JP2009502345A - 潤滑な溶出ポリマーブレンド及びそれから作られるコーティング - Google Patents
潤滑な溶出ポリマーブレンド及びそれから作られるコーティング Download PDFInfo
- Publication number
- JP2009502345A JP2009502345A JP2008524119A JP2008524119A JP2009502345A JP 2009502345 A JP2009502345 A JP 2009502345A JP 2008524119 A JP2008524119 A JP 2008524119A JP 2008524119 A JP2008524119 A JP 2008524119A JP 2009502345 A JP2009502345 A JP 2009502345A
- Authority
- JP
- Japan
- Prior art keywords
- blend
- polymer
- polyethylene oxide
- molecular weight
- polymer blend
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229920002959 polymer blend Polymers 0.000 title claims abstract description 38
- 238000000576 coating method Methods 0.000 title claims description 22
- 230000001050 lubricating effect Effects 0.000 title description 3
- 239000003814 drug Substances 0.000 claims abstract description 67
- 229940079593 drug Drugs 0.000 claims abstract description 66
- 229920000642 polymer Polymers 0.000 claims abstract description 48
- 239000000203 mixture Substances 0.000 claims abstract description 42
- 239000000463 material Substances 0.000 claims abstract description 37
- 238000004132 cross linking Methods 0.000 claims abstract description 23
- 230000000975 bioactive effect Effects 0.000 claims abstract description 17
- 239000000126 substance Substances 0.000 claims abstract description 14
- 239000012867 bioactive agent Substances 0.000 claims abstract description 9
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 84
- 229920002614 Polyether block amide Polymers 0.000 claims description 25
- 239000011248 coating agent Substances 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 16
- 239000004814 polyurethane Substances 0.000 claims description 10
- 238000010894 electron beam technology Methods 0.000 claims description 9
- 229920002635 polyurethane Polymers 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 6
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 229920000570 polyether Polymers 0.000 claims description 3
- 150000003431 steroids Chemical class 0.000 claims description 3
- 239000004971 Cross linker Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000012620 biological material Substances 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 abstract description 15
- 230000015572 biosynthetic process Effects 0.000 abstract 2
- 229920001477 hydrophilic polymer Polymers 0.000 description 17
- 239000010410 layer Substances 0.000 description 14
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 14
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 14
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 14
- 230000036571 hydration Effects 0.000 description 11
- 238000006703 hydration reaction Methods 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 238000002156 mixing Methods 0.000 description 10
- 229920001903 high density polyethylene Polymers 0.000 description 7
- 239000004700 high-density polyethylene Substances 0.000 description 7
- 229920003169 water-soluble polymer Polymers 0.000 description 7
- 239000002861 polymer material Substances 0.000 description 6
- RYECOJGRJDOGPP-UHFFFAOYSA-N Ethylurea Chemical compound CCNC(N)=O RYECOJGRJDOGPP-UHFFFAOYSA-N 0.000 description 5
- 238000010828 elution Methods 0.000 description 5
- 239000000017 hydrogel Substances 0.000 description 5
- 239000011159 matrix material Substances 0.000 description 4
- -1 polyethylene Polymers 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 3
- 239000003146 anticoagulant agent Chemical class 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 229920001577 copolymer Polymers 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 238000001125 extrusion Methods 0.000 description 3
- 238000005470 impregnation Methods 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 229920001778 nylon Polymers 0.000 description 3
- 229920000728 polyester Polymers 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- OKOBUGCCXMIKDM-UHFFFAOYSA-N Irganox 1098 Chemical compound CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CCC(=O)NCCCCCCNC(=O)CCC=2C=C(C(O)=C(C=2)C(C)(C)C)C(C)(C)C)=C1 OKOBUGCCXMIKDM-UHFFFAOYSA-N 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000003125 aqueous solvent Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 150000002433 hydrophilic molecules Chemical class 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 229920002725 thermoplastic elastomer Polymers 0.000 description 2
- VOYADQIFGGIKAT-UHFFFAOYSA-N 1,3-dibutyl-4-hydroxy-2,6-dioxopyrimidine-5-carboximidamide Chemical compound CCCCn1c(O)c(C(N)=N)c(=O)n(CCCC)c1=O VOYADQIFGGIKAT-UHFFFAOYSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 229920001634 Copolyester Polymers 0.000 description 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 description 1
- 229920002633 Kraton (polymer) Polymers 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229920006099 Vestamid® Polymers 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 230000003409 anti-rejection Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 239000003529 anticholesteremic agent Substances 0.000 description 1
- 229940127226 anticholesterol agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 229940127218 antiplatelet drug Drugs 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 238000003618 dip coating Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- UFRKOOWSQGXVKV-UHFFFAOYSA-N ethene;ethenol Chemical compound C=C.OC=C UFRKOOWSQGXVKV-UHFFFAOYSA-N 0.000 description 1
- 239000004715 ethylene vinyl alcohol Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000012760 heat stabilizer Substances 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 description 1
- 229920001707 polybutylene terephthalate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 102220045258 rs587781957 Human genes 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 229920003031 santoprene Polymers 0.000 description 1
- 238000001878 scanning electron micrograph Methods 0.000 description 1
- 238000007613 slurry method Methods 0.000 description 1
- 239000008279 sol Substances 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229920003051 synthetic elastomer Polymers 0.000 description 1
- 239000005061 synthetic rubber Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/041—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/049—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
- A61L2300/222—Steroids, e.g. corticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/191,868 US20060240059A1 (en) | 2005-04-22 | 2005-07-28 | Lubricious eluting polymer blend and coating made from the same |
| PCT/US2006/029067 WO2007016182A2 (en) | 2005-07-28 | 2006-07-26 | Lubricious eluting polymer blend and coating made from the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009502345A true JP2009502345A (ja) | 2009-01-29 |
| JP2009502345A5 JP2009502345A5 (enExample) | 2009-09-17 |
Family
ID=37671919
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008524119A Pending JP2009502345A (ja) | 2005-07-28 | 2006-07-26 | 潤滑な溶出ポリマーブレンド及びそれから作られるコーティング |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20060240059A1 (enExample) |
| EP (2) | EP1907026A2 (enExample) |
| JP (1) | JP2009502345A (enExample) |
| WO (1) | WO2007016182A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022514368A (ja) * | 2018-12-19 | 2022-02-10 | アクセス・バスキュラー・インコーポレイテッド | 放出制御用高強度多孔質材料 |
| JP2024547174A (ja) * | 2021-12-30 | 2024-12-26 | テレフレックス メディカル インコーポレイテッド | 熱可塑性ポリマー組成物中の配合活性薬剤および製造方法 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8788062B2 (en) * | 2009-08-04 | 2014-07-22 | Cardiac Pacemakers, Inc. | Polymer compression joining in implantable lead |
| EP4411037A3 (en) | 2015-12-22 | 2024-11-06 | Access Vascular, Inc. | High strength biomedical materials |
| JP2020525097A (ja) | 2017-06-21 | 2020-08-27 | アクセス・バスキュラー・インコーポレイテッドAccess Vascular, Inc. | 水溶性ポリマーを組み込んだ高強度ポーラス状材 |
| CN115989054A (zh) | 2020-06-30 | 2023-04-18 | 阿塞斯血管有限公司 | 包含标记的制品和相关方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62500245A (ja) * | 1984-09-21 | 1987-01-29 | メンロ・ケアー、インコーポレイテッド | 複相ポリマ−組成物 |
| WO1995006670A1 (en) * | 1993-08-30 | 1995-03-09 | Nepera, Inc. | Low friction, hydrophilic, biocompatible compositions |
| JP2000144050A (ja) * | 1998-09-29 | 2000-05-26 | Medtronic Ave Inc | 滑性な薬物収容性コ―ティング |
| JP2000507997A (ja) * | 1996-02-09 | 2000-06-27 | サーフェス ソルーションズ ラボラトリーズ インコーポレイテッド | 水性の親水性被覆組成物及びそれから製造した物品 |
| JP2004000754A (ja) * | 1996-06-13 | 2004-01-08 | Schneider Usa Inc | 薬剤を放出するステントコーティング及び方法 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4119094A (en) * | 1977-08-08 | 1978-10-10 | Biosearch Medical Products Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
| US4170821A (en) * | 1977-12-02 | 1979-10-16 | Warner-Lambert Company | Razor cartridges |
| CA1174284A (en) * | 1980-09-02 | 1984-09-11 | Medtronic, Inc. | Body implantable lead |
| US4778640A (en) * | 1987-01-16 | 1988-10-18 | Warner-Lambert Company | Method of sequentially molding a razor cap |
| US4994047A (en) * | 1988-05-06 | 1991-02-19 | Menlo Care, Inc. | Multi-layer cannula structure |
| US5091205A (en) * | 1989-01-17 | 1992-02-25 | Union Carbide Chemicals & Plastics Technology Corporation | Hydrophilic lubricious coatings |
| US5256765A (en) * | 1989-03-09 | 1993-10-26 | The Johns Hopkins University School Of Medicine | Biodegradable poly(phosphate esters) |
| US5194581A (en) * | 1989-03-09 | 1993-03-16 | Leong Kam W | Biodegradable poly(phosphoesters) |
| US5041100A (en) * | 1989-04-28 | 1991-08-20 | Cordis Corporation | Catheter and hydrophilic, friction-reducing coating thereon |
| US4990357A (en) * | 1989-05-04 | 1991-02-05 | Becton, Dickinson And Company | Elastomeric segmented hydrophilic polyetherurethane based lubricious coatings |
| US4972848A (en) * | 1989-08-23 | 1990-11-27 | Medtronic, Inc. | Medical electrical lead with polymeric monolithic controlled release device and method of manufacture |
| US5674192A (en) * | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
| US5135516A (en) * | 1989-12-15 | 1992-08-04 | Boston Scientific Corporation | Lubricious antithrombogenic catheters, guidewires and coatings |
| US5084315A (en) * | 1990-02-01 | 1992-01-28 | Becton, Dickinson And Company | Lubricious coatings, medical articles containing same and method for their preparation |
| US5545208A (en) * | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
| US5115090A (en) * | 1990-03-30 | 1992-05-19 | Sachdev Krishna G | Viscosity stable, essentially gel-free polyamic acid compositions |
| US5077352A (en) * | 1990-04-23 | 1991-12-31 | C. R. Bard, Inc. | Flexible lubricious organic coatings |
| US5113585A (en) * | 1990-09-28 | 1992-05-19 | The Gillette Company | Shaving system |
| US5095619A (en) * | 1990-09-28 | 1992-03-17 | The Gillette Company | Shaving system |
| US5061424A (en) * | 1991-01-22 | 1991-10-29 | Becton, Dickinson And Company | Method for applying a lubricious coating to an article |
| US5176907A (en) * | 1991-08-13 | 1993-01-05 | The Johns Hopkins University School Of Medicine | Biocompatible and biodegradable poly (phosphoester-urethanes) |
| DE4134265C2 (de) * | 1991-10-16 | 1993-11-25 | Eos Electro Optical Syst | Vorrichtung und Verfahren zur Herstellung eines dreidimensionalen Objekts mittels Stereographie |
| US5217026A (en) * | 1992-04-06 | 1993-06-08 | Kingston Technologies, Inc. | Guidewires with lubricious surface and method of their production |
| US5531715A (en) * | 1993-05-12 | 1996-07-02 | Target Therapeutics, Inc. | Lubricious catheters |
| US5454164A (en) * | 1994-03-17 | 1995-10-03 | The Gillette Company | Wet shaving system with a lubricating device |
| DE19514740C1 (de) * | 1995-04-21 | 1996-04-11 | Eos Electro Optical Syst | Vorrichtung und Verfahren zum Herstellen eines dreidimensionalen Objektes |
| DE19516972C1 (de) * | 1995-05-09 | 1996-12-12 | Eos Electro Optical Syst | Vorrichtung zum Herstellen eines dreidimensionalen Objektes mittels Lasersintern |
| US5603991A (en) * | 1995-09-29 | 1997-02-18 | Target Therapeutics, Inc. | Method for coating catheter lumens |
| US6071266A (en) * | 1996-04-26 | 2000-06-06 | Kelley; Donald W. | Lubricious medical devices |
| JP3732281B2 (ja) * | 1996-08-30 | 2006-01-05 | シチズン時計株式会社 | 多機能時計 |
| US6568858B2 (en) * | 1997-08-01 | 2003-05-27 | Koyo Seiko Co., Ltd. | Ball bearing |
| US6245030B1 (en) * | 1998-03-04 | 2001-06-12 | C. R. Bard, Inc. | Flexible kink resistant, low friction guidewire with formable tip, and method for making same |
| EP1109591A4 (en) * | 1998-06-12 | 2004-08-18 | Cardiac Pacemakers Inc | MODIFIED WIRE GUIDE FOR LEFT VENTRICLE ACCESS DIVERSION |
| US6558732B1 (en) * | 1998-11-18 | 2003-05-06 | Alan M. Zamore | Process for producing an implantable apparatus comprising a biomedical device coated with crosslinked TPU |
| US6258121B1 (en) * | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
| US7682647B2 (en) * | 1999-09-03 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of a drug eluting implantable medical device |
| US6521284B1 (en) * | 1999-11-03 | 2003-02-18 | Scimed Life Systems, Inc. | Process for impregnating a porous material with a cross-linkable composition |
| US6419745B1 (en) * | 1999-11-16 | 2002-07-16 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for polymer application to intracorporeal device |
| EP1319044B1 (en) * | 2000-09-12 | 2007-06-06 | Union Carbide Chemicals & Plastics Technology Corporation | Polymer composites containing ethylene oxide copolymers |
| US6596402B2 (en) * | 2000-12-29 | 2003-07-22 | Kimberly-Clark Worldwide, Inc. | Absorbent, lubricious coating and articles coated therewith |
| GB0100760D0 (en) * | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
| US6571125B2 (en) * | 2001-02-12 | 2003-05-27 | Medtronic, Inc. | Drug delivery device |
| KR100455343B1 (ko) * | 2001-08-29 | 2004-11-12 | 학교법인 인하학원 | 약물 방출 스텐트용 코팅 조성물 및 이를 사용하여 제조된약물 방출 스텐트 |
| US20030109628A1 (en) * | 2001-12-11 | 2003-06-12 | The Procter & Gamble Company | Liquid absorbing thermoplastic materials and the utilization thereof in absorbent articles |
| JP2005527302A (ja) * | 2002-05-24 | 2005-09-15 | アンジオテック インターナショナル アーゲー | 医療用移植物をコーティングするための組成物および方法 |
| US6702850B1 (en) * | 2002-09-30 | 2004-03-09 | Mediplex Corporation Korea | Multi-coated drug-eluting stent for antithrombosis and antirestenosis |
| US20050095267A1 (en) * | 2002-12-04 | 2005-05-05 | Todd Campbell | Nanoparticle-based controlled release polymer coatings for medical implants |
| US20040236415A1 (en) * | 2003-01-02 | 2004-11-25 | Richard Thomas | Medical devices having drug releasing polymer reservoirs |
| US20040167572A1 (en) * | 2003-02-20 | 2004-08-26 | Roth Noah M. | Coated medical devices |
| US20050070996A1 (en) * | 2003-04-08 | 2005-03-31 | Dinh Thomas Q. | Drug-eluting stent for controlled drug delivery |
| US7357940B2 (en) * | 2003-07-31 | 2008-04-15 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents |
| US20050033417A1 (en) * | 2003-07-31 | 2005-02-10 | John Borges | Coating for controlled release of a therapeutic agent |
| US7544381B2 (en) * | 2003-09-09 | 2009-06-09 | Boston Scientific Scimed, Inc. | Lubricious coatings for medical device |
-
2005
- 2005-07-28 US US11/191,868 patent/US20060240059A1/en not_active Abandoned
-
2006
- 2006-07-26 JP JP2008524119A patent/JP2009502345A/ja active Pending
- 2006-07-26 EP EP06788585A patent/EP1907026A2/en not_active Withdrawn
- 2006-07-26 WO PCT/US2006/029067 patent/WO2007016182A2/en not_active Ceased
- 2006-07-26 EP EP09167492A patent/EP2172230A3/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62500245A (ja) * | 1984-09-21 | 1987-01-29 | メンロ・ケアー、インコーポレイテッド | 複相ポリマ−組成物 |
| WO1995006670A1 (en) * | 1993-08-30 | 1995-03-09 | Nepera, Inc. | Low friction, hydrophilic, biocompatible compositions |
| JP2000507997A (ja) * | 1996-02-09 | 2000-06-27 | サーフェス ソルーションズ ラボラトリーズ インコーポレイテッド | 水性の親水性被覆組成物及びそれから製造した物品 |
| JP2004000754A (ja) * | 1996-06-13 | 2004-01-08 | Schneider Usa Inc | 薬剤を放出するステントコーティング及び方法 |
| JP2000144050A (ja) * | 1998-09-29 | 2000-05-26 | Medtronic Ave Inc | 滑性な薬物収容性コ―ティング |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022514368A (ja) * | 2018-12-19 | 2022-02-10 | アクセス・バスキュラー・インコーポレイテッド | 放出制御用高強度多孔質材料 |
| JP2024547174A (ja) * | 2021-12-30 | 2024-12-26 | テレフレックス メディカル インコーポレイテッド | 熱可塑性ポリマー組成物中の配合活性薬剤および製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007016182A2 (en) | 2007-02-08 |
| EP1907026A2 (en) | 2008-04-09 |
| WO2007016182A3 (en) | 2007-08-02 |
| EP2172230A3 (en) | 2012-08-15 |
| US20060240059A1 (en) | 2006-10-26 |
| EP2172230A2 (en) | 2010-04-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP1526879B1 (en) | Controlled drug delivery | |
| CA2004367C (en) | Anti-infective and lubricious medical articles and method for their preparation | |
| EP2509647B1 (en) | Coatings with tunable molecular architecture for drug-coated ballon | |
| EP2037882B1 (en) | Combination degradable and non-degradable matrices for active agent delivery | |
| US5084315A (en) | Lubricious coatings, medical articles containing same and method for their preparation | |
| DE60316595T2 (de) | Sperrschicht für wirkstoffhaltige polymere beschichtungen | |
| US12194198B2 (en) | High strength porous materials for controlled release | |
| EP1951330B1 (en) | Lubricious compound and medical device made of the same | |
| JP6147906B2 (ja) | 薬剤バルーン用組織接着コーティング | |
| EP1003571A2 (en) | Adherent, flexible hydrogel and medicated coatings | |
| JP2007502281A (ja) | 混和性ポリマー配合物を含む活性剤放出系、医療機器、及び方法 | |
| JPH0722952B2 (ja) | 物品に滑らかな被覆を適用する方法 | |
| WO2011071630A1 (en) | Tunable hydrophilic coating for drug coated balloons | |
| KR20180098325A (ko) | 친수성 의료 장치 | |
| JP2009502345A (ja) | 潤滑な溶出ポリマーブレンド及びそれから作られるコーティング | |
| EP0195813A1 (en) | MULTIPLE PHASE POLYMER COMPOSITIONS. | |
| US20060240253A1 (en) | Guidewire and tube with lubricious coating | |
| US20060241000A1 (en) | Lubricious compound and medical device made of the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20090205 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20090213 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20090213 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20090313 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20090313 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090723 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20090723 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20120302 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120605 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20121106 |