JP2009505980A5 - - Google Patents
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- Publication number
- JP2009505980A5 JP2009505980A5 JP2008526231A JP2008526231A JP2009505980A5 JP 2009505980 A5 JP2009505980 A5 JP 2009505980A5 JP 2008526231 A JP2008526231 A JP 2008526231A JP 2008526231 A JP2008526231 A JP 2008526231A JP 2009505980 A5 JP2009505980 A5 JP 2009505980A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound according
- heteroaryl
- nrr
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 30
- 125000001072 heteroaryl group Chemical group 0.000 claims 15
- 125000001931 aliphatic group Chemical group 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000005418 aryl aryl group Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000011780 sodium chloride Substances 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- -1 heteroaliphatic Chemical group 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 150000002431 hydrogen Chemical group 0.000 claims 4
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 206010024324 Leukaemias Diseases 0.000 claims 2
- 206010027476 Metastasis Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102000030951 Phosphotransferases Human genes 0.000 claims 2
- 108091000081 Phosphotransferases Proteins 0.000 claims 2
- 125000002015 acyclic group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 230000001404 mediated Effects 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 230000004614 tumor growth Effects 0.000 claims 2
- 125000001960 7 membered carbocyclic group Chemical group 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 125000005842 heteroatoms Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70742305P | 2005-08-11 | 2005-08-11 | |
| US60/707,423 | 2005-08-11 | ||
| PCT/US2006/031382 WO2007021937A2 (en) | 2005-08-11 | 2006-08-11 | Unsaturated heterocyclic derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009505980A JP2009505980A (ja) | 2009-02-12 |
| JP2009505980A5 true JP2009505980A5 (US07652168-20100126-C00055.png) | 2009-09-24 |
| JP5321061B2 JP5321061B2 (ja) | 2013-10-23 |
Family
ID=37758204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008526231A Active JP5321061B2 (ja) | 2005-08-11 | 2006-08-11 | 不飽和複素環誘導体 |
Country Status (5)
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005231507B2 (en) | 2004-04-08 | 2012-03-01 | Targegen, Inc. | Benzotriazine inhibitors of kinases |
| US7652051B2 (en) | 2004-08-25 | 2010-01-26 | Targegen, Inc. | Heterocyclic compounds and methods of use |
| US8071609B2 (en) | 2005-08-11 | 2011-12-06 | Ariad Pharmaceuticals, Inc. | Unsaturated heterocyclic derivatives |
| WO2007075869A2 (en) | 2005-12-23 | 2007-07-05 | Ariad Pharmaceuticals, Inc. | Bicyclic heteroaryl compounds |
| MX2008013205A (es) | 2006-04-14 | 2008-10-22 | Abbott Lab | Procedimiento para la preparacion de indazolil ureas que inhibien receptores de vanilloides del subtipo 1 (vr1). |
| AU2013203928B2 (en) * | 2006-05-08 | 2015-07-16 | Ariad Pharmaceuticals, Inc. | Monocyclic heteroaryl compounds |
| CN101489558A (zh) * | 2006-05-08 | 2009-07-22 | 阿里亚德医药股份有限公司 | 炔类杂芳基化合物 |
| MX2008014290A (es) | 2006-05-08 | 2008-11-26 | Ariad Pharma Inc | Compuestos heteroarilicos monociclicos. |
| CN103435595A (zh) | 2006-05-08 | 2013-12-11 | 阿里亚德医药股份有限公司 | 炔类杂芳基化合物 |
| RU2681081C2 (ru) | 2007-10-05 | 2019-03-04 | Верастэм, Инк. | Пиримидинзамещенные производные пурина, фармацевтическая композиция на их основе, способ ингибирования протеинкиназ, способ лечения или профилактики заболеваний, чувствительных к ингибированию протеинкиназ, и способ лечения пролиферативных заболеваний |
| EP2300013B1 (en) * | 2008-05-21 | 2017-09-06 | Ariad Pharmaceuticals, Inc. | Phosphorous derivatives as kinase inhibitors |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| CA2743449C (en) | 2008-11-12 | 2016-10-18 | Ariad Pharmaceuticals, Inc. | Pyrazinopyrazines and derivatives as kinase inhibitors |
| RU2506264C2 (ru) | 2009-04-03 | 2014-02-10 | Вэрастэм, Инк. | Пиримидин-замещенные пуриновые соединения в качестве ингибиторов киназы (или киназ) |
| TW201100441A (en) | 2009-06-01 | 2011-01-01 | Osi Pharm Inc | Amino pyrimidine anticancer compounds |
| JP6000273B2 (ja) | 2010-11-29 | 2016-09-28 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 大環状キナーゼ阻害剤 |
| JP5999177B2 (ja) | 2011-05-04 | 2016-09-28 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物 |
| AU2013250726B2 (en) * | 2012-04-20 | 2017-01-05 | Advinus Therapeutics Limited | Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof |
| US20150166591A1 (en) | 2012-05-05 | 2015-06-18 | Ariad Pharmaceuticals, Inc. | Methods and compositions for raf kinase mediated diseases |
| CA3022250A1 (en) | 2012-12-12 | 2014-06-12 | Ariad Pharmaceuticals, Inc. | Crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| CN106132406B (zh) | 2014-02-03 | 2020-03-27 | 夸德里加生物科学公司 | 作为化疗剂的β-取代的γ-氨基酸和类似物 |
| CN106163509B (zh) | 2014-02-03 | 2019-05-03 | 夸德里加生物科学公司 | 作为化疗剂的β-取代的β-氨基酸及类似物 |
| EP3331851A1 (en) | 2015-08-03 | 2018-06-13 | Quadriga Biosciences, Inc. | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof |
| WO2018224455A1 (en) | 2017-06-07 | 2018-12-13 | Basf Se | Substituted cyclopropyl derivatives |
| EP4249070A3 (en) | 2019-04-12 | 2024-04-17 | Riboscience LLC | Bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors |
| CN114292269B (zh) * | 2021-12-21 | 2024-03-29 | 南昌大学 | 一种邻氨基嘌呤苯甲酰胺类衍生物及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5866702A (en) | 1996-08-02 | 1999-02-02 | Cv Therapeutics, Incorporation | Purine inhibitors of cyclin dependent kinase 2 |
| GB9903762D0 (en) | 1999-02-18 | 1999-04-14 | Novartis Ag | Organic compounds |
| WO2001044260A2 (en) * | 1999-12-17 | 2001-06-21 | Ariad Pharmaceuticals, Inc. | Novel purines |
| PT1399468E (pt) | 2001-05-30 | 2006-05-31 | Novartis Ag | Derivados do acido 2-{[n-(2-amino-3-(heteroaril ou aril)propionil)-aminoacil]-amino}-alquilboronico |
| US6770652B2 (en) * | 2001-10-18 | 2004-08-03 | Duquesne University Of The Holy Ghost | Multiple acting anti-angiogenic and cytotoxic compounds and methods for using the same |
| WO2003087087A2 (en) * | 2002-04-09 | 2003-10-23 | Astex Technology Limited | Heterocyclic compounds and their use as modulators of p38 map kinase |
| US20050288503A1 (en) * | 2002-09-06 | 2005-12-29 | Adams Jerry L | Novel compounds |
| US20050054614A1 (en) * | 2003-08-14 | 2005-03-10 | Diacovo Thomas G. | Methods of inhibiting leukocyte accumulation |
| US8071609B2 (en) | 2005-08-11 | 2011-12-06 | Ariad Pharmaceuticals, Inc. | Unsaturated heterocyclic derivatives |
| WO2007075869A2 (en) | 2005-12-23 | 2007-07-05 | Ariad Pharmaceuticals, Inc. | Bicyclic heteroaryl compounds |
| MX2008014290A (es) | 2006-05-08 | 2008-11-26 | Ariad Pharma Inc | Compuestos heteroarilicos monociclicos. |
| EP2107054A1 (en) | 2008-04-01 | 2009-10-07 | Università Degli Studi Di Milano - Bicocca | Antiproliferative compounds and therapeutic uses thereof |
-
2006
- 2006-08-11 US US11/990,299 patent/US8071609B2/en active Active
- 2006-08-11 EP EP20060813381 patent/EP1940843A4/en not_active Withdrawn
- 2006-08-11 JP JP2008526231A patent/JP5321061B2/ja active Active
- 2006-08-11 CA CA002618513A patent/CA2618513A1/en not_active Abandoned
- 2006-08-11 WO PCT/US2006/031382 patent/WO2007021937A2/en active Application Filing
-
2011
- 2011-12-05 US US13/311,106 patent/US8586566B2/en active Active
