JP2009509533A - 包括的な転写機構エンジニアリング - Google Patents

包括的な転写機構エンジニアリング Download PDF

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Publication number
JP2009509533A
JP2009509533A JP2008533553A JP2008533553A JP2009509533A JP 2009509533 A JP2009509533 A JP 2009509533A JP 2008533553 A JP2008533553 A JP 2008533553A JP 2008533553 A JP2008533553 A JP 2008533553A JP 2009509533 A JP2009509533 A JP 2009509533A
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Prior art keywords
cell
nucleic acid
gene
cells
transcription machinery
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JP2008533553A
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Japanese (ja)
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JP2009509533A5 (enExample
Inventor
アルパー，ハル，エス．
ステファノプーロス，グレゴリー
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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Priority claimed from US11/238,096 external-priority patent/US20070072194A1/en
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of JP2009509533A publication Critical patent/JP2009509533A/ja
Publication of JP2009509533A5 publication Critical patent/JP2009509533A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00—Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ecology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Processing Of Solid Wastes (AREA)
JP2008533553A 2005-09-28 2006-09-28 包括的な転写機構エンジニアリング Pending JP2009509533A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/238,096 US20070072194A1 (en) 2005-09-28 2005-09-28 Global transcription machinery engineering
US74831505P 2005-12-07 2005-12-07
PCT/US2006/037597 WO2007038564A2 (en) 2005-09-28 2006-09-28 Global transcription machinery engineering

Publications (2)

Publication Number Publication Date
JP2009509533A true JP2009509533A (ja) 2009-03-12
JP2009509533A5 JP2009509533A5 (enExample) 2009-11-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008533553A Pending JP2009509533A (ja) 2005-09-28 2006-09-28 包括的な転写機構エンジニアリング

Country Status (3)

Country Link
EP (1) EP1943343A2 (enExample)
JP (1) JP2009509533A (enExample)
WO (1) WO2007038564A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016521763A (ja) * 2013-06-24 2016-07-25 シージェイ チェイルジェダン コーポレーションＣｊ Ｃｈｅｉｌｊｅｄａｎｇ Ｃｏｒｐｏｒａｔｉｏｎ Ｌ−スレオニン産生微生物およびこれを用いたｌ−スレオニンの産生方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010512147A (ja) * 2006-12-07 2010-04-22 マサチューセッツ インスティテュート オブ テクノロジー 包括的転写マシナリーエンジニアリング
US8193314B2 (en) 2007-07-12 2012-06-05 Massachusetts Institute Of Technology Transcriptional engineering of Lactobacillus
WO2009025761A2 (en) 2007-08-17 2009-02-26 Massachusetts Institute Of Technology Methods for identifying bacterial strains that produce l-tyrosine
WO2009061429A2 (en) * 2007-11-06 2009-05-14 Massachusetts Institute Of Technology Global transcription machinery engineering targeting the rnap alpha subunit (rpoa)
WO2011159629A2 (en) * 2010-06-14 2011-12-22 Cobalt Technologies, Inc. Salt selection of microbial mutants to increase bioproduct tolerance, titer, or osmotic shock tolerance
CN104630149B (zh) * 2013-11-08 2018-08-21 中国科学院广州生物医药与健康研究院 外源线粒体导入到哺乳动物细胞中的方法
CN104845924B (zh) * 2015-04-01 2018-03-16 农业部沼气科学研究所 一株耐呋喃甲醛的运动发酵单胞菌及其制备方法和应用

Non-Patent Citations (11)

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Title
JPN6012011297; Ｊ．　Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．　１８６，　Ｎｏ．　１２, 2004, ｐ．　４０３４-４０３７ *
JPN6012011300; Ｊ．　Ｍｏｌ．　Ｂｉｏｌ． Ｖｏｌ．　２０３, 1988, ｐ．　２９-３７ *
JPN6012011303; Ｍｏｌ．　Ｇｅｎ．　Ｇｅｎｅｔ． Ｖｏｌ．　１８４, 1981, ｐ．　１６６-１７３ *
JPN6012011304; Ｇｅｎｅｔｉｃｓ Ｖｏｌ．　１５３, 1999, ｐ．　６４３-６５２ *
JPN6012011305; Ｊ．　Ｍｏｌ．　Ｂｉｏｌ． Ｖｏｌ．　２５４, 1995, ｐ．　８１５-８３７ *
JPN6012011307; Ｊ．　Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．　１８３，　Ｎｏ．　２１, 2001, ｐ．　６４１３-６４２１ *
JPN6013027445; Ｊ．　Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．　１８７，　Ｎｏ．　３, 2005, ｐ．　１０２２-１０３５ *
JPN6013027447; Ｂｉｏｃｈｅｍ．　Ｂｉｏｐｈｙｓ．　Ｒｅｓ．　Ｃｏｍｍｕｎ． Ｖｏｌ．　２８８, 2001, ｐ．　３８５-３８９ *
JPN6013027449; ＦＥＭＳ　Ｍｉｃｒｏｂｉｏｌ．　Ｌｅｔｔ． Ｖｏｌ．　２４２, 2005, ｐ．　１６１-１６７ *
JPN6013027451; Ｊ．　Ｂｉｏｌ．　Ｃｈｅｍ． Ｖｏｌ．　２７９, 2004, ｐ．　５４３６９-５４３７９ *
JPN6013027452; Ｊ．　Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．　１８１，　Ｎｏ．　１８, 1999, ｐ．　５８５５-５８５９ *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016521763A (ja) * 2013-06-24 2016-07-25 シージェイ チェイルジェダン コーポレーションＣｊ Ｃｈｅｉｌｊｅｄａｎｇ Ｃｏｒｐｏｒａｔｉｏｎ Ｌ−スレオニン産生微生物およびこれを用いたｌ−スレオニンの産生方法
US9758772B2 (en) 2013-06-24 2017-09-12 Cj Cheiljedang Corporation L-threonine-producing microorganism and production method for L-threonine using the same

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WO2007038564A3 (en) 2007-06-28
EP1943343A2 (en) 2008-07-16
WO2007038564A2 (en) 2007-04-05

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