JP2009501046A - 肥満及び糖尿病を治療するための胃腸及び膵臓用装置 - Google Patents
肥満及び糖尿病を治療するための胃腸及び膵臓用装置 Download PDFInfo
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
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| US72095105P | 2005-09-26 | 2005-09-26 | |
| US11/279,355 US20070016262A1 (en) | 2005-07-13 | 2006-04-11 | Gi and pancreatic device for treating obesity and diabetes |
| PCT/IL2006/000819 WO2007007339A2 (en) | 2005-07-13 | 2006-07-13 | Gi and pancreatic device for treating obesity and diabetes |
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| JP2009501046A true JP2009501046A (ja) | 2009-01-15 |
| JP2009501046A5 JP2009501046A5 (enExample) | 2009-09-17 |
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Cited By (1)
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| JP2021519632A (ja) * | 2018-03-29 | 2021-08-12 | ネヴロ コーポレイション | ２型糖尿病を含む血糖異常を治療する、および／またはＨｂＡ１ｃレベルを低下させるための治療的調節、ならびに関連するシステムおよび方法 |
Families Citing this family (269)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9289618B1 (en) | 1996-01-08 | 2016-03-22 | Impulse Dynamics Nv | Electrical muscle controller |
| US8825152B2 (en) * | 1996-01-08 | 2014-09-02 | Impulse Dynamics, N.V. | Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue |
| US7167748B2 (en) | 1996-01-08 | 2007-01-23 | Impulse Dynamics Nv | Electrical muscle controller |
| US8700161B2 (en) * | 1999-03-05 | 2014-04-15 | Metacure Limited | Blood glucose level control |
| US8019421B2 (en) * | 1999-03-05 | 2011-09-13 | Metacure Limited | Blood glucose level control |
| US8666495B2 (en) * | 1999-03-05 | 2014-03-04 | Metacure Limited | Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar |
| US20040249421A1 (en) * | 2000-09-13 | 2004-12-09 | Impulse Dynamics Nv | Blood glucose level control |
| US9101765B2 (en) * | 1999-03-05 | 2015-08-11 | Metacure Limited | Non-immediate effects of therapy |
| US8346363B2 (en) * | 1999-03-05 | 2013-01-01 | Metacure Limited | Blood glucose level control |
| US8914114B2 (en) * | 2000-05-23 | 2014-12-16 | The Feinstein Institute For Medical Research | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| US20090187230A1 (en) * | 2001-07-23 | 2009-07-23 | Dilorenzo Daniel J | Method and apparatus for programming of autonomic neuromodulation for the treatment of obesity |
| US8845672B2 (en) | 2002-05-09 | 2014-09-30 | Reshape Medical, Inc. | Balloon system and methods for treating obesity |
| US7338433B2 (en) | 2002-08-13 | 2008-03-04 | Allergan, Inc. | Remotely adjustable gastric banding method |
| EP1553878B1 (en) * | 2002-08-28 | 2010-02-24 | Allergan, Inc. | Fatigue-resistant gastric banding device |
| US7901419B2 (en) * | 2002-09-04 | 2011-03-08 | Allergan, Inc. | Telemetrically controlled band for regulating functioning of a body organ or duct, and methods of making, implantation and use |
| US9060844B2 (en) | 2002-11-01 | 2015-06-23 | Valentx, Inc. | Apparatus and methods for treatment of morbid obesity |
| US8070743B2 (en) | 2002-11-01 | 2011-12-06 | Valentx, Inc. | Devices and methods for attaching an endolumenal gastrointestinal implant |
| US7167750B2 (en) | 2003-02-03 | 2007-01-23 | Enteromedics, Inc. | Obesity treatment with electrically induced vagal down regulation |
| US7844338B2 (en) | 2003-02-03 | 2010-11-30 | Enteromedics Inc. | High frequency obesity treatment |
| US20040172084A1 (en) | 2003-02-03 | 2004-09-02 | Knudson Mark B. | Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) |
| WO2004080533A1 (en) * | 2003-03-10 | 2004-09-23 | Impulse Dynamics Nv | Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue |
| EP1638638B1 (en) | 2003-06-20 | 2009-08-05 | Allergan, Inc. | Two-way slit valve |
| US8792985B2 (en) * | 2003-07-21 | 2014-07-29 | Metacure Limited | Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar |
| US9700450B2 (en) * | 2003-07-28 | 2017-07-11 | Baronova, Inc. | Devices and methods for gastrointestinal stimulation |
| US20090259236A2 (en) * | 2003-07-28 | 2009-10-15 | Baronova, Inc. | Gastric retaining devices and methods |
| US9498366B2 (en) * | 2003-07-28 | 2016-11-22 | Baronova, Inc. | Devices and methods for pyloric anchoring |
| US8821521B2 (en) * | 2003-07-28 | 2014-09-02 | Baronova, Inc. | Gastro-intestinal device and method for treating addiction |
| US8048169B2 (en) | 2003-07-28 | 2011-11-01 | Baronova, Inc. | Pyloric valve obstructing devices and methods |
| EP2399528B1 (en) | 2004-01-23 | 2013-01-09 | Allergan, Inc. | Releasably-securable one-piece adjustable gastric band |
| ES2333024T3 (es) * | 2004-03-08 | 2010-02-16 | Allergan Medical S.A. | Sistema de cierre para organos tubulares. |
| US8352031B2 (en) | 2004-03-10 | 2013-01-08 | Impulse Dynamics Nv | Protein activity modification |
| WO2006119467A2 (en) * | 2005-05-04 | 2006-11-09 | Impulse Dynamics Nv | Protein activity modification |
| AU2004317849B2 (en) * | 2004-03-18 | 2011-03-31 | Allergan, Inc. | Apparatus and method for volume adjustment of intragastric balloons |
| US10912712B2 (en) | 2004-03-25 | 2021-02-09 | The Feinstein Institutes For Medical Research | Treatment of bleeding by non-invasive stimulation |
| US20160250097A9 (en) * | 2004-03-25 | 2016-09-01 | The Feinstein Institute For Medical Research | Treatment of inflammation by non-invasive stimulation |
| WO2006069322A2 (en) * | 2004-12-22 | 2006-06-29 | Proteus Biomedical, Inc. | Implantable addressable segmented electrodes |
| EP1827571B1 (en) | 2004-12-09 | 2016-09-07 | Impulse Dynamics NV | Protein activity modification |
| US20080077186A1 (en) * | 2006-04-18 | 2008-03-27 | Proteus Biomedical, Inc. | High phrenic, low capture threshold pacing devices and methods |
| US11207518B2 (en) | 2004-12-27 | 2021-12-28 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway |
| ATE489132T1 (de) | 2004-12-27 | 2010-12-15 | The Feinstein Inst Medical Res | Behandlung von entzündlichen erkrankungen durch elektrische stimulation des vagus-nervs |
| US9821158B2 (en) | 2005-02-17 | 2017-11-21 | Metacure Limited | Non-immediate effects of therapy |
| US8244371B2 (en) * | 2005-03-18 | 2012-08-14 | Metacure Limited | Pancreas lead |
| US8251888B2 (en) | 2005-04-13 | 2012-08-28 | Mitchell Steven Roslin | Artificial gastric valve |
| US20070016262A1 (en) | 2005-07-13 | 2007-01-18 | Betastim, Ltd. | Gi and pancreatic device for treating obesity and diabetes |
| WO2007013065A2 (en) | 2005-07-25 | 2007-02-01 | Rainbow Medical Ltd. | Electrical stimulation of blood vessels |
| US20070100369A1 (en) * | 2005-10-31 | 2007-05-03 | Cragg Andrew H | Intragastric space filler |
| US20070100368A1 (en) * | 2005-10-31 | 2007-05-03 | Quijano Rodolfo C | Intragastric space filler |
| US8204586B2 (en) * | 2005-11-22 | 2012-06-19 | Proteus Biomedical, Inc. | External continuous field tomography |
| US8043206B2 (en) | 2006-01-04 | 2011-10-25 | Allergan, Inc. | Self-regulating gastric band with pressure data processing |
| US7798954B2 (en) | 2006-01-04 | 2010-09-21 | Allergan, Inc. | Hydraulic gastric band with collapsible reservoir |
| US7881797B2 (en) * | 2006-04-25 | 2011-02-01 | Valentx, Inc. | Methods and devices for gastrointestinal stimulation |
| EP2023841A1 (en) * | 2006-05-23 | 2009-02-18 | Emcision Limited | Apparatus and method for treating tissue such as tumours |
| US20070288033A1 (en) * | 2006-06-09 | 2007-12-13 | Allergan, Inc. | Intragastric balloon retrieval mechanisms |
| US20080097566A1 (en) * | 2006-07-13 | 2008-04-24 | Olivier Colliou | Focused segmented electrode |
| US20080039916A1 (en) * | 2006-08-08 | 2008-02-14 | Olivier Colliou | Distally distributed multi-electrode lead |
| US9326877B2 (en) | 2006-09-29 | 2016-05-03 | Apollo Endosurgery, Inc. | Apparatus and method for intragastric balloon with in situ adjustment means |
| US20080114230A1 (en) * | 2006-11-14 | 2008-05-15 | Bruce Addis | Electrode support |
| US8926648B2 (en) * | 2007-02-13 | 2015-01-06 | Brian Charles Weiner | Multi-method and multi-apparatus for treating obesity |
| WO2008100974A2 (en) * | 2007-02-13 | 2008-08-21 | Sharma Virender K | Method and apparatus for electrical stimulation of the pancreatico-biliary system |
| US8068918B2 (en) | 2007-03-09 | 2011-11-29 | Enteromedics Inc. | Remote monitoring and control of implantable devices |
| US8226602B2 (en) * | 2007-03-30 | 2012-07-24 | Reshape Medical, Inc. | Intragastric balloon system and therapeutic processes and products |
| US20080255601A1 (en) * | 2007-04-13 | 2008-10-16 | Allergan, Inc. | Apparatus and method for remote deflation of intragastric balloon |
| US7962214B2 (en) * | 2007-04-26 | 2011-06-14 | Cyberonics, Inc. | Non-surgical device and methods for trans-esophageal vagus nerve stimulation |
| US9364666B2 (en) * | 2007-05-07 | 2016-06-14 | Transtimulation Research, Inc. | Method of using a gastrointestinal stimulator device for digestive and eating disorders |
| US20080281365A1 (en) * | 2007-05-09 | 2008-11-13 | Tweden Katherine S | Neural signal duty cycle |
| US7634315B2 (en) * | 2007-05-31 | 2009-12-15 | Pacesetter, Inc. | Techniques to monitor and trend nerve damage and recovery |
| US20080300648A1 (en) * | 2007-05-31 | 2008-12-04 | Pacesetter, Inc. | Treatment of cardiomyopathy, heart failure and cardiac ischemia using stimulation induced secretion of glp-1 |
| US20080300645A1 (en) * | 2007-05-31 | 2008-12-04 | Pacesetter, Inc. | Treatment of cardiomyopathy, heart failure and cardiac ischemia using stimulation induced secretion of glp-1 |
| US20080300646A1 (en) * | 2007-05-31 | 2008-12-04 | Pacesetter, Inc. | Treatment of cardiomyopathy, heart failure and cardiac ischemia using stimulation induced secretion of glp-1 |
| US20080300647A1 (en) * | 2007-05-31 | 2008-12-04 | Pacesetter, Inc. | Treatment of cardiomyopathy, heart failure and cardiac ischemia using stimulation induced secretion of glp-1 |
| US8140167B2 (en) | 2007-05-31 | 2012-03-20 | Enteromedics, Inc. | Implantable therapy system with external component having multiple operating modes |
| US20090012544A1 (en) * | 2007-06-08 | 2009-01-08 | Valen Tx, Inc. | Gastrointestinal bypass sleeve as an adjunct to bariatric surgery |
| WO2008154450A1 (en) * | 2007-06-08 | 2008-12-18 | Valentx, Inc. | Methods and devices for intragastric support of functional or prosthetic gastrointestinal devices |
| US20090012541A1 (en) * | 2007-06-11 | 2009-01-08 | Valentx, Inc. | Expandable fastener system with flower petal-shaped retention elements |
| US8032222B2 (en) | 2007-06-19 | 2011-10-04 | Loushin Michael K H | Device for electrically and mechanically stimulating a compartment in a body |
| US8142469B2 (en) | 2007-06-25 | 2012-03-27 | Reshape Medical, Inc. | Gastric space filler device, delivery system, and related methods |
| EP2178597A4 (en) * | 2007-07-24 | 2010-09-22 | Betastim Ltd | Duodenal ESSSENSOR |
| US20090047930A1 (en) * | 2007-08-17 | 2009-02-19 | Qualcomm Incorporated | Method for a heterogeneous wireless ad hoc mobile service provider |
| US9392445B2 (en) * | 2007-08-17 | 2016-07-12 | Qualcomm Incorporated | Handoff at an ad-hoc mobile service provider |
| US9398453B2 (en) | 2007-08-17 | 2016-07-19 | Qualcomm Incorporated | Ad hoc service provider's ability to provide service for a wireless network |
| WO2009029614A1 (en) | 2007-08-27 | 2009-03-05 | The Feinstein Institute For Medical Research | Devices and methods for inhibiting granulocyte activation by neural stimulation |
| US8888797B2 (en) | 2007-09-07 | 2014-11-18 | Baronova, Inc. | Device for intermittently obstructing a gastric opening and method of use |
| ES2986535T3 (es) * | 2007-10-11 | 2024-11-11 | Implantica Patent Ltd | Aparato para controlar el flujo en un órgano corporal |
| EP2211768B1 (en) * | 2007-10-11 | 2021-03-24 | Implantica Patent Ltd. | Apparatus for controlling flow in a bodily organ |
| EP2211789B1 (en) * | 2007-10-11 | 2023-06-07 | Implantica Patent Ltd. | Apparatus and method for controlling food flow through a compartmentalized stomach of a patient |
| WO2009048368A1 (en) | 2007-10-11 | 2009-04-16 | Milux Holding Sa | Apparatus and method for controlling food flow through the stomach of a patient |
| MX2010004486A (es) * | 2007-10-23 | 2010-05-17 | Allergan Inc | Balon intragastrico sensible a la presion. |
| US8475449B2 (en) * | 2007-12-10 | 2013-07-02 | Medtronic Ablation Frontiers Llc | RF energy delivery system and method |
| US20090177223A1 (en) * | 2008-01-03 | 2009-07-09 | Tara Chand Singhal | System and method for management of type 2 diabetes |
| US8538535B2 (en) | 2010-08-05 | 2013-09-17 | Rainbow Medical Ltd. | Enhancing perfusion by contraction |
| AU2009214632B2 (en) * | 2008-02-14 | 2015-02-19 | Reshape Lifesciences, Inc. | Treatment of excess weight by neural downregulation in combination with compositions |
| US9211409B2 (en) | 2008-03-31 | 2015-12-15 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation of T-cell activity |
| US9662490B2 (en) | 2008-03-31 | 2017-05-30 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug |
| AU2009231601B2 (en) * | 2008-04-04 | 2014-02-27 | Reshape Lifesciences, Inc. | Methods and systems for glucose regulation |
| US8768469B2 (en) | 2008-08-08 | 2014-07-01 | Enteromedics Inc. | Systems for regulation of blood pressure and heart rate |
| BRPI0917925A2 (pt) * | 2008-08-26 | 2015-11-10 | Centocor Ortho Biotech Inc | estimulação da liberação de hormônio da saciedade |
| EP2362762A1 (en) * | 2008-10-06 | 2011-09-07 | Allergan Medical Sàrl | Mechanical gastric band with cushions |
| US10603489B2 (en) | 2008-10-09 | 2020-03-31 | Virender K. Sharma | Methods and apparatuses for stimulating blood vessels in order to control, treat, and/or prevent a hemorrhage |
| WO2010042686A1 (en) | 2008-10-09 | 2010-04-15 | Sharma Virender K | Method and apparatus for stimulating the vascular system |
| US20100185049A1 (en) * | 2008-10-22 | 2010-07-22 | Allergan, Inc. | Dome and screw valves for remotely adjustable gastric banding systems |
| ES2452484T3 (es) * | 2008-11-18 | 2014-04-01 | Setpoint Medical Corporation | Dispositivos para optimizar la colocación de electrodos para la estimulación antiinflamatoria |
| US9174031B2 (en) * | 2009-03-13 | 2015-11-03 | Reshape Medical, Inc. | Device and method for deflation and removal of implantable and inflatable devices |
| CA2757547A1 (en) * | 2009-04-03 | 2010-10-07 | Reshape Medical, Inc. | Improved intragastric space fillers and methods of manufacturing including in vitro testing |
| US20110184229A1 (en) * | 2009-05-01 | 2011-07-28 | Allergan, Inc. | Laparoscopic gastric band with active agents |
| US8996116B2 (en) | 2009-10-30 | 2015-03-31 | Setpoint Medical Corporation | Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction |
| US9211410B2 (en) | 2009-05-01 | 2015-12-15 | Setpoint Medical Corporation | Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| US8788034B2 (en) | 2011-05-09 | 2014-07-22 | Setpoint Medical Corporation | Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
| WO2010127248A2 (en) * | 2009-05-01 | 2010-11-04 | Allergan, Inc. | Laparoscopic gastric band with active agents |
| US20110066175A1 (en) * | 2009-05-07 | 2011-03-17 | Rainbow Medical Ltd. | Gastric anchor |
| US20100286628A1 (en) * | 2009-05-07 | 2010-11-11 | Rainbow Medical Ltd | Gastric anchor |
| US8414559B2 (en) * | 2009-05-07 | 2013-04-09 | Rainbow Medical Ltd. | Gastroretentive duodenal pill |
| US9179367B2 (en) | 2009-05-26 | 2015-11-03 | Qualcomm Incorporated | Maximizing service provider utility in a heterogeneous wireless ad-hoc network |
| US20100305655A1 (en) * | 2009-05-28 | 2010-12-02 | ElectroCore, LLC | Methods and apparatus for treating gastrointestinal disorders using electrical signals |
| EP2440284B1 (en) | 2009-06-09 | 2018-09-12 | Setpoint Medical Corporation | Nerve cuff with pocket for leadless stimulator |
| EP2456507A4 (en) | 2009-07-22 | 2013-07-03 | Reshape Medical Inc | RETENTION MECHANISMS FOR IMPLANTABLE MEDICAL DEVICES |
| US9604038B2 (en) | 2009-07-23 | 2017-03-28 | Reshape Medical, Inc. | Inflation and deflation mechanisms for inflatable medical devices |
| WO2011011743A2 (en) | 2009-07-23 | 2011-01-27 | Reshape Medical, Inc. | Deflation and removal of implantable medical devices |
| CN109157742B (zh) | 2009-08-03 | 2022-04-05 | 因卡伯实验室有限责任公司 | 用于刺激肠道内肠促胰岛素产生的吞咽式囊和方法 |
| WO2011031400A2 (en) * | 2009-08-28 | 2011-03-17 | Allergan, Inc. | Gastric band with electric stimulation |
| US20110137112A1 (en) * | 2009-08-28 | 2011-06-09 | Allergan, Inc. | Gastric band with electric stimulation |
| WO2011038270A2 (en) | 2009-09-24 | 2011-03-31 | Reshape Medical, Inc. | Normalization and stabilization of balloon surfaces for deflation |
| CA2778590A1 (en) | 2009-10-21 | 2011-04-28 | Innovelle, Llc | Bariatric device and method for weight loss |
| US9833621B2 (en) | 2011-09-23 | 2017-12-05 | Setpoint Medical Corporation | Modulation of sirtuins by vagus nerve stimulation |
| US11051744B2 (en) | 2009-11-17 | 2021-07-06 | Setpoint Medical Corporation | Closed-loop vagus nerve stimulation |
| EP3636314B1 (en) | 2009-12-23 | 2021-09-08 | Setpoint Medical Corporation | Neural stimulation devices and systems for treatment of chronic inflammation |
| US8721620B2 (en) | 2009-12-24 | 2014-05-13 | Rani Therapeutics, Llc | Swallowable drug delivery device and methods of drug delivery |
| US20110184258A1 (en) * | 2010-01-28 | 2011-07-28 | Abbott Diabetes Care Inc. | Balloon Catheter Analyte Measurement Sensors and Methods for Using the Same |
| US8934975B2 (en) | 2010-02-01 | 2015-01-13 | Metacure Limited | Gastrointestinal electrical therapy |
| WO2011097636A1 (en) | 2010-02-08 | 2011-08-11 | Reshape Medical, Inc. | Improved and enhanced aspiration processes and mechanisms for intragastric devices |
| WO2011097637A1 (en) | 2010-02-08 | 2011-08-11 | Reshape Medical, Inc. | Materials and methods for improved intragastric balloon devices |
| US8678993B2 (en) * | 2010-02-12 | 2014-03-25 | Apollo Endosurgery, Inc. | Remotely adjustable gastric banding system |
| US20110201874A1 (en) * | 2010-02-12 | 2011-08-18 | Allergan, Inc. | Remotely adjustable gastric banding system |
| US8758221B2 (en) * | 2010-02-24 | 2014-06-24 | Apollo Endosurgery, Inc. | Source reservoir with potential energy for remotely adjustable gastric banding system |
| US8840541B2 (en) | 2010-02-25 | 2014-09-23 | Apollo Endosurgery, Inc. | Pressure sensing gastric banding system |
| US9681973B2 (en) | 2010-02-25 | 2017-06-20 | Reshape Medical, Inc. | Enhanced explant processes and mechanisms for intragastric devices |
| US8764624B2 (en) | 2010-02-25 | 2014-07-01 | Apollo Endosurgery, Inc. | Inductively powered remotely adjustable gastric banding system |
| CA2793367C (en) | 2010-03-15 | 2018-01-02 | Allergan, Inc. | Bariatric device and method for weight loss |
| WO2011127205A1 (en) | 2010-04-06 | 2011-10-13 | Reshape Medical , Inc. | Inflation devices for intragastric devices with improved attachment and detachment and associated systems and methods |
| US9028394B2 (en) | 2010-04-29 | 2015-05-12 | Apollo Endosurgery, Inc. | Self-adjusting mechanical gastric band |
| US20110270024A1 (en) | 2010-04-29 | 2011-11-03 | Allergan, Inc. | Self-adjusting gastric band having various compliant components |
| US9044298B2 (en) | 2010-04-29 | 2015-06-02 | Apollo Endosurgery, Inc. | Self-adjusting gastric band |
| US20110270025A1 (en) | 2010-04-30 | 2011-11-03 | Allergan, Inc. | Remotely powered remotely adjustable gastric band system |
| US9226840B2 (en) | 2010-06-03 | 2016-01-05 | Apollo Endosurgery, Inc. | Magnetically coupled implantable pump system and method |
| US8517915B2 (en) | 2010-06-10 | 2013-08-27 | Allergan, Inc. | Remotely adjustable gastric banding system |
| US8825164B2 (en) | 2010-06-11 | 2014-09-02 | Enteromedics Inc. | Neural modulation devices and methods |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| US9211207B2 (en) | 2010-08-18 | 2015-12-15 | Apollo Endosurgery, Inc. | Power regulated implant |
| US8698373B2 (en) | 2010-08-18 | 2014-04-15 | Apollo Endosurgery, Inc. | Pare piezo power with energy recovery |
| US20120059216A1 (en) | 2010-09-07 | 2012-03-08 | Allergan, Inc. | Remotely adjustable gastric banding system |
| US8870966B2 (en) | 2010-10-18 | 2014-10-28 | Apollo Endosurgery, Inc. | Intragastric balloon for treating obesity |
| US9233016B2 (en) | 2010-10-18 | 2016-01-12 | Apollo Endosurgery, Inc. | Elevating stomach stimulation device |
| WO2012054514A2 (en) | 2010-10-18 | 2012-04-26 | Allergan, Inc. | Intragastric implants with duodenal anchors |
| US9463107B2 (en) | 2010-10-18 | 2016-10-11 | Apollo Endosurgery, Inc. | Variable size intragastric implant devices |
| WO2012054519A2 (en) | 2010-10-18 | 2012-04-26 | Allergan, Inc. | Reactive intragastric implant devices |
| EP2629716B1 (en) | 2010-10-19 | 2016-07-13 | Apollo Endosurgery, Inc. | Anchored non-piercing duodenal sleeve |
| US9498365B2 (en) | 2010-10-19 | 2016-11-22 | Apollo Endosurgery, Inc. | Intragastric implants with multiple fluid chambers |
| US8920447B2 (en) | 2010-10-19 | 2014-12-30 | Apollo Endosurgery, Inc. | Articulated gastric implant clip |
| US9198790B2 (en) | 2010-10-19 | 2015-12-01 | Apollo Endosurgery, Inc. | Upper stomach gastric implants |
| US9398969B2 (en) | 2010-10-19 | 2016-07-26 | Apollo Endosurgery, Inc. | Upper stomach gastric implants |
| US9095405B2 (en) | 2010-10-19 | 2015-08-04 | Apollo Endosurgery, Inc. | Space-filling intragastric implants with fluid flow |
| US8864840B2 (en) | 2010-10-19 | 2014-10-21 | Apollo Endosurgery, Inc. | Intragastric implants with collapsible frames |
| US8961393B2 (en) | 2010-11-15 | 2015-02-24 | Apollo Endosurgery, Inc. | Gastric band devices and drive systems |
| CA2822079A1 (en) | 2010-12-17 | 2012-06-21 | Neural Diabetes Llc | Method, system and apparatus for control of pancreatic beta cell function to improve glucose homeostatis and insulin production |
| US8809269B2 (en) | 2010-12-23 | 2014-08-19 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9629799B2 (en) | 2010-12-23 | 2017-04-25 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8980822B2 (en) | 2010-12-23 | 2015-03-17 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9861683B2 (en) | 2010-12-23 | 2018-01-09 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9283179B2 (en) | 2010-12-23 | 2016-03-15 | Rani Therapeutics, Llc | GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9259386B2 (en) | 2010-12-23 | 2016-02-16 | Rani Therapeutics, Llc | Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9402807B2 (en) | 2010-12-23 | 2016-08-02 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8846040B2 (en) | 2010-12-23 | 2014-09-30 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9149617B2 (en) | 2010-12-23 | 2015-10-06 | Rani Therapeutics, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
| US9402806B2 (en) | 2010-12-23 | 2016-08-02 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US9284367B2 (en) | 2010-12-23 | 2016-03-15 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8764733B2 (en) | 2010-12-23 | 2014-07-01 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US10639272B2 (en) | 2010-12-23 | 2020-05-05 | Rani Therapeutics, Llc | Methods for delivering etanercept preparations into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8969293B2 (en) | 2010-12-23 | 2015-03-03 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8734429B2 (en) | 2010-12-23 | 2014-05-27 | Rani Therapeutics, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
| US9415004B2 (en) | 2010-12-23 | 2016-08-16 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8809271B2 (en) | 2010-12-23 | 2014-08-19 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| US8696616B2 (en) | 2010-12-29 | 2014-04-15 | Ethicon Endo-Surgery, Inc. | Obesity therapy and heart rate variability |
| KR102584819B1 (ko) | 2011-01-19 | 2023-10-05 | 프랙틸 헬쓰, 인코포레이티드 | 조직의 치료를 위한 장치 및 방법 |
| US8888732B2 (en) | 2011-03-11 | 2014-11-18 | Apollo Endosurgery, Inc. | Intraluminal sleeve with active agents |
| US12172017B2 (en) | 2011-05-09 | 2024-12-24 | Setpoint Medical Corporation | Vagus nerve stimulation to treat neurodegenerative disorders |
| US9526637B2 (en) | 2011-09-09 | 2016-12-27 | Enopace Biomedical Ltd. | Wireless endovascular stent-based electrodes |
| CN102500057B (zh) * | 2011-09-28 | 2014-02-26 | 上海交通大学 | 多功能植入式胃肠电刺激系统 |
| US10136883B2 (en) | 2011-11-16 | 2018-11-27 | VentureMD Innovations, LLC | Method of anchoring a suture |
| US10548585B2 (en) | 2011-11-16 | 2020-02-04 | VentureMD Innovations, LLC | Soft tissue attachment |
| US10470756B2 (en) | 2011-11-16 | 2019-11-12 | VentureMD Innovations, LLC | Suture anchor and method |
| US10675014B2 (en) | 2011-11-16 | 2020-06-09 | Crossroads Extremity Systems, Llc | Knotless soft tissue attachment |
| US8876694B2 (en) | 2011-12-07 | 2014-11-04 | Apollo Endosurgery, Inc. | Tube connector with a guiding tip |
| JP2013123484A (ja) * | 2011-12-13 | 2013-06-24 | Olympus Corp | 神経刺激装置および神経刺激システム |
| US8961394B2 (en) | 2011-12-20 | 2015-02-24 | Apollo Endosurgery, Inc. | Self-sealing fluid joint for use with a gastric band |
| US8986337B2 (en) | 2012-02-24 | 2015-03-24 | Elwha Llc | Devices, systems, and methods to control stomach volume |
| WO2015077571A1 (en) | 2013-11-22 | 2015-05-28 | Fractyl Laboratories, Inc. | Systems, devices and methods for the creation of a therapeutic restriction in the gastrointestinal tract |
| IL296643B2 (en) | 2012-02-27 | 2025-03-01 | Fractyl Health Inc | Hot ablation systems, devices and methods for tissue treatment |
| US20150111918A1 (en) | 2012-03-08 | 2015-04-23 | Medtronic Ardian Luxembourg S.a.r.l | Immune system neuromodulation and associated systems and methods |
| AU2013202807B2 (en) | 2012-03-09 | 2016-05-12 | Reshape Lifesciences, Inc. | Safety features for use in medical devices |
| US9572983B2 (en) | 2012-03-26 | 2017-02-21 | Setpoint Medical Corporation | Devices and methods for modulation of bone erosion |
| WO2013143599A1 (en) * | 2012-03-30 | 2013-10-03 | Ethicon Endo-Surgery, Inc. | Devices and methods for the treatment of metabolic disorders. |
| WO2013143609A1 (en) * | 2012-03-30 | 2013-10-03 | Ethicon Endo-Surgery, Inc. | Devices and methods for the treatment of metabolic disorders |
| WO2013143603A1 (en) * | 2012-03-30 | 2013-10-03 | Ethicon Endo-Surgery, Inc. | Devices and methods for the treatment of metabolic disorders |
| WO2013143600A1 (en) * | 2012-03-30 | 2013-10-03 | Ethicon Endo-Surgery, Inc. | Devices and methods for the treatment of metabolic disorders. |
| WO2013159066A1 (en) | 2012-04-19 | 2013-10-24 | Fractyl Laboratories, Inc. | Tissue expansion devices, system and methods |
| US9050168B2 (en) | 2012-05-31 | 2015-06-09 | Valentx, Inc. | Devices and methods for gastrointestinal bypass |
| US9451960B2 (en) | 2012-05-31 | 2016-09-27 | Valentx, Inc. | Devices and methods for gastrointestinal bypass |
| US9681975B2 (en) | 2012-05-31 | 2017-06-20 | Valentx, Inc. | Devices and methods for gastrointestinal bypass |
| US9456916B2 (en) | 2013-03-12 | 2016-10-04 | Medibotics Llc | Device for selectively reducing absorption of unhealthy food |
| EP3714826A1 (en) | 2012-07-30 | 2020-09-30 | Fractyl Laboratories, Inc. | Electrical energy ablation systems and devices for the treatment of tissue |
| EP2882362B1 (en) | 2012-08-09 | 2024-01-03 | Fractyl Health, Inc. | Ablation systems, devices and methods for the treatment of tissue |
| WO2014055997A1 (en) * | 2012-10-05 | 2014-04-10 | Fractyl Laboratories Inc. | Methods, systems and devices for performing multiple treatments on a patient |
| CA3178035A1 (en) | 2012-12-24 | 2014-07-03 | Neurogastrx, Inc. | Methods for treating gi tract disorders |
| CN105073186B (zh) | 2013-01-31 | 2018-07-10 | 迪格玛医疗有限公司 | 用于减少受试者的器官中的神经活性的方法和系统 |
| US9011365B2 (en) | 2013-03-12 | 2015-04-21 | Medibotics Llc | Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food |
| US9067070B2 (en) | 2013-03-12 | 2015-06-30 | Medibotics Llc | Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type |
| US9168000B2 (en) | 2013-03-13 | 2015-10-27 | Ethicon Endo-Surgery, Inc. | Meal detection devices and methods |
| US9757264B2 (en) | 2013-03-13 | 2017-09-12 | Valentx, Inc. | Devices and methods for gastrointestinal bypass |
| WO2014150894A1 (en) | 2013-03-15 | 2014-09-25 | Baronova, Inc. | Locking gastric obstruction device and method of use |
| WO2014197632A2 (en) | 2013-06-04 | 2014-12-11 | Fractyl Laboratories, Inc. | Methods, systems and devices for reducing the luminal surface area of the gastrointestinal tract |
| US11986235B2 (en) | 2013-09-12 | 2024-05-21 | Fractyl Health, Inc. | Systems, methods and devices for treatment of target tissue |
| US10779965B2 (en) | 2013-11-06 | 2020-09-22 | Enopace Biomedical Ltd. | Posts with compliant junctions |
| US20150188765A1 (en) * | 2013-12-31 | 2015-07-02 | Microsoft Corporation | Multimode gaming server |
| US9486623B2 (en) | 2014-03-05 | 2016-11-08 | Rainbow Medical Ltd. | Electrical stimulation of a pancreas |
| US10959774B2 (en) | 2014-03-24 | 2021-03-30 | Fractyl Laboratories, Inc. | Injectate delivery devices, systems and methods |
| EP3578228B1 (en) | 2014-04-17 | 2022-02-16 | Digma Medical Ltd. | Systems for blocking neural activity in the duodenum |
| US9844554B2 (en) | 2014-06-24 | 2017-12-19 | Neurogastrx, Inc. | Prodrugs of metopimazine |
| US9492396B2 (en) | 2014-07-15 | 2016-11-15 | Yossi Gross | Enhanced drug delivery pill |
| US11185367B2 (en) | 2014-07-16 | 2021-11-30 | Fractyl Health, Inc. | Methods and systems for treating diabetes and related diseases and disorders |
| EP3169260B1 (en) | 2014-07-16 | 2019-09-25 | Fractyl Laboratories, Inc. | System for treating diabetes and related diseases and disorders |
| US9757535B2 (en) | 2014-07-16 | 2017-09-12 | Fractyl Laboratories, Inc. | Systems, devices and methods for performing medical procedures in the intestine |
| US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
| EP3226795B1 (en) | 2014-12-03 | 2020-08-26 | Metavention, Inc. | Systems for modulating nerves or other tissue |
| WO2016126807A1 (en) | 2015-02-03 | 2016-08-11 | Setpoint Medical Corporation | Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator |
| US9956393B2 (en) | 2015-02-24 | 2018-05-01 | Elira, Inc. | Systems for increasing a delay in the gastric emptying time for a patient using a transcutaneous electro-dermal patch |
| CN108271363B (zh) | 2015-02-24 | 2022-08-09 | 伊莱拉股份有限公司 | 使用电极皮肤贴实现食欲调节和/或改善饮食依从性的系统和方法 |
| US10335302B2 (en) | 2015-02-24 | 2019-07-02 | Elira, Inc. | Systems and methods for using transcutaneous electrical stimulation to enable dietary interventions |
| US10864367B2 (en) | 2015-02-24 | 2020-12-15 | Elira, Inc. | Methods for using an electrical dermal patch in a manner that reduces adverse patient reactions |
| US10376145B2 (en) | 2015-02-24 | 2019-08-13 | Elira, Inc. | Systems and methods for enabling a patient to achieve a weight loss objective using an electrical dermal patch |
| US10765863B2 (en) | 2015-02-24 | 2020-09-08 | Elira, Inc. | Systems and methods for using a transcutaneous electrical stimulation device to deliver titrated therapy |
| US20220062621A1 (en) | 2015-02-24 | 2022-03-03 | Elira, Inc. | Electrical Stimulation-Based Weight Management System |
| CA3000878A1 (en) * | 2015-10-07 | 2017-04-13 | Mayo Foundation For Medical Education And Research | Electroporation for obesity or diabetes treatment |
| US10596367B2 (en) | 2016-01-13 | 2020-03-24 | Setpoint Medical Corporation | Systems and methods for establishing a nerve block |
| US11471681B2 (en) | 2016-01-20 | 2022-10-18 | Setpoint Medical Corporation | Batteryless implantable microstimulators |
| CN108882885A (zh) | 2016-01-20 | 2018-11-23 | 赛博恩特医疗器械公司 | 迷走神经刺激的控制 |
| WO2017127758A1 (en) | 2016-01-20 | 2017-07-27 | Setpoint Medical Corporation | Implantable microstimulators and inductive charging systems |
| US10583304B2 (en) | 2016-01-25 | 2020-03-10 | Setpoint Medical Corporation | Implantable neurostimulator having power control and thermal regulation and methods of use |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| EP3811999B1 (en) | 2016-08-14 | 2023-10-04 | Digma Medical Ltd. | Apparatus for nerve ablation in the wall of the gastointestinal tract |
| US10575904B1 (en) | 2016-08-14 | 2020-03-03 | Digma Medical Ltd. | Apparatus and method for selective submucosal ablation |
| US11083613B2 (en) | 2017-01-23 | 2021-08-10 | Baronova, Inc. | Gastric obstruction device deployment assembly and methods of delivering and deploying a gastric obstruction device |
| US10537454B2 (en) | 2017-06-16 | 2020-01-21 | Proximate Concepts Llc | Electrophysiologically active transducer intragastric balloon system and method |
| WO2019036470A1 (en) | 2017-08-14 | 2019-02-21 | Setpoint Medical Corporation | TESTING TEST FOR STIMULATION OF NERVE WAVE |
| US11420051B2 (en) | 2018-05-17 | 2022-08-23 | Imam Abdulrahman Bin Faisal University | Medical device for treating diabetes |
| US10675248B2 (en) | 2018-08-14 | 2020-06-09 | Alma Therapeutics Ltd. | Expandable pill |
| US11260229B2 (en) | 2018-09-25 | 2022-03-01 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation |
| US20200261730A1 (en) * | 2019-02-14 | 2020-08-20 | Morton M. Mower | Method and apparatus for electrical current therapy or biological tissue and insulin release therefrom |
| WO2020177720A1 (en) | 2019-03-06 | 2020-09-10 | Enteromed Ltd | Devices, systems, and methods for delivering therapy to intestinal muscle |
| EP3952982B1 (en) | 2019-04-12 | 2024-03-27 | Setpoint Medical Corporation | Vagus nerve stimulation system to treat neurodegenerative disorders |
| US12017073B2 (en) | 2019-05-16 | 2024-06-25 | Enteromed Ltd | Devices, systems, and methods for delivering therapy to a sacral nerve |
| CN114786605A (zh) | 2019-10-21 | 2022-07-22 | 英杜基奈克斯公司 | 用于十二指肠脉冲电场治疗的装置、系统和方法 |
| WO2021146535A1 (en) | 2020-01-15 | 2021-07-22 | Fractyl Laboratories, Inc. | Automated tissue treatment devices, systems, and methods |
| US10836757B1 (en) | 2020-04-02 | 2020-11-17 | Neurogastrx, Inc. | Polymorphic forms of metopimazine |
| WO2021236977A1 (en) | 2020-05-21 | 2021-11-25 | The Feinstein Institutes For Medical Research | Systems and methods for vagus nerve stimulation |
| US20220152195A1 (en) * | 2020-11-13 | 2022-05-19 | Leonhardt Ventures Llc | Methods of preventing and treating viral infections |
| US12444497B2 (en) | 2021-05-17 | 2025-10-14 | Setpoint Medical Corporation | Neurostimulation parameter authentication and expiration system for neurostimulation |
| US11400299B1 (en) | 2021-09-14 | 2022-08-02 | Rainbow Medical Ltd. | Flexible antenna for stimulator |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004112563A2 (en) * | 2003-06-20 | 2004-12-29 | Metacure N.V., | Gastrointestinal methods and apparatus for use in treating disorders |
| WO2005007232A2 (en) * | 2003-07-21 | 2005-01-27 | Metacure N.V. | Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4416267A (en) | 1981-12-10 | 1983-11-22 | Garren Lloyd R | Method and apparatus for treating obesity |
| US4899747A (en) | 1981-12-10 | 1990-02-13 | Garren Lloyd R | Method and appartus for treating obesity |
| US4723547A (en) | 1985-05-07 | 1988-02-09 | C. R. Bard, Inc. | Anti-obesity balloon placement system |
| GB8517092D0 (en) | 1985-07-05 | 1985-08-14 | Taylor T V | Artificial bezoar |
| US4694827A (en) | 1986-01-14 | 1987-09-22 | Weiner Brian C | Inflatable gastric device for treating obesity and method of using the same |
| US4739758A (en) | 1986-05-19 | 1988-04-26 | Criticare Systems, Inc. | Apparatus for stomach cavity reduction |
| US5188104A (en) | 1991-02-01 | 1993-02-23 | Cyberonics, Inc. | Treatment of eating disorders by nerve stimulation |
| US5263480A (en) * | 1991-02-01 | 1993-11-23 | Cyberonics, Inc. | Treatment of eating disorders by nerve stimulation |
| US5234454A (en) | 1991-08-05 | 1993-08-10 | Akron City Hospital | Percutaneous intragastric balloon catheter and method for controlling body weight therewith |
| IT1260485B (it) | 1992-05-29 | 1996-04-09 | Procedimento e dispositivo per il trattamento dell'obesita' di un paziente | |
| US5541951A (en) | 1994-11-14 | 1996-07-30 | Intelligent Surgical Lasers, Inc. | Device and method for high-power end pumping |
| US6575969B1 (en) | 1995-05-04 | 2003-06-10 | Sherwood Services Ag | Cool-tip radiofrequency thermosurgery electrode system for tumor ablation |
| US5690691A (en) * | 1996-05-08 | 1997-11-25 | The Center For Innovative Technology | Gastro-intestinal pacemaker having phased multi-point stimulation |
| AU4107297A (en) * | 1996-09-05 | 1998-03-26 | Governors Of The University Of Alberta, The | Gastro-intestinal electrical pacemaker |
| UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| US6404755B1 (en) | 1996-11-07 | 2002-06-11 | Harris Broadband Wireless Access, Inc. | Multi-level information mapping system and method |
| IT1290866B1 (it) | 1996-12-24 | 1998-12-14 | Francesco Garbagnati | Sonda-catetere per il trattamento di tumori di organi parenchimatosi con ipertermia interstiziale indotta da radiofrequenza |
| US5836994A (en) * | 1997-04-30 | 1998-11-17 | Medtronic, Inc. | Method and apparatus for electrical stimulation of the gastrointestinal tract |
| US5868141A (en) | 1997-05-14 | 1999-02-09 | Ellias; Yakub A. | Endoscopic stomach insert for treating obesity and method for use |
| US5987060A (en) | 1997-06-13 | 1999-11-16 | Innova Corporation | System and method of radio communications with an up-down digital signal link |
| US5919216A (en) * | 1997-06-16 | 1999-07-06 | Medtronic, Inc. | System and method for enhancement of glucose production by stimulation of pancreatic beta cells |
| US6093167A (en) | 1997-06-16 | 2000-07-25 | Medtronic, Inc. | System for pancreatic stimulation and glucose measurement |
| US7006871B1 (en) * | 1997-07-16 | 2006-02-28 | Metacure N.V. | Blood glucose level control |
| EP0996482B1 (en) | 1997-07-16 | 2007-02-14 | Metacure NV | Smooth muscle controller |
| US6091992A (en) | 1997-12-15 | 2000-07-18 | Medtronic, Inc. | Method and apparatus for electrical stimulation of the gastrointestinal tract |
| JP2000026434A (ja) * | 1998-06-05 | 2000-01-25 | Zeria Pharmaceut Co Ltd | 新規１，５−ベンゾジアゼピン誘導体 |
| US6697345B1 (en) | 1998-07-24 | 2004-02-24 | Hughes Electronics Corporation | Multi-transport mode radio communications having synchronous and asynchronous transport mode capability |
| AU2937600A (en) | 1999-03-05 | 2000-09-28 | Impulse Dynamics N.V. | Blood glucose level control |
| US8019421B2 (en) | 1999-03-05 | 2011-09-13 | Metacure Limited | Blood glucose level control |
| WO2005087310A2 (en) | 2004-03-18 | 2005-09-22 | Metacure Nv | Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar |
| US20040249421A1 (en) | 2000-09-13 | 2004-12-09 | Impulse Dynamics Nv | Blood glucose level control |
| US8700161B2 (en) | 1999-03-05 | 2014-04-15 | Metacure Limited | Blood glucose level control |
| JP3589086B2 (ja) | 1999-05-17 | 2004-11-17 | 松下電器産業株式会社 | 電源装置 |
| US6853862B1 (en) | 1999-12-03 | 2005-02-08 | Medtronic, Inc. | Gastroelectric stimulation for influencing pancreatic secretions |
| US6600953B2 (en) | 2000-12-11 | 2003-07-29 | Impulse Dynamics N.V. | Acute and chronic electrical signal therapy for obesity |
| MXPA00001922A (es) | 2000-02-24 | 2002-03-08 | De Hayos Garza Andres | Cateter de balon intragastrico percutaneo para tratamiento de la obesidad. |
| FR2805986B1 (fr) | 2000-03-13 | 2002-10-11 | Districlass Madical | Dispositif intra-gastrique a volume variable |
| US6826428B1 (en) * | 2000-04-11 | 2004-11-30 | The Board Of Regents Of The University Of Texas System | Gastrointestinal electrical stimulation |
| DE60144429D1 (de) | 2000-09-07 | 2011-05-26 | Apparat zur kontrolle der darmfunktion | |
| US6895279B2 (en) | 2000-09-15 | 2005-05-17 | Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California | Method and apparatus to treat disorders of gastrointestinal peristalsis |
| US7016296B2 (en) | 2000-10-16 | 2006-03-21 | Broadcom Corporation | Adaptive modulation for fixed wireless link in cable transmission system |
| US6579301B1 (en) * | 2000-11-17 | 2003-06-17 | Syntheon, Llc | Intragastric balloon device adapted to be repeatedly varied in volume without external assistance |
| US6832114B1 (en) | 2000-11-21 | 2004-12-14 | Advanced Bionics Corporation | Systems and methods for modulation of pancreatic endocrine secretion and treatment of diabetes |
| US6684105B2 (en) | 2001-08-31 | 2004-01-27 | Biocontrol Medical, Ltd. | Treatment of disorders by unidirectional nerve stimulation |
| US6928320B2 (en) | 2001-05-17 | 2005-08-09 | Medtronic, Inc. | Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated |
| RU2211712C2 (ru) | 2001-08-23 | 2003-09-10 | Надточий Александр Иванович | Адаптивный электростимулятор |
| US7047029B1 (en) | 2001-09-10 | 2006-05-16 | The Directv Group, Inc. | Adaptive transmission system |
| DE60110942T2 (de) | 2001-10-12 | 2005-11-10 | Nokia Corp. | Adaptives punkt-zu-punkt-mikrowellenfunksystem |
| US20070060812A1 (en) | 2001-11-29 | 2007-03-15 | Metacure N.V. | Sensing of pancreatic electrical activity |
| FR2834202B1 (fr) | 2001-12-28 | 2004-03-19 | Cie Euro Etude Rech Paroscopie | Ballon intra-gastrique a poches multiples, dispositif chirurgical d'expansion dudit ballon et procede de fabrication correspondant |
| US6733512B2 (en) | 2002-03-07 | 2004-05-11 | Mcghan Jim J. | Self-deflating intragastric balloon |
| US7239912B2 (en) * | 2002-03-22 | 2007-07-03 | Leptos Biomedical, Inc. | Electric modulation of sympathetic nervous system |
| US7069078B2 (en) * | 2002-04-22 | 2006-06-27 | Medtronic, Inc. | Insulin-mediated glucose uptake monitor |
| CN1713933A (zh) * | 2002-07-26 | 2005-12-28 | 特兰施钮罗尼克斯股份有限公司 | 改进的电刺激治疗病态性肥胖症的方法 |
| WO2004049982A2 (en) | 2002-12-02 | 2004-06-17 | Gi Dynamics, Inc. | Bariatric sleeve |
| US20040172084A1 (en) * | 2003-02-03 | 2004-09-02 | Knudson Mark B. | Method and apparatus for treatment of gastro-esophageal reflux disease (GERD) |
| US7167750B2 (en) | 2003-02-03 | 2007-01-23 | Enteromedics, Inc. | Obesity treatment with electrically induced vagal down regulation |
| JP4149838B2 (ja) * | 2003-03-04 | 2008-09-17 | オリンパス株式会社 | カプセル型医療装置 |
| FR2852821B1 (fr) | 2003-03-31 | 2007-06-01 | Cie Euro Etude Rech Paroscopie | Ballon intra-gastrique enduit de parylene, procede de fabrication d'un tel ballon et utilisation de parylene pour revetir un ballon intra-gastrique |
| US7427909B2 (en) | 2003-06-12 | 2008-09-23 | Nec Tokin Corporation | Coil component and fabrication method of the same |
| KR20030068070A (ko) | 2003-06-26 | 2003-08-19 | 이정환 | 비만치료를 위한 내시경적 풍선 삽입장치 및 삽입기술 |
| US20070060971A1 (en) * | 2003-07-21 | 2007-03-15 | Ofer Glasberg | Hepatic device for treatment or glucose detection |
| WO2005051486A1 (en) | 2003-11-28 | 2005-06-09 | University Technologies International Inc. | Method and apparatus for gastrointestinal motility control |
| US7194307B2 (en) * | 2003-12-22 | 2007-03-20 | Cardiac Pacemakers, Inc. | Pacing method and device for preserving native conduction system |
| US8612016B2 (en) | 2004-08-18 | 2013-12-17 | Metacure Limited | Monitoring, analysis, and regulation of eating habits |
| US20070016262A1 (en) | 2005-07-13 | 2007-01-18 | Betastim, Ltd. | Gi and pancreatic device for treating obesity and diabetes |
-
2006
- 2006-04-11 US US11/279,355 patent/US20070016262A1/en not_active Abandoned
- 2006-07-13 WO PCT/IL2006/000819 patent/WO2007007339A2/en not_active Ceased
- 2006-07-13 EP EP06766139A patent/EP1907046A4/en not_active Ceased
- 2006-07-13 US US11/995,663 patent/US8095218B2/en not_active Expired - Fee Related
- 2006-07-13 JP JP2008521036A patent/JP2009501046A/ja active Pending
-
2011
- 2011-12-15 US US13/326,631 patent/US20120083855A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004112563A2 (en) * | 2003-06-20 | 2004-12-29 | Metacure N.V., | Gastrointestinal methods and apparatus for use in treating disorders |
| WO2005007232A2 (en) * | 2003-07-21 | 2005-01-27 | Metacure N.V. | Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021519632A (ja) * | 2018-03-29 | 2021-08-12 | ネヴロ コーポレイション | ２型糖尿病を含む血糖異常を治療する、および／またはＨｂＡ１ｃレベルを低下させるための治療的調節、ならびに関連するシステムおよび方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US8095218B2 (en) | 2012-01-10 |
| EP1907046A2 (en) | 2008-04-09 |
| EP1907046A4 (en) | 2009-10-21 |
| US20090062881A1 (en) | 2009-03-05 |
| US20070016262A1 (en) | 2007-01-18 |
| WO2007007339A2 (en) | 2007-01-18 |
| WO2007007339A3 (en) | 2009-04-30 |
| US20120083855A1 (en) | 2012-04-05 |
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