JP2009288031A - Stirrer and autoanalyzer using the same - Google Patents

Stirrer and autoanalyzer using the same Download PDF

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JP2009288031A
JP2009288031A JP2008140174A JP2008140174A JP2009288031A JP 2009288031 A JP2009288031 A JP 2009288031A JP 2008140174 A JP2008140174 A JP 2008140174A JP 2008140174 A JP2008140174 A JP 2008140174A JP 2009288031 A JP2009288031 A JP 2009288031A
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reagent
stirring
rotating shaft
shaft
stirring shaft
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Kenichiro Nishiki
健一郎 西木
Takeshi Setomaru
武 瀬戸丸
Akihiro Yasui
晃啓 安居
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Hitachi High Tech Corp
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Hitachi High Technologies Corp
Hitachi High Tech Corp
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Abstract

<P>PROBLEM TO BE SOLVED: To provide a stirrer capable of more certainly stirring the whole of the reagent in a reagent container in a shorter time, and an autoanalyzer using the same. <P>SOLUTION: A stirring shaft 2 with stirring blades 1 is rotationally driven not only to produce the circumferential flow of the stirring shaft 2 in the reagent containing magnetic particles 15 but also to discharge air in the reagent from the lower end of the air feed passage 2b provided to the stirring shaft 2 so as to pierce the stirring shaft 2 to produce the axial flow of the stirring shaft 2 in the reagent. The reagent is stirred by producing both of the circumferential flow of the stirring shaft 2 and the axial flow of the stirring shaft 2 in the reagent. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

本発明は、液体試料等を攪拌する攪拌装置及びそれを用いた自動分析装置に関する。   The present invention relates to a stirrer that stirs a liquid sample or the like and an automatic analyzer using the stirrer.

自動分析装置や化学実験装置等では、種々の試薬を用いて分析や実験を行っている。例えば、臨床検査用免疫分析装置においては、一般的に、測定対象をそれ以外の物質と分離するための試薬のひとつとして磁性粒子が用いられている。この磁性粒子は緩衝液の中に均一に分散された状態で分析等に用いられるが、時間をおくと比重差のために試薬容器の底部に沈降してしまい、さらに、この状態で長時間放置すると磁性粒子が凝縮してしまう。このため、試薬として磁性粒子を使用する場合は、その直前に攪拌装置を用いて試薬を攪拌し、磁性粒子を緩衝液の中に均一に分散させている。   Automatic analyzers and chemical experimental devices perform analysis and experiments using various reagents. For example, in an immunoassay apparatus for clinical examination, magnetic particles are generally used as one of reagents for separating a measurement target from other substances. These magnetic particles are used for analysis and the like in a state of being uniformly dispersed in the buffer solution. However, if time is passed, the magnetic particles settle on the bottom of the reagent container due to the difference in specific gravity. Then, magnetic particles will condense. For this reason, when using magnetic particles as a reagent, the reagent is stirred using a stirrer immediately before that to disperse the magnetic particles uniformly in the buffer solution.

このような場合に用いる攪拌装置としては、例えば、攪拌体を攪拌棒に突設し、その攪拌体を試薬容器中の試薬に浸漬させた状態で攪拌棒を回転させることにより攪拌体の周辺に乱流を発生させて試薬の攪拌を行うものが知られている（特許文献１等参照）。   As a stirring device used in such a case, for example, a stirring body is protruded from a stirring rod, and the stirring rod is rotated in a state where the stirring body is immersed in a reagent in a reagent container. A device that stirs a reagent by generating a turbulent flow is known (see Patent Document 1).

特開平０５−３０２９２８号公報Japanese Patent Laid-Open No. 05-302928

臨床検査用免疫分析装置などにおいては、できるだけ早く分析結果を知ることができるようにするため、分析に要する時間をより短縮することが望まれている。したがって、分析過程の一つである攪拌に要する時間の短縮も分析効率を向上させる上で重要である。また、試薬中で凝縮した磁性粒子をより確実に攪拌するための高い攪拌能力も求められている。   In an immunoassay apparatus for clinical tests and the like, it is desired to further reduce the time required for analysis in order to be able to know the analysis result as soon as possible. Therefore, shortening the time required for stirring, which is one of the analysis processes, is also important for improving the analysis efficiency. Further, a high stirring ability is required for stirring magnetic particles condensed in the reagent more reliably.

しかしながら、上記従来技術においては、攪拌棒中心に攪拌体を回転させ、この攪拌体の周辺に発生する乱流により試薬の攪拌を行う構成であるので、攪拌体から離れた位置や攪拌棒の軸方向（試薬容器の底部方向）などには乱流が到達しにくいことが予想され、試薬全体の攪拌効率及び攪拌能力については依然改善の余地が残されていた。   However, in the above prior art, the stirrer is rotated around the stirrer and the reagent is stirred by the turbulent flow generated around the stirrer, so the position away from the stirrer and the shaft of the stirrer It is expected that turbulent flow is difficult to reach in the direction (bottom direction of the reagent container) and the like, and there is still room for improvement in the stirring efficiency and stirring capacity of the entire reagent.

本発明は上記に鑑みてなされたものであり、試薬容器中の試薬全体をより短時間でより確実に攪拌することができる攪拌装置及びそれを用いた自動分析装置を提供することを目的とする。   The present invention has been made in view of the above, and an object of the present invention is to provide a stirrer that can stir the entire reagent in the reagent container more reliably in a shorter time and an automatic analyzer using the stirrer. .

上記目的を達成するために、本発明は、磁性粒子を含んだ試薬に一端を浸漬する回転軸と、前記回転軸を回転駆動させる回転駆動手段と、前記回転軸を軸方向に駆動させる軸方向駆動手段と、前記回転軸の浸漬部分に前記回転軸の径方向に突出して設けられ、前記試薬に前記回転軸の周方向の流れを発生させる攪拌羽根と、前記試薬に前記回転軸の軸方向の流れを発生させる縦旋回流発生手段とを備えるものとする。   In order to achieve the above object, the present invention provides a rotating shaft for immersing one end in a reagent containing magnetic particles, a rotation driving means for rotating the rotating shaft, and an axial direction for driving the rotating shaft in the axial direction. A driving means; a stirring blade provided in a radial direction of the rotating shaft at an immersion portion of the rotating shaft; and causing the reagent to generate a flow in a circumferential direction of the rotating shaft; and an axial direction of the rotating shaft in the reagent And a vertical swirl flow generating means for generating a flow of

本発明においては、試薬容器中の試薬全体をより短時間でより確実に攪拌することができる。   In the present invention, the entire reagent in the reagent container can be stirred more reliably in a shorter time.

以下、本発明の実施の形態を図面を用いて説明する。   Hereinafter, embodiments of the present invention will be described with reference to the drawings.

本発明の第１の実施の形態を図１を用いて説明する。   A first embodiment of the present invention will be described with reference to FIG.

図１は、本実施の形態に係る攪拌装置の全体構成をその攪拌対象である試薬と共に示す図である。   FIG. 1 is a diagram showing the overall configuration of the stirring device according to the present embodiment, together with the reagent that is the stirring target.

本実施の形態における攪拌対象である試薬は、緩衝液１４に磁性粒子１５を加えたものであり、図１においては試薬（緩衝液１４）中の磁性粒子１５が試薬容器１３の底部に沈降（凝縮）した様子を示している。   The reagent to be stirred in the present embodiment is obtained by adding magnetic particles 15 to the buffer solution 14, and in FIG. 1, the magnetic particles 15 in the reagent (buffer solution 14) settle on the bottom of the reagent container 13 ( (Condensed).

図１において、本実施の形態の攪拌装置は、軸方向を上下方向に向けて配置された攪拌軸２と、攪拌軸２の下端に設けられた複数（例えば２つ）の攪拌羽根１と、攪拌軸２の上端に設けられ、この攪拌軸２を回転駆動する回転駆動装置３と、回転駆動装置３と駆動軸４を介して連結され、回転駆動装置３を上下方向（攪拌軸２の軸方向）に駆動する上下駆動装置５とを備えている。   In FIG. 1, the agitation device of the present embodiment includes an agitation shaft 2 arranged with its axial direction directed in the vertical direction, and a plurality of (for example, two) agitation blades 1 provided at the lower end of the agitation shaft 2, The rotary drive device 3 is provided at the upper end of the stirring shaft 2 and is connected to the rotary drive device 3 for rotationally driving the stirring shaft 2 via the rotary drive device 3 and the drive shaft 4. And a vertical driving device 5 for driving in the direction).

攪拌羽根１は、攪拌軸２の径方向に突出して設けられた方形の板状部材であり、攪拌軸２の外周部の例えば下端部、若しくはその近傍に周方向に等間隔に配置されている。攪拌軸２の下端（攪拌羽根１）が試薬中に浸漬され、攪拌軸２が回転駆動されると、試薬中で攪拌軸２周りに回転する攪拌羽根１の流体抵抗により、試薬中に攪拌軸２の周方向の流れ（乱流）が発生し、この乱流により試薬が攪拌される。以降、攪拌軸２の周方向の流れ（乱流）を横旋回流と称する。横旋回流は、攪拌軸２周りに攪拌軸２の回転方向に旋回する。   The stirring blade 1 is a rectangular plate-like member provided so as to protrude in the radial direction of the stirring shaft 2 and is disposed at equal intervals in the circumferential direction, for example, at the lower end portion of the outer peripheral portion of the stirring shaft 2 or in the vicinity thereof. . When the lower end (stirring blade 1) of the stirring shaft 2 is immersed in the reagent and the stirring shaft 2 is driven to rotate, the fluid resistance of the stirring blade 1 rotating around the stirring shaft 2 in the reagent causes the stirring shaft in the reagent. Two circumferential flows (turbulent flow) are generated, and the reagent is stirred by this turbulent flow. Hereinafter, the flow (turbulent flow) in the circumferential direction of the stirring shaft 2 is referred to as a transverse swirl flow. The transverse swirl flow swirls around the stirring shaft 2 in the rotation direction of the stirring shaft 2.

回転駆動装置３は攪拌軸２の上端に攪拌軸２と同軸状に設けられたプーリ９と、図示しない制御装置により回転を制御されるモータ１２と、モータ１２の出力軸にこの出力軸と同軸状に設けられたプーリ１０と、２つのプーリ９，１０に巻装された伝達ベルト１１とを備えている。モータ１２からの回転をプーリ１０及び伝達ベルト１１を介してプーリ９に伝達することにより攪拌軸２を回転駆動する。   The rotation driving device 3 includes a pulley 9 provided coaxially with the stirring shaft 2 at the upper end of the stirring shaft 2, a motor 12 whose rotation is controlled by a control device (not shown), and an output shaft of the motor 12 coaxial with the output shaft. And a transmission belt 11 wound around two pulleys 9 and 10. The stirring shaft 2 is rotationally driven by transmitting the rotation from the motor 12 to the pulley 9 via the pulley 10 and the transmission belt 11.

上下駆動装置５は、攪拌軸２の軸方向（本例では鉛直方向）に延びる駆動軸４を備えている。駆動軸４の上端部には前述した回転駆動装置３が連結されている。上下駆動装置５は、駆動軸４をその軸方向に駆動することにより回転駆動装置３とともに攪拌軸２を軸方向に駆動する。   The vertical drive device 5 includes a drive shaft 4 that extends in the axial direction (vertical direction in this example) of the stirring shaft 2. The rotary drive device 3 described above is connected to the upper end portion of the drive shaft 4. The vertical drive device 5 drives the stirring shaft 2 in the axial direction together with the rotary drive device 3 by driving the drive shaft 4 in the axial direction.

また、本実施の形態の攪拌装置は、攪拌軸２の内部に軸方向に貫通して設けられた気体搬送路２ａと、攪拌軸２の上端（又はプーリ９）に対し、攪拌軸２（又はプーリ９）の回転を許容するように接続されて気体搬送路２ａに連通した気体輸送管７と、気体輸送管７に接続した気体ポンプ６と、気体輸送管７に設けられ、気体ポンプ６から気体搬送路２ａに送られる気体（例えば空気）の量を調整するバルブ８とを備えている。   In addition, the stirring device according to the present embodiment is configured so that the stirring shaft 2 (or the pulley 9) is opposed to the gas transport path 2a provided in the stirring shaft 2 so as to penetrate in the axial direction. A pulley 9) connected to allow the rotation of the pulley 9, and communicated with the gas transport path 2 a, a gas pump 6 connected to the gas transport tube 7, and a gas transport tube 7. And a valve 8 for adjusting the amount of gas (for example, air) sent to the gas conveyance path 2a.

気体ポンプ６から吐出された気体は、気体輸送管７及びバルブ８を介して攪拌軸２の気体搬送路２ａに送られ、気体搬送路２ａ（攪拌軸２）の下端から軸方向下方に気泡となって吐出される。攪拌軸２の下端が試薬中に浸漬され、気体搬送路２ａの下端から気体（気泡）が吐出されると、その気体の流体抵抗により、試薬中に攪拌軸２の軸方向下向きの流れ（乱流）が発生し、これにより試薬が攪拌される。また、気体搬送路２ａから吐出された気体が試薬容器１３の底部に衝突し、その後、試薬中を上昇（浮上）することにより、試薬中の軸方向上向きの流れ（乱流）が発生する。このように、試薬中に下方に向けて吐出され、さらに上昇する気体（気泡）の流体抵抗により、試薬中に攪拌軸２の軸方向の流れ（乱流）が発生し、これにより試薬が攪拌される。以降、攪拌軸２の軸方向の流れ（乱流）を縦旋回流と称する。縦旋回流は試薬容器１３の内壁側（外周側）で上昇し、攪拌軸２の近傍（内周側）で下降する向きに旋回する。攪拌軸２を回転させつつ気体を吐出した場合には、横旋回流と縦旋回流の速度成分が合成され、より複雑な乱流が発生する。   The gas discharged from the gas pump 6 is sent to the gas transport path 2a of the stirring shaft 2 through the gas transport pipe 7 and the valve 8, and bubbles are formed downward from the lower end of the gas transport path 2a (stirring shaft 2) in the axial direction. It is discharged. When the lower end of the stirring shaft 2 is immersed in the reagent and a gas (bubble) is discharged from the lower end of the gas transport path 2a, the flow of the stirring shaft 2 downward (turbulence) into the reagent due to the fluid resistance of the gas. Flow), which stirs the reagent. Further, the gas discharged from the gas transport path 2a collides with the bottom of the reagent container 13, and then rises (floats) in the reagent, thereby generating an axially upward flow (turbulent flow) in the reagent. As described above, the flow (turbulent flow) in the axial direction of the stirring shaft 2 is generated in the reagent due to the fluid resistance of the gas (bubbles) which is discharged downward into the reagent and rises, thereby stirring the reagent. Is done. Hereinafter, the axial flow (turbulent flow) of the stirring shaft 2 is referred to as a longitudinal swirl flow. The vertical swirling flow swirls in the direction of rising on the inner wall side (outer peripheral side) of the reagent container 13 and lowering in the vicinity of the stirring shaft 2 (inner peripheral side). When gas is discharged while rotating the stirring shaft 2, the velocity components of the transverse swirl flow and the longitudinal swirl flow are combined, and a more complicated turbulent flow is generated.

以上において、気体ポンプ６、気体輸送管７、及び気体搬送路２ａは、試薬に攪拌軸２の軸方向の流れを発生させる縦旋回流発生手段を構成する。   In the above, the gas pump 6, the gas transport pipe 7, and the gas transport path 2 a constitute a longitudinal swirl flow generating unit that causes the reagent to generate a flow in the axial direction of the stirring shaft 2.

次に、以上のように構成した本実施の形態の動作及び作用効果を順次説明する。   Next, operations and effects of the present embodiment configured as described above will be sequentially described.

オペレータは、攪拌対象である試薬が入れられた試薬容器１３を、その開口部の中心が攪拌軸２の真下付近となるように配置する。次に、上下駆動装置５により攪拌軸２を下方向に移動させて攪拌羽根１を試薬中（試薬容器１３の底面部付近）に浸漬する。この状態で、回転駆動装置３により攪拌軸２を回転駆動させ、試薬中に横旋回流を誘起すると同時に、気体ポンプ６により攪拌軸２の気体搬送路２ａの下端から気体を試薬中に吐出させ、試薬中に縦旋回流を誘起する。   The operator arranges the reagent container 13 in which the reagent to be agitated is placed so that the center of the opening is directly below the agitation shaft 2. Next, the stirring shaft 2 is moved downward by the vertical drive device 5 to immerse the stirring blade 1 in the reagent (near the bottom surface of the reagent container 13). In this state, the agitation shaft 2 is rotationally driven by the rotation drive device 3 to induce a transverse swirling flow in the reagent, and at the same time, the gas is discharged from the lower end of the gas conveyance path 2a of the agitation shaft 2 into the reagent by the gas pump 6. Inducing a longitudinal swirl in the reagent.

したがって、本実施の形態によれば、試薬中の磁性粒子１５が試薬容器１３の底部に沈降していても、この磁性粒子１５を、縦旋回流成分により試薬中に巻き上げて拡散し、さらに横旋回流成分により試薬全体に拡散することができる。また、気体搬送路２ａからの気泡との接触による、一部の磁性粒子１５が気泡に同伴して浮上することも期待できる。これにより、攪拌羽根１の動きにより発生する乱流（横旋回流）のみにより試薬の攪拌を行う場合と比較して、試薬容器１３中の試薬全体をより短時間でより確実に攪拌することができる。また、このように横旋回流成分に加えて縦旋回流成分を付与することにより、攪拌能力が大幅に向上し、試薬容器１３の底部に磁性粒子１５が凝固した試薬の攪拌も効果的に行うことができる。   Therefore, according to the present embodiment, even if the magnetic particles 15 in the reagent are settled at the bottom of the reagent container 13, the magnetic particles 15 are rolled up and diffused in the reagent by the longitudinal swirl component, and further, It can be diffused throughout the reagent by the swirl component. It can also be expected that some of the magnetic particles 15 are caused to float along with the bubbles due to contact with the bubbles from the gas conveyance path 2a. This makes it possible to more reliably stir the entire reagent in the reagent container 13 in a shorter time than when the reagent is stirred only by the turbulent flow (lateral swirl flow) generated by the movement of the stirring blade 1. it can. Further, by adding the vertical swirl flow component in addition to the transverse swirl flow component, the stirring ability is greatly improved, and the reagent having the magnetic particles 15 coagulated at the bottom of the reagent container 13 is also effectively stirred. be able to.

また、気体搬送路２ａの下端から吐出した気体により試薬容器１３の底部付近の試薬を攪拌するので、攪拌装置を構成する部材と試薬容器１３との接触による試薬容器１３、或いは攪拌装置の損傷を抑制することができる。   Further, since the reagent near the bottom of the reagent container 13 is agitated by the gas discharged from the lower end of the gas conveyance path 2a, the reagent container 13 or the agitator is damaged by the contact between the member constituting the agitator and the reagent container 13. Can be suppressed.

なお、本実施の形態においては、攪拌軸２に設けた攪拌羽根１の数は２つである場合を例にとり説明したが、これに限られず、例えば攪拌羽根１を１つのみ設けた構成、又は３つ以上の攪拌羽根１を攪拌軸２の周方向に等間隔に設けた構成とすることもできる。また、攪拌羽根１の形状は方形に限られず、例えば、三角形など、攪拌軸２が回転駆動されたときに、攪拌羽根１の進行方向（攪拌軸２の周方向）に流体抵抗が生じ、試薬に乱流が発生するような形状であれば良い。   In the present embodiment, the case where the number of the stirring blades 1 provided on the stirring shaft 2 is two has been described as an example. However, the present invention is not limited to this. For example, a configuration in which only one stirring blade 1 is provided, Alternatively, three or more stirring blades 1 may be provided at equal intervals in the circumferential direction of the stirring shaft 2. Further, the shape of the stirring blade 1 is not limited to a square, and for example, when the stirring shaft 2 is rotationally driven, such as a triangle, fluid resistance is generated in the traveling direction of the stirring blade 1 (circumferential direction of the stirring shaft 2). Any shape can be used as long as turbulent flow is generated.

本発明の第２の実施の形態を図２を用いて説明する。   A second embodiment of the present invention will be described with reference to FIG.

上記第１の実施の形態においては、試薬中に気体を吐出することにより縦旋回流を発生させたのに対し、本実施の形態においては、試薬の吸引・吐出により縦旋回流を発生させる。図中、図１に示した部材と同様のものには同じ符号を付し、説明を省略する。   In the first embodiment, a vertical swirling flow is generated by discharging a gas into the reagent. In the present embodiment, a vertical swirling flow is generated by aspirating and discharging the reagent. In the figure, the same members as those shown in FIG.

図２は、本実施の形態に係る攪拌装置の全体構成をその攪拌対象である試薬と共に示す図である。   FIG. 2 is a diagram showing the overall configuration of the stirring apparatus according to the present embodiment, together with the reagent that is the stirring target.

図２において、本実施の形態の攪拌装置は、軸方向を上下方向に向けて配置された攪拌軸２と、攪拌軸２の下端に設けられた複数（例えば２つ）の攪拌羽根１と、攪拌軸２の上端に設けられ、この攪拌軸２を回転駆動する回転駆動装置３と、回転駆動装置３と駆動軸４を介して連結され、回転駆動装置３を上下方向（攪拌軸２の軸方向）に駆動する上下駆動装置５とに加え、攪拌軸２の内部に軸方向に貫通して設けられた吸引吐出路２ｂと、攪拌軸２の上端（又はプーリ９）に対し攪拌軸２（又はプーリ９）の回転を許容するように接続されて連通した吸引吐出管７ｂと、吸引吐出管７ｂに接続したシリンジ１６と、シリンジ１６の容積を調節するためのピストン１７を駆動するピストン駆動手段１８とを備えている。   In FIG. 2, the stirring device of the present embodiment includes a stirring shaft 2 arranged with its axial direction directed in the vertical direction, and a plurality of (for example, two) stirring blades 1 provided at the lower end of the stirring shaft 2, The rotary drive device 3 is provided at the upper end of the stirring shaft 2 and is connected to the rotary drive device 3 for rotationally driving the stirring shaft 2 via the rotary drive device 3 and the drive shaft 4. In addition to the vertical drive device 5 driven in the direction), the agitating shaft 2 (with respect to the upper end (or pulley 9) of the agitating shaft 2 and the suction / discharge path 2b provided through the agitating shaft 2 in the axial direction) Alternatively, a suction / discharge pipe 7b connected so as to allow rotation of the pulley 9), a syringe 16 connected to the suction / discharge pipe 7b, and a piston drive means for driving a piston 17 for adjusting the volume of the syringe 16 18.

攪拌軸２の下端が試薬中に浸漬された状態で、ピストン駆動手段１８によりシリンジ１６のピストン部１７をシリンジ１６内の容積が増加する方向（吸引方向）に駆動すると、吸引吐出管７ｂ内及び吸引吐出路２ｂ内の空気がシリンジ１６方向に引かれ、これに伴って、試薬容器１３中の試薬が吸引吐出路２ｂ内に吸引される。また、ピストン駆動手段１８により、シリンジ１６のピストン部１７をシリンジ１６内の容積が減少する方向（吐出方向）に駆動すると、シリンジ１６内の空気が吸引吐出管７ｂ内及び吸引吐出路２ｂ内に送られ、これに伴って、吸引吐出路２ｂ内の試薬が試薬容器１３内に吐出される。このようにして、吸引吐出路２ｂの下端から攪拌軸２の軸方向下向きに試薬が吐出されることにより、試薬中に縦旋回流が発生し、これにより試薬が攪拌される。また、吸引吐出路２ｂから吐出された試薬が試薬容器１３の底部に衝突し、その後、攪拌容器１３の側面に沿って試薬中を上昇することにより、試薬中の磁性粒子１５が巻き上げられる。   When the piston drive unit 18 drives the piston portion 17 of the syringe 16 in the direction in which the volume in the syringe 16 increases (suction direction) with the lower end of the stirring shaft 2 immersed in the reagent, the suction and discharge pipes 7b and The air in the suction / discharge path 2b is drawn in the direction of the syringe 16, and accordingly, the reagent in the reagent container 13 is sucked into the suction / discharge path 2b. Further, when the piston drive means 18 drives the piston portion 17 of the syringe 16 in a direction (discharge direction) in which the volume in the syringe 16 decreases, the air in the syringe 16 enters the suction / discharge pipe 7b and the suction / discharge path 2b. Along with this, the reagent in the suction / discharge path 2 b is discharged into the reagent container 13. In this way, the reagent is discharged from the lower end of the suction / discharge path 2b downward in the axial direction of the stirring shaft 2, whereby a vertical swirling flow is generated in the reagent, whereby the reagent is stirred. In addition, the reagent discharged from the suction / discharge path 2b collides with the bottom of the reagent container 13, and then moves up along the side surface of the stirring container 13, whereby the magnetic particles 15 in the reagent are wound up.

以上において、シリンジ１６、吸引吐出管７ｂ、及び吸引吐出路２ｂは、試薬に攪拌軸２の軸方向の流れを発生させる縦旋回流発生手段を構成する。   In the above, the syringe 16, the suction / discharge tube 7b, and the suction / discharge path 2b constitute a vertical swirl flow generating means for causing the reagent to generate a flow in the axial direction of the stirring shaft 2.

その他の構成は、第１の実施の形態と同様である。   Other configurations are the same as those of the first embodiment.

次に、以上のように構成した本実施の形態の動作及び作用効果を順次説明する。   Next, operations and effects of the present embodiment configured as described above will be sequentially described.

オペレータは、攪拌対象である試薬が入れられた試薬容器１３を、その開口部の中心が攪拌軸２の真下付近となるように配置する。次に、上下駆動装置５により攪拌軸２を下方向に移動させて攪拌羽根１を試薬中（試薬容器１３の底面部付近）に浸漬する。この状態で、回転駆動装置３により攪拌軸２を回転駆動させ、試薬中に横旋回流を誘起すると同時に、シリンジ１６により攪拌軸２の吸引吐出路２ｂに試薬を吸引し、吸引吐出路２ｂの下端から試薬を試薬容器１３中に吐出させ、試薬中に縦旋回流を誘起する。   The operator arranges the reagent container 13 in which the reagent to be agitated is placed so that the center of the opening is directly below the agitation shaft 2. Next, the stirring shaft 2 is moved downward by the vertical drive device 5 to immerse the stirring blade 1 in the reagent (near the bottom surface of the reagent container 13). In this state, the agitation shaft 2 is rotationally driven by the rotation drive device 3 to induce a transverse swirling flow in the reagent, and at the same time, the reagent is aspirated by the syringe 16 into the aspiration / discharge path 2b of the agitation shaft 2 and The reagent is discharged into the reagent container 13 from the lower end, and a vertical swirling flow is induced in the reagent.

以上のように構成した本実施の形態においても、第１の実施の形態と同様の効果を得ることができる。   Also in the present embodiment configured as described above, the same effects as those of the first embodiment can be obtained.

また、試薬中に浸漬した攪拌軸２の下端からの試薬の吸引および吐出により、試薬容器１３中の試薬の撹拌を行うので、第１の実施の形態と比較して試薬の泡立ちを抑制することができる。   Further, since the reagent in the reagent container 13 is agitated by suction and discharge of the reagent from the lower end of the agitation shaft 2 immersed in the reagent, the bubbling of the reagent is suppressed as compared with the first embodiment. Can do.

本発明の第３の実施の形態を図３を用いて説明する。   A third embodiment of the present invention will be described with reference to FIG.

上記第１の実施の形態においては、試薬中に気体を吐出することにより縦旋回流を発生させたのに対し、本実施の形態においては、超音波により縦旋回流を発生させる。図中、図１に示した部材と同様のものには同じ符号を付し、説明を省略する。   In the first embodiment, a vertical swirling flow is generated by discharging a gas into the reagent. In the present embodiment, a vertical swirling flow is generated by ultrasonic waves. In the figure, the same members as those shown in FIG.

図３は、本実施の形態に係る攪拌装置の全体構成をその攪拌対象である試薬と共に示す図である。   FIG. 3 is a diagram showing the entire configuration of the stirring device according to the present embodiment, together with the reagent that is the stirring target.

図３において、本実施の形態の攪拌装置は、軸方向を上下方向に向けて配置された攪拌軸２と、攪拌軸２の下端に設けられた複数（例えば２つ）の攪拌羽根１と、攪拌軸２の上端に設けられ、この攪拌軸２を回転駆動する回転駆動装置３と、回転駆動装置３と駆動軸４を介して連結され、回転駆動装置３を上下方向（攪拌軸２の軸方向）に駆動する上下駆動装置５とに加え、攪拌軸２の下端に設けられた超音波振動子１９を備えている。   In FIG. 3, the stirring device according to the present embodiment includes a stirring shaft 2 arranged with its axial direction directed in the vertical direction, and a plurality of (for example, two) stirring blades 1 provided at the lower end of the stirring shaft 2, The rotary drive device 3 is provided at the upper end of the stirring shaft 2 and is connected to the rotary drive device 3 for rotationally driving the stirring shaft 2 via the rotary drive device 3 and the drive shaft 4. In addition to the vertical drive device 5 driven in the direction), an ultrasonic transducer 19 provided at the lower end of the stirring shaft 2 is provided.

超音波振動子１９は、攪拌軸２の軸方向に振動し、その軸方向に超音波を照射する。攪拌軸２の下端が試薬中に浸漬された状態で、超音波振動子１９により超音波を照射すると、その超音波振動は試薬中を攪拌軸２の軸方向下向きに伝搬し、試薬中に攪拌軸２の軸方向下向きの流れ（縦旋回流）が発生し、これにより試薬が攪拌される。   The ultrasonic vibrator 19 vibrates in the axial direction of the stirring shaft 2 and irradiates ultrasonic waves in the axial direction. When the ultrasonic vibrator 19 irradiates ultrasonic waves with the lower end of the stirring shaft 2 immersed in the reagent, the ultrasonic vibration propagates downward in the axial direction of the stirring shaft 2 and stirs into the reagent. A downward flow (longitudinal swirl flow) in the axial direction of the shaft 2 is generated, whereby the reagent is stirred.

その他の構成は、第１の実施の形態と同様である。   Other configurations are the same as those of the first embodiment.

次に、以上のように構成した本実施の形態の動作及び作用効果を順次説明する。   Next, operations and effects of the present embodiment configured as described above will be sequentially described.

オペレータは、攪拌対象である試薬が入れられた試薬容器１３を、その開口部の中心が攪拌軸２の真下付近となるように配置する。次に、上下駆動装置５により攪拌軸２を下方向に移動させて攪拌羽根１を試薬中（試薬容器１３の底面部付近）に浸漬する。この状態で、回転駆動装置３により攪拌軸２を回転駆動させ、試薬中に横旋回流を誘起すると同時に、超音波振動子１９から超音波を照射し、試薬中に縦旋回流を誘起する。   The operator arranges the reagent container 13 in which the reagent to be agitated is placed so that the center of the opening is directly below the agitation shaft 2. Next, the stirring shaft 2 is moved downward by the vertical drive device 5 to immerse the stirring blade 1 in the reagent (near the bottom surface of the reagent container 13). In this state, the rotation shaft 3 is rotationally driven by the rotation drive device 3 to induce a transverse swirling flow in the reagent, and at the same time, an ultrasonic wave is irradiated from the ultrasonic vibrator 19 to induce a vertical swirling flow in the reagent.

以上のように構成した本実施の形態においても、第１の実施の形態と同様の効果を得ることができる。   Also in the present embodiment configured as described above, the same effects as those of the first embodiment can be obtained.

また、試薬中の磁性粒子１５が試薬容器１３の底部に沈降して凝縮していても、超音波振動子１９からの超音波により磁性粒子１５同士の結合が弱めるので、試薬容器１３中の試薬全体をより短時間でより確実に攪拌することができる。   Even if the magnetic particles 15 in the reagent are settled and condensed on the bottom of the reagent container 13, the bonds between the magnetic particles 15 are weakened by the ultrasonic waves from the ultrasonic vibrator 19, so that the reagent in the reagent container 13 The whole can be stirred more reliably in a shorter time.

本発明の第４の実施の形態を図４を用いて説明する。   A fourth embodiment of the present invention will be described with reference to FIG.

上記第１の実施の形態においては、試薬中に気体を吐出することにより縦旋回流を発生させたのに対し、本実施の形態においては、攪拌羽根１を攪拌軸２の軸方向に振動させることより縦旋回流を発生させる。図中、図１に示した部材と同様のものには同じ符号を付し、説明を省略する。   In the first embodiment, a vertical swirling flow is generated by discharging a gas into the reagent, whereas in this embodiment, the stirring blade 1 is vibrated in the axial direction of the stirring shaft 2. Therefore, a vertical swirl flow is generated. In the figure, the same members as those shown in FIG.

図４は、本実施の形態に係る攪拌装置の全体構成をその攪拌対象である試薬と共に示す図である。   FIG. 4 is a diagram showing the overall configuration of the stirring device according to the present embodiment, together with the reagent that is the stirring target.

図４において、本実施の形態の攪拌装置は、軸方向を上下方向に向けて配置された攪拌軸２と、攪拌軸２の下端に設けられた複数（例えば２つ）の攪拌羽根１と、攪拌軸２の上端に設けられ、この攪拌軸２を回転駆動する回転駆動装置３と、回転駆動装置３と駆動軸４を介して連結され、回転駆動装置３を上下方向（攪拌軸２の軸方向）に駆動する上下駆動装置５とに加え、攪拌軸２の上端に設けられた振動装置２０を備えている。   In FIG. 4, the stirring device of the present embodiment includes a stirring shaft 2 arranged with its axial direction directed in the vertical direction, and a plurality of (for example, two) stirring blades 1 provided at the lower end of the stirring shaft 2, The rotary drive device 3 is provided at the upper end of the stirring shaft 2 and is connected to the rotary drive device 3 for rotationally driving the stirring shaft 2 via the rotary drive device 3 and the drive shaft 4. In addition to the vertical drive device 5 driven in the direction), a vibration device 20 provided at the upper end of the stirring shaft 2 is provided.

振動装置２０は、攪拌軸２０を軸方向に振動させる。攪拌軸２の下端が試薬中に浸漬された状態で、振動装置２０により攪拌軸２を軸方向に振動させると、これに伴って攪拌軸２の下端に設けられた攪拌羽根１が試薬中において軸方向に振動し、この攪拌羽根１の振動により試薬中に攪拌軸２の軸方向下向きの流れ（縦旋回流）が発生し、これにより試薬が攪拌される。   The vibration device 20 vibrates the stirring shaft 20 in the axial direction. When the stirring shaft 2 is vibrated in the axial direction by the vibration device 20 in a state in which the lower end of the stirring shaft 2 is immersed in the reagent, the stirring blade 1 provided at the lower end of the stirring shaft 2 is accordingly moved in the reagent. It vibrates in the axial direction, and the vibration of the stirring blade 1 generates a downward flow (longitudinal swirl flow) of the stirring shaft 2 in the reagent, thereby stirring the reagent.

その他の構成は第１の実施の形態と同様である。   Other configurations are the same as those of the first embodiment.

次に、以上のように構成した本実施の形態の動作及び作用効果を順次説明する。   Next, operations and effects of the present embodiment configured as described above will be sequentially described.

オペレータは、攪拌対象である試薬が入れられた試薬容器１３を、その開口部の中心が攪拌軸２の真下付近となるように配置する。次に、上下駆動装置５により攪拌軸２を下方向に移動させて攪拌羽根１を試薬中（試薬容器１３の底面部付近）に浸漬する。この状態で、回転駆動装置３により攪拌軸２を回転駆動させ、試薬中に横旋回流を誘起すると同時に、振動装置２０により攪拌羽根１（攪拌軸）を振動させ、試薬中に縦旋回流を誘起する。   The operator arranges the reagent container 13 in which the reagent to be agitated is placed so that the center of the opening is directly below the agitation shaft 2. Next, the stirring shaft 2 is moved downward by the vertical drive device 5 to immerse the stirring blade 1 in the reagent (near the bottom surface of the reagent container 13). In this state, the agitation shaft 2 is rotationally driven by the rotation driving device 3 to induce a transverse swirling flow in the reagent, and at the same time, the agitating blade 1 (stirring shaft) is vibrated by the vibration device 20 to cause a vertical swirling flow in the reagent. Induce.

以上のように構成した本実施の形態においても、第１の実施の形態と同様の効果を得ることができる。   Also in the present embodiment configured as described above, the same effects as those of the first embodiment can be obtained.

また、振動装置２０を攪拌軸２の上端に設け、攪拌軸２を軸方向に振動させることにより攪拌羽根１を振動させるよう構成したので、振動装置２０が試薬容器１３の中に挿入可能な大きさである必要がなく、したがって、本実施の形態の攪拌装置に必要な大きさの振動装置２０をより容易に得ることができる。   Further, since the vibration device 20 is provided at the upper end of the stirring shaft 2 and the stirring blade 1 is vibrated by vibrating the stirring shaft 2 in the axial direction, the vibration device 20 can be inserted into the reagent container 13. Therefore, the vibration device 20 having a size necessary for the stirring device according to the present embodiment can be obtained more easily.

本発明の第５の実施の形態を図５を用いて説明する。   A fifth embodiment of the present invention will be described with reference to FIG.

本実施の形態は、上記第４の実施の形態において、攪拌軸２に縦旋回流を発生させるための撹拌板をそなえたものである。図中、図１及び図４に示した部材と同様のものには同じ符号を付し、説明を省略する。   In the fourth embodiment, a stirring plate for generating a vertical swirling flow is provided on the stirring shaft 2 in the fourth embodiment. In the figure, the same members as those shown in FIGS. 1 and 4 are denoted by the same reference numerals, and description thereof is omitted.

図５は、本実施の形態に係る攪拌装置の全体構成をその攪拌対象である試薬と共に示す図である。   FIG. 5 is a diagram showing the entire configuration of the stirring apparatus according to the present embodiment, together with the reagent that is the stirring target.

図５において、本実施の形態の攪拌装置は、軸方向を上下方向に向けて配置された攪拌軸２と、攪拌軸２の下端に設けられた複数（例えば２つ）の攪拌羽根１と、攪拌軸２の上端に設けられ、この攪拌軸２を回転駆動する回転駆動装置３と、回転駆動装置３と駆動軸４を介して連結され、回転駆動装置３を上下方向（攪拌軸２の軸方向）に駆動する上下駆動装置５と、攪拌軸２を軸方向に振動する振動装置２０とに加え、攪拌軸２に設けられ、振動装置２０による攪拌軸２の振動を試薬に伝達する攪拌板２１を備えている。   In FIG. 5, the stirring device of the present embodiment includes a stirring shaft 2 arranged with its axial direction directed in the vertical direction, and a plurality of (for example, two) stirring blades 1 provided at the lower end of the stirring shaft 2, The rotary drive device 3 is provided at the upper end of the stirring shaft 2 and is connected to the rotary drive device 3 for rotationally driving the stirring shaft 2 via the rotary drive device 3 and the drive shaft 4. In addition to the vertical drive device 5 that drives the stirring shaft 2 in the axial direction and the vibration device 20 that vibrates the stirring shaft 2 in the axial direction. 21 is provided.

攪拌板２１は略円盤状の部材であり、その中心部に攪拌軸２を通すように配置され、攪拌軸２に対して垂直に固定されている。攪拌板２１は、攪拌軸２における攪拌羽根１の上側かつ試薬に浸漬される部分に配置されており、試薬の攪拌を行う場合には、攪拌羽根１と共に試薬中に浸漬される。この攪拌板２１の直径は、試薬容器１３の開口部を通過可能な大きさであり、例えば、試薬容器１３の開口部の直径とほぼ同じ大きさである。   The stirring plate 21 is a substantially disk-shaped member, and is disposed so that the stirring shaft 2 passes through the center thereof, and is fixed perpendicularly to the stirring shaft 2. The stirring plate 21 is disposed on the stirring shaft 2 above the stirring blade 1 and in a portion immersed in the reagent. When stirring the reagent, the stirring plate 21 is immersed in the reagent together with the stirring blade 1. The diameter of the stirring plate 21 is large enough to pass through the opening of the reagent container 13 and is, for example, approximately the same as the diameter of the opening of the reagent container 13.

攪拌軸２の下端、すなわち、振動羽根１及び攪拌板２１が試薬中に浸漬された状態で、振動装置２０により攪拌軸２を軸方向に振動させると、これに伴って攪拌軸２に設けられた攪拌羽根１及び攪拌板２１が試薬中において軸方向に振動し、この攪拌羽根１及び攪拌板２１の振動により試薬中に攪拌軸２の軸方向下向きの流れ（縦旋回流）が発生し、これにより試薬が攪拌される。   When the stirring shaft 2 is vibrated in the axial direction by the vibration device 20 in a state where the lower end of the stirring shaft 2, that is, the vibrating blade 1 and the stirring plate 21 are immersed in the reagent, the stirring shaft 2 is provided along with this. The stirring blade 1 and the stirring plate 21 vibrate in the axial direction in the reagent, and the vibration of the stirring blade 1 and the stirring plate 21 generates a downward flow (longitudinal swirling flow) of the stirring shaft 2 in the reagent. This stirs the reagent.

その他の構成は、第４の実施の形態と同様である。   Other configurations are the same as those of the fourth embodiment.

次に、以上のように構成した本実施の形態の動作及び作用効果を順次説明する。   Next, operations and effects of the present embodiment configured as described above will be sequentially described.

オペレータは、攪拌対象である試薬が入れられた試薬容器１３を、その開口部の中心が攪拌軸２の真下付近となるように配置する。次に、上下駆動装置５により攪拌軸２を下方向に移動させて攪拌羽根１及び撹拌板２１を試薬中（試薬容器１３の底面部付近）に浸漬する。この状態で、回転駆動装置３により攪拌軸２を回転駆動させ、試薬中に横旋回流を誘起すると同時に、振動装置２０により攪拌羽根１（攪拌軸）及び撹拌板２１を振動させ、試薬中に縦旋回流を誘起する。   The operator arranges the reagent container 13 in which the reagent to be agitated is placed so that the center of the opening is directly below the agitation shaft 2. Next, the stirring shaft 2 is moved downward by the vertical drive device 5 so that the stirring blade 1 and the stirring plate 21 are immersed in the reagent (near the bottom surface of the reagent container 13). In this state, the agitation shaft 2 is rotationally driven by the rotation drive device 3 to induce a transverse swirling flow in the reagent, and at the same time, the agitation blade 1 (agitation shaft) and the agitation plate 21 are vibrated by the vibration device 20 to enter the reagent. Induces longitudinal swirl.

以上のように構成した本実施の形態においても、第１の実施の形態と同様の効果を得ることができる。   Also in the present embodiment configured as described above, the same effects as those of the first embodiment can be obtained.

また、攪拌羽根１よりも攪拌軸２の軸方向に対する流体抵抗が大きな攪拌板２１を設け、この攪拌板２１を攪拌羽根１と同時に攪拌軸２の軸方向に振動するように構成したので、攪拌羽根１のみが軸方向に振動する場合と比較してより強い乱流（縦旋回流）が試薬中に発生し、試薬容器１３中の試薬全体をより短時間でより確実に攪拌することができる。   In addition, a stirring plate 21 having a larger fluid resistance in the axial direction of the stirring shaft 2 than the stirring blade 1 is provided, and the stirring plate 21 is configured to vibrate in the axial direction of the stirring shaft 2 simultaneously with the stirring blade 1. Compared with the case where only the blade 1 vibrates in the axial direction, a stronger turbulent flow (longitudinal swirl flow) is generated in the reagent, and the entire reagent in the reagent container 13 can be stirred more reliably in a shorter time. .

本発明の第１の実施の形態に係る攪拌装置の全体構成を示す図である。It is a figure which shows the whole structure of the stirring apparatus which concerns on the 1st Embodiment of this invention. 本発明の第２の実施の形態に係る攪拌装置の全体構成を示す図である。It is a figure which shows the whole structure of the stirring apparatus which concerns on the 2nd Embodiment of this invention. 本発明の第３の実施の形態に係る攪拌装置の全体構成を示す図である。It is a figure which shows the whole structure of the stirring apparatus which concerns on the 3rd Embodiment of this invention. 本発明の第４の実施の形態に係る攪拌装置の全体構成を示す図である。It is a figure which shows the whole structure of the stirring apparatus which concerns on the 4th Embodiment of this invention. 本発明の第５の実施の形態に係る攪拌装置の全体構成を示す図である。It is a figure which shows the whole structure of the stirring apparatus which concerns on the 5th Embodiment of this invention.

符号の説明Explanation of symbols

１ 攪拌羽根
２ 攪拌軸
３ 回転駆動装置
４ 駆動軸
５ 駆動装置
６ 気体ポンプ
７ 気体搬送管
８ バルブ
９，１０ プーリ
１１ 伝達ベルト
１２ モータ
１３ 試薬容器
１４ 緩衝液
１５ 磁性粒子
１６ シリンジ
１７ ピストン部
１８ 駆動装置
１９ 超音波振動子
２０ 振動装置
２１ 攪拌板 DESCRIPTION OF SYMBOLS 1 Stirring blade 2 Stirring shaft 3 Rotation drive device 4 Drive shaft 5 Drive device 6 Gas pump 7 Gas conveyance pipe 8 Valve 9, 10 Pulley 11 Transmission belt 12 Motor 13 Reagent container 14 Buffer solution 15 Magnetic particle 16 Syringe 17 Piston part 18 Drive Device 19 Ultrasonic vibrator 20 Vibration device 21 Stirring plate

Claims (7)

磁性粒子を含んだ試薬に一端を浸漬する回転軸と、
前記回転軸を回転駆動させる回転駆動手段と、
前記回転軸を軸方向に駆動させる軸方向駆動手段と、
前記回転軸の浸漬部分に前記回転軸の径方向に突出して設けられ、前記試薬に前記回転軸の周方向の流れを発生させる攪拌羽根と、
前記試薬に前記回転軸の軸方向の流れを発生させる縦旋回流発生手段と
を備えたことを特徴とする攪拌装置。 A rotating shaft that immerses one end in a reagent containing magnetic particles;
Rotation driving means for rotating the rotation shaft;
Axial driving means for driving the rotating shaft in the axial direction;
An agitating blade provided in the immersion portion of the rotating shaft so as to protrude in the radial direction of the rotating shaft, and causing the reagent to generate a flow in the circumferential direction of the rotating shaft;
A stirrer characterized by comprising a vertical swirling flow generating means for generating a flow in the axial direction of the rotating shaft in the reagent. 請求項１記載の攪拌装置において、
前記縦旋回流発生手段は、前記回転軸の軸内に貫通して設けられた気体搬送路と、
前記気体搬送路に気体を供給する気体供給手段とを備えたことを特徴とする攪拌装置。 The stirrer according to claim 1, wherein
The vertical swirl flow generating means includes a gas conveyance path provided penetrating in the axis of the rotating shaft,
A stirrer comprising gas supply means for supplying gas to the gas conveyance path. 請求項１記載の攪拌装置において、
前記縦旋回流発生手段は、前記回転軸の回転軸内に軸方向に貫通して設けられた液体搬送路と、
前記液体搬送路における前記攪拌羽根と反対側の一端に接続され、前記試薬を前記液体搬送路に吸引し、液体搬送路から吐出する吸引吐出手段とを備えたことを特徴とする攪拌装置。 The stirrer according to claim 1, wherein
The vertical swirl flow generating means includes a liquid transport path provided in an axial direction in the rotation shaft of the rotation shaft;
An agitation apparatus comprising: an aspiration / discharge means connected to one end of the liquid conveyance path opposite to the agitation blade, for aspirating the reagent into the liquid conveyance path and discharging the reagent from the liquid conveyance path. 請求項１記載の攪拌装置において、
前記縦旋回流発生手段は、前記回転軸の前記攪拌羽根側の一端に設けられ、前記回転軸の軸方向に超音波を照射する超音波振動子であることを特徴とする攪拌装置。 The stirrer according to claim 1, wherein
The stirring device, wherein the vertical swirling flow generating means is an ultrasonic vibrator that is provided at one end of the rotating shaft on the stirring blade side and that emits ultrasonic waves in the axial direction of the rotating shaft. 請求項１記載の攪拌装置において、
前記縦旋回流発生手段は、前記回転軸に設けられ、その回転軸を軸方向に振動させる振動手段であることを特徴とする攪拌装置。 The stirrer according to claim 1, wherein
The agitating device, wherein the vertical swirling flow generating means is a vibrating means provided on the rotating shaft and vibrates the rotating shaft in the axial direction. 請求項５記載の攪拌装置において、
前記回転軸の浸漬部分に径方向に突出した攪拌板をさらに備えたことを特徴とする攪拌装置。 The stirrer according to claim 5, wherein
The stirring device further comprising a stirring plate protruding in a radial direction at an immersion portion of the rotating shaft. 請求項１乃至６の何れか１項に記載の攪拌装置を備えた自動分析装置。   The automatic analyzer provided with the stirring apparatus of any one of Claims 1 thru | or 6.
JP2008140174A 2008-05-28 2008-05-28 Stirrer and autoanalyzer using the same Pending JP2009288031A (en)

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