JP2009506063A - トリアゾール化合物ならびにこれを作製する方法および使用する方法 - Google Patents
トリアゾール化合物ならびにこれを作製する方法および使用する方法 Download PDFInfo
- Publication number
- JP2009506063A JP2009506063A JP2008528163A JP2008528163A JP2009506063A JP 2009506063 A JP2009506063 A JP 2009506063A JP 2008528163 A JP2008528163 A JP 2008528163A JP 2008528163 A JP2008528163 A JP 2008528163A JP 2009506063 A JP2009506063 A JP 2009506063A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- unsaturated
- group
- groups
- aromatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC(C)(C[C@]1C(*)(*)C2(C)*)C[C@]1[C@](C)(*)CC(*)(*)NC(*)(*)[C@](C)(*)[C@](*)C(*)OC2=[O+] Chemical compound CC(C)(C[C@]1C(*)(*)C2(C)*)C[C@]1[C@](C)(*)CC(*)(*)NC(*)(*)[C@](C)(*)[C@](*)C(*)OC2=[O+] 0.000 description 11
- JYVNZINQFKMVFO-QJVISHNMSA-N CCC([C@](C)([C@@H]([C@@H](C)N(C)C[C@H](C)C1)O)O)OC(C)[C@H](C)[C@@H](C(C[C@@H]2C)O[C@@H](C)[C@@H]2O)[C@H](C)[C@@H](C)[C@]1(C)O Chemical compound CCC([C@](C)([C@@H]([C@@H](C)N(C)C[C@H](C)C1)O)O)OC(C)[C@H](C)[C@@H](C(C[C@@H]2C)O[C@@H](C)[C@@H]2O)[C@H](C)[C@@H](C)[C@]1(C)O JYVNZINQFKMVFO-QJVISHNMSA-N 0.000 description 1
- VCZOVKWKJJSQOJ-FCZOXVKFSA-N CC[C@H](C(C)([C@@H]([C@@H](C)N(C)C[C@H](C)CC(C)([C@H](C)[C@@H](C)C([C@H]1C)=O)OC)O)O)OC1=O Chemical compound CC[C@H](C(C)([C@@H]([C@@H](C)N(C)C[C@H](C)CC(C)([C@H](C)[C@@H](C)C([C@H]1C)=O)OC)O)O)OC1=O VCZOVKWKJJSQOJ-FCZOXVKFSA-N 0.000 description 1
- UJJGTUGBHZUHOW-JCFJGXJASA-N CC[C@H](C(C)([C@@H]([C@@H](C)N(C)C[C@H](C)CC(C)([C@H](C)[C@@H](C)C([C@H]1C)=O)OCCNCCCN)O)O)OC1=O Chemical compound CC[C@H](C(C)([C@@H]([C@@H](C)N(C)C[C@H](C)CC(C)([C@H](C)[C@@H](C)C([C@H]1C)=O)OCCNCCCN)O)O)OC1=O UJJGTUGBHZUHOW-JCFJGXJASA-N 0.000 description 1
- IEAZLKDPYQMCJD-HMEZCREDSA-N CC[C@H]([C@](C)([C@@H]([C@@H](C)C([C@H](C)C[C@](C)(C(C)(C)[C@@H](C)C([C@]1(C)F)=O)OC/C=C/c2cc3ccccc3nc2)=O)N2)OC2=O)OC1=O Chemical compound CC[C@H]([C@](C)([C@@H]([C@@H](C)C([C@H](C)C[C@](C)(C(C)(C)[C@@H](C)C([C@]1(C)F)=O)OC/C=C/c2cc3ccccc3nc2)=O)N2)OC2=O)OC1=O IEAZLKDPYQMCJD-HMEZCREDSA-N 0.000 description 1
- RIHZEWMSCKATNB-TVLBWKGNSA-N CC[C@H]([C@](C)([C@@H]([C@@H](C)C([C@H](C)C[C@](C)([C@@H]([C@@H](C)C([C@H]1C)=O)I)OC/C=C/c2cc3ccccc3nc2)=O)N2)OC2=O)OC1=O Chemical compound CC[C@H]([C@](C)([C@@H]([C@@H](C)C([C@H](C)C[C@](C)([C@@H]([C@@H](C)C([C@H]1C)=O)I)OC/C=C/c2cc3ccccc3nc2)=O)N2)OC2=O)OC1=O RIHZEWMSCKATNB-TVLBWKGNSA-N 0.000 description 1
- FHEKGXXBVSUUTI-LAMXZHTCSA-N CC[C@H]([C@](C)([C@@H]([C@@H](C)C([C@H](C)C[C@](C)([C@H](C)[C@@H](C)[C@@H]([C@H]1C)O[C@@H](C[C@@H]2C)O[C@@H](C)[C@@H]2O)OC)=O)O)O)OC1=O Chemical compound CC[C@H]([C@](C)([C@@H]([C@@H](C)C([C@H](C)C[C@](C)([C@H](C)[C@@H](C)[C@@H]([C@H]1C)O[C@@H](C[C@@H]2C)O[C@@H](C)[C@@H]2O)OC)=O)O)O)OC1=O FHEKGXXBVSUUTI-LAMXZHTCSA-N 0.000 description 1
- MOXQEARUYJFFKI-FQFLFQHTSA-N CC[C@H]([C@](C)([C@@H]([C@@H](C)N(C)C[C@H](C)C[C@](C)(C(C)(C)[C@@H](C)C([C@@H](CC1(C)C)OC(C)[C@@H]1N)[C@H]1C)O)O)O)OC1=O Chemical compound CC[C@H]([C@](C)([C@@H]([C@@H](C)N(C)C[C@H](C)C[C@](C)(C(C)(C)[C@@H](C)C([C@@H](CC1(C)C)OC(C)[C@@H]1N)[C@H]1C)O)O)O)OC1=O MOXQEARUYJFFKI-FQFLFQHTSA-N 0.000 description 1
- IWFQPKVPLNUDFH-UHFFFAOYSA-N OCCOCc(cc1)ccc1I Chemical compound OCCOCc(cc1)ccc1I IWFQPKVPLNUDFH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71144005P | 2005-08-24 | 2005-08-24 | |
| US79792606P | 2006-05-05 | 2006-05-05 | |
| PCT/US2006/033157 WO2007025089A2 (en) | 2005-08-24 | 2006-08-24 | Triazole compounds and methods of making and using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009506063A true JP2009506063A (ja) | 2009-02-12 |
| JP2009506063A5 JP2009506063A5 (https=) | 2009-10-08 |
Family
ID=37631779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008528163A Withdrawn JP2009506063A (ja) | 2005-08-24 | 2006-08-24 | トリアゾール化合物ならびにこれを作製する方法および使用する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (5) | US8470985B2 (https=) |
| EP (1) | EP1934237A2 (https=) |
| JP (1) | JP2009506063A (https=) |
| WO (1) | WO2007025089A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014533710A (ja) * | 2011-11-25 | 2014-12-15 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 抗菌性チロシン誘導体およびその製造方法 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5383037B2 (ja) | 2004-02-27 | 2014-01-08 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | 大環状化合物およびそれらを製造し使用する方法 |
| JP2009506063A (ja) * | 2005-08-24 | 2009-02-12 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | トリアゾール化合物ならびにこれを作製する方法および使用する方法 |
| EP3290427A1 (en) | 2005-08-24 | 2018-03-07 | Melinta Therapeutics, Inc. | Triazole compounds and methods of making and using the same |
| WO2008106224A1 (en) * | 2007-02-28 | 2008-09-04 | Rib-X Pharmaceuticals, Inc. | Macrolide compounds and methods of making and using the same |
| BRPI0917693A2 (pt) * | 2008-09-02 | 2016-05-17 | Neurosearch As | composto derivado de triazol, composição farmacêutica, e, uso de um derivado de triazol |
| HK1244211A1 (zh) | 2014-11-14 | 2018-08-03 | Melinta Therapeutics, Inc. | 治疗、预防或降低皮肤感染风险的方法 |
| AR107928A1 (es) | 2016-03-22 | 2018-06-28 | Merck Sharp & Dohme | Moduladores alostéricos de receptores de acetilcolina nicotínicos |
| WO2022146980A1 (en) | 2020-12-28 | 2022-07-07 | Georgia Tech Research Corporation | Compositions and methods for inhibiting fibrosis, inflammation and cancer |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY113693A (en) | 1992-05-26 | 2002-05-31 | Chugai Pharmaceutical Co Ltd | Erythromycin derivatives having an enterokinesis stimulating action |
| DE19604223A1 (de) | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue substituierte Oxazolidinone |
| FR2748746B1 (fr) | 1996-05-14 | 1998-08-14 | Hoechst Marion Roussel Inc | Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine |
| DK1025114T3 (da) | 1997-09-30 | 2004-07-05 | Abbott Lab | 3'-N-modificerede 6-O-substituerede erythromycin-ketolidderivater med antibakteriel aktivitet |
| ZA989885B (en) | 1997-10-31 | 1999-05-05 | Abbott Lab | Use of macrolides for the treatment of cancer and macular degeneration |
| WO1999063929A2 (en) | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
| HRP980646B1 (en) | 1998-12-30 | 2008-02-29 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | Novel oleandomycin derivatives |
| US6413981B1 (en) | 1999-08-12 | 2002-07-02 | Ortho-Mcneil Pharamceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| JP2003522763A (ja) | 2000-02-10 | 2003-07-29 | ファルマシア・アンド・アップジョン・カンパニー | ピペラジンアミド置換基を持つオキサゾリジノンチオアミド |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| AU2002225724A1 (en) | 2000-12-01 | 2002-07-08 | Kosan Biosciences, Inc. | Motilide compounds |
| US6680299B2 (en) | 2001-07-27 | 2004-01-20 | Enanta Pharmaceuticals, Inc. | 4'-substituted leucomycins |
| US7396847B2 (en) | 2001-09-11 | 2008-07-08 | Astrazeneca Ab | Oxazolidinone and/or isoxazoline as antibacterial agents |
| EP1443930A1 (en) | 2001-10-25 | 2004-08-11 | AstraZeneca AB | Isoxazoline derivatives useful as antimicrobials |
| ITMI20021726A1 (it) | 2002-08-01 | 2004-02-02 | Zambon Spa | Macrolidi ad attivita' antiinfiammatoria. |
| AR043050A1 (es) * | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
| WO2005042554A1 (en) | 2003-10-30 | 2005-05-12 | Rib-X Pharmaceuticals, Inc. | Bifunctional macrolide heterocyclic compounds and methods of making and using the same |
| JP2007512256A (ja) | 2003-11-18 | 2007-05-17 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法 |
| JP5383037B2 (ja) * | 2004-02-27 | 2014-01-08 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | 大環状化合物およびそれらを製造し使用する方法 |
| WO2005118610A2 (en) * | 2004-06-01 | 2005-12-15 | Rib-X Pharmaceuticals, Inc. | Macrocyclic compounds and methods of making and using the same |
| EP3290427A1 (en) | 2005-08-24 | 2018-03-07 | Melinta Therapeutics, Inc. | Triazole compounds and methods of making and using the same |
| JP2009506063A (ja) * | 2005-08-24 | 2009-02-12 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | トリアゾール化合物ならびにこれを作製する方法および使用する方法 |
-
2006
- 2006-08-24 JP JP2008528163A patent/JP2009506063A/ja not_active Withdrawn
- 2006-08-24 WO PCT/US2006/033157 patent/WO2007025089A2/en not_active Ceased
- 2006-08-24 US US11/990,833 patent/US8470985B2/en not_active Expired - Fee Related
- 2006-08-24 EP EP06802297A patent/EP1934237A2/en not_active Withdrawn
-
2013
- 2013-06-14 US US13/918,344 patent/US9085600B2/en not_active Expired - Fee Related
-
2015
- 2015-06-26 US US14/751,625 patent/US20160152654A1/en not_active Abandoned
-
2017
- 2017-01-12 US US15/404,757 patent/US20170349621A1/en not_active Abandoned
-
2018
- 2018-08-08 US US16/058,352 patent/US20190211046A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014533710A (ja) * | 2011-11-25 | 2014-12-15 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 抗菌性チロシン誘導体およびその製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007025089A3 (en) | 2007-05-18 |
| US20170349621A1 (en) | 2017-12-07 |
| US20100016955A1 (en) | 2010-01-21 |
| WO2007025089A2 (en) | 2007-03-01 |
| US20140094422A1 (en) | 2014-04-03 |
| US9085600B2 (en) | 2015-07-21 |
| US20190211046A1 (en) | 2019-07-11 |
| EP1934237A2 (en) | 2008-06-25 |
| US20160152654A1 (en) | 2016-06-02 |
| US8470985B2 (en) | 2013-06-25 |
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