JP2009508521A - タンパク凝集に関連する疾患の診断予防及び治療のためのｖｈｈ - Google Patents

タンパク凝集に関連する疾患の診断予防及び治療のためのｖｈｈ Download PDF

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JP2009508521A
JP2009508521A JP2008532177A JP2008532177A JP2009508521A JP 2009508521 A JP2009508521 A JP 2009508521A JP 2008532177 A JP2008532177 A JP 2008532177A JP 2008532177 A JP2008532177 A JP 2008532177A JP 2009508521 A JP2009508521 A JP 2009508521A
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Prior art keywords
vhh
antigen
protein
selection
gene
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JP2008532177A
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Japanese (ja)
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JP2009508521A5 (https=
Inventor
コルネリス テオドルス フェリップス
デル マーレル シルヴェレ マリア ファン
ペーター フェルヘーセン
フルシク ダヴィッド ルティエ
オーメン ハリティアン バウデウィン ファン
Original Assignee
アカデミッシュ ジーケンハイス レイデン
ユニヴェルシテイト ユトレヒト ホールディング ベースローテン フェンノートシャップ
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Publication of JP2009508521A publication Critical patent/JP2009508521A/ja
Publication of JP2009508521A5 publication Critical patent/JP2009508521A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
    • C07K2317/82—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies functional in the cytoplasm, the inner aspect of the cell membrane, the nucleus or the mitochondria

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2008532177A 2005-09-23 2006-09-25 タンパク凝集に関連する疾患の診断予防及び治療のためのｖｈｈ Pending JP2009508521A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05077180 2005-09-23
PCT/NL2006/000475 WO2007035092A2 (en) 2005-09-23 2006-09-25 Vhh for the diagnosis, prevention and treatment of diseases associated with protein aggregates

Publications (2)

Publication Number Publication Date
JP2009508521A true JP2009508521A (ja) 2009-03-05
JP2009508521A5 JP2009508521A5 (https=) 2009-11-05

Family

ID=35700351

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008532177A Pending JP2009508521A (ja) 2005-09-23 2006-09-25 タンパク凝集に関連する疾患の診断予防及び治療のためのｖｈｈ

Country Status (6)

Country Link
US (1) US20100323905A1 (https=)
EP (1) EP1934611A2 (https=)
JP (1) JP2009508521A (https=)
AU (1) AU2006292871A1 (https=)
CA (1) CA2622968A1 (https=)
WO (1) WO2007035092A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160102971A (ko) * 2013-11-13 2016-08-31 에프. 호프만-라 로슈 아게 올리고펩티드 및 그 결합체를 생산하는 방법
JP2019210267A (ja) * 2018-06-08 2019-12-12 パナソニックＩｐマネジメント株式会社 Ｖｈｈ抗体

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006040153A2 (en) * 2004-10-13 2006-04-20 Ablynx N.V. Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease
US20100136584A1 (en) * 2008-09-22 2010-06-03 Icb International, Inc. Methods for using antibodies and analogs thereof
WO2010033913A1 (en) * 2008-09-22 2010-03-25 Icb International, Inc. Antibodies, analogs and uses thereof
WO2011049449A1 (en) 2009-10-22 2011-04-28 University Of Twente Vhh for application in tissue repair, organ regeneration, organ replacement and tissue engineering
NZ601117A (en) * 2010-03-03 2014-06-27 Boehringer Ingelheim Int Biparatopic abeta binding polypeptides
PE20141522A1 (es) 2011-08-17 2014-11-17 Glaxo Group Ltd Proteinas y peptidos modificados
US10112988B2 (en) 2012-01-09 2018-10-30 Icb International, Inc. Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide
US10112987B2 (en) 2012-01-09 2018-10-30 Icb International, Inc. Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide
WO2018222587A1 (en) 2017-05-30 2018-12-06 The Regents Of The University Of California NANOBODIES AGAINST CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) INHIBITORY FACTOR (Cif)
CN109206519B (zh) * 2018-09-21 2021-12-03 成都阿帕克生物科技有限公司 一种抗尿素酶b亚单位的纳米抗体及核酸分子和应用
CA3174330A1 (en) * 2021-03-31 2022-09-30 Shugang YAO Binding agents targeting tumors and/or immune cells
EP4713364A1 (en) * 2023-05-17 2026-03-25 Odyssey Therapeutics, Inc. Modified single-domain antibodies
TW202543670A (zh) * 2023-12-22 2025-11-16 比利時商艾伯霖克斯公司 用於核內投予之基於蛋白質的接合載劑

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037681A2 (en) * 1998-01-26 1999-07-29 Unilever Plc Method for producing antibody fragments

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1027439T3 (da) * 1997-10-27 2010-05-10 Bac Ip Bv Multivalente antigenbindende proteiner
AUPR546801A0 (en) * 2001-06-05 2001-06-28 Commonwealth Scientific And Industrial Research Organisation Recombinant antibodies
AR038568A1 (es) * 2002-02-20 2005-01-19 Hoffmann La Roche Anticuerpos anti-a beta y su uso
FR2846667B1 (fr) * 2002-11-06 2004-12-31 Pasteur Institut Fragments variables d'anticorps de camelides a chaine unique diriges contre le peptide beta-amyloide 1-42 et leurs applications pour le diagnostic et le traitement des maladies neuroagregatives
WO2004041863A2 (en) * 2002-11-08 2004-05-21 Ablynx N.V. Single domain antibodies directed against interferon- gamma and uses therefor
JP2006517789A (ja) * 2003-01-10 2006-08-03 アブリンクス エン．ヴェー． 治療用ポリペプチド、その相同物、その断片、および血小板媒介凝集の調節での使用
US20050226863A1 (en) * 2003-11-20 2005-10-13 Massachusetts Institute Of Technology Single-domain antibodies and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037681A2 (en) * 1998-01-26 1999-07-29 Unilever Plc Method for producing antibody fragments

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160102971A (ko) * 2013-11-13 2016-08-31 에프. 호프만-라 로슈 아게 올리고펩티드 및 그 결합체를 생산하는 방법
JP2017503475A (ja) * 2013-11-13 2017-02-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ アミロイドβを指向するラクダ科動物単一ドメイン抗体及びその接合体を製造する方法
KR102306065B1 (ko) 2013-11-13 2021-09-29 에프. 호프만-라 로슈 아게 올리고펩티드 및 그 결합체를 생산하는 방법
JP2019210267A (ja) * 2018-06-08 2019-12-12 パナソニックＩｐマネジメント株式会社 Ｖｈｈ抗体
JP7122672B2 (ja) 2018-06-08 2022-08-22 パナソニックＩｐマネジメント株式会社 Ｖｈｈ抗体

Also Published As

Publication number Publication date
AU2006292871A1 (en) 2007-03-29
WO2007035092A2 (en) 2007-03-29
EP1934611A2 (en) 2008-06-25
US20100323905A1 (en) 2010-12-23
CA2622968A1 (en) 2007-03-29
WO2007035092A3 (en) 2007-07-12

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