JP2009035545A5 - - Google Patents

Info

Publication number

JP2009035545A5

JP2009035545A5 JP2008178569A JP2008178569A JP2009035545A5 JP 2009035545 A5 JP2009035545 A5 JP 2009035545A5 JP 2008178569 A JP2008178569 A JP 2008178569A JP 2008178569 A JP2008178569 A JP 2008178569A JP 2009035545 A5 JP2009035545 A5 JP 2009035545A5

Authority

JP

Japan

Prior art keywords

weight

amlodipine

stable

jelly

solution according

Prior art date

2008-07-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 claims 19
• 229960000528 amlodipine Drugs 0.000 claims 19
• 235000015110 jellies Nutrition 0.000 claims 11
• 239000008274 jelly Substances 0.000 claims 11
• 239000000203 mixture Substances 0.000 claims 10
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical group [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 6
• 239000003945 anionic surfactant Substances 0.000 claims 4
• 239000003349 gelling agent Substances 0.000 claims 4
• QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 4
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 3
• 239000000679 carrageenan Substances 0.000 claims 3
• 235000010418 carrageenan Nutrition 0.000 claims 3
• 229920001525 carrageenan Polymers 0.000 claims 3
• 229940113118 carrageenan Drugs 0.000 claims 3
• 239000003795 chemical substances by application Substances 0.000 claims 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
• 235000003599 food sweetener Nutrition 0.000 claims 3
• 238000001879 gelation Methods 0.000 claims 3
• 239000001103 potassium chloride Substances 0.000 claims 3
• 235000011164 potassium chloride Nutrition 0.000 claims 3
• 235000019333 sodium laurylsulphate Nutrition 0.000 claims 3
• 239000007787 solid Substances 0.000 claims 3
• 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 3
• 239000003765 sweetening agent Substances 0.000 claims 3
• UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical group [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 3
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
• 239000001913 cellulose Substances 0.000 claims 2
• 229920002678 cellulose Polymers 0.000 claims 2
• 239000003607 modifier Substances 0.000 claims 2
• 239000002736 nonionic surfactant Substances 0.000 claims 2
• 150000007524 organic acids Chemical class 0.000 claims 2
• RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 2
• 235000012239 silicon dioxide Nutrition 0.000 claims 2
• 239000000600 sorbitol Substances 0.000 claims 2
• 229930006000 Sucrose Natural products 0.000 claims 1
• 235000014113 dietary fatty acids Nutrition 0.000 claims 1
• 239000000194 fatty acid Substances 0.000 claims 1
• 229930195729 fatty acid Natural products 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• 159000000000 sodium salts Chemical class 0.000 claims 1
• 239000005720 sucrose Substances 0.000 claims 1
• -1 sucrose fatty acid ester Chemical class 0.000 claims 1
• 150000005846 sugar alcohols Chemical class 0.000 claims 1