JP2009509533A - 包括的な転写機構エンジニアリング - Google Patents

包括的な転写機構エンジニアリング Download PDF

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Publication number
JP2009509533A
JP2009509533A JP2008533553A JP2008533553A JP2009509533A JP 2009509533 A JP2009509533 A JP 2009509533A JP 2008533553 A JP2008533553 A JP 2008533553A JP 2008533553 A JP2008533553 A JP 2008533553A JP 2009509533 A JP2009509533 A JP 2009509533A
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Prior art keywords
cell
nucleic acid
gene
cells
transcription machinery
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JP2008533553A
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Japanese (ja)
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JP2009509533A5 (enExample
Inventor
アルパー,ハル,エス.
ステファノプーロス,グレゴリー
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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Priority claimed from US11/238,096 external-priority patent/US20070072194A1/en
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Publication of JP2009509533A5 publication Critical patent/JP2009509533A5/ja
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245Escherichia (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1058Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1079Screening libraries by altering the phenotype or phenotypic trait of the host
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06Ethanol, i.e. non-beverage
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/62Carboxylic acid esters
    • C12P7/625Polyesters of hydroxy carboxylic acids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02EREDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00Technologies for the production of fuel of non-fossil origin
    • Y02E50/10Biofuels, e.g. bio-diesel

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ecology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Processing Of Solid Wastes (AREA)
JP2008533553A 2005-09-28 2006-09-28 包括的な転写機構エンジニアリング Pending JP2009509533A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/238,096 US20070072194A1 (en) 2005-09-28 2005-09-28 Global transcription machinery engineering
US74831505P 2005-12-07 2005-12-07
PCT/US2006/037597 WO2007038564A2 (en) 2005-09-28 2006-09-28 Global transcription machinery engineering

Publications (2)

Publication Number Publication Date
JP2009509533A true JP2009509533A (ja) 2009-03-12
JP2009509533A5 JP2009509533A5 (enExample) 2009-11-12

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JP2008533553A Pending JP2009509533A (ja) 2005-09-28 2006-09-28 包括的な転写機構エンジニアリング

Country Status (3)

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EP (1) EP1943343A2 (enExample)
JP (1) JP2009509533A (enExample)
WO (1) WO2007038564A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016521763A (ja) * 2013-06-24 2016-07-25 シージェイ チェイルジェダン コーポレーションCj Cheiljedang Corporation L−スレオニン産生微生物およびこれを用いたl−スレオニンの産生方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010512147A (ja) * 2006-12-07 2010-04-22 マサチューセッツ インスティテュート オブ テクノロジー 包括的転写マシナリーエンジニアリング
WO2009009084A2 (en) * 2007-07-12 2009-01-15 Massachusetts Institute Of Technology Transcriptional engineering of lactobacillus
WO2009025761A2 (en) 2007-08-17 2009-02-26 Massachusetts Institute Of Technology Methods for identifying bacterial strains that produce l-tyrosine
US20100330614A1 (en) * 2007-11-06 2010-12-30 Massachusetts Institute Of Technology Global transcription machinery engineering targeting the rnap alpha subunit (rpoa)
WO2011159629A2 (en) * 2010-06-14 2011-12-22 Cobalt Technologies, Inc. Salt selection of microbial mutants to increase bioproduct tolerance, titer, or osmotic shock tolerance
CN104630149B (zh) * 2013-11-08 2018-08-21 中国科学院广州生物医药与健康研究院 外源线粒体导入到哺乳动物细胞中的方法
CN104845924B (zh) * 2015-04-01 2018-03-16 农业部沼气科学研究所 一株耐呋喃甲醛的运动发酵单胞菌及其制备方法和应用

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
JPN6012011297; J. Bacteriol. Vol. 186, No. 12, 2004, p. 4034-4037 *
JPN6012011300; J. Mol. Biol. Vol. 203, 1988, p. 29-37 *
JPN6012011303; Mol. Gen. Genet. Vol. 184, 1981, p. 166-173 *
JPN6012011304; Genetics Vol. 153, 1999, p. 643-652 *
JPN6012011305; J. Mol. Biol. Vol. 254, 1995, p. 815-837 *
JPN6012011307; J. Bacteriol. Vol. 183, No. 21, 2001, p. 6413-6421 *
JPN6013027445; J. Bacteriol. Vol. 187, No. 3, 2005, p. 1022-1035 *
JPN6013027447; Biochem. Biophys. Res. Commun. Vol. 288, 2001, p. 385-389 *
JPN6013027449; FEMS Microbiol. Lett. Vol. 242, 2005, p. 161-167 *
JPN6013027451; J. Biol. Chem. Vol. 279, 2004, p. 54369-54379 *
JPN6013027452; J. Bacteriol. Vol. 181, No. 18, 1999, p. 5855-5859 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016521763A (ja) * 2013-06-24 2016-07-25 シージェイ チェイルジェダン コーポレーションCj Cheiljedang Corporation L−スレオニン産生微生物およびこれを用いたl−スレオニンの産生方法
US9758772B2 (en) 2013-06-24 2017-09-12 Cj Cheiljedang Corporation L-threonine-producing microorganism and production method for L-threonine using the same

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Publication number Publication date
EP1943343A2 (en) 2008-07-16
WO2007038564A2 (en) 2007-04-05
WO2007038564A3 (en) 2007-06-28

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