JP2008546842A5 - - Google Patents
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- Publication number
- JP2008546842A5 JP2008546842A5 JP2008519483A JP2008519483A JP2008546842A5 JP 2008546842 A5 JP2008546842 A5 JP 2008546842A5 JP 2008519483 A JP2008519483 A JP 2008519483A JP 2008519483 A JP2008519483 A JP 2008519483A JP 2008546842 A5 JP2008546842 A5 JP 2008546842A5
- Authority
- JP
- Japan
- Prior art keywords
- cerium oxide
- oxide nanoparticles
- cell
- disease
- size
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910000420 cerium oxide Inorganic materials 0.000 claims 24
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 claims 24
- 239000002105 nanoparticle Substances 0.000 claims 22
- 210000004027 cell Anatomy 0.000 claims 18
- 239000003814 drug Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 150000003254 radicals Chemical class 0.000 claims 5
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 2
- 230000007613 environmental effect Effects 0.000 claims 2
- 210000000987 immune system Anatomy 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000014644 Brain disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 208000012659 Joint disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000017442 Retinal disease Diseases 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 208000029033 Spinal Cord disease Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000004768 organ dysfunction Effects 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000003980 solgel method Methods 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69393005P | 2005-06-27 | 2005-06-27 | |
| PCT/US2006/024963 WO2007002662A2 (en) | 2005-06-27 | 2006-06-27 | Anti-inflammatory, radioprotective, and longevity enhancing capabilities of cerium oxide nanoparticles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008546842A JP2008546842A (ja) | 2008-12-25 |
| JP2008546842A5 true JP2008546842A5 (enExample) | 2009-08-13 |
Family
ID=37595977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008519483A Pending JP2008546842A (ja) | 2005-06-27 | 2006-06-27 | 酸化セリウムナノ粒子の抗炎症性、放射線防護性および寿命促進能 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20100166821A1 (enExample) |
| EP (1) | EP1904072A4 (enExample) |
| JP (1) | JP2008546842A (enExample) |
| AU (1) | AU2006261764A1 (enExample) |
| CA (1) | CA2613086A1 (enExample) |
| WO (1) | WO2007002662A2 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10857178B2 (en) * | 2005-06-27 | 2020-12-08 | Edward Via Virginia College Of Osteopathic Medicine | Cerium oxide nanoparticles for treatment and prevention of Alzheimer's disease, Parkinson's disease, and disorders associated with free radical production and/or mitochondrial dysfunction |
| US9649337B2 (en) | 2005-06-27 | 2017-05-16 | Edward Via Virginia College Of Osteopathic Medicine | Cerium oxide nanoparticles for the treatment and prevention of stroke and cardiovascular disease |
| US7959949B2 (en) | 2006-04-27 | 2011-06-14 | University Of Central Florida Research Foundation, Inc. | Functionalized nanoceria composition for ophthalmic treatment |
| WO2008018932A2 (en) | 2006-05-01 | 2008-02-14 | The Board Of Trustees Of The Leland Stanford Junior University | Method and use of nano-scale devices for reduction of tissue injury in ischemic and reperfusion injury |
| US8333993B1 (en) * | 2006-12-29 | 2012-12-18 | University Of Central Florida Research Foundation, Inc. | Synthesis of polymer coated ceria nanoparticles for biomedical applications |
| US20080166412A1 (en) | 2007-01-02 | 2008-07-10 | Kiminobu Sugaya | Methods and materials for stimulating proliferation of stem cell |
| KR100876361B1 (ko) * | 2007-05-11 | 2008-12-29 | 주식회사 태웅이엘에스 | 슬리밍용 조성물 |
| US9119391B1 (en) * | 2007-07-16 | 2015-09-01 | University Of Central Florida Research Foundation, Inc. | Polymer coated ceria nanoparticles for selective cytoprotection |
| EP2288258A4 (en) * | 2008-04-25 | 2012-10-31 | Univ Oklahoma | INHIBITION OF NEOVASCULARIZATION BY CERIUM OXIDE NANOPARTICLES |
| US8916199B1 (en) | 2008-04-25 | 2014-12-23 | University of Central Florida Research Foundation, Ind. | Inhibition of angiogenesis associated with ovarian cancer by nanoparticles of cerium oxide |
| US9127202B1 (en) | 2008-07-18 | 2015-09-08 | University Of Central Florida Research Foundation, Inc. | Biocompatible nano rare earth oxide upconverters for imaging and therapeutics |
| US8883519B1 (en) | 2009-03-17 | 2014-11-11 | University Of Central Florida Research Foundation, Inc. | Oxidase activity of polymeric coated cerium oxide nanoparticles |
| US9585840B1 (en) | 2009-07-10 | 2017-03-07 | University Of Central Florida Research Foundation, Inc. | Redox active cerium oxide nanoparticles and associated methods |
| US8795731B1 (en) | 2009-10-12 | 2014-08-05 | University Of Central Florida Research Foundation, Inc. | Cerium oxide nanoparticle-based device for the detection of reactive oxygen species and monitoring of chronic inflammation |
| US20160074434A1 (en) * | 2010-07-22 | 2016-03-17 | University Of Central Florida Research Foundation, Inc. | Application Device for Inducing Cytotoxicity to Tumor Cells Via Coated Cerium Oxide Nanoparticles |
| WO2012036786A1 (en) | 2010-09-17 | 2012-03-22 | University Of L'aquila | Nanoparticles of cerium oxide targeted to an amyloid-beta antigen of alzheimer's disease |
| DK201000969A (en) * | 2010-10-25 | 2012-04-26 | Entomopharm Aps | Insect-based ex vivo model for testing blood-brainbarrier penetration and method for exposinginsect brain to nanoparticles |
| US11116792B1 (en) | 2010-12-22 | 2021-09-14 | Biocurity Holdings, Inc. | Cerium oxide nanoparticle formulation for use in skin radioprotection and associated methods |
| US8951539B1 (en) | 2011-06-07 | 2015-02-10 | University Of Central Florida Research Foundation, Inc. | Methods of promoting angiogenesis using cerium oxide nanoparticles |
| US9161950B2 (en) | 2011-09-21 | 2015-10-20 | University Of Central Florida Foundation, Inc. | Neuronal protection by cerium oxide nanoparticles |
| CA2869554A1 (en) * | 2012-04-04 | 2013-10-10 | Duke University | Methods of using cerium oxide nanoparticles to mitigate or protect against radiation injury |
| WO2013158744A2 (en) | 2012-04-17 | 2013-10-24 | Cerion Enterprises, Llc | Nanoparticles of cerium and amino acids |
| US9446070B2 (en) | 2012-06-13 | 2016-09-20 | Cerion, Llc | Nanoceria with citric acid additive |
| JP6174692B2 (ja) | 2012-06-13 | 2017-08-02 | セリオン エンタープライジズ リミテッド ライアビリティ カンパニー | 酸化ストレスの処置のためのナノセリア |
| WO2014008503A1 (en) * | 2012-07-06 | 2014-01-09 | University Of Central Florida Research Foundation, Inc. | Methods of using ceo2 and tio2 nanoparticles in modulation of the immune system |
| US9463437B2 (en) | 2013-02-14 | 2016-10-11 | University Of Central Florida Research Foundation, Inc. | Methods for scavenging nitric oxide using cerium oxide nanoparticles |
| WO2014134286A2 (en) * | 2013-03-01 | 2014-09-04 | University Of Central Florida Research Foundation, Inc. | Cerium oxide nanoparticles accelerate the decay of peroxynitrite (onoo-) |
| US9549950B2 (en) | 2013-04-25 | 2017-01-24 | Cerion, Llc | Chelated nanoceria for the treatment of oxidative stress |
| US9623110B2 (en) | 2013-08-09 | 2017-04-18 | Cerion, Llc | Nanoparticles of a metal and a nucleobase |
| WO2015058037A1 (en) | 2013-10-17 | 2015-04-23 | Cerion, Llc | Malic acid stabilized nanoceria particles |
| US9669055B1 (en) * | 2014-04-11 | 2017-06-06 | Marshall University Research Corporation | Methods for treating sepsis |
| CN103983777A (zh) * | 2014-05-07 | 2014-08-13 | 大连理工大学 | 一种基于纳米二氧化铈仿生氧化酶的微囊藻毒素比色检测方法 |
| AU2015289504B2 (en) * | 2014-07-17 | 2020-12-17 | BioCurity Pharmaceuticals Inc. | Treatment of cancer with a combination of radiation, cerium oxide nanoparticles, and a chemotherapeutic agent |
| JP2018508568A (ja) | 2015-01-20 | 2018-03-29 | セリオン，リミティド ライアビリティ カンパニー | カタラーゼ様活性を有するｅｄｄｓでキレート化されたナノセリア |
| JP2016204368A (ja) * | 2015-04-14 | 2016-12-08 | 株式会社Ａｐｐｌａｕｓｅ | 酸化セリウム微粒子を含有する組成物 |
| US11389536B2 (en) | 2015-07-17 | 2022-07-19 | BioCurity Pharmaceuticals Inc. | Treatment of cancer with a combination of radiation, cerium oxide nanoparticles, and a chemotherapeutic agent |
| US11833172B2 (en) | 2015-11-25 | 2023-12-05 | The Regents Of The University Of Colorado | Use of microRNA-146A and nanoceria conjugate to improve wound healing and promote tissue regeneration |
| KR101696903B1 (ko) | 2016-04-20 | 2017-01-17 | 서울대학교병원 | 세리아 나노복합체를 포함하는 비외상성 두개내 출혈 치료용 약학적 조성물 |
| CN107789627B (zh) * | 2017-09-26 | 2021-05-07 | 西北农林科技大学 | 可降解聚多巴胺包封的靶向双刺激响应性多功能二氧化铈纳米载药体系 |
| KR102102535B1 (ko) * | 2018-07-26 | 2020-04-21 | 서울대학교산학협력단 | 방사선 보호 나노입자 |
| EP3867407A4 (en) * | 2018-07-26 | 2022-09-14 | Edward Via College of Osteopathic Medicine | BLOOD PRESERVATION COMPOSITIONS, DEVICES, AND USES THEREOF |
| JP7328480B2 (ja) * | 2018-09-14 | 2023-08-17 | 株式会社applause Pharma | チロシン－チロシナーゼ反応阻害剤 |
| WO2020069292A1 (en) * | 2018-09-28 | 2020-04-02 | The Regents Of The University Of Colorado, A Body Corporate | Methods for preventing and treating pulmonary inflammation and fibrosis |
| CN112516294B (zh) * | 2020-12-22 | 2023-04-07 | 浙江大学 | 一种氧化铈纳米稳定剂在制备预防过敏性疾病药物中的应用及预防过敏性疾病的药物组合物 |
| US12480009B2 (en) | 2021-07-30 | 2025-11-25 | Xheme Inc. | Nanoporous cerium oxide nanoparticle macro-structure |
| WO2023060246A1 (en) * | 2021-10-08 | 2023-04-13 | Xheme Inc. | Blood preservation compositions, devices and uses thereof utilizing: a. zirconium dioxide nanoparticles or nanoporous zirconium dioxide nanoparticle macrostructures; and b. nanoporous cerium oxide nanoparticle macrostructures |
| CN116942695A (zh) * | 2022-04-20 | 2023-10-27 | 中国科学院深圳先进技术研究院 | 二氧化铈作为炎症小体抑制剂在疾病治疗中的应用 |
| CN116270729A (zh) * | 2022-11-09 | 2023-06-23 | 西安交通大学医学院第一附属医院 | 多孔纳米棒状氧化铈在制备治疗特应性皮炎的药物中的应用 |
| AU2024285952A1 (en) * | 2023-06-09 | 2025-12-04 | Xheme Inc. | Bioreactors providing cerium oxide and zirconium dioxide |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG38903A1 (en) * | 1995-03-16 | 1997-04-17 | Gen Electric | Acrylic coatings containing inorganic UV screen |
| JP2746861B2 (ja) * | 1995-11-20 | 1998-05-06 | 三井金属鉱業株式会社 | 酸化セリウム超微粒子の製造方法 |
| US6413489B1 (en) * | 1997-04-15 | 2002-07-02 | Massachusetts Institute Of Technology | Synthesis of nanometer-sized particles by reverse micelle mediated techniques |
| GB0126663D0 (en) * | 2001-11-06 | 2002-01-02 | Oxonica Ltd | Cerium oxide nanoparticles |
| US6669823B1 (en) * | 2002-06-17 | 2003-12-30 | Nanophase Technologies Corporation | Process for preparing nanostructured materials of controlled surface chemistry |
| US7534453B1 (en) * | 2002-09-05 | 2009-05-19 | University Of Central Florida Research Foundation, Inc. | Cerium oxide nanoparticles and use in enhancing cell survivability |
| JP4054869B2 (ja) * | 2002-12-25 | 2008-03-05 | 独立行政法人産業技術総合研究所 | 抵抗型酸素センサの酸素分圧検出部分の製造方法 |
| DE10337199A1 (de) * | 2003-08-13 | 2005-03-10 | Degussa | Ceroxidpulver |
| CA2610296C (en) * | 2005-04-29 | 2016-06-14 | University Of Central Florida Research Foundation, Inc. | Inhibition of reactive oxygen species and protection of mammalian cells |
-
2006
- 2006-06-27 EP EP06785640A patent/EP1904072A4/en not_active Ceased
- 2006-06-27 CA CA002613086A patent/CA2613086A1/en not_active Abandoned
- 2006-06-27 WO PCT/US2006/024963 patent/WO2007002662A2/en not_active Ceased
- 2006-06-27 JP JP2008519483A patent/JP2008546842A/ja active Pending
- 2006-06-27 AU AU2006261764A patent/AU2006261764A1/en not_active Abandoned
- 2006-06-27 US US11/993,260 patent/US20100166821A1/en not_active Abandoned
-
2012
- 2012-07-02 US US13/539,564 patent/US8747907B2/en active Active
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