 prokaryotic cell Anatomy 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 230000002103 transcriptional effect Effects 0.000 claims 3
- 210000005253 yeast cell Anatomy 0.000 claims 3
- 229940090248 4-hydroxybenzoic acid Drugs 0.000 claims 2
- 101100306508 Bacillus subtilis (strain 168) sigB gene Proteins 0.000 claims 2
- 101100334569 Escherichia coli (strain K12) fecI gene Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 claims 2
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 claims 2
- 101100091878 Plasmodium falciparum (isolate 3D7) rpoC2 gene Proteins 0.000 claims 2
- 101150033071 RPO7 gene Proteins 0.000 claims 2
- 101100259732 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) TAF10 gene Proteins 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 244000061458 Solanum melongena Species 0.000 claims 2
- 235000002597 Solanum melongena Nutrition 0.000 claims 2
- 102000006290 Transcription Factor TFIID Human genes 0.000 claims 2
- 108010083268 Transcription Factor TFIID Proteins 0.000 claims 2
- 210000003763 chloroplast Anatomy 0.000 claims 2
- 101150017109 fliA gene Proteins 0.000 claims 2
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 claims 2
- 229960004999 lycopene Drugs 0.000 claims 2
- 235000012661 lycopene Nutrition 0.000 claims 2
- 239000001751 lycopene Substances 0.000 claims 2
- 230000002503 metabolic effect Effects 0.000 claims 2
- 238000002493 microarray Methods 0.000 claims 2
- 210000003470 mitochondria Anatomy 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 101150067683 rpo10 gene Proteins 0.000 claims 2
- 101150029016 rpo3 gene Proteins 0.000 claims 2
- 101150084116 rpo4 gene Proteins 0.000 claims 2
- 101150034869 rpo5 gene Proteins 0.000 claims 2
- 101150102864 rpoD gene Proteins 0.000 claims 2
- 101150040886 rpoE gene Proteins 0.000 claims 2
- 101150106872 rpoH gene Proteins 0.000 claims 2
- 101150011750 rpoN gene Proteins 0.000 claims 2
- 101150076849 rpoS gene Proteins 0.000 claims 2
- 101150117326 sigA gene Proteins 0.000 claims 2
- 101150077142 sigH gene Proteins 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 230000001629 suppression Effects 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 231100000331 toxic Toxicity 0.000 claims 2
- 230000002588 toxic effect Effects 0.000 claims 2
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- 101150098914 GAL11 gene Proteins 0.000 claims 1
- 101150009285 HRS1 gene Proteins 0.000 claims 1
- 102000011787 Histone Methyltransferases Human genes 0.000 claims 1
- 108010036115 Histone Methyltransferases Proteins 0.000 claims 1
- 101150113148 MED2 gene Proteins 0.000 claims 1
- 101150031895 PAF1 gene Proteins 0.000 claims 1
- 206010035148 Plague Diseases 0.000 claims 1
- 102000055027 Protein Methyltransferases Human genes 0.000 claims 1
- 108700040121 Protein Methyltransferases Proteins 0.000 claims 1
- 101150102885 RGR1 gene Proteins 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 101150109831 SIN4 gene Proteins 0.000 claims 1
- 101150112782 SNF2 gene Proteins 0.000 claims 1
- 101150016929 SWI1 gene Proteins 0.000 claims 1
- 101100533773 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) SNF6 gene Proteins 0.000 claims 1
- 101100422887 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) SWI1 gene Proteins 0.000 claims 1
- 102000004357 Transferases Human genes 0.000 claims 1
- 108090000992 Transferases Proteins 0.000 claims 1
- 241000607479 Yersinia pestis Species 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 235000013399 edible fruits Nutrition 0.000 claims 1
- 239000002920 hazardous waste Substances 0.000 claims 1
- 238000012203 high throughput assay Methods 0.000 claims 1
- 239000000543 intermediate Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 230000008723 osmotic stress Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 230000003698 anagen phase Effects 0.000 description 1
- 239000006481 glucose medium Substances 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/238,096 US20070072194A1 (en) | 2005-09-28 | 2005-09-28 | Global transcription machinery engineering |
| US74831505P | 2005-12-07 | 2005-12-07 | |
| PCT/US2006/037597 WO2007038564A2 (en) | 2005-09-28 | 2006-09-28 | Global transcription machinery engineering |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009509533A JP2009509533A (ja) | 2009-03-12 |
| JP2009509533A5 true JP2009509533A5 (enExample) | 2009-11-12 |
Family
ID=37891512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008533553A Pending JP2009509533A (ja) | 2005-09-28 | 2006-09-28 | 包括的な転写機構エンジニアリング |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1943343A2 (enExample) |
| JP (1) | JP2009509533A (enExample) |
| WO (1) | WO2007038564A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010512147A (ja) * | 2006-12-07 | 2010-04-22 | マサチューセッツ インスティテュート オブ テクノロジー | 包括的転写マシナリーエンジニアリング |
| WO2009009084A2 (en) * | 2007-07-12 | 2009-01-15 | Massachusetts Institute Of Technology | Transcriptional engineering of lactobacillus |
| WO2009025761A2 (en) | 2007-08-17 | 2009-02-26 | Massachusetts Institute Of Technology | Methods for identifying bacterial strains that produce l-tyrosine |
| US20100330614A1 (en) * | 2007-11-06 | 2010-12-30 | Massachusetts Institute Of Technology | Global transcription machinery engineering targeting the rnap alpha subunit (rpoa) |
| WO2011159629A2 (en) * | 2010-06-14 | 2011-12-22 | Cobalt Technologies, Inc. | Salt selection of microbial mutants to increase bioproduct tolerance, titer, or osmotic shock tolerance |
| KR101646310B1 (ko) * | 2013-06-24 | 2016-08-12 | 씨제이제일제당 (주) | L-쓰레오닌 생산 미생물 및 이를 이용한 l-쓰레오닌의 생산방법 |
| CN104630149B (zh) * | 2013-11-08 | 2018-08-21 | 中国科学院广州生物医药与健康研究院 | 外源线粒体导入到哺乳动物细胞中的方法 |
| CN104845924B (zh) * | 2015-04-01 | 2018-03-16 | 农业部沼气科学研究所 | 一株耐呋喃甲醛的运动发酵单胞菌及其制备方法和应用 |
-
2006
- 2006-09-28 WO PCT/US2006/037597 patent/WO2007038564A2/en not_active Ceased
- 2006-09-28 EP EP06825155A patent/EP1943343A2/en not_active Withdrawn
- 2006-09-28 JP JP2008533553A patent/JP2009509533A/ja active Pending
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