JP2008545793A5 - - Google Patents
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- JP2008545793A5 JP2008545793A5 JP2008515915A JP2008515915A JP2008545793A5 JP 2008545793 A5 JP2008545793 A5 JP 2008545793A5 JP 2008515915 A JP2008515915 A JP 2008515915A JP 2008515915 A JP2008515915 A JP 2008515915A JP 2008545793 A5 JP2008545793 A5 JP 2008545793A5
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- JP
- Japan
- Prior art keywords
- group
- hydrogen atom
- aralkyl
- alkyl
- aryl
- Prior art date
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- 0 *C(C1*)C(*C(*=C(C*I*)C=*)=O)*C1I* Chemical compound *C(C1*)C(*C(*=C(C*I*)C=*)=O)*C1I* 0.000 description 12
- CXIGIXHNCUFRDV-UHFFFAOYSA-N CCCN(CCO)c1ccc(C(c(cc2)ccc2N(CCO)CCO)c(cc2)ccc2Cl)cc1 Chemical compound CCCN(CCO)c1ccc(C(c(cc2)ccc2N(CCO)CCO)c(cc2)ccc2Cl)cc1 CXIGIXHNCUFRDV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68876705P | 2005-06-08 | 2005-06-08 | |
| US60/688,767 | 2005-06-08 | ||
| PCT/US2006/022268 WO2006133353A2 (en) | 2005-06-08 | 2006-06-08 | Methods of facilitating neural cell survival using non-peptide and peptide bdnf neurotrophin mimetics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008545793A JP2008545793A (ja) | 2008-12-18 |
| JP2008545793A5 true JP2008545793A5 (https=) | 2009-07-30 |
| JP5461009B2 JP5461009B2 (ja) | 2014-04-02 |
Family
ID=37499118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008515915A Active JP5461009B2 (ja) | 2005-06-08 | 2006-06-08 | 非ペプチド及びペプチドbdnfニューロトロフィン類似体を用いた神経細胞生存促進法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8686045B2 (https=) |
| EP (3) | EP2526942B1 (https=) |
| JP (1) | JP5461009B2 (https=) |
| ES (1) | ES2569881T3 (https=) |
| WO (1) | WO2006133353A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2519227C (en) | 2003-03-19 | 2013-12-03 | Biogen Idec Ma Inc. | Nogo receptor binding protein |
| US8486893B2 (en) | 2004-06-24 | 2013-07-16 | Biogen Idec Ma Inc. | Treatment of conditions involving demyelination |
| US20110230479A1 (en) * | 2005-04-15 | 2011-09-22 | Longo Frank M | Neurotrophin mimetics and uses thereof |
| EP2586445A1 (en) * | 2005-04-15 | 2013-05-01 | University Of North Carolina At Chapel Hill | Methods of facilitating cell survival using neurotrophin mimetics |
| ES2569881T3 (es) | 2005-06-08 | 2016-05-12 | The University Of North Carolina At Chapel Hill | Procedimientos para facilitar la supervivencia de células neuronales usando miméticos de neurotrofina BDNF peptídicos y no peptídicos |
| HRP20131066T1 (hr) | 2005-07-08 | 2013-12-06 | Biogen Idec Ma Inc. | Sp35 antitijela i njihova upotreba |
| WO2008078179A1 (en) * | 2006-12-20 | 2008-07-03 | Rinat Neuroscience Corporation | Trkb agonists for treating autoimmune disorders |
| WO2009048605A1 (en) * | 2007-10-11 | 2009-04-16 | Biogen Idec Ma Inc. | Methods for treating pressure induced optic neuropathy, preventing neuronal degeneration and promoting neuronal cell, survival via administration of lingo-1 antagonists and trkb agonists |
| WO2009061500A1 (en) * | 2007-11-08 | 2009-05-14 | Biogen Idec Ma Inc. | Use of lingo-4 antagonists in the treatment of conditions involving demyelination |
| US20110217280A1 (en) * | 2007-12-19 | 2011-09-08 | Vollrath Benedikt | Methods for treating neuropsychiatric conditions |
| US20100317715A1 (en) * | 2007-12-21 | 2010-12-16 | Vollrath Benedikt | Methods for treating neuropsychiatric conditions |
| CA2729961C (en) | 2008-07-09 | 2018-05-01 | Biogen Idec Ma Inc. | Li113, li62 variant co2, anti-lingo antibodies |
| EP2432776B1 (en) | 2009-05-21 | 2019-09-11 | Universite Laval | Methyl sulfanyl pyrimidines useful as antiinflammatories, analgesics, and antiepileptics |
| KR101138048B1 (ko) | 2009-11-06 | 2012-04-23 | 성균관대학교산학협력단 | Bdnf의 발현을 증가시키는 신규 펩타이드 및 이를 포함하는 알츠하이머병 또는 파킨슨병의 예방 및 치료용 약학 조성물 |
| EP3470402B1 (en) | 2009-11-12 | 2021-01-06 | Pharmatrophix Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
| US10273219B2 (en) | 2009-11-12 | 2019-04-30 | Pharmatrophix, Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
| US8901129B2 (en) | 2009-12-11 | 2014-12-02 | Genecode As | Methods of facilitating neural cell survival using GDNF family ligand (GFL) mimetics or RET signaling pathway activators |
| US20120004310A1 (en) * | 2010-05-28 | 2012-01-05 | Longo Frank M | Non-peptide bdnf neurotrophin mimetics |
| KR102142161B1 (ko) | 2012-05-14 | 2020-08-06 | 바이오젠 엠에이 인코포레이티드 | 운동 뉴런 관련 병태 치료용 lingo-2 길항제 |
| JP6120311B2 (ja) * | 2013-02-12 | 2017-04-26 | 学校法人銀杏学園 | ポリフェノール化合物 |
| CN105189449A (zh) * | 2013-03-15 | 2015-12-23 | 特罗菲克斯制药股份有限公司 | 非肽bdnf神经营养蛋白模拟物 |
| CN105209427B (zh) * | 2013-03-15 | 2018-05-25 | 特罗菲克斯制药股份有限公司 | 非肽bdnf神经营养蛋白模拟物 |
| US9447132B2 (en) | 2013-04-12 | 2016-09-20 | Achillion Pharmaceuticals, Inc. | Highly active nucleoside derivative for the treatment of HCV |
| JP7381190B2 (ja) | 2014-12-26 | 2023-11-15 | エモリー・ユニバーシテイ | N4-ヒドロキシシチジン及び誘導体並びにそれに関連する抗ウイルス用途 |
| JP2018504400A (ja) | 2015-01-08 | 2018-02-15 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | Lingo‐1拮抗薬及び脱髄障害の治療のための使用 |
| SG11201707513QA (en) * | 2015-05-29 | 2017-10-30 | Univ Leland Stanford Junior | Nucleoside agents for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
| US10066229B2 (en) * | 2015-07-28 | 2018-09-04 | Otonomy, Inc. | Treatment using truncated Trk B and Trk C antagonists |
| CA3010615C (en) | 2016-01-14 | 2024-02-20 | Beth Israel Deaconess Medical Center, Inc. | Mast-cell modulators and uses thereof |
| PT3706762T (pt) | 2017-12-07 | 2024-12-05 | Univ Emory | N4-hidroxicitidina e derivados e utilizações antivirais relacionadas com os mesmos |
| CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| JP2023527792A (ja) | 2020-05-27 | 2023-06-30 | アキシャル セラピューティクス,インク. | Tlr2調節剤化合物、医薬組成物、及びそれらの使用 |
| EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
| PT4426434T (pt) | 2021-11-02 | 2025-11-24 | Flare Therapeutics Inc | Agonistas inversos de pparg e suas utilizações |
| WO2024118503A1 (en) | 2022-11-28 | 2024-06-06 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
| CN116554123A (zh) * | 2023-04-27 | 2023-08-08 | 山东大学 | 六种噻唑酰腙类化合物在抗肿瘤药物中的应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2109262A5 (https=) * | 1970-10-08 | 1972-05-26 | Inst Francais Du Petrole | |
| US3953416A (en) * | 1971-12-20 | 1976-04-27 | Karl Folkers | Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same |
| JPS5025442B2 (https=) * | 1972-03-14 | 1975-08-23 | ||
| DE2343037A1 (de) | 1973-08-25 | 1975-03-06 | Hoechst Ag | Arzneimittel mit antidepressiver wirkung |
| HU185535B (en) | 1982-05-25 | 1985-02-28 | Mta Koezponti Hivatala | Process for preparing new gonadoliberin derivatives |
| US5321029A (en) | 1988-11-14 | 1994-06-14 | Beecham-Wuelfing Gmbh & Co.K.G. | Xanthines |
| GB9402331D0 (en) | 1994-02-07 | 1994-03-30 | Univ Mcgill | Nerve growth factor structural analogs and their uses |
| AU4117396A (en) | 1994-11-29 | 1996-06-19 | Novartis Ag | Morpholinoethylamide derivatives |
| US5958875A (en) | 1996-03-29 | 1999-09-28 | The Regents Of The University Of California | Synthetic peptides derivatives with nerve growth factor-like neurotrophic activity |
| WO1999007874A1 (en) * | 1996-06-13 | 1999-02-18 | Itoham Foods Inc. | Process for producing lh-rh derivatives |
| ES2230880T3 (es) * | 1998-07-30 | 2005-05-01 | Abbott Laboratories | Agentes selectivos anti-inflmatorios de glucocorticoides. |
| ATE323283T1 (de) | 1999-03-17 | 2006-04-15 | Univ North Carolina | Screening-verfahren von kandidaten verbindungen für empfindlichkeit gegenüber gallenexkretion |
| US6583148B1 (en) | 1999-04-08 | 2003-06-24 | Krenitsky Pharmaceuticals, Inc. | Neurotrophic substituted pyrimidines |
| ATE340571T1 (de) * | 2000-01-18 | 2006-10-15 | Univ Mcgill | Pharmazeutische zubereitungen enthaltend beta- turn peptidomimetische zyklische substanzen |
| AU2002228316A1 (en) * | 2001-01-29 | 2002-08-12 | Insight Strategy And Marketing Ltd | Carbazole derivatives and their uses as heparanase inhibitors |
| EP1553964A4 (en) | 2002-09-25 | 2009-08-12 | Georgia Tech Res Inst | KETOAMID INHIBITORS IN CHRONIC NERVE DISEASES |
| EP2586445A1 (en) | 2005-04-15 | 2013-05-01 | University Of North Carolina At Chapel Hill | Methods of facilitating cell survival using neurotrophin mimetics |
| ES2569881T3 (es) | 2005-06-08 | 2016-05-12 | The University Of North Carolina At Chapel Hill | Procedimientos para facilitar la supervivencia de células neuronales usando miméticos de neurotrofina BDNF peptídicos y no peptídicos |
-
2006
- 2006-06-08 ES ES12169982.1T patent/ES2569881T3/es active Active
- 2006-06-08 EP EP12169984.7A patent/EP2526942B1/en active Active
- 2006-06-08 EP EP12169982.1A patent/EP2581440B1/en not_active Not-in-force
- 2006-06-08 JP JP2008515915A patent/JP5461009B2/ja active Active
- 2006-06-08 EP EP06784665A patent/EP1893192A4/en not_active Withdrawn
- 2006-06-08 WO PCT/US2006/022268 patent/WO2006133353A2/en not_active Ceased
- 2006-06-08 US US11/449,381 patent/US8686045B2/en active Active
-
2014
- 2014-01-27 US US14/165,090 patent/US9604907B2/en active Active
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