JP2009107962A - Yeast extract-containing composition - Google Patents

Yeast extract-containing composition Download PDF

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JP2009107962A
JP2009107962A JP2007280771A JP2007280771A JP2009107962A JP 2009107962 A JP2009107962 A JP 2009107962A JP 2007280771 A JP2007280771 A JP 2007280771A JP 2007280771 A JP2007280771 A JP 2007280771A JP 2009107962 A JP2009107962 A JP 2009107962A
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yeast extract
containing composition
iii
yeast
content
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Naoko Nozato
直子 野里
Mariko Saito
真理子 齋藤
Kyoichi Takeda
恭一 武田
Yoshinori Iguchi
佳則 井口
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Asahi Breweries Ltd
Asahi Food and Healthcare Ltd
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Asahi Food and Healthcare Ltd
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Abstract

<P>PROBLEM TO BE SOLVED: To provide a yeast extract-containing composition which is a composition derived from a natural material utilizable as a nutritional supplement and has favorable effect on the duration of athletic performance and prophylaxis or recovery of fatigue. <P>SOLUTION: The yeast extract-containing composition comprises (I) a yeast extract with 0.1-12% vitamin B<SB>1</SB>content, (II) a yeast extract with 40-80% peptide content, and (III) a yeast extract with 5-50% glutathione content, wherein the ratio (I):(II):(III) of the (I) to the (III) is within the range of (6-3):(3-1):(2-1). Preferably, the yeast extract-containing composition has 0.1-0.16% vitamin B<SB>1</SB>content in the (I). Preferably, the yeast extract-containing composition has 60-80% peptide content in the (II). Preferably, the yeast extract-containing composition has 15-20% glutathione content in the (III). In the yeast extract-containing composition, the ratio (I):(II):(III) is preferably 4:2:1. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

本発明は、酵母エキスを含有した組成物に関する。さらに詳しくは、運動能力の持続や疲労の予防・回復、さらには慢性疲労症候群に効果を有する酵母エキス含有組成物に関する。   The present invention relates to a composition containing a yeast extract. More particularly, the present invention relates to a yeast extract-containing composition that has an effect on persistence of exercise ability, prevention / recovery of fatigue, and chronic fatigue syndrome.

従来から、肉体疲労の予防又は回復効果を目的として、種々の疲労回復飲食品もしくは医薬品が提供されてきた。近年、健康志向の高まりから、栄養補助食品として様々な食品やサプリメントが提供されているが、天然噂好の高まりから人工的な混合物よりも天然に近い素材が好まれるようになった。そのため、天然素材由来の食品やサプリメントが注目され、種々の酵母や酵母エキスの利用が検討されている。   Conventionally, various fatigue-recovered foods and drinks or pharmaceuticals have been provided for the purpose of preventing or recovering physical fatigue. In recent years, various foods and supplements have been provided as dietary supplements due to an increase in health consciousness. However, due to the growing popularity of natural rumors, materials that are closer to nature are preferred over artificial mixtures. Therefore, attention has been paid to foods and supplements derived from natural materials, and the use of various yeasts and yeast extracts has been studied.

ビール酵母やパン酵母を始めとするサッカロミセス酵母は、天然のビタミンB群、アミノ酸、ミネラル等をバランス良く含有しており、ビールやパンの製造に使われる以外にも有効活用されている。例えば、乾燥酵母は我が国において長年にわたって医薬品、食品原料、調味料などとして使われており、栄養価と安全性の高い素材として認知されている。例えば、特許文献1には、ビタミン類やグルタチオンを含有する酵母が開示されている。   Saccharomyces yeasts such as brewer's yeast and baker's yeast contain natural vitamin B groups, amino acids, minerals and the like in a well-balanced manner, and are effectively used in addition to being used for producing beer and bread. For example, dry yeast has been used in Japan for many years as a pharmaceutical, food material, seasoning, etc., and is recognized as a material with high nutritional value and safety. For example, Patent Document 1 discloses a yeast containing vitamins and glutathione.

また、酵母エキスは、従来から旨味調味料として広く利用されており、特許文献2には、飲食品の濃厚感を付与した酵母エキスとしてペプチド含有の比率を高めた酵母エキスが開示されている。しかし、疲労の予防・回復効果に関する研究は少なく、乾燥酵母と比較して人間の健康増進を目的とした用途には殆ど使われていなかったため、今後の開発が期待されている。
このような酵母エキスとして、例えば、特許文献3には、肉体の疲労予防・疲労に関するビタミンBを含有する酵母エキスが開示されている。また、非特許文献1には、グルタチオン高含有の酵母エキスが開示されている。
特開2003‐180338号公報 特開2005‐245438号公報 特開2005‐239550号公報 月刊フードケミカル,’91/10,70‐74(1991)
Yeast extract has been widely used as an umami seasoning. Patent Document 2 discloses a yeast extract having a high peptide-containing ratio as a yeast extract imparting a rich feeling of food and drink. However, there is little research on the prevention and recovery effect of fatigue, and it has been rarely used for the purpose of promoting human health compared to dry yeast, so future development is expected.
Such yeast extract, for example, Patent Document 3, the yeast extract is disclosed containing Vitamin B 1 relates to physical fatigue prevention and fatigue. Non-Patent Document 1 discloses a yeast extract having a high glutathione content.
JP 2003-180338 A JP 2005-245438 A JP 2005-239550 A Monthly Food Chemical, '91 / 10, 70-74 (1991)

しかしながら、従来の酵母エキスでは、運動能力の持続や疲労の予防・回復効果、慢性疲労症候群に対する効果が十分ではなかった。
本発明は、上記事情に鑑みてなされたものであり、栄養補助食品として利用可能な天然素材由来の組成物であって、運動能力の持続や疲労の予防・回復に対して効果を有する酵母エキス含有組成物を提供することを目的とする。
However, conventional yeast extracts have not been sufficient in sustaining exercise ability, preventing and recovering from fatigue, and chronic fatigue syndrome.
The present invention has been made in view of the above circumstances, and is a composition derived from a natural material that can be used as a dietary supplement, and has an effect on the maintenance of exercise capacity and the prevention / recovery of fatigue. It aims at providing a containing composition.

本発明者らは、種々検討の結果、特別な酵母エキスを組み合わせることにより、運動能力の持続や疲労の予防・回復に対して効果を有する組成物を得ることができることを見出し、本発明を完成した。   As a result of various studies, the present inventors have found that by combining a special yeast extract, a composition having an effect on the maintenance of exercise ability and the prevention / recovery of fatigue can be obtained, and the present invention has been completed. did.

すなわち、本発明は下記に示す[1]〜[6]の態様である。
[1](I)ビタミンB含有量0.1〜12%の酵母エキスと、(II)ペプチド含有量40〜80%の酵母エキスと、(III)グルタチオン含有量5〜50%の酵母エキスを含有し、前記(I)〜(III)の比率(I):(II):(III)が6〜3:3〜1:2〜1の範囲であることを特徴とする酵母エキス含有組成物。
[2]前記(I)のビタミンB含有量が、0.1〜0.16%である前記[1]に記載の酵母エキス含有組成物。
[3]前記(II)のぺプチド含有量が、60〜80%である前記[1]または[2]に記載の酵母エキス含有組成物。
[4]前記(III)のグルタチオン含有量が、15〜20%である前記[1]〜[3]の何れか1項に記載の酵母エキス含有組成物。
[5]前記(I)〜(III)の比率(I):(II):(III)が、4:2:1である前記[1]〜[4]の何れか1項に記載の酵母エキス含有組成物。
[6] 前記(I)が200〜1000mg、前記(II)が100〜500mg、及び前記(III)が50〜250mg配合されていることを特徴とする前記[1]〜[5]の何れか1項に記載の酵母エキス含有組成物。
That is, this invention is the aspect of [1]-[6] shown below.
[1] (I) Yeast extract with vitamin B 1 content of 0.1-12%, (II) Yeast extract with peptide content of 40-80%, and (III) Yeast extract with glutathione content of 5-50% Yeast extract-containing composition, wherein the ratio (I) :( II) :( III) of (I) to (III) is in the range of 6-3: 3: 1: 2-1 object.
[2] Vitamin B 1 The content of the (I) is, yeast extract-containing composition according to the a from 0.1 to 0.16% [1].
[3] The yeast extract-containing composition according to [1] or [2], wherein the peptide content of (II) is 60 to 80%.
[4] The yeast extract-containing composition according to any one of [1] to [3], wherein the glutathione content of (III) is 15 to 20%.
[5] The yeast according to any one of [1] to [4], wherein the ratio (I) :( II) :( III) of (I) to (III) is 4: 2: 1. Extract-containing composition.
[6] Any of [1] to [5] above, wherein (I) is blended in an amount of 200 to 1000 mg, (II) is blended in an amount of 100 to 500 mg, and (III) is blended in an amount of 50 to 250 mg. The yeast extract-containing composition according to item 1.

本発明の酵母エキス含有組成物は、栄養補助食品として利用可能な天然素材由来の組成物であって、運動能力の持続や疲労の予防・回復に対して効果を有する。   The yeast extract-containing composition of the present invention is a composition derived from a natural material that can be used as a dietary supplement, and has an effect on the maintenance of exercise ability and the prevention / recovery of fatigue.

以下に、本発明の実施形態例について詳細に説明する。
本発明の酵母エキス含有組成物は、(I)ビタミンB含有量0.1〜12%の酵母エキス(以下、(I)成分と略す)、(II)ペプチド含有量40〜80%の酵母エキス(以下、(II)成分と略す)、および(III)グルタチオン含有量5〜50%の酵母エキス(以下、(III)成分と略す)を含有するものである。
Hereinafter, exemplary embodiments of the present invention will be described in detail.
The yeast extract-containing composition of the present invention comprises (I) a yeast extract having a vitamin B 1 content of 0.1 to 12% (hereinafter abbreviated as (I) component), and (II) a yeast having a peptide content of 40 to 80%. An extract (hereinafter abbreviated as component (II)) and (III) a yeast extract having a glutathione content of 5 to 50% (hereinafter abbreviated as component (III)) are contained.

本発明における酵母エキスの原料となる酵母は、可食性のものであれば特に制限はなく、ビール酵母,パン酵母,アルコール酵母,清酒用酵母など一般に食品工業で用いられているものを使用することが出来る。
このような酵母としては、例えばサッカロマイセス( Saccharomyces)属、ピキア( Pichia)属、ハンゼヌラ(Hansenula)属、デバリオマイセス(Debariomyces)属、キャンディダ(Candida)属、クリベロマイセス(Kluyveromyces)属、チゴサッカロマイセス(Zygosaccharomyces)属等に属する酵母が挙げられる。このような酵母の例としては、サッカロマイセス・セレビシエ(Saccharomyces cerevisiae IFO1954,IFO03019,IAM4274)、ピキア・ステイピティス(Pichia stipitis IFO1720)、ハンゼヌラ・アノマラ(Hansenula anomala IFO1150)、デバリオマイセス・ハンセニイ(Debariomyces hansenii IFO0855,IFO1752)、キャンディダ・ユーティリス(Candida utilis IFO0619,ATCC15239)、クリベロマイセス・ラクチス(Kluyveromyces ATCC56498)、クリベロマイセス・マルキシアヌス( Kluyveromyces marxianus ATCC36534)、チゴサッカロマイセス・ルーキシー(Zygosaccharomyces rouxii ATCC28253,ATCC13356)等に属する酵母が挙げられ、好ましくはサッカロマイセス・セレビシエ及びキャンディダ・ユーティリスである。これらの酵母の中から1種若しくは2種以上の酵母を用いることができる。
The yeast used as a raw material for the yeast extract in the present invention is not particularly limited as long as it is edible, and those commonly used in the food industry such as brewer's yeast, baker's yeast, alcoholic yeast, and sake yeast are used. I can do it.
Examples of such yeast include, for example, the genus Saccharomyces, the Pichia genus, the Hansenula genus, the Debariomyces genus, the Candida genus, the Kluyveromyces genus Examples include yeast belonging to the genus and the like. Examples of such yeasts are Saccharomyces cerevisiae IFO1954, IFO03019, IAM4274, Pichia stipetis IFO1720, Hansenula anomala (Hansenula anomala) Candida utilis IFO0619, ATCC 15239, Kryberomyces lactis (Kluyveromyces ATCC 56498), Kryberomyces marxianus ATCC 36534, Gore Saccharomyces Seth Rukishi (Zygosaccharomyces rouxii ATCC28253, ATCC13356), etc. include yeast belonging to, preferably Saccharomyces cerevisiae and Candida Yu Tirith. Among these yeasts, one or more yeasts can be used.

酵母エキスは、一般的には、酵母の自己消化、消化酵素処理、アルカリ、酸あるいは熱水処理、もしくは物理的損傷等により細胞壁の物質透過性を高めた後、水又は有機溶媒単独、あるいはこれらの混合物により、細胞内に含まれる可溶性成分を抽出することにより得られる。
酵母エキスは、溶媒に溶解した状態で使用することもできるが、真空乾燥、凍結乾燥等により粉末化してもよい。粉末化に際して、適当な賦形剤を加えても差し支えない。
In general, yeast extract is prepared by increasing the cell wall material permeability by yeast self-digestion, digestive enzyme treatment, alkali, acid or hot water treatment, physical damage, etc., and then water or an organic solvent alone or these. It is obtained by extracting the soluble component contained in a cell by a mixture of
The yeast extract can be used in a state dissolved in a solvent, but may be pulverized by vacuum drying, freeze drying or the like. An appropriate excipient may be added during powdering.

本発明の酵母エキス含有組成物を構成する(I)成分は、ビタミンB含有量が0.1〜12%、好ましくは0.1〜0.16%である酵母エキスであれば、特に限定されるものではない。例えば、特許文献1に記載の方法に準じて製造することができ、ビタミンBを0.25〜3重量%含む培地で培養して得られる酵母に、酵母細胞壁溶解酵素などの生化学的処理もしくはフレンチプレスや加圧処理などの物理的処理を行なって得られる可溶性成分を、凍結乾燥もしくは噴霧乾燥することにより得られる。また、商品名「ミーストP5チアミン」(アサヒフードアンドヘスルケア社製)等の市販の酵母エキスを用いることができる。 The component (I) constituting the yeast extract-containing composition of the present invention is particularly limited as long as it is a yeast extract having a vitamin B 1 content of 0.1 to 12%, preferably 0.1 to 0.16%. Is not to be done. For example, can be produced according to the method described in Patent Document 1, a yeast obtained by culturing in a medium containing vitamin B 1 0.25 to 3 wt%, biochemical processes, such as yeast cell wall lytic enzyme Alternatively, it can be obtained by freeze-drying or spray-drying a soluble component obtained by performing physical treatment such as French press or pressure treatment. Commercially available yeast extracts such as “Mist P5 Thiamine” (manufactured by Asahi Food and Health Care Co., Ltd.) can be used.

本発明の酵母エキス含有組成物を構成する(II)成分は、ペプチド含有量が40〜80%、好ましくは60〜80%である酵母エキスであれば、特に限定されるものではない。例えば、特許文献2に記載の方法に準じて製造することができる。また、商品名「SPRINGER HYP A」(Bio Springer SA社製)等の市販の酵母エキスを用いることもできる。
なお、ペプチド含量は、酵母エキス中の加水分解アミノ酸の合計から遊離アミノ酸の合計を引いた値であり、ペプチドとは、キャンベル生化学第2版(廣川書店平成13年9月15日発行)のP75よりアミノ酸100残基未満をペプチドと定義できる。また、アミノ酸の平均分子量約120から、分子量12000未満がペプチドとも定義することが出来る。
The component (II) constituting the yeast extract-containing composition of the present invention is not particularly limited as long as it is a yeast extract having a peptide content of 40 to 80%, preferably 60 to 80%. For example, it can be produced according to the method described in Patent Document 2. Commercially available yeast extracts such as trade name “SPRINGER HYP A” (manufactured by Bio Springer SA) can also be used.
The peptide content is a value obtained by subtracting the total of free amino acids from the total amount of hydrolyzed amino acids in the yeast extract, and the peptide is that of Campbell Biochemistry 2nd edition (published on September 15, 2001, Yodogawa Shoten). From P75, less than 100 amino acids can be defined as a peptide. Further, an average molecular weight of amino acids of about 120 to a molecular weight of less than 12,000 can be defined as a peptide.

本発明の酵母エキス含有組成物を構成する(III)成分は、グルタチオン含有量5〜50%、好ましくは15〜20%である酵母エキスであれば、特に限定されるものではない。例えば、特許文献3に記載の方法に準じて製造することができる。また、商品名「ハイチオンエキスYH‐15」(株式会社興人製)等の市販の酵母エキスを用いることもできる。また、グルタチオンはシステインペプチドとも呼ばれる。   The component (III) constituting the yeast extract-containing composition of the present invention is not particularly limited as long as it is a yeast extract having a glutathione content of 5 to 50%, preferably 15 to 20%. For example, it can be produced according to the method described in Patent Document 3. Moreover, commercially available yeast extracts, such as a brand name "Hythion extract YH-15" (made by Kojin Co., Ltd.), can also be used. Glutathione is also called a cysteine peptide.

各(I)〜(III)成分の成人(体重60kgとして)の1日当たりの好ましい摂取量は、疲労度によって異なるが、(I)成分は200〜1000mg、より好ましくは500〜700mg、(II)成分は100〜500mg、より好ましくは200〜400mg、(III)成分は50〜250mg、より好ましくは100〜200mgである。
また、各(I)〜(III)成分の比率(I):(II):(III)は6〜3:3〜1:2〜1の範囲で構成され、好ましくは、(I):(II):(III)が、4:2:1である。
また、摂取回数としては、1日1回又は複数回に分けて摂取することができる。
The preferred daily intake of each component (I) to (III) adult (with a body weight of 60 kg) varies depending on the degree of fatigue, but the component (I) is 200 to 1000 mg, more preferably 500 to 700 mg, (II) A component is 100-500 mg, More preferably, it is 200-400 mg, (III) component is 50-250 mg, More preferably, it is 100-200 mg.
Moreover, ratio (I) :( II) :( III) of each (I)-(III) component is comprised in the range of 6-3: 3: 1: 2-1, Preferably, (I) :( II) :( III) is 4: 2: 1.
In addition, the number of intakes can be taken once a day or divided into multiple times.

本発明の酵母エキス含有組成物は、上記(I)、(II)、(III)成分を、目的とする形態に合わせて、混合、攪拌、加熱、造粒、乾燥等することにより調製することができる。本発明の酵母エキス含有組成物の形態は、特に限定されるものではなく、固形状(粉剤、微粒剤、顆粒剤、錠剤、カプセル剤など)、半固形状(ゼリー状、水飴状など)、もしくは液状のいずれでもよい。本発明の酵母エキス含有組成物を医薬品または飲食品として製造する場合、上記(I)、(II)、(III)成分に賦形剤、安定剤その他の成分を添加し、一般的に用いられる製造方法で製造することができる。   The yeast extract-containing composition of the present invention is prepared by mixing, stirring, heating, granulating, drying, etc. the above components (I), (II), (III) according to the intended form. Can do. The form of the yeast extract-containing composition of the present invention is not particularly limited, and is solid (powder, fine granules, granules, tablets, capsules, etc.), semi-solid (jelly, syrup, etc.), Or any of liquid may be sufficient. When the yeast extract-containing composition of the present invention is produced as a pharmaceutical or a food or drink, it is generally used by adding excipients, stabilizers and other components to the components (I), (II) and (III). It can be manufactured by a manufacturing method.

以上説明したように、本発明の酵母エキス含有組成物は、運動能力の持続や疲労の予防・回復に対して効果を有し、さらには慢性疲労症候群に対しても効果が期待される。   As described above, the yeast extract-containing composition of the present invention is effective for maintaining exercise ability and preventing / recovering fatigue, and is also expected to be effective for chronic fatigue syndrome.

次に、実施例を示して本発明をさらに詳細に説明するが、本発明は以下の実施例に限定されるものではない。   EXAMPLES Next, although an Example is shown and this invention is demonstrated further in detail, this invention is not limited to a following example.

「実施例1」
表1に示す各成分を均一に混合し、常法に従ってカプセル剤(2号ハードカプセル)を製造した。
"Example 1"
Each component shown in Table 1 was uniformly mixed, and a capsule (No. 2 hard capsule) was produced according to a conventional method.

Figure 2009107962
Figure 2009107962

(I)成分として、「ミーストP5チアミン」(アサヒフードアンドヘスルケア株式会社製)を用いた。(II)成分として、「SPRINGER HYP A」(Bio Springer SA社製)を用いた。(III)成分として、「ハイチオンエキスYH‐15」(株式会社興人製)を用いた。
このようにして、カプセル1粒に267mg充填し、カプセル約374粒を得た。
As the component (I), “Mist P5 thiamine” (manufactured by Asahi Food and Health Care Co., Ltd.) was used. As a component (II), “SPRINGER HYP A” (manufactured by Bio Springer SA) was used. As the component (III), “Hythion extract YH-15” (manufactured by Kojin Co., Ltd.) was used.
In this way, 267 mg was filled in one capsule to obtain about 374 capsules.

「実施例2」
表2に示す各成分を均一に混合し、常法に従ってカプセル剤(1号ハードカプセル)を製造した。
"Example 2"
Each component shown in Table 2 was uniformly mixed, and a capsule (No. 1 hard capsule) was produced according to a conventional method.

Figure 2009107962
Figure 2009107962

(I)成分として、「ミーストP5チアミン」(アサヒフードアンドヘスルケア株式会社製)を用いた。(II)成分として、「SPRINGER HYP A」(Bio Springer SA社製)を用いた。(III)成分として、「ハイチオンエキスYH‐15」(株式会社興人製)を用いた。
このようにして、カプセル1粒に350mg充填し、カプセル約285粒を得た。
As the component (I), “Mist P5 thiamine” (manufactured by Asahi Food and Health Care Co., Ltd.) was used. As a component (II), “SPRINGER HYP A” (manufactured by Bio Springer SA) was used. As the component (III), “Hythion extract YH-15” (manufactured by Kojin Co., Ltd.) was used.
Thus, 350 mg was filled in 1 capsule, and about 285 capsules were obtained.

「試験例1」動物試験での評価
雄性マウスBALB/c(10週齢 日本SLC)に粉末飼料CRF‐1(オリエンタル酵母工業株式会社製)を与え、予備飼育1週間後に体重と30分間の自発運動量をSupermex(室町機械株式会社製)で測定し、自発運動量が均等になるように1群8匹(対照のみ6匹)で6群に群分けした。群分け後、各群には、表3に示す組成の酵母エキスを、CRF‐1にそれぞれ混合して、自由摂取させた。
"Test Example 1" Evaluation in animal test Male mouse BALB / c (10-week-old Japan SLC) was given a powdered feed CRF-1 (manufactured by Oriental Yeast Co., Ltd.). The amount of exercise was measured with Supermex (Muromachi Kikai Co., Ltd.), and the group was divided into 6 groups of 8 per group (6 only for controls) so that the spontaneous exercise amount was equal. After grouping, each group was allowed to freely ingest the yeast extract having the composition shown in Table 3 and mixed with CRF-1.

Figure 2009107962
Figure 2009107962

投与開始3週間後に、遊泳試験による抗疲労効果を評価した。遊泳試験は2Lビーカーに25℃の水1.5Lを入れ、15分間水中に入れたマウスが遊泳動作を行った時間を、Supermex(室町機械株式会社製)を用いて測定した。結果を図1に示す。
図1の結果から、本発明の酵母エキス含有組成物を摂取させた(5)群は、有意に遊泳時間延長効果が見られた。特に、対照の(1)群に対して約1.8倍(p<0.05 t検定)の遊泳時間延長効果が見られ、肉体疲労予防や疲労回復改善において効果的であることが示唆された。
Three weeks after the start of administration, the anti-fatigue effect by the swimming test was evaluated. In the swimming test, 1.5 L of water at 25 ° C. was placed in a 2 L beaker, and the time during which the mouse placed in water for 15 minutes performed swimming was measured using Supermex (Muromachi Kikai Co., Ltd.). The results are shown in FIG.
From the result of FIG. 1, the swimming time extending effect was significantly seen in the group (5) fed with the yeast extract-containing composition of the present invention. In particular, the effect of extending swimming time by about 1.8 times (p <0.05 t test) compared to the control group (1) was observed, suggesting that it is effective in preventing physical fatigue and improving fatigue recovery. It was.

本発明の酵母エキス含有組成物は、医薬品、サプリメント等の栄養補助食品、および一般的な飲食品に広く利用可能である。特に、運動能力の持続や疲労の予防・回復に対して効果を有し、さらには慢性疲労症候群に対しても効果が期待されるため、重労働後の疲労緩和、運動時のパフォーマンス向上などを目的に様々な用途に応用が可能である。   The yeast extract-containing composition of the present invention can be widely used for nutritional supplements such as pharmaceuticals and supplements, and general foods and drinks. In particular, it is effective for duration of exercise ability and prevention / recovery of fatigue, and also expected to be effective for chronic fatigue syndrome. It can be applied to various purposes.

図1は、試験例1のマウスの遊泳試験において、酵母エキス含有組成物と抗疲労効果の関係を示す。FIG. 1 shows the relationship between the yeast extract-containing composition and the anti-fatigue effect in the mouse swimming test of Test Example 1.

Claims (6)

(I)ビタミンB含有量0.1〜12%の酵母エキスと、
(II)ペプチド含有量40〜80%の酵母エキスと、
(III)グルタチオン含有量5〜50%の酵母エキスを含有し、
前記(I)〜(III)の比率(I):(II):(III)が、6〜3:3〜1:2〜1の範囲であることを特徴とする酵母エキス含有組成物。
(I) Vitamin B 1 content 0.1-12% yeast extract,
(II) a yeast extract having a peptide content of 40 to 80%;
(III) containing a yeast extract having a glutathione content of 5 to 50%,
The yeast extract-containing composition, wherein the ratio (I) :( II) :( III) of (I) to (III) is in the range of 6-3: 3: 1: 2-1.
前記(I)のビタミンB含有量が、0.1〜0.16%である請求項1記載の酵母エキス含有組成物。 The vitamin B 1 content of (I) is, according to claim 1 yeast extract-containing composition wherein the 0.1 to 0.16%. 前記(II)のぺプチド含有量が、60〜80%である請求項1または2に記載の酵母エキス含有組成物。   The yeast extract-containing composition according to claim 1 or 2, wherein the peptide content of (II) is 60 to 80%. 前記(III)のグルタチオン含有量が、15〜20%である請求項1〜3の何れか1項に記載の酵母エキス含有組成物。   The yeast extract-containing composition according to any one of claims 1 to 3, wherein the glutathione content of (III) is 15 to 20%. 前記(I)〜(III)の比率(I):(II):(III)が、4:2:1である請求項1〜4の何れか1項に記載の酵母エキス含有組成物。   The ratio (I) :( II) :( III) of said (I)-(III) is 4: 2: 1, The yeast extract containing composition in any one of Claims 1-4. 前記(I)が200〜1000mg、前記(II)が100〜500mg、及び前記(III)が50〜250mg配合されていることを特徴とする請求項1〜5の何れか1項に記載の酵母エキス含有組成物。   The yeast according to any one of claims 1 to 5, wherein (I) is 200 to 1000 mg, (II) is 100 to 500 mg, and (III) is 50 to 250 mg. Extract-containing composition.
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JP2015040204A (en) * 2013-08-23 2015-03-02 京都府公立大学法人 Physical function improver
JP2017063633A (en) * 2015-09-28 2017-04-06 株式会社シー・アクト Medium for increasing content of odd-numbered fatty acids in cultured aurantiochytrium algae
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JP2018027983A (en) * 2017-11-22 2018-02-22 京都府公立大学法人 Physical function improver
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