JP2009505976A - 方法 - Google Patents

方法 Download PDF

Info

Publication number
JP2009505976A
JP2009505976A JP2008525960A JP2008525960A JP2009505976A JP 2009505976 A JP2009505976 A JP 2009505976A JP 2008525960 A JP2008525960 A JP 2008525960A JP 2008525960 A JP2008525960 A JP 2008525960A JP 2009505976 A JP2009505976 A JP 2009505976A
Authority
JP
Japan
Prior art keywords
inhibitor
water
particles
insoluble substance
dispersion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008525960A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009505976A5 (enExample
Inventor
レンナルト・リンドフォッシュ
ウルバン・スカンツェ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of JP2009505976A publication Critical patent/JP2009505976A/ja
Publication of JP2009505976A5 publication Critical patent/JP2009505976A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2008525960A 2005-08-12 2006-08-09 方法 Pending JP2009505976A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0501807 2005-08-12
PCT/SE2006/000933 WO2007021228A1 (en) 2005-08-12 2006-08-09 Process

Publications (2)

Publication Number Publication Date
JP2009505976A true JP2009505976A (ja) 2009-02-12
JP2009505976A5 JP2009505976A5 (enExample) 2009-08-27

Family

ID=37757817

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008525960A Pending JP2009505976A (ja) 2005-08-12 2006-08-09 方法

Country Status (13)

Country Link
US (1) US20080193534A1 (enExample)
EP (1) EP1915131A4 (enExample)
JP (1) JP2009505976A (enExample)
KR (1) KR20080033383A (enExample)
CN (1) CN101242809A (enExample)
AU (1) AU2006280511A1 (enExample)
BR (1) BRPI0614904A2 (enExample)
CA (1) CA2618468A1 (enExample)
IL (1) IL188971A0 (enExample)
MX (1) MX2008001919A (enExample)
NO (1) NO20081311L (enExample)
WO (1) WO2007021228A1 (enExample)
ZA (1) ZA200800919B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010517759A (ja) * 2007-02-09 2010-05-27 アストラゼネカ・アクチエボラーグ 水性媒体中における固体非晶質サブミクロン粒子の安定な分散体を製造する方法
TW200848039A (en) * 2007-02-09 2008-12-16 Astrazeneca Ab Pharmaceutical compositions
US8920682B2 (en) * 2010-03-19 2014-12-30 Eastern Michigan University Nanoparticle dispersions with ionic liquid-based stabilizers
KR102803055B1 (ko) * 2019-03-27 2025-04-30 신젠타 크롭 프로텍션 아게 결정 성장이 감소된 살진균제 제형

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07163862A (ja) * 1993-09-01 1995-06-27 Basf Ag 微粉の着色剤または作用物質調製物の製造方法
JPH09510180A (ja) * 1993-09-15 1997-10-14 ダウエランコ 安定な水性分散液の貯蔵および希釈
JP2002538199A (ja) * 1999-03-08 2002-11-12 エラン ファーマ インターナショナル，リミティド ナノ粒子組成物における結晶成長および粒子凝集を防止するための方法
JP2005500362A (ja) * 2001-08-06 2005-01-06 アストラゼネカ・アクチエボラーグ 水不溶性の活性でかつ賦形剤様の中鎖トリグリセリド（ｍｃｔ）の安定なナノ粒子を含む水性分散液
JP2005515224A (ja) * 2002-01-14 2005-05-26 ダウ グローバル テクノロジーズ インコーポレイティド テンプレート乳剤からの薬剤ナノ粒子

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
US4832953A (en) * 1987-08-13 1989-05-23 Alza Corporation Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
FR2651680B1 (fr) * 1989-09-14 1991-12-27 Medgenix Group Sa Nouveau procede de preparation de microparticules lipidiques.
US5110717A (en) * 1990-12-17 1992-05-05 Eastman Kodak Company Stability improvement of amorphous particle dispersions
US5145684A (en) * 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
DE4327063A1 (de) * 1993-08-12 1995-02-16 Kirsten Dr Westesen Ubidecarenon-Partikel mit modifizierten physikochemischen Eigenschaften
FR2714057B1 (fr) * 1993-12-17 1996-03-08 Sanofi Elf Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
PT901786E (pt) * 1997-08-11 2007-08-07 Pfizer Prod Inc Disperções farmacêuticas sólidas com biodisponibilidade melhorada
US6375986B1 (en) * 2000-09-21 2002-04-23 Elan Pharma International Ltd. Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate
JP2004502642A (ja) * 2000-02-11 2004-01-29 ブリストル−マイヤーズ　スクイブ　カンパニー カンナビノイドレセプターモジュレーター、それらの製造方法、および呼吸系および非呼吸系疾患の処置のためのカンナビノイドレセプターモジュレーターの使用
AU2001257115B2 (en) * 2000-04-20 2005-01-27 Rtp Pharma Inc. Improved water-insoluble drug particle process
DE60320940D1 (de) * 2002-02-01 2008-06-26 Pfizer Prod Inc Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien
US6825209B2 (en) * 2002-04-15 2004-11-30 Research Triangle Institute Compounds having unique CB1 receptor binding selectivity and methods for their production and use
CA2489153A1 (en) * 2002-06-11 2003-12-18 Merck Patent Gesellschaft Mit Beschraenkter Haftung Modified byrodin 1 with reduced immunogenicity
US7390505B2 (en) * 2003-01-31 2008-06-24 Elan Pharma International, Ltd. Nanoparticulate topiramate formulations
GB0302672D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
US20060198856A1 (en) * 2005-03-01 2006-09-07 Keith Whitehead Ibuprofen suspension stabilized with docusate sodium

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07163862A (ja) * 1993-09-01 1995-06-27 Basf Ag 微粉の着色剤または作用物質調製物の製造方法
JPH09510180A (ja) * 1993-09-15 1997-10-14 ダウエランコ 安定な水性分散液の貯蔵および希釈
JP2002538199A (ja) * 1999-03-08 2002-11-12 エラン ファーマ インターナショナル，リミティド ナノ粒子組成物における結晶成長および粒子凝集を防止するための方法
JP2005500362A (ja) * 2001-08-06 2005-01-06 アストラゼネカ・アクチエボラーグ 水不溶性の活性でかつ賦形剤様の中鎖トリグリセリド（ｍｃｔ）の安定なナノ粒子を含む水性分散液
JP2005515224A (ja) * 2002-01-14 2005-05-26 ダウ グローバル テクノロジーズ インコーポレイティド テンプレート乳剤からの薬剤ナノ粒子

Also Published As

Publication number Publication date
EP1915131A1 (en) 2008-04-30
CA2618468A1 (en) 2007-02-22
EP1915131A4 (en) 2012-07-25
CN101242809A (zh) 2008-08-13
ZA200800919B (en) 2008-12-31
NO20081311L (no) 2008-05-13
BRPI0614904A2 (pt) 2012-12-25
AU2006280511A1 (en) 2007-02-22
WO2007021228A1 (en) 2007-02-22
IL188971A0 (en) 2008-08-07
US20080193534A1 (en) 2008-08-14
KR20080033383A (ko) 2008-04-16
MX2008001919A (es) 2008-03-24

Similar Documents

Publication Publication Date Title
JP4714412B2 (ja) 水不溶性の活性でかつ賦形剤様の中鎖トリグリセリド（ｍｃｔ）の安定なナノ粒子を含む水性分散液
US7780989B2 (en) Process for the preparation of crystalline nano-particle dispersions
AU2002317409A1 (en) Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like middle chain triglycerides (MCT)
JP4830019B2 (ja) ナノスケールの活物質粒子の製造方法
de Melo Barbosa et al. Lipid-based colloidal carriers for transdermal administration of bioactives
US20080193534A1 (en) Process
CN101605533B (zh) 制备固体非晶亚微米颗粒在水性介质中的稳定分散体的方法
ZA200400847B (en) Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like Middle Chain Triglycerides (MCT).
HK1064048B (en) Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like middle chain triglycerides (mct)
US20080214611A1 (en) Pharmaceutical Compositions - 659
VERMA et al. Indian Journal of Novel Drug Delivery An Official Publication of
HK1075199B (en) Process for the preparation of crystalline nano-particle dispersions

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090707

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090707

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120424

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20120925