JP2009067763A - Agent for preventing or ameliorating hangover - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an agent for preventing or ameliorating hangover, preventing hangover after drinking an alcohol and having rapid effect on unpleasant symptom of hangover in order to solve problems in which effect for preventing or amelioration hangover is not sufficient yet, though hangover-preventing or ameliorating agent improving unpleasant symptoms such as hangover after taking an alcohol is required hitherto and a liquid agent (suspension) in which various ingredients having pharmacodynamic effects are formulated with an antacid is suggested as such a liquid preparation for oral administration. <P>SOLUTION: The agent for preventing or ameliorating hangover comprises an extract of Lepidium meyenii Walp. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to an agent for preventing or improving hangover.

  Maca (Lepidium meyenii Walp) is a cruciferous plant native to the highlands of the Andes in Peru, South America. Maca is a plant that has been cultivated in the Andes region for over 2,000 years and has been eaten as a food for health maintenance. Maca is rich in essential amino acids, various vitamins and minerals. In addition, maca is said to be effective in restoring vitality and nourishing, and it is also proposed to take maca extract to improve sleep disorders, improve peripheral blood flow, and improve skin moisture retention. (Patent Documents 1 to 3).

On the other hand, there has been a need for a hangover prevention or improvement agent that can improve unpleasant symptoms such as hangover after alcohol consumption. As this type of internal use liquid, a liquid (suspension) in which various medicinal ingredients are blended with an antacid is proposed, but its effect is not yet sufficient.
JP 2007-31371 A JP 2005-281272 A JP 2005-281271 A

  An object of the present invention is to provide an agent for preventing or improving a hangover that prevents hangover after ingestion of alcohol and has a rapid effect on the unpleasant symptoms of hangover.

  The present invention provides an agent for preventing or improving hangover characterized by containing an extract of maca (Lepidium meyenii Walp).

  ADVANTAGE OF THE INVENTION According to this invention, while preventing the hangover after alcohol intake, the hangover prevention or improvement agent which has a rapid effect with respect to the unpleasant symptom of a hangover can be provided. In addition, it is the viewpoint which the present inventors discovered for the first time that the effect of preventing and improving hangover exists in maca.

  Maca (Lepidium meyenii Walp) is a root vegetable plant native to or cultivated in the highlands of the Andes region, mainly 4000-5000 meters above sea level in Peru, and its rhizome has been used for food since ancient times.

  Maca (Lepidium meyenii Walp) is a cruciferous plant native to the highlands of the Andes in Peru, South America. In order to obtain an extract of maca, any part such as whole grass, flowers, fruits, leaves, stems including rhizomes, bulbs, etc. may be used, but extraction is preferably performed using an extraction solvent using the bulb part. Can be obtained by doing.

Although there is no restriction | limiting in particular as an extraction solvent used here, Water, an organic solvent, or these mixed solutions can be illustrated.
Specifically, lower alcohols such as methanol, ethanol and butanol as hydrophilic organic solvents; polyhydric alcohols such as propylene glycol and 1,3-butylene glycol; esters such as ethyl acetate and amyl acetate; acetone and methyl ethyl ketone And ketones. Alcohols such as methanol, ethanol, propylene glycol, and 1,3-butylene glycol are preferable, and ethanol and 1,3-butylene glycol are more preferable. Examples of the lipophilic solvent include hexane and ethyl acetate.

  These organic solvents may be used alone or in any combination of two or more. It can also be used as a mixed solvent of one or more hydrophilic organic solvents and water. In this case, the mixing ratio of the hydrophilic organic solvent and water is not particularly limited, but can usually be used at a ratio of 1: 1 to 9: 1 (weight ratio).

However, considering that the extract is finally taken orally, from the viewpoint of safety, a water-ethanol mixed aqueous solution (preferably an aqueous solution containing 40 to 99% ethanol) is used as an extraction solvent. preferable.
In addition, the temperature of the extraction solvent at the time of extraction is preferably, for example, 40 to 100 ° C., particularly 60 to 85 ° C.

  The mixing ratio of the maca and the solvent during the extraction is not particularly limited, but it is preferable to use about 0.3 to 5000 parts by weight of the solvent with respect to 1 part by weight of the maca. From the point of view, it is preferably 5 to 100 parts by weight.

  In the extraction, specifically, maca can be prepared by extracting the bulb part as it is or by subjecting it to a drying treatment, cutting and pulverizing it if necessary, and immersing it in the above solvent. Although there is no restriction | limiting in particular about immersion conditions, Any of low temperature-room temperature-heating conditions can be used. Further, the immersion treatment may be performed while refluxing, preferably heating and refluxing. The obtained immersion liquid can be filtered as necessary to obtain an extract as it is, or it can be concentrated and used as an extract or a dry powder. Moreover, you may refine | purify the obtained extract (including an extract) further by an ion exchange resin or a distribution column as needed. The maca extract referred to in the present invention includes any of these extracts, extract-concentrated extracts, and dry powder products.

  In the hangover preventive or ameliorating agent of the present invention, the amount of maca extract can be determined in a timely manner in consideration of its effect, scent when added, color tone, and the like. However, as a blending range, the maca extract is converted to a dry weight, and it is desirable that the concentration range be 0.01 to 99.9%, preferably 0.01 to 99.5%. In addition, since the peculiar smell of a maca extract will become strong when a maca extract is used in high concentration, what is necessary is just to determine the density | concentration of a maca extract suitably so that it may not have a bad influence on oral ingestion.

  The daily intake of the maca extract is not particularly limited, and can be, for example, about 0.01 mg to 10 g in terms of dry weight. 000 mg is desirable.

  The agent for preventing or improving hangover of the present invention is desirably taken orally in the form of a beverage. Examples of the beverage include alcoholic beverages, coffee beverages, juices, fruit juice beverages, carbonated beverages, and soft drinks.

  In addition, these food / beverage products can mix | blend various additives as needed, and can prepare them according to a conventional method. Specifically, when preparing these beverages, for example, glucose, fructose, sucrose, maltose, sorbitol, stevioside, rubusoside, corn syrup, lactose, citric acid, tartaric acid, malic acid, succinic acid, lactic acid, L-ascorbic acid, dl-α-tocophenol, sodium erythorbate, glycerin, propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, gum arabic, carrageenan, casein , Gelatin, pectin, agar, vitamin B, nicotinic acid amide, calcium pantothenate, amino acids, calcium salts, pigments, fragrances, preservatives, etc. It can be produced according to a conventional method.

  In addition, the liquor is not particularly limited, but is preferably an alcohol having an alcohol concentration of 10% or more and less than 45%. Specific examples of the alcoholic beverages used as the raw material include sake, shochu, awamori, wine, beer, liqueurs, whiskey, brandy, spirits, brewing alcohol, and mirin.

  EXAMPLES Hereinafter, although an Example and a comparative example further demonstrate this invention, this invention is not restrict | limited to the following example.

Example 1
3 kg of dried maca pulverized product was placed in a stainless steel container, and 30 L of a 50% by volume aqueous solution of ethanol was added thereto, followed by stirring and extraction at 60 ° C. for 3 hours. The solution was filtered and the solvent was removed from the resulting liquid to obtain 100 g of maca extract (powder).

Subsequently, the maca extract (powder) was redispersed in water to obtain a drug sample.
Wistar male rats (7-8 weeks old), 6 rats per group, were fasted overnight and then orally administered the next morning with a drug sample (10 ml / kg). 20 minutes later, 15% (W / V) ethanol aqueous solution 20 ml / kg Was administered orally. After administration of the aqueous ethanol solution, blood was collected from the tip of the tail after 1, 3, and 5 hours, and the blood alcohol concentration was measured using a blood alcohol measurement kit (manufactured by Sigma). The dosage of the drug sample is 300 mg / kg as maca extract (powder).

  As a result, the blood alcohol concentration in rats was 150 mg / dl immediately after administration of the ethanol aqueous solution, whereas it was 105 mg / dl after 1 hour, 82 mg / dl after 3 hours, and 40 mg / dl after 5 hours. Yes (average). In contrast, in the control group to which no maca extract was administered, 150 mg / dl was immediately after ethanol aqueous solution administration, whereas 140 mg / dl after 1 hour, 107 mg / dl after 3 hours, and 88 mg after 5 hours. / Dl.

Example 2
Juice was prepared according to the following formulation.
Frozen concentrated orange juice 5.0 parts by weight Fructose glucose liquid sugar 1.0 part by weight Citric acid 0.10 parts by weight L-ascorbic acid 0.09 parts by weight Maca extract of Example 1 0.05 parts by weight

  A panel of 5 healthy individuals (aged 25-32 years old, 3 men, 2 women) who were determined to be aldehyde dehydrogenase-deficient by the ethanol patch test, and the maca extract was removed from the juice and juice Juice was used. In addition, the amount of the maca extract in the juice was adjusted to 50 mg in the following test.

Twenty minutes after taking the juice and control juice, 135 ml of beer (alcohol concentration of about 5.5%) was drunk, and subjective symptoms 20 minutes after drinking were answered in a questionnaire.
The panel test was conducted blindly considering the order effect, and the day was changed at the same time zone.
The subjective symptom was evaluated in 1 to 5 (1: no symptom, 2: somewhat symptomatic, 3: symptomatic, 4: slightly terrible, 5: terrible), and the significant difference was tested by Paired-t test. .

  The results are shown below. The juice of Example 2 was found to improve the degree of intoxication and hot flashes at a risk rate of 5%, and prevent sickness.

Anti-drunkenness effect of juice and control juice (average value)
Juice of Example 2:
The degree of sickness 2.3 *
Hot flash 2.1 *
Heartbeat 2.5
Degree of sleepiness 3.3
Control juice:
Sickness 3.5
Hot flashes of face 3.7
Heartbeat 3.3
Degree of sleepiness 3.4
*: Significantly different from control juice (P <0.05)

Claims (1)

  An agent for preventing or improving hangover, comprising an extract of maca (Lepidium meyenii Walp).