JP2009013123A - Health-retaining preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a health-retaining preparation and a food/drink maximally taking nutrients other than energy through removing surplus energy while making an ordinary diet pattern, in view of the fact that while there is a need for taking preventive measures not to become visceral fat obesity, eating decreasing habit by changing liking can hardly be continued with mental pain. <P>SOLUTION: The health-retaining preparation and the food/drink each contains, as the active ingredient, Gnetum's resveratrol dimer suppressing or inhibiting the digestive absorption of carbohydrates and lipids by lipase inhibitory effect, α-amylase inhibitory effect and α-glucosidase inhibitory effect. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

The present invention relates to a novel health maintenance agent and food having a lipase inhibitory action and a polysaccharide hydrolase inhibitory action. That is, by suppressing or inhibiting the digestion and absorption of lipids and carbohydrates that are energy sources in the body, blood neutral fat and total cholesterol are reduced to prevent visceral fat-type obesity, which is said to cause all diseases The present invention relates to a novel health maintenance agent and food.

In recent years, there has been a demand for polyphenols having an antioxidative action that have become well known because they are contained in red wine that is the basis of the French paradox. In Japan, the intake of animal foods is increasing, while the intake of vegetables, vegetable foods, is declining, so naturally the intake of polyphenols, which are responsible for the defense mechanism of plants, is also decreasing. Therefore, lifestyle-related diseases such as adult diseases and juvenile adult diseases (visceral fat-type obesity and metabolic syndrome) continue to increase. Therefore, the inventors of the present invention focused on the fruit of Gnetum gnemon L. for the first time. Invention of fermented food (patent document 3) and meringo tea (patent document 4) is performed.

Gnetsum Gunemon is a vegetable that uses young leaves, flowers, and immature fruits as vegetables, and is only used as a food that has been crushed and dried in oil (unping; emping). Currently, it is not used for food.

Examples of physiological actions of plants belonging to the genus Gnetum family include hair nourishing action of Bimitou (scientific name: Gnetumu montanum) (patent document 5), antibacterial action of resveratrol polymer contained in extracts obtained from roots of Gnetsum family (Patent document 6), collagen production promoting action, hyaluronic acid production promoting action, elastase inhibiting action, hyaluronidase inhibiting action (patent document 7) of gnetum extract is disclosed. The main useful components of gnetsum seeds are stilbenoids resveratrol dimer gnetin C, gnemonoside A, gnemonoside C and gnemonoside D, which are a kind of polyphenols, and have antibacterial and antioxidant effects (radical scavenging action). (Patent Document 2).

Patent Document 8 discloses that resveratrol monomer is contained in grapes, locust roots and peanuts, and is a lipid metabolism activator / obesity inhibitor / diabetes prevention / improving agent by AMPK activation action.・ Liver hypertrophy inhibitor ・ Food and drink as fatty liver inhibitor (Patent Document 9), Circulatory system disorder due to activation of peroxisome proliferative responsive receptor α (brain tissue disorder-cerebral infarction, head injury, cerebral embolism As a cerebral ischemic attack, cardiovascular disorder-ischemic heart disease-angina pectoris / myocardial infarction, spinal cord tissue disorder-spinal cord infarction / spinal cord trauma) progression inhibitory pharmaceutical composition (Patent Document 10), as a blood glucose level lowering agent Food and drink (Patent Document 11), food composition (Patent Document 12) to improve foot edema / coldness, endurance improver (Patent Document 13), prevention of recurrence of joint pain, low back pain and sciatica in limb joints Useful for symptom relief Mouth composition (patent document 14), composition for prevention and treatment of symptoms related to colds and influenza-like diseases (patent document 15), therapeutic agent for influenza virus infection (patent document 16), neuropathy and nerve Degenerative disease treatment composition (Patent Document 17), central nervous system disease progression retarder (Patent Document 18), anti-inflammatory dietary supplement composition (Patent Document 19), protein hypertrophy and protein kinase that suppresses heart disease The utilization to C-micro (PKD) inhibitor (patent document 20) and the manufacturing method (patent document 21) of the food / beverage products which contain 15 mg / kg or more of grape-derived resveratrol are disclosed. In addition, there are many reports such as a skin cancer inhibitory action using a mouse (Non-patent Document 1) and a life extension by improving the health of mice fed with a high calorie diet (Non-Patent Document 2).

However, with respect to resveratrol dimer, the antibacterial action / antioxidant action (Patent Document 2) and testosterone 5α-reductase inhibitory action (Non-Patent Document 3) are only studied.

JP 2006-81405 A International Patent Application PCT / JP2005-016824 Japanese Patent Application No. 2006-196293 Japanese Patent Application No. 2007-159904 Japanese Patent Laid-Open No. 11-60450 JP 2005-23000 A JP 2006-169225 A JP 2005-281179 A JP 2006-273434 A JP 2003-300904 A JP 2007-126390 A JP 2003-286809 A JP 2007-145809 A JP 2001-72582 A Special table 2003-505500 gazette JP-T-2006-507295 JP-T-2003-513917 JP 2005-530442 A JP 2006-528950 A Special table 2007-505158 JP 2005-143377 A Science, 275, 218-220 (1997). Nature, 444, 337-342 (2006) J. et al. Wood Sci. , 48, 64-68 (2002)

In recent years, the number of people who become visceral fat-type obesity has increased because Japanese people have increased the consumption of meat foods due to the westernization of foods, and increased intake of fat and excessive intake of energy (calories). . If left untreated, patients suffer from lifestyle-related diseases such as hyperlipidemia, hypertension and diabetes, and finally arteriosclerosis causing angina, myocardial infarction, cerebral infarction, obstructive arteriosclerosis, etc. become. It is necessary to prevent visceral fat obesity so as not to become such a disease, but changing the taste and reducing eating feels mentally painful, so it does not last long . In view of this point, an object of the present invention is to provide a health-preserving agent and a food product that can take in nutrients other than energy as much as possible except for excess energy while taking a normal meal form.

As a result of continuing intensive studies to solve the above-mentioned problems as part of the use of gnetsum fruit, the present inventors have not only contained resveratrol monomer as a secondary component in seeds, but also two amounts thereof. The body was newly found to have a lipase inhibitory action and an α-amylase inhibitory action, and the present invention was completed. That is, the present invention relates to a health-preserving agent comprising as an active ingredient a resveratrol dimer of gnetum that suppresses or inhibits digestion and absorption of carbohydrates and lipids by lipase inhibitory activity, α-amylase inhibitory activity and α-glucosidase inhibitory activity. And food.

According to the present invention, resveratrol monomer and dimer contained in gnetsum which is abundant and regular in Southeast Asia are safe, and in addition to various biological effects of monomer, dimer has antibacterial activity and Since it has not only radical scavenging action but also lipase inhibitory action, α-amylase inhibitory action and α-glucosidase inhibitory action, taking a health preservative suppresses digestion and absorption of carbohydrates and lipids in the gastrointestinal tract, thereby increasing blood sugar and An increase in sex fat (blood triglycerides) is suppressed, blood cholesterol is also lowered, and prevention of visceral fat obesity is expected. Moreover, it can contribute to improving or preventing visceral fat type obesity or mere obesity in daily life by ingesting a food or drink containing a resveratrol dimer having such an action.

Gnetsum referred to in the present invention is a plant belonging to the family Gnetum, among which Gnemon (also known as Melinjo, scientific name Gnetum gnemon L., English name Gnemon tree, Indonesian name Melinjo, Belinjo) is widely cultivated in Southeast Asia, in Indonesia Young leaves, flowers, and fruits are eaten as vegetables, and the seeds are crushed and then dried, fried in oil (eating), and eaten. In the present invention, fruits, seeds, leaves and flowers which are edible parts are used. Roots can be mixed if necessary. The fruits and seeds to be used may be left as they are, whether they are immature or completely ripe, and the contents are peeled from the pericarp and seed coat, that is, embryos and endosperm (inner milk) are preferred, and both dried and undried (raw) are suitable. It may be crushed with a cutter or a crusher, or may be crushed with a crusher. An extract obtained by solvent extraction of gnetum as it is or in such a manner by a general method or an extract in Patent Document 2 is preferable. In addition, the crushed inner milk remaining in Patent Document 2 and the unpinn that is not fried with oil can be used as well.

The resveratrol dimer referred to in the present invention is a compound in which two molecules of resveratrol belonging to the stilbenoid are bound, and includes gnetin C and its glycosides genomonoside A, genomonoside B, gnemonoside C and gnemonoside D, Examples thereof include gnetin D, vinyliferin and its glycoside, gmonomonoside E, gemonmonol M, and gemonmonol E.

The health-preserving agent referred to in the present invention comprises resveratrol dimer as an active ingredient, and is mixed with any auxiliary, excipient, etc. to form a solid or water or an organic solvent as appropriate. It is a liquid formulation. When the health-preserving agent of the present invention is used as an oral preparation for improving or preventing visceral fat-type obesity or mere obesity, the dosage (administration) amount is the purpose of taking or the situation of the user (gender, age, weight, Usually, as a daily dose, gnetum extract (extract) can be taken in the range of 1 to 500 mg / kg body weight in terms of weight, although it varies depending on the degree of obesity, overall health, etc. There is no problem with taking more than 500 mg / kg body weight.

The lipase in the present invention does not mean in a narrow sense to hydrolyze glycerol esters to release fatty acids, but refers to enzymes that hydrolyze so-called fatty acid esters into fatty acids and alcohols, and are widely distributed in animals, plants and microorganisms. .

The polysaccharide hydrolase in the present invention is an enzyme that shortens a sugar chain by hydrolyzing a polysaccharide of two or more disaccharides. For example, α-amylase in human and animal saliva and pancreatic juice hydrolyzes starch. It is an enzyme that produces maltose. α-Glucosidase is present in the small intestine of humans and animals, is widely present in plants and microorganisms, includes maltase and sucrose, and hydrolyzes the α-glucoside bond at the non-reducing end. Disaccharides such as sugar are hydrolyzed and converted to monosaccharides.

The triglyceride-lowering action and the hypoglycemic action referred to in the present invention are not only triglyceride and blood sugar but also total cholesterol and low-density lipoprotein cholesterol (LDL-C), which are also considered as factors of visceral fat type obesity. It means that the increase is suppressed to within the standard (normal), and high density lipoprotein cholesterol (HDL-C) is increased to suppress obesity (anti-obesity).

The food and drink referred to in the present invention is a food or drink containing or blending resveratrol dimer as an active ingredient, and can be used as a food for specified health use, as it is or together with various components used in conventional foods. Manufactured by blending. The food form can be any food form such as solid food, cream or jam-like semi-fluid food, gel food, beverage, etc., for example, formulations such as granules, tablets, capsules, drinks, etc. Soft drinks, juices, coffee, tea, liqueurs, milk, whey drinks, lactic acid bacteria drinks, yogurt, candy, caramel, chewing gum, chocolate, gummy, ice cream, pudding, eggs Foods and drinks such as products, sheepskin, water sheepskin, rice cakes, rice cakes, dumplings, rice crackers, crepes, okonomiyaki, bread, cookies, noodles, hamburgers, water-dried products, tempura, fermented foods and the like.

If necessary, tomorrow leaves, sweet tea, candy tea leaves, aloe, ginkgo biloba leaves, oolong tea, turmeric, radish, sorghum, sorghum, plantain, plantain, chamomile, chamomile, karin, garcinia, kawahara decision, chrysanthemum, gardenia, mulberry, Wolfberry, laurel, tea, red bean cedar, comfrey, kelp, cherry, saffron, shiitake mushroom, perilla, ginger, ginger, cedar, swangi, budgerigar, sendangsa, assembly, buckwheat, tamarin degree, taranki, dandelion, chicory, tanaka, peanut , Elderberry, rodent, pearl barley, hub, pine needles, mate, barley tea, barley tea, eucalyptus, mugwort, rahan fruit, green tea, rooibos, ganoderma, galangal, gymnema, guava leaf, geno shoko, brown rice, burdock, dokudami, banaba, loquat leaves , So-called herbal medicine such as safflower Beauty may be added blended and their extracts.

If necessary, sugar alcohols such as erythritol, sorbitol, maltitol, and xylitol, glucose, fructose, sucrose, lactose, dextrin, cyclodextrin, and the like can be mixed to mask bitterness and astringency.

When the food and drink of the present invention is used for improving or preventing visceral fat-type obesity or mere obesity, considering the flavor and color tone of the food and drink, the amount of gnetum as it is and / or its extract is 0 in terms of dry weight. The range is 0.01 to 90%, preferably 0.05 to 80%. According to the type of the food or drink of the present invention, sweeteners such as glucose, fructose, sucrose, maltose, sorbitol, stevioside, rubusoside, corn syrup, lactose, citric acid, tartaric acid, malic acid, succinic acid, lactic acid, etc. Acidulant, L-ascorbic acid, dl-α-tocopherol, antioxidants such as sodium erythorbate, quality improvers such as glycerin and propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester , Emulsifiers such as propylene glycol fatty acid esters, gum arabic, carrageenan, casein, gelatin, pectin, agar and other pastes (thickener, stabilizer, gelling agent), vitamin B, nicotinamide, calcium pantothenate, etc. Strengthening agent Seasonings such as Amino Acids, calcium salts, colorants, leavening agents, flavoring agents, such as preservatives, what is used as a general food or drink material can be produced by appropriately blending.

In addition, various ingredients usually used in animal feeds are appropriately blended according to the purpose to form powders, granules, pastes, capsules, syrups, solids, gels, liquids, suspensions, emulsions, etc. Can be used as animal feed such as livestock feed, cat food, pet food such as dog food and rabbit food.

EXAMPLES Hereinafter, although an Example demonstrates this invention in detail, this invention is not limited to these Examples.

Example 1 (Production of powder)
Gnemon dry inner milk 10 kg was pulverized with a pulverizer to obtain 9.7 kg of gnetum powder.

Implementation ceremony 2 (Manufacture of extract and isolation of ingredients)
A crushed product of 16.2 kg of dried gnemon fruit was immersed in 80 L of 50% ethanol for 2 days, and the extract was concentrated to dryness under reduced pressure to obtain 1300 g of a gnetum extract (yield 8%). A 1/20 amount of this extract, 65 g, was collected in the order of elution by Sepabead SP825 (Diaion) column chromatography to give fractions 1, 2, and 3. Fraction 2 was separated and purified by Sephadex LH20 column chromatography to obtain 2.7 g of gnemonoside A as a light brown amorphous solid of [α] ₅₄₆ + 68.3 ° (c = 0.7, methanol, 23) (yield) 0.34%) was obtained. Trans fractions 3 as a white fine columnar crystals Mp275-6 ° C. was separated and purified by silica gel column chromatography (decomposition) - Resveratrol 0.16 g (0.02% yield), _[α] 546 -23. 2 ° (c = 0.5, methanol, 23) light (0.45% yield) 3.66 g of Gunechin C as a yellow amorphous solid and _{mp205-6 °, [α] 546 -65.6} ° ( 4.36 g (yield 0.54%) of gnemonoside D was obtained as fine brown needles of c = 0.6, methanol, 34). The thus obtained gnetum extract and gnemonoside A, trans-resveratrol, gnetin C and gnemonoside D were used as samples for the following tests.

Example 3 (Lipase inhibition test)
In this test, a 13 mM Tris buffer solution at pH 8 containing sodium chloride (0.15 M) and calcium chloride (1.3 mM) was used. 0.25 mL of 10% methanol solution of the sample was added to 0.5 mL of 0.1 mM 4-methylumbelliferyl solution dissolved in this buffer solution, and then lipase solution (derived from porcine pancreatic juice, manufactured by Sigma) ) 0.25 mL was added and mixed well. After reacting at 25 ° C. for 30 minutes, 4 mL of 0.1 M citrate buffer having a pH of 4.2 was added to stop the reaction. The fluorescence intensity (excitation wavelength: 355 nm, emission wavelength: 460 nm) of this reaction solution based on 4-methylumbelliferone generated by the action of lipase was measured to determine the concentration (IC50) of the sample that inhibits lipase activity by 50%. As a result, the gnetum extract of Example 2 was 7.1 ppm, gnetin C was 3.4 μM, gnemonoside D was 14 μM, and gnemonoside A was 17 μM, but resveratrol was 20 μM and the inhibition rate was 8%. .

Example 4 (α-amylase inhibition test)
In this test, a 10 mM Tris buffer solution of pH 7 containing sodium chloride (80 mM) and calcium chloride (10 mM) was used. 2 mL of 0.4% potato starch solution dissolved in this buffer solution is added to a mixture of 0.2 mL of α-amylase solution (derived from porcine pancreatic juice, Sigma) dissolved in this buffer solution and 2 mL of 10% methanol solution of the sample. And mixed well and allowed to react at 37 ° C. for 20 minutes. The reaction was stopped by adding 0.5 mL of 0.5 M hydrochloric acid to 1 mL of this reaction solution, and after adding and mixing 3.5 mL of 0.2 mM iodine solution, 5 mL of purified water was added and the absorbance at 600 nm was measured. Absorbance was measured in the same manner by adding 2 mL of 10% methanol instead of the sample solution and 0.2 mL of this buffer solution instead of the α-amylase solution to make a control and a blank, respectively. The concentration (IC50) of the sample that inhibits the α-amylase activity by 50% was determined from the absorbance. However, resveratrol had an inhibition rate of 6% at a concentration of 200 μM.

Example 5 (α-glucosidase inhibition test)
0.1% dissolved in the same buffer solution in a mixture of 0.25 mL of α-glucosidase (from yeast, Sigma) solution and 0.25 mL of 10% methanol solution of the sample dissolved in 30 mM phosphate buffer (pH 7) Add 0.5 mL of maltose solution, mix well, and react at 37 ° C. for 30 minutes, then add 0.5 mL of the reaction solution to 3 mL of glucose CII-Test Wako Coloring Solution (manufactured by Wako Pure Chemical Industries), and mix and develop the color. The absorbance at 505 nm was measured. 0.25 mL of 10% methanol was added instead of the sample solution, and 0.25 mL of the same buffer solution was added instead of the α-glucosidase solution to make a control and a blank, respectively, and the absorbance was measured in the same manner. The concentration (IC50) of the sample that inhibits the α-glucosidase activity by 50% was determined from the absorbance. Although resveratrol had a concentration of 50 μM, the inhibition rate was 7%.

Example 6 (Manufacture of tablets)
500 g of the gnetsum extract of Example 2, 500 g of dextrin (Max 1000, manufactured by Matsutani Chemical Co., Ltd.), 1000 g of lactose and 10 g of magnesium stearate were mixed, and this mixture was tableted with a single tableting machine. A tablet (containing 50 mg of gnetsum extract) was produced.

Example 7 (sucrose tolerance test-blood glucose level increase suppression test)
The subjects of the present invention who have a high level of triglyceride and total cholesterol (35-59 years old; 3 males; 2 females) who have agreed to the purpose of this study on postprandial blood glucose levels over the past 3 years. A sucrose tolerance test was conducted to examine the effects of health-preserving agents. The subject fasted after 22:00 on the day before the test, and started the test by drinking 50 g of sucrose with 200 mL of water around 9 o'clock on that day. The tablets of Example 6 were taken 4 minutes (extract amount: 200 mg) 5 minutes before the test, and blood glucose was collected at the start, 30 minutes, 1 hour and 2 hours later to collect glucose CII-Test Wako (Wako Pure Chemical). It was measured by a method using a product manufactured by Kogyo). Moreover, the same test was performed on the same subject using a tablet containing no gnetum extract as a placebo. Both tests were conducted with a one week interval. As a result, the average blood glucose level when taking the tablet of Example 6 was 93 mg / dL at the start, 132 mg / dL after 30 minutes, 114 mg / dL after 1 hour, and 87 mg / dL after 2 hours. In the case of placebo, it was 93 mg / dL at the start, 145 mg / dL after 30 minutes, 126 mg / dL after 1 hour, and 93 mg / dL after 2 hours. Therefore, the effect of suppressing an increase in blood glucose level was observed by taking the health maintenance agent of the present invention.

Example 8 (blood lipid lowering test)
5 tablets (neutral fat value: 185 to 249 mg / dL, total cholesterol value: 211 to 245 mg / dL) as in Example 7 and 4 tablets (extract amount: 200 mg) after each meal. I was taken 3 times a day for 14 days. The meal was a regular menu with no restrictions. Blood tests were conducted before the test and after 14 days of administration, and neutral fat, total cholesterol and high density lipoprotein cholesterol levels were examined. As a result, the triglyceride level was 228 mg / dL before the test, 120 mg / dL after the test, and 194 mg / dL before the test and 139 mg / dL after the test. It was. As for the total cholesterol value, the average value of male subjects was 231 mg / dL before the test, 202 mg / dL after the test, and the average value of the female subjects was 217 mg / dL before the test and 188 mg / dL after the test. The high density lipoprotein cholesterol level was 47 mg / dL for male subjects before the test, 52 mg / dL after the test, and 57 mg / dL for female subjects before the test, and 86 mg / dL after the test. . Therefore, by taking the health-preserving agent of the present invention, the neutral fat decreased by 47% for men and 29% for women, and the total cholesterol decreased by 13% for men and 13% for women. On the other hand, high-density lipoprotein cholesterol increased by 11% in men and 51% in women, so neutral fat and total cholesterol, which are indicators of visceral fat-type obesity, decrease and are said to be good cholesterol. Protein cholesterol increased and health improved. In addition, there was no change in the physical condition by taking the health maintenance agent of the present invention, and none of the test values of blood test, other blood biochemical tests and urine tests were abnormal, and no side effects were observed.

Example 9 (candy)
A candy was prepared by blending 1 part of the gnetsum extract of Example 2, 280 parts of granulated sugar, 210 parts of starch syrup, 5 parts of citric acid, 1 part of perfume and 1 part of pigment. The candy was not bitter and tasted good.

Example 10 (juice)
1 part of the gnetsum extract of Example 2, 25 parts of frozen and concentrated mandarin orange juice, 55 parts of fructose glucose liquid sugar, 1 part of citric acid, 0.1 part of L-ascorbic acid, 1 part of fragrance, 0.5 part of pigment, and water 400 The juice was prepared by blending the parts. This juice had no change in the flavor and color of tangerines.

Example 11 (chewing gum)
A chewing gum was prepared by blending 1 part of the gnetsum extract of Example 2, 300 parts of chewing gum base, 800 parts of sucrose, 300 parts of starch syrup, softener 60, 13 parts of perfume and 1 part of pigment. The chewing gum had no bitterness and the taste was good.

Example 12 (chocolate)
A chocolate was prepared by blending 1 part of the gnetsum extract of Example 2, 220 parts of chocolate, 75 parts of sucrose, 100 parts of cacao butter and 100 parts of whole milk powder. The blended gnetum extract did not affect the flavor and color of the chocolate and was delicious.

Example 13 (cookies)
1 part of the powdered powder of Example 1, 2.3 parts of flour, 1.6 parts of whole egg, 1.9 parts of margarine, 2.5 parts of super white sugar, 0.02 parts of baking powder and 0.73 parts of water. Made cookies. This cookie had a good taste, no bitterness, and a good taste.

Example 14 (Okaki)
A pork was prepared by blending 1 part of the powder of Example 1 powder, 1 part of cocoon powder, 0.02 part of salt and 2 parts of water. The cooked rice was tasty and had a good taste.

Example 15 (crepe)
A crepe was prepared by blending 1 part of the powdered powder of Example 1, 0.4 part of flour, 0.2 part of whole egg, 0.2 part of milk, 0.01 part of salt, appropriate amount of vanilla essence and 1.2 part of water. did. The crepe had good flavor and taste.

Example 16 (solid dog food)
1 part of the powdered powder of Example 1, 1.9 parts of meat meal, 0.25 parts of chicken extract, 0.25 parts of vegetable oil and fat, 0.9 parts of carbohydrate, 0.025 part of calcium carbonate, 0.01 part of sodium chloride, composite A dog food was prepared by blending 0.05 part of a vitamin preparation and 0.5 part of water.

According to the present invention, resveratrol monomer and dimer contained in gnetsum which is abundant and regular in Southeast Asia are safe, and in addition to various biological effects of monomer, dimer has antibacterial activity and Since it has not only radical scavenging action but also lipase inhibitory action, α-amylase inhibitory action and α-glucosidase inhibitory action, taking a health preserving agent suppresses digestion and absorption of carbohydrates and lipids in the digestive tract, thereby increasing blood sugar and blood The rise in medium triglycerides (neutral fat) is suppressed, blood cholesterol is also lowered, high-density lipoprotein cholesterol is raised to prevent visceral fat obesity, and is useful for the prevention of lifestyle-related diseases. In addition, taking food and drink containing resveratrol dimer can contribute to the improvement or prevention of visceral fat-type obesity and mere obesity in daily life. Therefore, it is useful not only as a healthy person but also as a diet food or drink for fat people or a food or drink for diabetics. Furthermore, use of the health-preserving agent and food and drink of the present invention as feed is useful for dieting animals such as pets and livestock, and for improving or preventing diabetes and obesity.

Claims (5)

A health maintenance agent comprising resveratrol dimer of gnetsum as an active ingredient The health maintenance agent according to claim 1, wherein the active ingredient has a lipase inhibitory action. The health maintenance agent according to claim 1, wherein the active ingredient has a polysaccharide hydrolase inhibitory action. The health maintenance agent according to claim 1, wherein the active ingredient has a neutral fat lowering action and / or a blood sugar lowering action. A food or drink comprising a resveratrol dimer of gnetsum and having a neutral fat lowering action and / or a blood sugar lowering action