JP2009502937A - Ａｂｌキナーゼ阻害 - Google Patents

Ａｂｌキナーゼ阻害 Download PDF

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Publication number
JP2009502937A
JP2009502937A JP2008524094A JP2008524094A JP2009502937A JP 2009502937 A JP2009502937 A JP 2009502937A JP 2008524094 A JP2008524094 A JP 2008524094A JP 2008524094 A JP2008524094 A JP 2008524094A JP 2009502937 A JP2009502937 A JP 2009502937A
Authority
JP
Japan
Prior art keywords
compound
kinase
abl
patient
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008524094A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009502937A5 (enExample
Inventor
ジョン ポラード，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of JP2009502937A publication Critical patent/JP2009502937A/ja
Publication of JP2009502937A5 publication Critical patent/JP2009502937A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2008524094A 2005-07-26 2006-07-26 Ａｂｌキナーゼ阻害 Pending JP2009502937A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70277105P 2005-07-26 2005-07-26
US78516106P 2006-03-23 2006-03-23
US83025706P 2006-07-12 2006-07-12
PCT/US2006/028984 WO2007014250A2 (en) 2005-07-26 2006-07-26 Abl kinase inhibition

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012122081A Division JP2012158616A (ja) 2005-07-26 2012-05-29 Ａｂｌキナーゼ阻害

Publications (2)

Publication Number Publication Date
JP2009502937A true JP2009502937A (ja) 2009-01-29
JP2009502937A5 JP2009502937A5 (enExample) 2009-09-10

Family

ID=37683933

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008524094A Pending JP2009502937A (ja) 2005-07-26 2006-07-26 Ａｂｌキナーゼ阻害
JP2012122081A Pending JP2012158616A (ja) 2005-07-26 2012-05-29 Ａｂｌキナーゼ阻害

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012122081A Pending JP2012158616A (ja) 2005-07-26 2012-05-29 Ａｂｌキナーゼ阻害

Country Status (6)

Country Link
US (1) US20090298844A1 (enExample)
EP (1) EP1906967A4 (enExample)
JP (2) JP2009502937A (enExample)
AU (1) AU2006272609A1 (enExample)
CA (1) CA2616517A1 (enExample)
WO (1) WO2007014250A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE529536T1 (de) * 2005-12-01 2011-11-15 Bristol Myers Squibb Co Verfahren zur identifizierung und behandlung von komplexe karyotypen zeigenden individuen
JP2009544705A (ja) * 2006-07-26 2009-12-17 メルク エンド カムパニー インコーポレーテッド がんの治療のために有用なｍｋ−０４５７の新規乳酸製剤
IN2014KN02601A (enExample) 2012-04-24 2015-05-08 Vertex Pharma
SMT201900107T1 (it) 2013-03-12 2019-02-28 Vertex Pharma Inibitori della dna-pk
TWI647220B (zh) 2013-03-15 2019-01-11 美商西建卡爾有限責任公司 雜芳基化合物及其用途
UA120248C2 (uk) 2013-03-15 2019-11-11 Селджен Кар Ллс Гетероарильні сполуки та їх застосування
US9663524B2 (en) 2013-03-15 2017-05-30 Celgene Car Llc Substituted pyrido[2,3-d]pyrimidines as protein kinase inhibitors
PL3424920T3 (pl) 2013-10-17 2020-11-16 Vertex Pharmaceuticals Incorporated Kokryształy (S)-N-metylo-8-(1-((2'-metylo-4’,6'-dideutero-[4,5'-bipirymidyn]-6-ylo)amino)propan-2-ylo)chinolino-4-karboksyamidu i ich deuterowane pochodne jako inhibitory DNA-PK
MX394860B (es) 2016-09-27 2025-03-24 Vertex Pharma Metodo para tratar cancer usando una combinacion de agentes que dañan adn e inhibidores de proteina cinasa dependiente de adn (adn-pk).

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2017335B1 (en) * 2001-10-05 2010-12-01 Novartis AG Mutated Abl kinase domains
MY141867A (en) * 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
AU2005272815A1 (en) * 2004-08-13 2006-02-23 Genentech, Inc. Thiazole based inhibitors of ATP-utilizing enzymes

Also Published As

Publication number Publication date
WO2007014250A3 (en) 2007-06-28
US20090298844A1 (en) 2009-12-03
WO2007014250A8 (en) 2008-02-21
JP2012158616A (ja) 2012-08-23
EP1906967A4 (en) 2010-07-28
WO2007014250A2 (en) 2007-02-01
AU2006272609A1 (en) 2007-02-01
EP1906967A2 (en) 2008-04-09
CA2616517A1 (en) 2007-02-01

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