JP2008545793A5 - - Google Patents
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- JP2008545793A5 JP2008545793A5 JP2008515915A JP2008515915A JP2008545793A5 JP 2008545793 A5 JP2008545793 A5 JP 2008545793A5 JP 2008515915 A JP2008515915 A JP 2008515915A JP 2008515915 A JP2008515915 A JP 2008515915A JP 2008545793 A5 JP2008545793 A5 JP 2008545793A5
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- JP
- Japan
- Prior art keywords
- group
- hydrogen atom
- aralkyl
- alkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *C(C1*)C(*C(*=C(C*I*)C=*)=O)*C1I* Chemical compound *C(C1*)C(*C(*=C(C*I*)C=*)=O)*C1I* 0.000 description 12
- CXIGIXHNCUFRDV-UHFFFAOYSA-N CCCN(CCO)c1ccc(C(c(cc2)ccc2N(CCO)CCO)c(cc2)ccc2Cl)cc1 Chemical compound CCCN(CCO)c1ccc(C(c(cc2)ccc2N(CCO)CCO)c(cc2)ccc2Cl)cc1 CXIGIXHNCUFRDV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68876705P | 2005-06-08 | 2005-06-08 | |
| US60/688,767 | 2005-06-08 | ||
| PCT/US2006/022268 WO2006133353A2 (en) | 2005-06-08 | 2006-06-08 | Methods of facilitating neural cell survival using non-peptide and peptide bdnf neurotrophin mimetics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008545793A JP2008545793A (ja) | 2008-12-18 |
| JP2008545793A5 true JP2008545793A5 (https=) | 2009-07-30 |
| JP5461009B2 JP5461009B2 (ja) | 2014-04-02 |
Family
ID=37499118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008515915A Active JP5461009B2 (ja) | 2005-06-08 | 2006-06-08 | 非ペプチド及びペプチドbdnfニューロトロフィン類似体を用いた神経細胞生存促進法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US8686045B2 (https=) |
| EP (3) | EP2581440B1 (https=) |
| JP (1) | JP5461009B2 (https=) |
| ES (1) | ES2569881T3 (https=) |
| WO (1) | WO2006133353A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004085648A2 (en) | 2003-03-19 | 2004-10-07 | Biogen Idec Ma Inc. | Nogo receptor binding protein |
| PT1776136E (pt) | 2004-06-24 | 2012-12-05 | Biogen Idec Inc | Tratamento de estados que envolvem desmielinização |
| US20110230479A1 (en) * | 2005-04-15 | 2011-09-22 | Longo Frank M | Neurotrophin mimetics and uses thereof |
| EP1871420A4 (en) * | 2005-04-15 | 2010-09-22 | Univ North Carolina | PROCESS FOR ENABLING CELL SURVIVAL VIA NEUROTROPHINE MIMETICS |
| WO2006133353A2 (en) | 2005-06-08 | 2006-12-14 | The University Of North Carolina At Chapel Hill | Methods of facilitating neural cell survival using non-peptide and peptide bdnf neurotrophin mimetics |
| SI1904104T1 (sl) | 2005-07-08 | 2013-12-31 | Biogen Idec Ma Inc. | Protitelesa SP35 in njihova uporaba |
| CA2672750A1 (en) * | 2006-12-20 | 2008-07-03 | Rinat Neuroscience Corporation | Trkb agonists for treating autoimmune disorders |
| WO2009048605A1 (en) * | 2007-10-11 | 2009-04-16 | Biogen Idec Ma Inc. | Methods for treating pressure induced optic neuropathy, preventing neuronal degeneration and promoting neuronal cell, survival via administration of lingo-1 antagonists and trkb agonists |
| CA2702630C (en) * | 2007-11-08 | 2017-11-21 | Biogen Idec Ma Inc. | Use of lingo-4 antagonists in the treatment of conditions involving demyelination |
| WO2009086202A2 (en) * | 2007-12-19 | 2009-07-09 | Afraxis, Inc. | Methods for treating neuropsychiatric conditions |
| US20100317715A1 (en) * | 2007-12-21 | 2010-12-16 | Vollrath Benedikt | Methods for treating neuropsychiatric conditions |
| DK2982695T3 (da) | 2008-07-09 | 2019-05-13 | Biogen Ma Inc | Sammensætninger, der omfatter antistoffer mod lingo eller fragmenter deraf |
| AR076601A1 (es) | 2009-05-21 | 2011-06-22 | Chlorion Pharma Inc | Pirimidinas como agentes terapeuticos |
| KR101138048B1 (ko) | 2009-11-06 | 2012-04-23 | 성균관대학교산학협력단 | Bdnf의 발현을 증가시키는 신규 펩타이드 및 이를 포함하는 알츠하이머병 또는 파킨슨병의 예방 및 치료용 약학 조성물 |
| ES2712752T3 (es) | 2009-11-12 | 2019-05-14 | Pharmatrophix Inc | Formas cristalinas de compuestos miméticos de neurotrofina y sus sales |
| US10273219B2 (en) | 2009-11-12 | 2019-04-30 | Pharmatrophix, Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
| CN103180297A (zh) | 2009-12-11 | 2013-06-26 | 基因密码公司 | 使用gdnf家族配体(gfl)模拟剂或ret信号传导通路活化剂促进神经细胞存活的方法 |
| US20120004310A1 (en) * | 2010-05-28 | 2012-01-05 | Longo Frank M | Non-peptide bdnf neurotrophin mimetics |
| CN104470541A (zh) | 2012-05-14 | 2015-03-25 | 比奥根艾迪克Ma公司 | 用于治疗涉及运动神经元的疾患的lingo-2拮抗剂 |
| JP6120311B2 (ja) * | 2013-02-12 | 2017-04-26 | 学校法人銀杏学園 | ポリフェノール化合物 |
| JP2016519668A (ja) | 2013-03-15 | 2016-07-07 | ファーマトロフィックス, インコーポレイテッド | 非ペプチドbdnfニューロトロフィン模倣化合物 |
| RU2015141934A (ru) | 2013-03-15 | 2017-04-20 | Фарматрофикс, Инк. | Непептидные миметики нейротрофина bdnf |
| AU2014250762A1 (en) | 2013-04-12 | 2015-10-29 | Achillion Pharmaceuticals, Inc. | Highly active nucleoside derivative for the treatment of HCV |
| DK3236972T3 (en) | 2014-12-26 | 2021-10-04 | Univ Emory | Antivirale N4-hydroxycytidin-derivativer |
| JP2018504400A (ja) | 2015-01-08 | 2018-02-15 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | Lingo‐1拮抗薬及び脱髄障害の治療のための使用 |
| US10675293B2 (en) * | 2015-05-29 | 2020-06-09 | The Board Of Trustees Of The Leland Stanford Junior University | Nucleoside agents for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
| EP3328440A4 (en) | 2015-07-28 | 2019-01-16 | Otonomy, Inc. | TREATMENT WITH REDUCED TRK-B AND TRK-C ANTAGONISTS |
| CN108602775B (zh) | 2016-01-14 | 2022-04-29 | 贝思以色列女会吏医学中心公司 | 肥大细胞调节剂及其用途 |
| JP6804790B1 (ja) | 2017-12-07 | 2020-12-23 | エモリー ユニバーシティー | N4−ヒドロキシシチジンおよび誘導体ならびにそれらに関連する抗ウイルス用途 |
| WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| JP2023527792A (ja) | 2020-05-27 | 2023-06-30 | アキシャル セラピューティクス,インク. | Tlr2調節剤化合物、医薬組成物、及びそれらの使用 |
| EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
| FI4426434T3 (fi) | 2021-11-02 | 2025-11-24 | Flare Therapeutics Inc | Pparg:n käänteisagonisteja ja niiden käyttöjä |
| WO2024118503A1 (en) | 2022-11-28 | 2024-06-06 | Hongene Biotech Corporation | Functionalized n-acetylgalactosamine analogs |
| CN116554123A (zh) * | 2023-04-27 | 2023-08-08 | 山东大学 | 六种噻唑酰腙类化合物在抗肿瘤药物中的应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2109262A5 (https=) * | 1970-10-08 | 1972-05-26 | Inst Francais Du Petrole | |
| US3953416A (en) * | 1971-12-20 | 1976-04-27 | Karl Folkers | Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same |
| JPS5025442B2 (https=) * | 1972-03-14 | 1975-08-23 | ||
| DE2343037A1 (de) * | 1973-08-25 | 1975-03-06 | Hoechst Ag | Arzneimittel mit antidepressiver wirkung |
| HU185535B (en) * | 1982-05-25 | 1985-02-28 | Mta Koezponti Hivatala | Process for preparing new gonadoliberin derivatives |
| US5321029A (en) | 1988-11-14 | 1994-06-14 | Beecham-Wuelfing Gmbh & Co.K.G. | Xanthines |
| GB9402331D0 (en) | 1994-02-07 | 1994-03-30 | Univ Mcgill | Nerve growth factor structural analogs and their uses |
| AU4117396A (en) | 1994-11-29 | 1996-06-19 | Novartis Ag | Morpholinoethylamide derivatives |
| US5958875A (en) | 1996-03-29 | 1999-09-28 | The Regents Of The University Of California | Synthetic peptides derivatives with nerve growth factor-like neurotrophic activity |
| US6448031B1 (en) * | 1996-06-13 | 2002-09-10 | Itoham Foods Inc. | Process for producing LH-RH derivatives |
| ES2230880T3 (es) * | 1998-07-30 | 2005-05-01 | Abbott Laboratories | Agentes selectivos anti-inflmatorios de glucocorticoides. |
| CA2365398C (en) | 1999-03-17 | 2013-01-08 | University Of North Carolina At Chapel Hill | Method of screening candidate compounds for susceptibility to biliary excretion |
| US6583148B1 (en) | 1999-04-08 | 2003-06-24 | Krenitsky Pharmaceuticals, Inc. | Neurotrophic substituted pyrimidines |
| DE60123399T2 (de) * | 2000-01-18 | 2007-08-23 | The Texas A & M University System, College Station | Pharmazeutische zubereitungen enthaltend beta-turn peptidomimetische zyklische substanzen |
| WO2002060867A2 (en) | 2001-01-29 | 2002-08-08 | Insight Strategy And Marketing Ltd | Carbazole derivatives and their uses as heparanase inhibitors |
| JP2006503069A (ja) | 2002-09-25 | 2006-01-26 | ジョージア テック リサーチ コーポレイション | 慢性神経疾患におけるケトアミド阻害剤 |
| EP1871420A4 (en) | 2005-04-15 | 2010-09-22 | Univ North Carolina | PROCESS FOR ENABLING CELL SURVIVAL VIA NEUROTROPHINE MIMETICS |
| WO2006133353A2 (en) | 2005-06-08 | 2006-12-14 | The University Of North Carolina At Chapel Hill | Methods of facilitating neural cell survival using non-peptide and peptide bdnf neurotrophin mimetics |
-
2006
- 2006-06-08 WO PCT/US2006/022268 patent/WO2006133353A2/en not_active Ceased
- 2006-06-08 EP EP12169982.1A patent/EP2581440B1/en not_active Not-in-force
- 2006-06-08 JP JP2008515915A patent/JP5461009B2/ja active Active
- 2006-06-08 EP EP06784665A patent/EP1893192A4/en not_active Withdrawn
- 2006-06-08 EP EP12169984.7A patent/EP2526942B1/en active Active
- 2006-06-08 US US11/449,381 patent/US8686045B2/en active Active
- 2006-06-08 ES ES12169982.1T patent/ES2569881T3/es active Active
-
2014
- 2014-01-27 US US14/165,090 patent/US9604907B2/en active Active
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