JP2009507193A - 流体装置におけるバルブの機械的作動に対する方法及び装置 - Google Patents

流体装置におけるバルブの機械的作動に対する方法及び装置 Download PDF

Info

Publication number
JP2009507193A
JP2009507193A JP2008529284A JP2008529284A JP2009507193A JP 2009507193 A JP2009507193 A JP 2009507193A JP 2008529284 A JP2008529284 A JP 2008529284A JP 2008529284 A JP2008529284 A JP 2008529284A JP 2009507193 A JP2009507193 A JP 2009507193A
Authority
JP
Japan
Prior art keywords
layer
fluid
pin
structure according
fluid structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008529284A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009507193A5 (enExample
Inventor
エリザロフ，アルカディ
アール ヒース，ジェームズ
ダム，マイケル ヴァン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology
Original Assignee
California Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute of Technology filed Critical California Institute of Technology
Publication of JP2009507193A publication Critical patent/JP2009507193A/ja
Publication of JP2009507193A5 publication Critical patent/JP2009507193A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/567—Valves, taps or stop-cocks
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0015—Diaphragm or membrane valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0026—Valves using channel deformation
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0046—Electric operating means therefor using magnets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
    • F16K99/0059—Operating means specially adapted for microvalves actuated by fluids actuated by a pilot fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/046—Chemical or electrochemical formation of bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/0074—Fabrication methods specifically adapted for microvalves using photolithography, e.g. etching
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/0076—Fabrication methods specifically adapted for microvalves using electrical discharge machining [EDM], milling or drilling
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/0078—Fabrication methods specifically adapted for microvalves using moulding or stamping
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/008—Multi-layer fabrications
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Micromachines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
JP2008529284A 2005-09-02 2006-08-30 流体装置におけるバルブの機械的作動に対する方法及び装置 Pending JP2009507193A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71383505P 2005-09-02 2005-09-02
US76515006P 2006-02-03 2006-02-03
US79177806P 2006-04-13 2006-04-13
PCT/US2006/034083 WO2007027928A1 (en) 2005-09-02 2006-08-30 Method and apparatus for the mechanical actuation of valves in fluidic devices

Publications (2)

Publication Number Publication Date
JP2009507193A true JP2009507193A (ja) 2009-02-19
JP2009507193A5 JP2009507193A5 (enExample) 2009-10-01

Family

ID=37565141

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008529284A Pending JP2009507193A (ja) 2005-09-02 2006-08-30 流体装置におけるバルブの機械的作動に対する方法及び装置

Country Status (6)

Country Link
US (1) US8480053B2 (enExample)
EP (1) EP1928603A1 (enExample)
JP (1) JP2009507193A (enExample)
KR (1) KR20080044306A (enExample)
CA (1) CA2620629A1 (enExample)
WO (1) WO2007027928A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017534816A (ja) * 2014-07-07 2017-11-24 ナノテック・アナリシス・ソチエタ・ア・レスポンサビリタ・リミタータ・センプリフィカータＮＡＮＯＴＥＣＨ ＡＮＡＬＹＳＩＳ Ｓ．ｒ．ｌ．ｓ． ガス流を制御するためのデバイス、デバイスを利用するシステム及び方法

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITBO20040420A1 (it) * 2004-07-07 2004-10-07 Type S R L Macchina per taglio e formatura di piattine metalliche
ITBO20050481A1 (it) * 2005-07-19 2007-01-20 Silicon Biosystems S R L Metodo ed apparato per la manipolazione e/o l'individuazione di particelle
US8480053B2 (en) 2005-09-02 2013-07-09 California Institute Of Technology Method and apparatus for the mechanical actuation of valves in fluidic devices
US8075851B2 (en) 2005-09-29 2011-12-13 Siemens Medical Solutions Usa, Inc. Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography
ITBO20050646A1 (it) * 2005-10-26 2007-04-27 Silicon Biosystem S R L Metodo ed apparato per la caratterizzazione ed il conteggio di particelle
US7862000B2 (en) * 2006-02-03 2011-01-04 California Institute Of Technology Microfluidic method and structure with an elastomeric gas-permeable gasket
ITTO20060226A1 (it) 2006-03-27 2007-09-28 Silicon Biosystem S P A Metodo ed apparato per il processamento e o l'analisi e o la selezione di particelle, in particolare particelle biologiche
WO2007125468A2 (en) * 2006-05-01 2007-11-08 Koninklijke Philips Electronics N.V. Fluid sample transport device with reduced dead volume for processing, controlling and/or detecting a fluid sample
US20080131327A1 (en) * 2006-09-28 2008-06-05 California Institute Of Technology System and method for interfacing with a microfluidic chip
WO2008055915A2 (en) 2006-11-06 2008-05-15 Clondiag Gmbh Device and process for assays using binding members
US20080163946A1 (en) * 2006-12-28 2008-07-10 The Trustees Of California State University Magnetically controlled valve for flow manipulation in polymer microfluidic devices
US7829032B2 (en) * 2007-01-23 2010-11-09 Siemens Medical Solutions Usa, Inc. Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography
US8071035B2 (en) 2007-04-12 2011-12-06 Siemens Medical Solutions Usa, Inc. Microfluidic radiosynthesis system for positron emission tomography biomarkers
WO2008128201A1 (en) 2007-04-12 2008-10-23 Siemens Medical Solutions Usa, Inc. Microfluidic radiosynthesis system for positron emission tomography biomarkers
CN105543084B (zh) * 2007-07-23 2019-09-06 美艾利尔技术公司 分析系统
ITBO20070588A1 (it) 2007-08-13 2009-02-14 Silicon Biosystems Spa Metodo per legare uno strato di silicone ad un substrato di polimero metacrilico
ITTO20070771A1 (it) 2007-10-29 2009-04-30 Silicon Biosystems Spa Metodo e apparato per la identificazione e manipolazione di particelle
WO2009092106A1 (en) * 2008-01-18 2009-07-23 The Regents Of The University Of California Accurate and rapid micromixer for integrated microfluidic devices
US20110168269A1 (en) * 2008-09-17 2011-07-14 Koninklijke Philips Electronics N.V. Microfluidic device
US20100102261A1 (en) * 2008-10-28 2010-04-29 Microfluidic Systems, Inc. Microfluidic valve mechanism
US10895575B2 (en) 2008-11-04 2021-01-19 Menarini Silicon Biosystems S.P.A. Method for identification, selection and analysis of tumour cells
IT1391619B1 (it) 2008-11-04 2012-01-11 Silicon Biosystems Spa Metodo per l'individuazione, selezione e analisi di cellule tumorali
ES2672366T3 (es) * 2009-03-17 2018-06-14 Menarini Silicon Biosystems S.P.A. Dispositivo microfluídico para el aislamiento de celdas
US8273300B2 (en) * 2009-07-09 2012-09-25 Siemens Medical Solutions Usa, Inc. Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
US8435454B2 (en) * 2009-07-09 2013-05-07 Siemens Medical Solutions Usa, Inc. Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
WO2011094605A1 (en) * 2010-01-29 2011-08-04 Columbia University Microfluidic flow devices, methods and systems
ITBO20100502A1 (it) * 2010-08-04 2012-02-05 Silicon Biosystems Spa Sistema microfluidico
IT1403518B1 (it) 2010-12-22 2013-10-31 Silicon Biosystems Spa Dispositivo microfluidico per la manipolazione di particelle
ITTO20110990A1 (it) 2011-10-28 2013-04-29 Silicon Biosystems Spa Metodo ed apparato per l'analisi ottica di particelle a basse temperature
ITBO20110766A1 (it) 2011-12-28 2013-06-29 Silicon Biosystems Spa Dispositivi, apparato, kit e metodo per il trattamento di un campione biologico
SG11201406551WA (en) * 2012-07-12 2014-11-27 Agency Science Tech & Res A connector for microfluidic device, a method for injecting fluid into microfluidic device using the connector and a method of providing and operating a valve
WO2014066378A2 (en) * 2012-10-22 2014-05-01 President And Fellows Of Harvard College Apparatus, systems, and methods for actuating pressurizable chambers
CN106688076B (zh) * 2014-07-07 2019-08-30 纳米技术分析责任有限公司 用于生成组成受控和强度受控离子流的设备和相关方法
DE102014221309B4 (de) * 2014-10-21 2025-04-24 Robert Bosch Gmbh Mikrofluidisches System sowie Verfahren zum Analysieren einer Probenlösung und Verfahren zum Herstellen eines mikrofluidischen Systems zum Analysieren einer Probenlösung
US11236846B1 (en) * 2019-07-11 2022-02-01 Facebook Technologies, Llc Fluidic control: using exhaust as a control mechanism
US20220333048A1 (en) * 2020-09-22 2022-10-20 Boe Technology Group Co., Ltd. Nucleic acid extraction microfluidic chip, and nucleic acid extraction device and extraction method
EP4119652A1 (en) * 2021-07-15 2023-01-18 Hooke Bio Ltd. An assay plate assembly to assay a cell culture model
EP4119226A1 (en) * 2021-07-15 2023-01-18 Hooke Bio Ltd. An assay plate system to assay a cell culture model
LU102877B1 (en) * 2021-11-12 2023-05-17 STRATEC CONSUMABLES GmbH System for providing fluids in microfluidic products

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
JP2003522521A (ja) * 1999-05-28 2003-07-29 シーフィード 流体試料分析装置および方法
US6830729B1 (en) * 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2716017A (en) 1952-08-28 1955-08-23 Grinnell Corp Diaphragm valves
US2971851A (en) 1958-11-25 1961-02-14 Miles Lab Scavenger packet
US3378406A (en) 1965-12-30 1968-04-16 Leesona Corp Metal-oxygen-containing electro-chemical battery
US3407096A (en) 1966-01-25 1968-10-22 American Cyanamid Co Fuel cell and method for preparing the electrodes
FR1501835A (fr) 1966-09-22 1967-11-18 Wonder Piles Perfectionnements aux membranes étanches aux liquides mais perméables aux gaz, notamment pour piles et accumulateurs
US3613729A (en) 1970-02-16 1971-10-19 Packard Instrument Co Inc Valve system
US3663409A (en) 1970-05-14 1972-05-16 Beckman Instruments Inc Pressure compensation of membranetype sensors
US4062750A (en) 1974-12-18 1977-12-13 James Francis Butler Thin film electrochemical electrode and cell
US4326518A (en) 1980-04-07 1982-04-27 Baxter Travenol Laboratories, Inc. Separable integral donor connector with manual clamping means
US4500905A (en) 1981-09-30 1985-02-19 Tokyo Shibaura Denki Kabushiki Kaisha Stacked semiconductor device with sloping sides
FI840846A0 (fi) 1984-03-02 1984-03-02 Labsystems Oy Ventilanordning
US4721133A (en) 1985-09-26 1988-01-26 Alcon Laboratories, Inc. Multiple use valving device
US4977948A (en) 1988-07-15 1990-12-18 General Motors Corporation Countergravity casting apparatus and method using elastomeric sealing gasket and cooled vacuum chamber
US4924241A (en) 1989-08-01 1990-05-08 Diagraph Corporation Printhead for ink jet printing apparatus
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5624555A (en) 1993-10-04 1997-04-29 National Research Council Of Canada Fluid fractionating, stacked permeable membrane assembly
US5765591A (en) 1995-11-20 1998-06-16 Argonaut Technologies, Inc. Valve apparatus and method for distributing fluids
US6399023B1 (en) 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5989402A (en) 1997-08-29 1999-11-23 Caliper Technologies Corp. Controller/detector interfaces for microfluidic systems
US5900201A (en) 1997-09-16 1999-05-04 Eastman Kodak Company Binder coagulation casting
US6145810A (en) 1998-04-14 2000-11-14 Asepco, Inc. Aseptic valve construction with diaphragm having straight neck
US6158712A (en) 1998-10-16 2000-12-12 Agilent Technologies, Inc. Multilayer integrated assembly having an integral microminiature valve
US6929030B2 (en) 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
EP1065378B1 (en) * 1999-06-28 2002-04-03 California Institute of Technology Microfabricated elastomeric valve and pump systems
US6875619B2 (en) 1999-11-12 2005-04-05 Motorola, Inc. Microfluidic devices comprising biochannels
DE10011022A1 (de) 2000-03-07 2001-09-27 Meinhard Knoll Vorrichtung und Verfahren zur Durchführung von Synthesen, Analysen oder Transportvorgängen
US6358387B1 (en) 2000-03-27 2002-03-19 Caliper Technologies Corporation Ultra high throughput microfluidic analytical systems and methods
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US20030196695A1 (en) 2000-11-06 2003-10-23 Nanostream, Inc. Microfluidic flow control devices
WO2002070932A2 (en) 2001-03-07 2002-09-12 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Microvalve
EP1366357A2 (en) * 2001-03-07 2003-12-03 Symyx Technologies, Inc. Gas chromatograph injection valve
US7223363B2 (en) 2001-03-09 2007-05-29 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
US6814337B2 (en) 2002-04-03 2004-11-09 Ronald Anthony Schmaltz Valve for controlling fluid flow through a tube, and related systems and methods
US6752371B2 (en) 2002-06-19 2004-06-22 Arichell Technologies, Inc. Valve actuator having small isolated plunger
US7125510B2 (en) 2002-05-15 2006-10-24 Zhili Huang Microstructure fabrication and microsystem integration
US20040101444A1 (en) 2002-07-15 2004-05-27 Xeotron Corporation Apparatus and method for fluid delivery to a hybridization station
US20050266582A1 (en) 2002-12-16 2005-12-01 Modlin Douglas N Microfluidic system with integrated permeable membrane
US7296592B2 (en) * 2003-09-16 2007-11-20 Eksigent Technologies, Llc Composite polymer microfluidic control device
EP1755783A1 (en) 2004-06-04 2007-02-28 Crystal Vision Microsystems LLC Device and process for continuous on-chip flow injection analysis
US20060078475A1 (en) 2004-07-29 2006-04-13 Yu-Chong Tai Modular microfluidic packaging system
US20070012891A1 (en) 2004-12-08 2007-01-18 George Maltezos Prototyping methods and devices for microfluidic components
US7582263B2 (en) 2005-01-27 2009-09-01 Octrolix Bv Universal interface for a micro-fluidic chip
US8480053B2 (en) 2005-09-02 2013-07-09 California Institute Of Technology Method and apparatus for the mechanical actuation of valves in fluidic devices
US7862000B2 (en) 2006-02-03 2011-01-04 California Institute Of Technology Microfluidic method and structure with an elastomeric gas-permeable gasket
US20080131327A1 (en) 2006-09-28 2008-06-05 California Institute Of Technology System and method for interfacing with a microfluidic chip

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863502A (en) * 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
US6830729B1 (en) * 1998-05-18 2004-12-14 University Of Washington Sample analysis instrument
JP2003522521A (ja) * 1999-05-28 2003-07-29 シーフィード 流体試料分析装置および方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017534816A (ja) * 2014-07-07 2017-11-24 ナノテック・アナリシス・ソチエタ・ア・レスポンサビリタ・リミタータ・センプリフィカータＮＡＮＯＴＥＣＨ ＡＮＡＬＹＳＩＳ Ｓ．ｒ．ｌ．ｓ． ガス流を制御するためのデバイス、デバイスを利用するシステム及び方法

Also Published As

Publication number Publication date
WO2007027928A9 (en) 2007-05-18
WO2007027928A1 (en) 2007-03-08
CA2620629A1 (en) 2007-03-08
KR20080044306A (ko) 2008-05-20
US20070051412A1 (en) 2007-03-08
US8480053B2 (en) 2013-07-09
EP1928603A1 (en) 2008-06-11

Similar Documents

Publication Publication Date Title
JP2009507193A (ja) 流体装置におけるバルブの機械的作動に対する方法及び装置
US7862000B2 (en) Microfluidic method and structure with an elastomeric gas-permeable gasket
JP5177705B2 (ja) 金属ボールを用いた磁気力マイクロバルブおよびその製造方法
US7052594B2 (en) Devices and methods for controlling fluid flow using elastic sheet deflection
CN101563562B (zh) 微流控装置
US20110315227A1 (en) Microfluidic system and method
EP1981636A1 (en) A microfluidic method and structure with an elastomeric gas-permeable gasket
JP2005299597A (ja) マイクロポンプ
Matsubara et al. A Microfabricated Pistonless Syringe Pump Driven by Electro‐Conjugate Fluid with Leakless On/Off Microvalves
KR100444751B1 (ko) 표면장력에 의한 유체제어 소자
WO2008150210A1 (en) Micropump
JP2010519460A5 (enExample)
KR101132657B1 (ko) 단일 제어 신호에 의해 구동되는 연동형 마이크로 펌프 및 그 제조 방법
US8096786B2 (en) Three dimensional micro-fluidic pumps and valves
US20060280629A1 (en) Loop-type microfluidic system
KR101635459B1 (ko) 프로그래밍 가능한 마이크로 펌프
US20100327211A1 (en) Method for the production of micro/nanofluidic devices for flow control and resulting device
Chang et al. An electronic Venturi-based pressure microregulator
TW201000761A (en) Bonded microfluidic system comprising thermal bend actuated valve
Scheuenpflug et al. Microfluidic module system with piezo driven microvalve for synthesis of radiopharmaceutical products
JP2006046605A (ja) 流体制御装置
JP4868527B2 (ja) 試料導入マイクロデバイス
Nguyen et al. A PIEZOELECTRIC MICROPUMP BASED ON POLYMERIC MICROMACHI~ I~ G
Rasmussen et al. Pumping techniques available for use in biomedical analysis systems
Chang et al. A Venturi microregulator array module for distributed pressure control

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090813

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090813

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20111011

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120327