JP2009507932A5 - - Google Patents
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- Publication number
- JP2009507932A5 JP2009507932A5 JP2008537701A JP2008537701A JP2009507932A5 JP 2009507932 A5 JP2009507932 A5 JP 2009507932A5 JP 2008537701 A JP2008537701 A JP 2008537701A JP 2008537701 A JP2008537701 A JP 2008537701A JP 2009507932 A5 JP2009507932 A5 JP 2009507932A5
- Authority
- JP
- Japan
- Prior art keywords
- nsc
- optionally substituted
- compound
- medicament
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- -1 NSC 130681 Chemical compound 0.000 claims 2
- 229910005965 SO 2 Inorganic materials 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 231100000572 poisoning Toxicity 0.000 claims 2
- 230000000607 poisoning effect Effects 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- GKQYGRWQCWWSHN-UHFFFAOYSA-N 1,3-bis(4-amino-2-methylquinolin-6-yl)urea;hydron;dichloride Chemical compound Cl.Cl.N1=C(C)C=C(N)C2=CC(NC(=O)NC3=CC4=C(N)C=C(N=C4C=C3)C)=CC=C21 GKQYGRWQCWWSHN-UHFFFAOYSA-N 0.000 claims 1
- IOQMTJOUDKMNPJ-UHFFFAOYSA-N 2-(4-carbamimidoylphenyl)-1-benzofuran-5-carboximidamide;dihydrochloride Chemical compound Cl.Cl.C1=CC(C(=N)N)=CC=C1C1=CC2=CC(C(N)=N)=CC=C2O1 IOQMTJOUDKMNPJ-UHFFFAOYSA-N 0.000 claims 1
- FOBROUGZPKFBBU-UHFFFAOYSA-N 2-(4-carbamimidoylphenyl)-1-benzothiophene-6-carboximidamide;2-hydroxypropanoic acid Chemical compound CC(O)C(O)=O.CC(O)C(O)=O.C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2S1 FOBROUGZPKFBBU-UHFFFAOYSA-N 0.000 claims 1
- DNSRXDNWULQNLB-UHFFFAOYSA-N 2-(4-carbamimidoylphenyl)benzotriazole-5-carboximidamide;dihydrochloride Chemical compound Cl.Cl.C1=CC(C(=N)N)=CC=C1N1N=C2C=C(C(N)=N)C=CC2=N1 DNSRXDNWULQNLB-UHFFFAOYSA-N 0.000 claims 1
- ZZQQXWDSSMQERZ-MDZDMXLPSA-N 2-[2-[(e)-2-(1h-benzimidazol-2-yl)ethenyl]benzimidazol-1-yl]ethanol Chemical compound C1=CC=C2N(CCO)C(\C=C\C=3NC4=CC=CC=C4N=3)=NC2=C1 ZZQQXWDSSMQERZ-MDZDMXLPSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70753105P | 2005-08-12 | 2005-08-12 | |
| US60/707,531 | 2005-08-12 | ||
| US72344205P | 2005-10-05 | 2005-10-05 | |
| US60/723,442 | 2005-10-05 | ||
| PCT/US2006/031550 WO2008041966A2 (en) | 2005-08-12 | 2006-08-11 | Broad spectrum antibacterial compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009507932A JP2009507932A (ja) | 2009-02-26 |
| JP2009507932A5 true JP2009507932A5 (https=) | 2009-09-17 |
| JP5390186B2 JP5390186B2 (ja) | 2014-01-15 |
Family
ID=39268919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008537701A Expired - Fee Related JP5390186B2 (ja) | 2005-08-12 | 2006-08-11 | 広い抗菌スペクトルを有する抗菌性化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7825154B2 (https=) |
| EP (1) | EP1945209B1 (https=) |
| JP (1) | JP5390186B2 (https=) |
| AU (1) | AU2006345003A1 (https=) |
| CA (1) | CA2617123C (https=) |
| WO (1) | WO2008041966A2 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7825154B2 (en) * | 2005-08-12 | 2010-11-02 | The United States Of America As Represented By The Secretary Of The Army | Small molecule inhibitors of botulinum neurotoxins |
| EP2120952A4 (en) * | 2007-01-15 | 2011-09-21 | Us Of America As Represented By The Secretary Of The Army On Behalf Of The U S Army Res Inst Of Infe | ANTIVIRAL COMPOUNDS AND METHODS OF USE |
| RU2010120686A (ru) * | 2007-10-24 | 2011-11-27 | Фанкшенл Дженетикс,Инк. (Us) | Способы ингибирования вирусной инфекции |
| AU2009232276B2 (en) * | 2008-01-15 | 2013-10-24 | Kineta Four Llc | Antiviral drugs for treatment of arenavirus infection |
| GB0821913D0 (en) | 2008-12-02 | 2009-01-07 | Price & Co | Antibacterial compounds |
| WO2011022721A1 (en) * | 2009-08-21 | 2011-02-24 | Microbiotix, Inc | Inhibitors of botulinum neurotoxins |
| US8569346B1 (en) | 2009-10-14 | 2013-10-29 | Biomadison, Inc. | Thiazoline ring compounds as botulinum antagonists |
| US20110152343A1 (en) * | 2009-12-22 | 2011-06-23 | Functional Genetics, Inc. | Protease inhibitors and broad-spectrum antiviral |
| WO2011151617A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| ES2803556T3 (es) | 2010-06-01 | 2021-01-27 | Summit Oxford Ltd | Compuestos para el tratamiento de enfermedades asociadas a clostridium difficile |
| WO2011151620A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| WO2011151619A1 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| WO2011151618A2 (en) | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile-associated disease |
| CA2822357A1 (en) | 2010-12-22 | 2012-06-28 | Abbvie Inc. | Hepatitis c inhibitors and uses thereof |
| US8765760B2 (en) * | 2011-01-11 | 2014-07-01 | Sunovion Pharmaceuticals, Inc. | [1,2,4] triazol [1,5-a] pyrazines useful as inhibitors of phosphodiesterases |
| WO2013052263A2 (en) * | 2011-09-16 | 2013-04-11 | Microbiotix, Inc. | Antifungal compounds |
| WO2013040526A1 (en) * | 2011-09-16 | 2013-03-21 | Microbiotix, Inc. | Antimicrobial compounds |
| US9079935B2 (en) | 2012-08-13 | 2015-07-14 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas | Reducing risk of contracting Clostridium-difficile associated disease |
| ES2660210T3 (es) * | 2012-09-07 | 2018-03-21 | Novartis Ag | Derivados de indolcarboxamida y usos de los mismos |
| US10724070B2 (en) * | 2012-11-14 | 2020-07-28 | University Of Cincinnati | Modified bacterial pathogens and methods for effectuating rapid response to contamination by known or unknown bacterial pathogens |
| WO2016127102A2 (en) | 2015-02-06 | 2016-08-11 | Ernesto Abel-Santos | Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis |
| GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| CN105287522B (zh) * | 2015-11-25 | 2017-12-15 | 临沂大学 | 双苯并咪唑胺类化合物在制备抗微生物药物中的用途 |
| CN105311020B (zh) * | 2015-11-25 | 2017-12-15 | 临沂大学 | 一种双苯并咪唑胺类化合物及其制备方法 |
| US10526343B2 (en) | 2018-03-26 | 2020-01-07 | University Of Sharjah | Heterocyclic systems and pharmaceutical applications thereof |
| US12522583B2 (en) | 2018-11-07 | 2026-01-13 | Dana-Farber Cancer Institute, Inc. | Benzimidazole derivatives and aza-benzimidazole derivatives as Janus kinase 2 inhibitors and uses thereof |
| EP3877371A4 (en) | 2018-11-07 | 2022-07-27 | Dana-Farber Cancer Institute, Inc. | IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF |
| EP3876939A4 (en) | 2018-11-07 | 2022-08-10 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| IL289453B2 (en) | 2019-07-17 | 2026-03-01 | Summit Oxford Ltd | Process for preparing ridinilazole and its crystalline forms |
| EP4027791B1 (en) * | 2019-09-11 | 2023-10-04 | DSM IP Assets B.V. | Microbiocidal use |
| JP7582751B2 (ja) * | 2019-09-11 | 2024-11-13 | ディーエスエム アイピー アセッツ ビー．ブイ． | 局所用組成物 |
| US20230054976A1 (en) * | 2019-12-19 | 2023-02-23 | The Scripps Research Institute | METHODS FOR INHIBITION OF ALPHA-SYNUCLEIN mRNA USING SMALL MOLECULES |
| IL272003A (en) | 2020-01-13 | 2021-07-29 | The Israel Institute Of Biological Res Iibr | Compounds for use in treatment and/or prevention of clostridial neurotoxins intoxication |
| TW202140477A (zh) | 2020-02-12 | 2021-11-01 | 美商必治妥美雅史谷比公司 | 雜環ｐａｄ４抑制劑 |
| US11691963B2 (en) | 2020-05-06 | 2023-07-04 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| TWI887510B (zh) * | 2020-12-22 | 2025-06-21 | 美商基利科學股份有限公司 | 6-取代之吲哚化合物 |
| TWI838670B (zh) * | 2020-12-22 | 2024-04-11 | 美商基利科學股份有限公司 | 經取代之吲哚化合物 |
| US12043632B2 (en) | 2020-12-23 | 2024-07-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| GB202100470D0 (en) | 2021-01-14 | 2021-03-03 | Summit Oxford Ltd | Solid tablet dosage for of ridinilazole |
| GB202100471D0 (en) | 2021-01-14 | 2021-03-03 | Summit Oxford Ltd | Preparation of antibacterial compounds |
| KR20230171469A (ko) | 2021-04-16 | 2023-12-20 | 길리애드 사이언시즈, 인코포레이티드 | 티에노피롤 화합물 |
| WO2023039159A2 (en) | 2021-09-09 | 2023-03-16 | Abel Santos Ernesto | Inhibitors of c. difficile spore germination |
| EP4398989A1 (en) | 2021-09-10 | 2024-07-17 | Gilead Sciences, Inc. | Thienopyrrole compounds |
| US12162881B2 (en) | 2021-11-09 | 2024-12-10 | Ajax Therapeutics, Inc. | Forms and compositions of inhibitors of JAK2 |
| WO2023086319A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10503501A (ja) * | 1994-08-03 | 1998-03-31 | アスタ メディカ アクチエンゲゼルシャフト | 抗喘息、抗アレルギー、抗炎症及び免疫修飾作用を有するインドール、インダゾール、ピリドピロール及びピリドピラゾール誘導体 |
| FR2819407B1 (fr) * | 2001-01-18 | 2003-02-21 | Oreal | Compositions antisolaires a base d'un extrait d'au moins une bacterie filamenteuse non photosynthetique et d'au moins un flitre organique insoluble |
| AU2003275225A1 (en) * | 2002-09-20 | 2004-04-08 | Genelabs Technologies, Inc. | Novel aromatic compounds possessing antifungal or antibacterial activity |
| EP1558341A4 (en) | 2002-11-01 | 2010-09-08 | Paratek Pharm Innc | TRANSCRIPTION FACTOR MODULATING CONNECTIONS AND THEIR USE |
| US7635685B2 (en) * | 2003-07-03 | 2009-12-22 | Technion Research & Development Foundation Ltd. | Bifunctional antibiotics for targeting rRNA and resistance-causing enzymes and for inhibition of anthrax lethal factor |
| JP2007521237A (ja) * | 2003-09-05 | 2007-08-02 | ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 微生物感染症処置用の新規アミジン化合物 |
| WO2005026193A2 (en) * | 2003-09-08 | 2005-03-24 | United States Army Medical Research And Materiel Command | Small molecules and a pharmacophore model for inhibition of botulinum toxin and methods of making and using thereof |
| WO2005109304A2 (en) * | 2003-12-24 | 2005-11-17 | United States Army Medical Research And Materiel Command | Small molecules and a pharmacophore model for inhibition of anthrax lethal factor |
| US7825154B2 (en) * | 2005-08-12 | 2010-11-02 | The United States Of America As Represented By The Secretary Of The Army | Small molecule inhibitors of botulinum neurotoxins |
-
2006
- 2006-08-11 US US11/464,007 patent/US7825154B2/en not_active Expired - Fee Related
- 2006-08-11 WO PCT/US2006/031550 patent/WO2008041966A2/en not_active Ceased
- 2006-08-11 CA CA2617123A patent/CA2617123C/en active Active
- 2006-08-11 JP JP2008537701A patent/JP5390186B2/ja not_active Expired - Fee Related
- 2006-08-11 AU AU2006345003A patent/AU2006345003A1/en not_active Abandoned
- 2006-08-11 EP EP06851682.2A patent/EP1945209B1/en not_active Not-in-force
- 2006-08-11 US US11/464,001 patent/US8691859B2/en not_active Expired - Fee Related
-
2010
- 2010-10-01 US US12/896,338 patent/US20110086877A1/en not_active Abandoned
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