JP2009504676A5 - - Google Patents
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- JP2009504676A5 JP2009504676A5 JP2008526279A JP2008526279A JP2009504676A5 JP 2009504676 A5 JP2009504676 A5 JP 2009504676A5 JP 2008526279 A JP2008526279 A JP 2008526279A JP 2008526279 A JP2008526279 A JP 2008526279A JP 2009504676 A5 JP2009504676 A5 JP 2009504676A5
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- JP
- Japan
- Prior art keywords
- compound
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 13
- 125000003003 spiro group Chemical group 0.000 claims 4
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 3
- 206010040984 Sleep disease Diseases 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 206010022437 Insomnia Diseases 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
- MXZWCVKSYUXGOK-UHFFFAOYSA-N CC(C)(CN(CC1)CCN1C1=Nc(cccc2)c2Nc2c1cc(C)[s]2)C(O)=O Chemical compound CC(C)(CN(CC1)CCN1C1=Nc(cccc2)c2Nc2c1cc(C)[s]2)C(O)=O MXZWCVKSYUXGOK-UHFFFAOYSA-N 0.000 description 2
- 0 Cc1c(*)c(C(N2CCN(CC(*)(*)*)CC2)=Nc(cc(*)c(*)c2)c2N2)c2[s]1 Chemical compound Cc1c(*)c(C(N2CCN(CC(*)(*)*)CC2)=Nc(cc(*)c(*)c2)c2N2)c2[s]1 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70736805P | 2005-08-11 | 2005-08-11 | |
| US11/502,789 US7807828B2 (en) | 2005-08-11 | 2006-08-10 | Olanzapine analogs and methods of use thereof |
| PCT/US2006/031602 WO2007022068A1 (en) | 2005-08-11 | 2006-08-11 | Olanzapine analogs and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009504676A JP2009504676A (ja) | 2009-02-05 |
| JP2009504676A5 true JP2009504676A5 (US20080242721A1-20081002-C00053.png) | 2009-09-24 |
Family
ID=37460090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008526279A Pending JP2009504676A (ja) | 2005-08-11 | 2006-08-11 | オランザピンアナログ及びその使用法 |
Country Status (8)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2623095A1 (en) * | 2004-11-16 | 2013-08-07 | Elan Pharma International Limited | Injectable nanoparticulate olanzapine formulations |
| WO2007092333A1 (en) * | 2006-02-03 | 2007-08-16 | Hypnion, Inc. | Use of olopatadine for treating sleep disorders |
| US8394790B2 (en) | 2006-10-25 | 2013-03-12 | Ramot At Tel-Aviv University Ltd. | Psychotropic agents having glutamate NMDA activity |
| MX2010006045A (es) | 2007-12-12 | 2010-06-23 | Amgen Inc | Inhibidores de transportador de glicina-1. |
| AR084867A1 (es) * | 2011-02-07 | 2013-07-10 | Lilly Co Eli | Compuestos de acido [(5h-pirrolo[2,1-c][1,4]benzodiazepin-11-il)piperazin-1-il]-2,2-dimetilpropanoico sustituido como antagonistas de 5-ht/agonistas inversos de actividad dual |
| PL395468A1 (pl) | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Zwiazki amidoalkilopiperazynylowe do leczenia chorób osrodkowego ukladu nerwowego |
| CA2840217C (en) * | 2011-07-08 | 2016-03-22 | Eli Lilly And Company | (thieno[2,3-b][1,5]benzoxazepin-4-yl)piperazin-1-yl compounds as dual activity h1 inverse agonists/5-ht2a antagonists |
| BR112014004557A2 (pt) | 2011-08-30 | 2017-05-30 | Lilly Co Eli | compostos (tieno[2,3-b][1,5]benzoxazepin-4-il)piperazin-1-ila como agonistas inversos de h1/antagonistas de 5-ht2a de dupla atividade |
| BR112015015491A8 (pt) * | 2013-01-14 | 2018-01-23 | Lilly Co Eli | (tieno[2,3-b][1,5] benzoxazepin-4-il) piperazin-1-ila, seus usos, e composição farmacêutica. |
| TW201625644A (zh) | 2014-04-29 | 2016-07-16 | 美國禮來大藥廠 | 作為選擇性５－ＨＴＡ反向促效劑之（噻吩并［２，３－ｂ］［１，５］苯并氧氮呯－４－基）哌嗪－１－基化合物 |
| CA3087698A1 (en) | 2018-01-05 | 2019-07-11 | Impel Neuropharma, Inc. | Intranasal delivery of olanzapine by precision olfactory device |
| CN114685527B (zh) * | 2020-12-25 | 2024-03-05 | 长沙博源医疗科技有限公司 | 一种奥氮平衍生物、免疫原、抗奥氮平特异性抗体及其制备方法与应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04211071A (ja) * | 1990-03-05 | 1992-08-03 | Hokuriku Seiyaku Co Ltd | 多環式化合物 |
| US5602124A (en) | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | 5-HT2 receptor ligands |
| US5744470A (en) * | 1996-03-11 | 1998-04-28 | Eli Lilly And Company | Method for treating insomnia |
| JP3156933B2 (ja) * | 1997-09-02 | 2001-04-16 | ウェルファイド株式会社 | 縮合チオフェン化合物およびその医薬用途 |
| US7355042B2 (en) * | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
| JP2005529840A (ja) * | 2001-10-16 | 2005-10-06 | ヒプニオン， インコーポレイテッド | Ｃｎｓ標的モジュレータを使用するｃｎｓ障害の治療 |
| US20060270656A1 (en) | 2003-09-09 | 2006-11-30 | Eli Lilly And Company | Substituted piperazines of azepines, oxazepines and thiazepines |
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2006
- 2006-08-10 US US11/502,789 patent/US7807828B2/en not_active Expired - Fee Related
- 2006-08-11 EP EP06801404A patent/EP1915379B1/en not_active Not-in-force
- 2006-08-11 CA CA2617107A patent/CA2617107C/en not_active Expired - Fee Related
- 2006-08-11 DE DE602006010400T patent/DE602006010400D1/de active Active
- 2006-08-11 ES ES06801404T patent/ES2333983T3/es active Active
- 2006-08-11 JP JP2008526279A patent/JP2009504676A/ja active Pending
- 2006-08-11 WO PCT/US2006/031602 patent/WO2007022068A1/en active Application Filing
- 2006-08-11 AT AT06801404T patent/ATE448234T1/de not_active IP Right Cessation
