JP2008543925A - 呼吸器系に影響を及ぼす炎症状態における組織因子系凝固インヒビターの気道投与 - Google Patents

呼吸器系に影響を及ぼす炎症状態における組織因子系凝固インヒビターの気道投与 Download PDF

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Publication number
JP2008543925A
JP2008543925A JP2008517629A JP2008517629A JP2008543925A JP 2008543925 A JP2008543925 A JP 2008543925A JP 2008517629 A JP2008517629 A JP 2008517629A JP 2008517629 A JP2008517629 A JP 2008517629A JP 2008543925 A JP2008543925 A JP 2008543925A
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JP
Japan
Prior art keywords
tissue factor
tfpi
use according
administration
coagulation inhibitor
Prior art date
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Pending
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JP2008517629A
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English (en)
Japanese (ja)
Inventor
ラルス・オット・ウッテンタル
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Drugrecure AS
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Drugrecure AS
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Publication of JP2008543925A publication Critical patent/JP2008543925A/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • A61K38/57Protease inhibitors from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/4866Protein C (3.4.21.69)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2008517629A 2005-06-24 2006-06-23 呼吸器系に影響を及ぼす炎症状態における組織因子系凝固インヒビターの気道投与 Pending JP2008543925A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69396805P 2005-06-24 2005-06-24
PCT/IB2006/002602 WO2006136962A2 (en) 2005-06-24 2006-06-23 Airway administration of tissue factor pathway inhibitor in inflammatory conditons affecting the respiratory tract

Publications (1)

Publication Number Publication Date
JP2008543925A true JP2008543925A (ja) 2008-12-04

Family

ID=37570814

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2008517629A Pending JP2008543925A (ja) 2005-06-24 2006-06-23 呼吸器系に影響を及ぼす炎症状態における組織因子系凝固インヒビターの気道投与
JP2008517630A Pending JP2008543926A (ja) 2005-06-24 2006-06-23 呼吸器系に影響を及ぼす炎症状態における活性化プロテインcの気道投与
JP2013037700A Pending JP2013151510A (ja) 2005-06-24 2013-02-27 呼吸器系に影響を及ぼす炎症状態における活性化プロテインcの気道投与

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2008517630A Pending JP2008543926A (ja) 2005-06-24 2006-06-23 呼吸器系に影響を及ぼす炎症状態における活性化プロテインcの気道投与
JP2013037700A Pending JP2013151510A (ja) 2005-06-24 2013-02-27 呼吸器系に影響を及ぼす炎症状態における活性化プロテインcの気道投与

Country Status (14)

Country Link
US (3) US20100297099A1 (https=)
EP (3) EP1898945B1 (https=)
JP (3) JP2008543925A (https=)
KR (2) KR20080071116A (https=)
CN (2) CN101262880A (https=)
AU (2) AU2006273696B2 (https=)
BR (2) BRPI0613137A2 (https=)
CA (2) CA2612597C (https=)
DK (3) DK1906994T3 (https=)
IL (2) IL188220A0 (https=)
NO (2) NO20080434L (https=)
RU (2) RU2496516C2 (https=)
WO (3) WO2006136962A2 (https=)
ZA (2) ZA200800251B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007331874B2 (en) * 2006-12-11 2012-10-11 Drugrecure Aps Methods for treating cystic fibrosis or pneumonia with bacterial infection via pulmonary administration of fosfomycin
JP6273272B2 (ja) 2012-07-04 2018-01-31 ジージー バイオテック エルエルシー 炎症性皮膚障害の治療
JP2017513944A (ja) 2014-04-16 2017-06-01 ジージー バイオテック エルエルシー 異常な皮膚瘢痕化の治療
CA2946032C (en) 2014-04-16 2022-06-14 Zz Biotech Llc Use of apc analogue for wound healing
CN109789193A (zh) * 2016-09-13 2019-05-21 普罗瑟拉生物公司 使用间α抑制蛋白治疗肺病的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003040797A (ja) * 2001-07-06 2003-02-13 Aventis Behring Gmbh 抗炎症性肺疾患およびardsにおける抗トロンビン吸入のための医薬製剤

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US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
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US4837028A (en) * 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
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US6013619A (en) * 1988-01-06 2000-01-11 The Scripps Research Institute Pulmonary surfactants and therapeutic uses, including pulmonary lavage
US4981952A (en) * 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins
US5378614A (en) 1989-08-18 1995-01-03 Novo Nordisk A/S Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast
DK408089D0 (da) 1989-08-18 1989-08-18 Novo Nordisk As Proteiner
SE9200541D0 (sv) * 1992-02-24 1992-02-24 Kabi Pharmacia Ab New usee of omega-3-fatty acids
US5212091A (en) 1992-03-02 1993-05-18 Monsanto Company Method of producing tissue factor pathway inhibitor
CA2271232C (en) * 1996-11-08 2005-02-22 Oklahoma Medical Research Foundation Modified protein c and methods of use thereof
AU6053698A (en) * 1997-01-29 1998-08-18 University Technology Corporation Plasminogen activator as an anti-inflammatory agent
HUP0001237A3 (en) * 1997-10-20 2002-01-28 Lilly Co Eli Methods for treating vascular disorders
US6049577A (en) * 1998-05-28 2000-04-11 Glenayre Electronics, Inc. Header synchronization detector
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Also Published As

Publication number Publication date
CA2612597A1 (en) 2007-02-01
US20100297099A1 (en) 2010-11-25
KR20080071116A (ko) 2008-08-01
DK1898945T3 (da) 2013-03-25
EP1896059B1 (en) 2012-12-19
ZA200800255B (en) 2009-04-29
EP1906994B1 (en) 2014-04-23
CA2612646A1 (en) 2006-12-28
JP2008543926A (ja) 2008-12-04
AU2006273696A1 (en) 2007-02-01
KR20080074085A (ko) 2008-08-12
EP1898945B1 (en) 2012-12-19
IL188221A0 (en) 2008-03-20
EP1896059A2 (en) 2008-03-12
CN101262880A (zh) 2008-09-10
DK1906994T3 (da) 2014-07-21
CN101262879B (zh) 2013-04-10
RU2496515C2 (ru) 2013-10-27
US8088728B2 (en) 2012-01-03
EP1906994A2 (en) 2008-04-09
AU2006273696B2 (en) 2012-08-30
RU2008102656A (ru) 2009-07-27
WO2007012976A3 (en) 2007-07-12
CA2612646C (en) 2015-11-24
IL188220A0 (en) 2008-03-20
US20100160218A1 (en) 2010-06-24
US20100279925A1 (en) 2010-11-04
AU2006260599A1 (en) 2006-12-28
WO2006136962A2 (en) 2006-12-28
RU2496516C2 (ru) 2013-10-27
CA2612597C (en) 2015-03-31
CN101262879A (zh) 2008-09-10
JP2013151510A (ja) 2013-08-08
NO20080434L (no) 2008-03-17
WO2006136962A3 (en) 2007-07-12
EP1898945A2 (en) 2008-03-19
WO2006136963A2 (en) 2006-12-28
DK1896059T3 (da) 2013-04-08
NO20080433L (no) 2008-03-19
BRPI0613137A2 (pt) 2010-12-21
RU2008102655A (ru) 2009-07-27
BRPI0611710A2 (pt) 2011-12-20
WO2006136963A3 (en) 2007-07-12
HK1114567A1 (en) 2008-11-07
ZA200800251B (en) 2009-04-29
WO2007012976A2 (en) 2007-02-01

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