JP2009506063A - トリアゾール化合物ならびにこれを作製する方法および使用する方法 - Google Patents
トリアゾール化合物ならびにこれを作製する方法および使用する方法 Download PDFInfo
- Publication number
- JP2009506063A JP2009506063A JP2008528163A JP2008528163A JP2009506063A JP 2009506063 A JP2009506063 A JP 2009506063A JP 2008528163 A JP2008528163 A JP 2008528163A JP 2008528163 A JP2008528163 A JP 2008528163A JP 2009506063 A JP2009506063 A JP 2009506063A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- unsaturated
- group
- groups
- aromatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC(C)(C[C@]1C(*)(*)C2(C)*)C[C@]1[C@](C)(*)CC(*)(*)NC(*)(*)[C@](C)(*)[C@](*)C(*)OC2=[O+] Chemical compound CC(C)(C[C@]1C(*)(*)C2(C)*)C[C@]1[C@](C)(*)CC(*)(*)NC(*)(*)[C@](C)(*)[C@](*)C(*)OC2=[O+] 0.000 description 11
- JYVNZINQFKMVFO-QJVISHNMSA-N CCC([C@](C)([C@@H]([C@@H](C)N(C)C[C@H](C)C1)O)O)OC(C)[C@H](C)[C@@H](C(C[C@@H]2C)O[C@@H](C)[C@@H]2O)[C@H](C)[C@@H](C)[C@]1(C)O Chemical compound CCC([C@](C)([C@@H]([C@@H](C)N(C)C[C@H](C)C1)O)O)OC(C)[C@H](C)[C@@H](C(C[C@@H]2C)O[C@@H](C)[C@@H]2O)[C@H](C)[C@@H](C)[C@]1(C)O JYVNZINQFKMVFO-QJVISHNMSA-N 0.000 description 1
- VCZOVKWKJJSQOJ-FCZOXVKFSA-N CC[C@H](C(C)([C@@H]([C@@H](C)N(C)C[C@H](C)CC(C)([C@H](C)[C@@H](C)C([C@H]1C)=O)OC)O)O)OC1=O Chemical compound CC[C@H](C(C)([C@@H]([C@@H](C)N(C)C[C@H](C)CC(C)([C@H](C)[C@@H](C)C([C@H]1C)=O)OC)O)O)OC1=O VCZOVKWKJJSQOJ-FCZOXVKFSA-N 0.000 description 1
- UJJGTUGBHZUHOW-JCFJGXJASA-N CC[C@H](C(C)([C@@H]([C@@H](C)N(C)C[C@H](C)CC(C)([C@H](C)[C@@H](C)C([C@H]1C)=O)OCCNCCCN)O)O)OC1=O Chemical compound CC[C@H](C(C)([C@@H]([C@@H](C)N(C)C[C@H](C)CC(C)([C@H](C)[C@@H](C)C([C@H]1C)=O)OCCNCCCN)O)O)OC1=O UJJGTUGBHZUHOW-JCFJGXJASA-N 0.000 description 1
- IEAZLKDPYQMCJD-HMEZCREDSA-N CC[C@H]([C@](C)([C@@H]([C@@H](C)C([C@H](C)C[C@](C)(C(C)(C)[C@@H](C)C([C@]1(C)F)=O)OC/C=C/c2cc3ccccc3nc2)=O)N2)OC2=O)OC1=O Chemical compound CC[C@H]([C@](C)([C@@H]([C@@H](C)C([C@H](C)C[C@](C)(C(C)(C)[C@@H](C)C([C@]1(C)F)=O)OC/C=C/c2cc3ccccc3nc2)=O)N2)OC2=O)OC1=O IEAZLKDPYQMCJD-HMEZCREDSA-N 0.000 description 1
- RIHZEWMSCKATNB-TVLBWKGNSA-N CC[C@H]([C@](C)([C@@H]([C@@H](C)C([C@H](C)C[C@](C)([C@@H]([C@@H](C)C([C@H]1C)=O)I)OC/C=C/c2cc3ccccc3nc2)=O)N2)OC2=O)OC1=O Chemical compound CC[C@H]([C@](C)([C@@H]([C@@H](C)C([C@H](C)C[C@](C)([C@@H]([C@@H](C)C([C@H]1C)=O)I)OC/C=C/c2cc3ccccc3nc2)=O)N2)OC2=O)OC1=O RIHZEWMSCKATNB-TVLBWKGNSA-N 0.000 description 1
- FHEKGXXBVSUUTI-LAMXZHTCSA-N CC[C@H]([C@](C)([C@@H]([C@@H](C)C([C@H](C)C[C@](C)([C@H](C)[C@@H](C)[C@@H]([C@H]1C)O[C@@H](C[C@@H]2C)O[C@@H](C)[C@@H]2O)OC)=O)O)O)OC1=O Chemical compound CC[C@H]([C@](C)([C@@H]([C@@H](C)C([C@H](C)C[C@](C)([C@H](C)[C@@H](C)[C@@H]([C@H]1C)O[C@@H](C[C@@H]2C)O[C@@H](C)[C@@H]2O)OC)=O)O)O)OC1=O FHEKGXXBVSUUTI-LAMXZHTCSA-N 0.000 description 1
- MOXQEARUYJFFKI-FQFLFQHTSA-N CC[C@H]([C@](C)([C@@H]([C@@H](C)N(C)C[C@H](C)C[C@](C)(C(C)(C)[C@@H](C)C([C@@H](CC1(C)C)OC(C)[C@@H]1N)[C@H]1C)O)O)O)OC1=O Chemical compound CC[C@H]([C@](C)([C@@H]([C@@H](C)N(C)C[C@H](C)C[C@](C)(C(C)(C)[C@@H](C)C([C@@H](CC1(C)C)OC(C)[C@@H]1N)[C@H]1C)O)O)O)OC1=O MOXQEARUYJFFKI-FQFLFQHTSA-N 0.000 description 1
- IWFQPKVPLNUDFH-UHFFFAOYSA-N OCCOCc(cc1)ccc1I Chemical compound OCCOCc(cc1)ccc1I IWFQPKVPLNUDFH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71144005P | 2005-08-24 | 2005-08-24 | |
| US79792606P | 2006-05-05 | 2006-05-05 | |
| PCT/US2006/033157 WO2007025089A2 (en) | 2005-08-24 | 2006-08-24 | Triazole compounds and methods of making and using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009506063A true JP2009506063A (ja) | 2009-02-12 |
| JP2009506063A5 JP2009506063A5 (https=) | 2009-10-08 |
Family
ID=37631779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008528163A Withdrawn JP2009506063A (ja) | 2005-08-24 | 2006-08-24 | トリアゾール化合物ならびにこれを作製する方法および使用する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (5) | US8470985B2 (https=) |
| EP (1) | EP1934237A2 (https=) |
| JP (1) | JP2009506063A (https=) |
| WO (1) | WO2007025089A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014533710A (ja) * | 2011-11-25 | 2014-12-15 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 抗菌性チロシン誘導体およびその製造方法 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1723159B1 (en) | 2004-02-27 | 2019-06-12 | Melinta Therapeutics, Inc. | Macrocyclic compounds and methods of making and using the same |
| EP1934237A2 (en) * | 2005-08-24 | 2008-06-25 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
| EP3290427A1 (en) | 2005-08-24 | 2018-03-07 | Melinta Therapeutics, Inc. | Triazole compounds and methods of making and using the same |
| WO2008106204A1 (en) * | 2007-02-28 | 2008-09-04 | Rib-X-Pharmaceuticals, Inc. | Macrolide compounds and methods of making and using the same |
| CA2735773A1 (en) * | 2008-09-02 | 2010-03-11 | Neurosearch A/S | Triazole derivatives and their use as nicotinic acetylcholine receptor modulators |
| CN107205989A (zh) | 2014-11-14 | 2017-09-26 | 梅琳塔治疗公司 | 治疗、预防或降低皮肤感染风险的方法 |
| UA120571C2 (uk) | 2016-03-22 | 2019-12-26 | Мерк Шарп Енд Дохме Корп. | Алостеричні модулятори нікотинових ацетилхолінових рецепторів |
| US20240076293A1 (en) * | 2020-12-28 | 2024-03-07 | Georgia Tech Research Corporation | Compositions and Methods for Inhibiting Fibrosis, Inflammation and Cancer |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY113693A (en) | 1992-05-26 | 2002-05-31 | Chugai Pharmaceutical Co Ltd | Erythromycin derivatives having an enterokinesis stimulating action |
| DE19604223A1 (de) * | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue substituierte Oxazolidinone |
| FR2748746B1 (fr) | 1996-05-14 | 1998-08-14 | Hoechst Marion Roussel Inc | Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine |
| BR9812577A (pt) | 1997-09-30 | 2000-10-17 | Abbott Lab | Composto, processo para preparar o mesmo, composição farmacêutica, e, processo para tratar infecções bacterianas |
| AR043071A1 (es) | 1997-10-31 | 2005-07-20 | Abbott Lab | Uso de macrolidos para el tratamiento del cancer y degeneracion macular y una composicion farmaceutica |
| US6288234B1 (en) | 1998-06-08 | 2001-09-11 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
| HRP980646B1 (en) | 1998-12-30 | 2008-02-29 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | Novel oleandomycin derivatives |
| US6413981B1 (en) | 1999-08-12 | 2002-07-02 | Ortho-Mcneil Pharamceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| KR20020072311A (ko) | 2000-02-10 | 2002-09-14 | 파마시아 앤드 업존 캄파니 | 피페라진 아미드 치환기를 갖는 옥사졸리디논 티오아미드 |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| CA2429709A1 (en) | 2000-12-01 | 2002-07-04 | Gary Ashley | Motilide compounds |
| US6680299B2 (en) | 2001-07-27 | 2004-01-20 | Enanta Pharmaceuticals, Inc. | 4'-substituted leucomycins |
| SI1427711T1 (sl) | 2001-09-11 | 2005-12-31 | Astrazeneca Ab | Oksazolidinonski in/ali izoksazolinski derivati kot antibakterijska sredstva |
| EP1443930A1 (en) | 2001-10-25 | 2004-08-11 | AstraZeneca AB | Isoxazoline derivatives useful as antimicrobials |
| ITMI20021726A1 (it) | 2002-08-01 | 2004-02-02 | Zambon Spa | Macrolidi ad attivita' antiinfiammatoria. |
| TW200420573A (en) * | 2002-09-26 | 2004-10-16 | Rib X Pharmaceuticals Inc | Bifunctional heterocyclic compounds and methods of making and using same |
| WO2005042554A1 (en) | 2003-10-30 | 2005-05-12 | Rib-X Pharmaceuticals, Inc. | Bifunctional macrolide heterocyclic compounds and methods of making and using the same |
| US20070270357A1 (en) | 2003-11-18 | 2007-11-22 | Farmer Jay J | Bifunctional Macrolide Heterocyclic Compounds and Methods of Making and Using the Same |
| EP1723159B1 (en) * | 2004-02-27 | 2019-06-12 | Melinta Therapeutics, Inc. | Macrocyclic compounds and methods of making and using the same |
| WO2005118610A2 (en) * | 2004-06-01 | 2005-12-15 | Rib-X Pharmaceuticals, Inc. | Macrocyclic compounds and methods of making and using the same |
| EP1934237A2 (en) * | 2005-08-24 | 2008-06-25 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
| EP3290427A1 (en) | 2005-08-24 | 2018-03-07 | Melinta Therapeutics, Inc. | Triazole compounds and methods of making and using the same |
-
2006
- 2006-08-24 EP EP06802297A patent/EP1934237A2/en not_active Withdrawn
- 2006-08-24 WO PCT/US2006/033157 patent/WO2007025089A2/en not_active Ceased
- 2006-08-24 US US11/990,833 patent/US8470985B2/en not_active Expired - Fee Related
- 2006-08-24 JP JP2008528163A patent/JP2009506063A/ja not_active Withdrawn
-
2013
- 2013-06-14 US US13/918,344 patent/US9085600B2/en not_active Expired - Fee Related
-
2015
- 2015-06-26 US US14/751,625 patent/US20160152654A1/en not_active Abandoned
-
2017
- 2017-01-12 US US15/404,757 patent/US20170349621A1/en not_active Abandoned
-
2018
- 2018-08-08 US US16/058,352 patent/US20190211046A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014533710A (ja) * | 2011-11-25 | 2014-12-15 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 抗菌性チロシン誘導体およびその製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20100016955A1 (en) | 2010-01-21 |
| US20190211046A1 (en) | 2019-07-11 |
| US20140094422A1 (en) | 2014-04-03 |
| US9085600B2 (en) | 2015-07-21 |
| US20160152654A1 (en) | 2016-06-02 |
| EP1934237A2 (en) | 2008-06-25 |
| WO2007025089A2 (en) | 2007-03-01 |
| WO2007025089A3 (en) | 2007-05-18 |
| US8470985B2 (en) | 2013-06-25 |
| US20170349621A1 (en) | 2017-12-07 |
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