JP2009035545A5 - - Google Patents
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- JP2009035545A5 JP2009035545A5 JP2008178569A JP2008178569A JP2009035545A5 JP 2009035545 A5 JP2009035545 A5 JP 2009035545A5 JP 2008178569 A JP2008178569 A JP 2008178569A JP 2008178569 A JP2008178569 A JP 2008178569A JP 2009035545 A5 JP2009035545 A5 JP 2009035545A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- amlodipine
- stable
- jelly
- solution according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- HTIQEAQVCYTUBX-UHFFFAOYSA-N Amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 claims 19
- 229960000528 amlodipine Drugs 0.000 claims 19
- 235000015110 jellies Nutrition 0.000 claims 11
- 239000008274 jelly Substances 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 10
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M potassium chloride Chemical group [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 6
- 239000003945 anionic surfactant Substances 0.000 claims 4
- 239000003349 gelling agent Substances 0.000 claims 4
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 4
- 229940113118 Carrageenan Drugs 0.000 claims 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 3
- 239000000679 carrageenan Substances 0.000 claims 3
- 235000010418 carrageenan Nutrition 0.000 claims 3
- 229920001525 carrageenan Polymers 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 235000003599 food sweetener Nutrition 0.000 claims 3
- 238000001879 gelation Methods 0.000 claims 3
- 239000001103 potassium chloride Substances 0.000 claims 3
- 235000011164 potassium chloride Nutrition 0.000 claims 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 3
- 239000003765 sweetening agent Substances 0.000 claims 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical group OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 2
- RMAQACBXLXPBSY-UHFFFAOYSA-N Silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 239000003607 modifier Substances 0.000 claims 2
- 239000002736 nonionic surfactant Substances 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- 235000012239 silicon dioxide Nutrition 0.000 claims 2
- 239000000600 sorbitol Substances 0.000 claims 2
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- -1 sucrose fatty acid ester Chemical class 0.000 claims 1
Claims (15)
ａ）アムロジピン０.１〜１重量％、
ｂ）硫酸基またはスルホン酸基を有する陰イオン性界面活性剤０．２〜２重量％、
ｃ）ゲル化剤０．１〜３重量％、
ｄ）ゲル化調節剤０．１〜２重量％、
ｅ）微粉末状固形物０．２〜３重量％、
であることを特徴とする、アムロジピンの安定なゼリー組成物。 An amlodipine jelly composition having at least the following composition and having a pH of 5 to 7,
a) 0.1 to 1% by weight of amlodipine,
b) 0.2 to 2% by weight of an anionic surfactant having a sulfate group or a sulfonate group,
c) 0.1 to 3% by weight of a gelling agent,
d) 0.1-2% by weight of a gelation modifier,
e) 0.2 to 3% by weight of finely divided solid,
A stable jelly composition of amlodipine, characterized in that
ａ）アムロジピン0.１〜１重量％、
ｂ）硫酸基またはスルホン酸基を有する陰イオン性界面活性剤がラウリル硫酸ナトリウムであり、
ｃ）ゲル化剤がカラギーナンであり、
ｄ）ゲル化調節剤が塩化カリウムであり、
ｅ）微粉末状固形物が結晶セルロースおよび軽質無水ケイ酸であり、
ｆ）甘味料がソルビトールである
ことを特徴とする、請求項１２記載のアムロジピンの安定なゼリー組成物。 An amlodipine jelly composition having at least the following composition and having a liquidity of pH 6-7,
a) 0.1 to 1% by weight of amlodipine,
b) the anionic surfactant having a sulfate group or a sulfonate group is sodium lauryl sulfate;
c) the gelling agent is carrageenan;
d) the gelation modifier is potassium chloride;
e) the finely divided solid is crystalline cellulose and light anhydrous silicic acid,
f) Stable jelly composition of amlodipine according to claim 12, characterized in that the sweetener is sorbitol.
ａ）アムロジピンが０.１〜１重量％、
ｂ）ラウリル硫酸ナトリウムが０．２〜０．８重量％、
ｃ）カラギーナンが０．５〜２重量％、
ｄ）塩化カリウムが０．２〜１重量％、
ｅ）結晶セルロースおよび軽質無水ケイ酸が０．５〜２重量％、
ｆ）ソルビトールが２０〜４５重量％、
であることを特徴とする、請求項１２記載のアムロジピンの安定なゼリー組成物。 An amlodipine jelly composition having at least the following composition and having a liquidity of pH 6-7,
a) 0.1 to 1% by weight of amlodipine,
b) 0.2 to 0.8% by weight of sodium lauryl sulfate,
c) 0.5-2% by weight of carrageenan,
d) 0.2 to 1% by weight of potassium chloride,
e) 0.5-2% by weight of crystalline cellulose and light anhydrous silicic acid,
f) 20 to 45% by weight of sorbitol,
The stable jelly composition of amlodipine according to claim 12, wherein
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008178569A JP5072748B2 (en) | 2007-07-10 | 2008-07-09 | Amlodipine stable solution and jelly |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007180579 | 2007-07-10 | ||
| JP2007180579 | 2007-07-10 | ||
| JP2008178569A JP5072748B2 (en) | 2007-07-10 | 2008-07-09 | Amlodipine stable solution and jelly |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009035545A JP2009035545A (en) | 2009-02-19 |
| JP2009035545A5 true JP2009035545A5 (en) | 2010-05-20 |
| JP5072748B2 JP5072748B2 (en) | 2012-11-14 |
Family
ID=40437775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008178569A Expired - Fee Related JP5072748B2 (en) | 2007-07-10 | 2008-07-09 | Amlodipine stable solution and jelly |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5072748B2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4509118B2 (en) * | 2004-10-06 | 2010-07-21 | エルメッド エーザイ株式会社 | PHARMACEUTICAL COMPOSITION AND METHOD FOR PRODUCING THE SAME, AND METHOD FOR STABILIZING DIHYDROPYRIDINE COMPOUNDS |
| EP2815747B8 (en) * | 2012-02-14 | 2018-06-27 | Kyukyu Pharmaceutical Co., Ltd. | Intraoral soluble-type film preparation |
| IL279121B2 (en) * | 2018-06-01 | 2024-06-01 | Tavanta Therapeutics Hungary Incorporated | Topical amlodipine salts for the treatment of anorectal diseases |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3424553A1 (en) * | 1984-07-04 | 1986-01-09 | Bayer Ag, 5090 Leverkusen | SOLID DRUG PREPARATIONS WITH DIHYDROPYRIDINE AND METHOD FOR THE PRODUCTION THEREOF |
| JP4439499B2 (en) * | 2005-08-01 | 2010-03-24 | 大日本住友製薬株式会社 | Amlodipine-containing particles and orally disintegrating tablets comprising the same |
| JP2009256216A (en) * | 2008-04-14 | 2009-11-05 | Towa Yakuhin Kk | Liquid amlodipine besylate formulation for internal administration stable in solution state |
-
2008
- 2008-07-09 JP JP2008178569A patent/JP5072748B2/en not_active Expired - Fee Related
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