JP2009210483A - Automatic analysis apparatus and temperature management method of liquid sample - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an automatic analysis apparatus and a temperature management method of a liquid sample for speedily making the temperature of the liquid sample into a target temperature without separately disposing a preheating means of the liquid sample when a reaction tub for keeping the liquid sample at the target temperature is used. <P>SOLUTION: The automatic analysis apparatus having the reaction tub and the temperature management method of the liquid sample are provided. The automatic analysis apparatus 1 includes: a stirring device 20 for stirring the liquid sample with sound wave issued by a surface acoustic wave element 24 attached to each reaction vessel 5; and a stirring control section for controlling the driving condition of the surface acoustic wave element. In stirring the liquid sample, the stirring control section controls the driving condition of the surface acoustic wave element so that insufficient heat quantity calculated from the difference between the target temperature of the reaction tub 4 and the temperature of the liquid sample, the amount of the liquid sample, and specific heat is equal to the heat quantity of temperature increase of the liquid sample by absorption of sound wave. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to an automatic analyzer and a temperature management method for a liquid sample.

  Conventionally, an automatic analyzer controls a liquid sample containing a sample and a reagent dispensed in a reaction container by heating to a target temperature (for example, 37 ° C.) and reacting it to a target temperature under a so-called dry method. Some reaction vessels hold reaction vessels (see, for example, Patent Document 1). Here, the automatic analyzer cools the reagent container containing the reagent in a reagent cooler cooler than the reaction tank. For this reason, automatic analyzers that use dry bath reaction vessels drop the temperature of the reaction vessel and its surroundings when dispensing low-temperature reagents, and the liquid sample reaches the target temperature compared to wet bath reaction vessels. Since it takes a long time to reach the target and the inspection results vary, a preheating means is provided to heat the temperature of the liquid sample to the target temperature.

JP 2007-248252 A

  By the way, since the automatic analyzer is provided with many components, the degree of freedom in design is limited, and there are many design difficulties in providing the preheating means.

  The present invention has been made in view of the above, and when a reaction vessel that keeps a liquid sample at a target temperature is used, the temperature of the liquid sample can be quickly increased without providing a separate preheating means for the liquid sample. An object of the present invention is to provide an automatic analyzer capable of setting a target temperature and a temperature management method for a liquid sample.

  In order to solve the above-described problems and achieve the object, the automatic analyzer of the present invention holds a plurality of reaction containers into which a liquid sample containing a specimen and a reagent is dispensed, and keeps the liquid sample at a target temperature. An automatic analyzer for agitating and reacting the liquid sample and analyzing the reaction liquid, wherein the liquid sample is agitated by a sound wave generated by a surface acoustic wave element attached to each reaction vessel. And a control means for controlling the driving condition of the surface acoustic wave element, wherein the control means utilizes the rise in temperature of the liquid sample due to absorption of the sound wave during stirring of the liquid sample, and The driving condition of the surface acoustic wave element is controlled so as to compensate for a temperature difference from the liquid sample lower than a target temperature, an amount of the liquid sample, and an insufficient heat amount calculated from specific heat.

  In the automatic analyzer of the present invention, in the above invention, the control means may be configured such that the environmental temperature of the analyzer is the temperature of the sample, the temperature of the reagent cooler storing the reagent, or the temperature of the reagent cooler. The temperature calculated from the temperature of the dilution water discharged from the reagent dispensing device to dilute the reagent is set as the temperature of the reagent, the temperature of the sample and the reagent, the dispensing amount information of the sample and the reagent, and the specific heat The deficient heat amount is calculated for each reaction vessel based on the information, and the driving condition of the surface acoustic wave element is controlled so as to compensate for the deficient heat amount.

  In the automatic analyzer of the present invention, in the above invention, the control means acquires the amount of the sample and the reagent to be dispensed from the dispensed amount for each analysis item input to the automatic analyzer. It is characterized by that.

  In the automatic analyzer according to the present invention as set forth in the invention described above, the control means controls at least one of a driving time, a driving voltage, a driving power, and a driving frequency as a driving condition of the surface acoustic wave element. It is characterized by that.

  In order to solve the above-described problems and achieve the object, the temperature management method for a liquid sample of the present invention holds a plurality of reaction containers into which a liquid sample containing a specimen and a reagent is dispensed, and the liquid sample A temperature control method for the liquid sample dispensed into the reaction vessel in an automatic analyzer that analyzes the reaction liquid by stirring and reacting the liquid sample. A calculation step of calculating a deficient heat amount of the liquid sample from a temperature difference with the liquid sample lower than the temperature, a quantity of the liquid sample and a specific heat, and the surface acoustic wave so as to compensate for the deficient heat amount calculated in the calculation step And a heating step of heating the liquid sample by controlling the driving conditions of the element.

  Here, in the present invention, a liquid sample containing a specimen and a reagent means a specimen or reagent (including a concentrated reagent) dispensed into a reaction container for the purpose of analyzing the specimen. Water for the purpose of washing the dispensing probe is referred to as “dilution water” means water discharged by the dispensing mechanism for the purpose of diluting the liquid sample.

  The automatic analyzer of the present invention includes a stirring unit that stirs a liquid sample by sound waves generated by the surface acoustic wave elements attached to each reaction vessel, and a control unit that controls the driving conditions of the surface acoustic wave elements. Using the rise in temperature of the liquid sample due to absorption of sound waves during stirring of the liquid sample, the temperature difference from the liquid sample lower than the target temperature, the amount of liquid sample, and the shortage of heat calculated from the specific heat are compensated The driving condition of the surface acoustic wave device is controlled, and the temperature management method of the liquid sample calculates the insufficient heat amount of the liquid sample from the temperature difference from the liquid sample lower than the target temperature, the amount of the liquid sample, and the specific heat. Since it includes a calculation step and a heating step for heating the liquid sample by controlling the driving conditions of the surface acoustic wave element so as to compensate for the insufficient heat amount calculated in the calculation step, Liquid to do Even if a preheating means for the sample is not separately provided, the temperature of the liquid sample lower than the target temperature can be quickly set to the target temperature by controlling the driving conditions of the surface acoustic wave element for stirring the liquid sample. Play.

  Hereinafter, embodiments of the automatic analyzer and the temperature management method for a liquid sample according to the present invention will be described in detail with reference to the drawings. FIG. 1 is a schematic configuration diagram of an automatic analyzer according to the present invention. FIG. 2 is a block diagram showing a configuration of the automatic analyzer of FIG. FIG. 3 is a perspective view of a reaction vessel used in the automatic analyzer of FIG. 1 and having a surface acoustic wave element attached thereto.

  As shown in FIGS. 1 and 2, the automatic analyzer 1 includes reagent cold storages 2 and 3, a reaction tank 4, a specimen container transfer mechanism 8, an analysis optical system 12, a cleaning mechanism 13, a control unit 15, and a stirring device 20. A temperature sensor (not shown) for detecting the environmental temperature of the automatic analyzer 1 is provided in the vicinity of the sample container transfer mechanism 8. The environmental temperature detected by the temperature sensor is output to the control unit 15 as temperature information of the specimen.

  As shown in FIG. 1, the reagent coolers 2 and 3 hold a plurality of reagent containers 2a and 3a arranged in the circumferential direction, respectively, and are rotated by driving means (not shown) to move the reagent containers 2a and 3a in the circumferential direction. It has a turntable to convey. At this time, the reagent cooler 2 holds the reagent container 2a containing the first reagent, and the reagent cooler 3 holds the reagent container 3a containing the second reagent. The reagent coolers 2 and 3 are each provided with a cooling device that cools the inside to a predetermined temperature and a temperature sensor that detects the cooling temperature, and the reagent is kept at a predetermined temperature by the cold air supplied from each cooling device. ing. The cooling temperature detected by each temperature sensor is output to the control unit 15 as temperature information. The reagent coolers 2 and 3 are internally cooled to a predetermined temperature by controlling the cooling device by the control unit 15 based on the temperature information. Therefore, the liquid sample containing the specimen and the reagent dispensed into the reaction vessel 5 is always at a lower temperature than the target temperature of the reaction vessel 4.

  The reaction tank 4 is heated to a preset target temperature (for example, 37 ° C.) by heating means controlled by the control unit 15, and as shown in FIG. 1, a plurality of reaction vessels 5 are arranged along the circumferential direction. Thus, this is a dry bath type reaction tank that is forwardly or reversely rotated in a direction indicated by an arrow by a driving means (not shown) and conveys the reaction vessel 5 in a heated state.

  As shown in FIG. 3, the reaction vessel 5 is a vessel made of an optically transparent material and made of a square cylinder having a holding portion 5a for holding a liquid, and the surface acoustic wave element 24 is integrated with the side wall 5c. It is attached. The reaction vessel 5 is made of a material that transmits 80% or more of the light contained in the analysis light emitted from the analysis optical system 12 to be described later, such as glass including heat-resistant glass, synthetic resin such as cyclic olefin and polystyrene. . The reaction vessel 5 is used as a photometric window 5b in which a portion surrounded by a dotted line on the lower side adjacent to a portion to which the surface acoustic wave element 24 is attached transmits the analysis light. The reaction container 5 is set in the reaction tank 4 with the surface acoustic wave element 24 facing outward, and as shown in FIG. 1, the reagent dispensing mechanisms 6 and 7 remove the reagent containers 2a and 3a from the reagent containers 2a and 3a. Reagent is dispensed.

  The reagent dispensing mechanisms 6 and 7 are provided with probes 6b and 7b for dispensing reagents on arms 6a and 7a that rotate in the direction of the arrow in the horizontal plane, respectively, and a cleaning means for cleaning the probes 6b and 7b with cleaning water ( (Not shown). Dilution water is used to dilute the reagent. The dilution water is also used for cleaning the probes 6b and 7b. The dilution water is used to dilute the dispensed reagent to a desired concentration by discharging the reagent excessively when the reagent is dispensed. At this time, the reagent dispensing mechanisms 6 and 7 are provided with temperature sensors that detect the temperature of the dilution water in pipes that guide the dilution water from the respective dilution water tanks to the probes 6b and 7b. The temperature sensor is preferably provided on the probe 6b, 7b side of the pipe.

  As shown in FIG. 1, the sample container transfer mechanism 8 is a transfer unit that transfers a plurality of racks 10 arranged in the feeder 9 one by one along the arrow direction, and transfers the racks 10 while stepping. The rack 10 holds a plurality of sample containers 10a containing samples. The sample held in the sample container 10a is dispensed to each reaction container 5 by the sample dispensing mechanism 11 every time the step of the rack 10 transferred by the sample container transfer mechanism 8 stops. Here, a temperature sensor (not shown) for detecting the environmental temperature of the automatic analyzer 1 is provided in the vicinity of the specimen container transfer mechanism 8. The environmental temperature detected by the temperature sensor is output to the control unit 15 as temperature information of the specimen.

  As shown in FIG. 1, the sample dispensing mechanism 11 has an arm 11a that rotates in the horizontal direction and a probe 11b, and a cleaning means (not shown) for cleaning the probe 11b after sample dispensing with cleaning water. Are arranged on the movement path of the probe 11b.

  The analysis optical system 12 emits analysis light for analyzing the liquid sample in the reaction vessel 5 in which the reagent and the sample have reacted. As shown in FIG. 1, the light emitting unit 12a, the spectroscopic unit 12b, and the light receiving unit. 12c. The analysis light emitted from the light emitting unit 12a passes through the liquid sample in the reaction vessel 5 and is received by the light receiving unit 12c provided at a position facing the spectroscopic unit 12b. The light receiving unit 12 c is connected to the control unit 15.

  The cleaning mechanism 13 sucks and discharges the liquid sample in the reaction vessel 5 with the nozzle 13a, and then repeatedly injects and sucks detergent, washing water, and the like with the nozzle 13a, thereby completing the analysis by the analysis optical system 12. The container 5 is washed.

  As shown in FIG. 2, the control unit 15 is connected to each unit of the automatic analyzer 1 to control the operation of each unit, and in the reaction container 5 based on the amount of light emitted from the light emitting unit 12 a and the amount of light received by the light receiving unit 12 c. Based on the absorbance of the liquid sample, the component and concentration of the specimen are analyzed. For example, a control means such as a microcomputer is used. As shown in FIGS. 1 and 2, the control unit 15 is connected to an input unit 16 such as a keyboard and a display unit 17 such as a display panel, and includes a drive control unit 15a, an information management unit 15b, a calculation unit 15c, and an agitation control unit. 15d.

  The drive control unit 15a controls driving of various drive units in the automatic analyzer 1, such as the reagent cold storages 2 and 3. The information management unit 15b manages management information such as temperature information and dispensed amount information related to the specimen and the reagent. That is, the information management unit 15b receives the sample temperature information input from the temperature sensor provided in the vicinity of the sample container transfer mechanism 8, the temperature information of the reagent input from the temperature sensor provided in the reagent coolers 2 and 3, and the reagent amount. Each reaction container 5 based on the temperature information of the dilution water input from the temperature sensor provided in the piping of the injection mechanisms 6 and 7, the target temperature information of the reaction tank 4, and the analysis information of the sample input from the host computer to the control unit 15. Management information such as the amount of sample and reagent to be dispensed and the amount of dispensing water related to the amount of dilution water, and specific heat information relating to a plurality of samples and reagents inputted in advance are managed.

  The calculation unit 15c includes temperature information, dispensing amount information, target temperature information of the reaction tank 4, temperature information of reagents and samples and dilution water input from each temperature sensor, samples and reagents managed by the information management unit 15b. The calorific value is calculated for each reaction vessel 5 based on the specific heat information and the management information such as the sample dispensing amount and the reagent dispensing amount. When the reagent is diluted with diluting water in the calculation of the insufficient heat amount, the calculating unit 15c calculates the temperature calculated based on the temperature of the reagent cold storage, the temperature of the diluting water, the amount of the reagent, and the amount of the diluting water. Use as a temperature.

  The stirring control unit 15d utilizes the temperature rise of the liquid sample due to absorption of sound waves when stirring the liquid sample, the temperature difference from the liquid sample that is lower than the target temperature of the reaction tank 4, the amount of liquid sample, and the specific heat Is a control means for controlling the driving conditions of the surface acoustic wave element 24 so as to compensate for the insufficient heat quantity calculated from the above, and controls the power transmission body 21 to generate a driving power consisting of a high-frequency signal of about several MHz to several hundred MHz to surface elasticity. The wave element 24 is made to output. At this time, the stirring control unit 15 d controls the driving condition of the surface acoustic wave element 24 based on the control signal input from the input unit 16. For example, the agitation control unit 15d controls at least one of the driving time, driving voltage, driving power, and driving frequency of the surface acoustic wave element 24. For this reason, the stirring control unit 15d has a correspondence table regarding the relationship between the shortage of heat obtained from the temperature difference between the target temperature and the liquid sample, the amount of the liquid sample, and the specific heat, and the driving time, driving voltage, driving power, and driving frequency. And graphs are stored.

  The stirrer 20 is a stirrer that stirs a liquid sample containing a specimen and a reagent dispensed into the reaction vessel 5 in a non-contact manner using sound waves. As shown in FIG. 1, as shown in FIG. have.

  The power transmission body 21 is disposed in a position facing the reaction vessel 5 in the horizontal direction at positions facing each other on the outer periphery of the reaction tank 4, and from a high frequency drive signal of about several MHz to several hundred MHz based on power supplied from a power source. Is transmitted to the surface acoustic wave element 24. As shown in FIG. 4, the power transmission body 21 has a brush-like contactor 21 a that abuts on the electrical terminal 24 c of the surface acoustic wave element 24. At this time, as shown in FIG. 1, the power transmission body 21 is supported by the arrangement determining member 22, and transmits driving power from the contact 21 a to the electrical terminal 24 c when the reaction tank 4 stops rotating.

  The operation of the arrangement determining member 22 is controlled by the control unit 15, and during power transmission in which driving power is transmitted from the power transmission body 21 to the electrical terminal 24 c, the reaction tank 4 between the power transmission body 21 and the electrical terminal 24 c is moved by moving the power transmission body 21. For example, a two-axis stage is used. Specifically, the arrangement determining member 22 is stopped during non-power transmission when the reaction tank 4 rotates and the driving power is not transmitted from the power transmission body 21 to the electric terminal 24c. 24c is kept at a constant distance. And the arrangement | positioning determination member 22 act | operates under control of the control part 15, and moves the power transmission body 21 at the time of the power transmission which the reaction tank 4 stops and transmits the drive power from the power transmission body 21 to the electrical terminal 24c. The position along the circumferential direction of the reaction tank 4 is adjusted so that the body 21 and the electrical terminal 24c face each other, and the contactor 21a and the electrical terminal 24c are brought into contact with each other by bringing the power transmission body 21 and the electrical terminal 24c close to each other. Thus, the relative arrangement of the power transmission body 21 and the electrical terminal 24c is determined.

  As shown in FIG. 3, the surface acoustic wave element 24 is provided with a vibrator 24b made of a comb electrode (IDT) on the surface of a substrate 24a. The vibrator 24b is a sound wave generating unit that converts electric power transmitted from the power transmitting body 21 into a surface acoustic wave (ultrasonic wave), and is connected to an electric terminal 24c serving as a power receiving unit by a conductor circuit 24d. The surface acoustic wave element 24 is attached to the side wall 5c of the reaction vessel 5 through an acoustic matching layer such as an epoxy resin with the vibrator 24b, the electric terminal 24c and the conductor circuit 24d facing outward.

  Here, the surface acoustic wave (ultrasonic wave) generated by the surface acoustic wave element 24 leaks from the side wall 5c to the liquid sample in the reaction vessel 5 to stir the liquid sample, but a part is absorbed by the liquid sample. To increase the temperature of the liquid sample. In the present invention, when the liquid sample is stirred, the insufficient heat quantity of the liquid sample is complemented by using the temperature rise of the liquid sample, and the liquid sample is heated to the target temperature. Therefore, the reaction vessel 5 grasps in advance the ratio between the surface acoustic wave (ultrasonic wave) used for stirring and the surface acoustic wave (ultrasonic wave) used for increasing the temperature of the liquid sample. The agitation control unit 15d controls the driving conditions of the surface acoustic wave element 24 in consideration of this ratio.

  In the automatic analyzer 1 configured as described above, the reagent dispensing mechanism 6 sequentially dispenses the first reagent from the reagent container 2a to the plurality of reaction containers 5 conveyed along the circumferential direction by the rotating reaction tank 4. After the injection, the specimens are sequentially dispensed from the plurality of specimen containers 10 a held in the rack 10 by the specimen dispensing mechanism 11 into the plurality of reaction containers 5. After dispensing the sample, in the automatic analyzer 1, the reagent dispensing mechanism 7 sequentially dispenses the second reagent from the reagent container 3a into the plurality of reaction containers 5. During this time, in the reaction container 5, the liquid sample containing the reagent and the sample dispensed by the stirring device 20 is stirred at each timing after dispensing the first reagent, after dispensing the sample, and after dispensing the second reagent. At the same time, when the reagent and the sample react and the reaction tank 4 rotates again, it passes through the analysis optical system 12. When the reaction container 5 passes through the analysis optical system 12, the liquid sample in the reaction container 5 is side-lighted by the light receiving unit 12c, and the control unit 15 analyzes the component, concentration, and the like. Then, after the analysis is completed, the reaction vessel 5 is washed by the washing mechanism 13 and then used again for analyzing the specimen.

  At this time, the control unit 15 manages the temperature of the liquid sample dispensed into the reaction vessel 5 as follows. Hereinafter, the temperature management method of the liquid sample by the control unit 15 will be described with reference to the flowchart shown in FIG.

  In the control unit 15, the calculation unit 15 c acquires management information related to temperature information, specific heat information, and dispensed amount information related to the sample and reagent dispensed for each reaction container 5 managed by the information management unit 15 b (Step S <b> 100). ). Next, in the control unit 15, the calculation unit 15c calculates an insufficient heat amount based on the management information acquired by the calculation unit 15c (step S102). Then, when the control unit 15 drives the surface acoustic wave element 24 to stir the liquid sample, the stirring control unit 15d supplements the surface acoustic wave for each reaction vessel 5 so as to complement the insufficient heat amount calculated by the calculation unit 15c. The driving condition of the element 24 is controlled, and the liquid sample is heated (step S104). The liquid sample temperature management method by the control unit 15 is individually executed for each of the plurality of reaction vessels 5 held in the reaction vessel 4.

  Accordingly, in the case of a liquid sample to be dispensed into the reaction vessel 5, for example, a very small amount of reagent having a small difference from the target temperature of the reaction tank 4, the surface acoustic wave element 24 is driven while controlling the driving condition by the stirring control unit 15d. And stir. Then, since the surface heat wave (ultrasonic wave) generated by the surface acoustic wave element 24 is absorbed by the reagent, the insufficient heat quantity of the reagent is complemented by the temperature rise of the reagent, so the temperature of the reagent is indicated by a solid line in FIG. As shown, it temporarily decreases immediately after dispensing, but quickly reaches the target temperature Tt (see solid arrow). At this time, the temperature of the reagent is measured immediately after dispensing using a temperature sensor such as a thermistor inserted into the reaction vessel 5. On the other hand, when the reaction vessel 5 in which the same reagent of the same temperature and the same amount is dispensed is left without driving the surface acoustic wave element 24 and heated by the reaction tank 4, the temperature of the reagent is shown by a broken line in FIG. It takes time to reach the target temperature Tt (see dotted arrows).

  On the other hand, the difference between the target temperature of the reaction tank 4 is large, and in the case of a reagent that is several times the amount of the reagent shown in FIG. 5, the amount of insufficient heat calculated by the calculation unit 15c is large. Driving conditions for driving the surface acoustic wave element 24, for example, driving power is increased. For this reason, as shown by the solid line in FIG. 6, the temperature of the reagent is temporarily greatly reduced immediately after dispensing, but the shortage of heat is supplemented, so that the target temperature can be quickly reached in substantially the same time as shown in FIG. The temperature Tt is reached (see solid arrow). In contrast, when the reaction vessel 5 in which the same temperature and the same amount of the same reagent are dispensed is heated only by the reaction tank 4, the temperature of the reagent changes as shown by a broken line in FIG. 6 and reaches the target temperature Tt. It takes longer time to do (see dotted arrows).

  As described above, the automatic analyzer 1 controls the driving condition of the surface acoustic wave element 24 by the control unit 15 to supplement the insufficient heat amount of the liquid sample by utilizing the temperature rise of the liquid sample accompanying stirring. The liquid sample is heated to the target temperature. For this reason, the automatic analyzer 1 can quickly set the temperature of the liquid sample to the target temperature without using a separate preheating means for the liquid sample even if the dry bath type reaction tank 4 is used. In addition, since the automatic analyzer 1 reacts the liquid sample containing the reagent and the sample heated to the target temperature, the reagent and the sample always start the reaction at the same temperature, thereby improving the reliability of the measurement value.

  Note that the automatic analyzer 1 described in the above embodiment compensates for the insufficient heat quantity of the liquid sample containing the specimen and the reagent at a temperature lower than the target temperature of the reaction tank 4, so that, for example, a reagent dispensing mechanism is provided. There is also a usage mode in which washing water is discharged in conjunction with dispensing of the concentrated reagent and used to compensate for the insufficient heat quantity of the diluted reagent obtained by diluting the concentrated reagent with the diluted water. Moreover, although the reaction tank 4 demonstrated the case of the dry bath type reaction tank, the automatic analyzer 1 of this invention may be a reaction tank in which the reaction tank 4 is not a dry bath type.

  In addition, the automatic analyzer 1 performed stirring by the surface acoustic wave element and heating for supplementing the amount of heat at each timing after dispensing the first reagent, after dispensing the sample, and after dispensing the second reagent. However, when the amount of the first reagent or the sample is small and the temperature difference between these temperatures and the target temperature of the reaction layer is small, the automatic analyzer 1 can remove the surface only after dispensing the second reagent. You may make it perform the stirring by an elastic wave element, and the heating for supplementing a calorie | heat amount.

It is a schematic block diagram of the automatic analyzer which concerns on this invention. It is a block diagram which shows the structure of the automatic analyzer of FIG. FIG. 2 is a perspective view of a reaction vessel used in the automatic analyzer of FIG. 1 and having a surface acoustic wave element attached thereto. It is a perspective view which shows the state which the power transmission body contact | abutted to the electrical terminal of the surface acoustic wave element of a container with a contactor. It is a figure which shows the temperature change in the trace amount reagent with a small difference with the target temperature of a reaction tank. It is a figure which shows the temperature change in the quantity of the reagent of the amount of several times the difference with the target temperature of a reaction tank being large, and the trace amount shown in FIG. It is a flowchart explaining the temperature management method of the liquid sample of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Automatic analyzer 2,3 Reagent cooler 4 Reaction tank 5 Reaction container 6,7 Reagent dispensing mechanism 8 Specimen container transfer mechanism 9 Feeder 10 Rack 11 Specimen dispensing mechanism 12 Analytical optics 13 Cleaning mechanism 15 Control part 16 Input part Reference Signs List 17 Display Unit 20 Stirrer 21 Power Transmitter 22 Arrangement Determination Member 24 Surface Acoustic Wave Element

Claims (5)

An automatic analyzer that holds a plurality of reaction vessels in which liquid samples containing a sample and a reagent are dispensed, and that includes a reaction tank that keeps the liquid sample at a target temperature, and the reaction is performed by stirring and reacting the liquid sample. An analyzer,
A stirring means for stirring the liquid sample by a sound wave generated by a surface acoustic wave element attached to each reaction vessel;
Control means for controlling the driving conditions of the surface acoustic wave device;
And the control means utilizes a temperature rise of the liquid sample due to absorption of the sound wave during stirring of the liquid sample, a temperature difference with the liquid sample lower than the target temperature, and the liquid sample An automatic analyzer for controlling a driving condition of the surface acoustic wave device so as to compensate for an insufficient heat amount calculated from the amount and specific heat.   The control means is configured such that the environmental temperature of the analyzer is the temperature of the sample, the temperature of the reagent that is stored in the reagent, or the temperature of the reagent that is stored in the reagent, and the dilution water that is discharged from the reagent dispensing device to dilute the reagent. The temperature calculated from the temperature is used as the temperature of the reagent, and the calorific value is calculated for each reaction vessel based on the temperature of the sample and the reagent, the dispensed amount information and specific heat information of the sample and the reagent. The automatic analyzer according to claim 1, wherein a driving condition of the surface acoustic wave element is controlled so as to compensate for the insufficient heat quantity.   The automatic analyzer according to claim 2, wherein the control means acquires the amount of the sample and the reagent to be dispensed from a dispensed amount for each analysis item input to the automatic analyzer.   The automatic analyzer according to claim 2, wherein the control unit controls at least one of a driving time, a driving voltage, a driving power, and a driving frequency as a driving condition of the surface acoustic wave element. An automatic analyzer that holds a plurality of reaction vessels in which liquid samples containing a sample and a reagent are dispensed, and that includes a reaction tank that keeps the liquid sample at a target temperature, and the reaction is performed by stirring and reacting the liquid sample. A temperature management method for a liquid sample dispensed into the reaction container in an analyzer,
A calculation step of calculating a shortage of heat of the liquid sample from a temperature difference with the liquid sample lower than the target temperature, an amount of the liquid sample and specific heat;
A heating step of heating the liquid sample by controlling a driving condition of the surface acoustic wave element so as to compensate for the insufficient heat amount calculated in the calculation step;
A temperature management method for a liquid sample, comprising:

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