JP2008538315A - 関節形成性人工円板の運動能力を保存する方法およびデバイス - Google Patents
関節形成性人工円板の運動能力を保存する方法およびデバイス Download PDFInfo
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Abstract
Description
背痛は、何百万人もの人々を苦しめ、そして中年の労働人口に一般的な廃疾原因である。数多くある背痛原因は、椎間円板の脱出(rupture)または変形である。隣接した椎骨の終板の間にある椎間円板は、脊椎を安定させ、椎骨の間に力を分散させ、そして椎体にクッションを与えている。椎間円板は、内部成分である髄核を取り囲み且つ閉じ込めている構造である線維輪を包含する。その線維輪は、概して無定形の基本物質中に埋め込まれた線維軟骨とコラーゲン線維の輪から構成されている。髄核は、主に糖タンパク質と若干のコラーゲンを含有するムコイド物質を含んで成る。健康な未損傷の脊椎の場合、線維輪は、髄核が椎間円板腔の外側に突出するのを妨げ、そして更に、椎間円板に加えられる捩れおよび曲げの力に抵抗する。
本発明は、人工椎間円板の関節形成性空間中のおよびその関節形成性表面上の望ましくない骨成長および/または好ましくない瘢痕組織形成の問題を克服する。本発明は、少なくとも一つの関節形成性表面を有する人工円板の運動能力を保存する方法であって、人工円板の関節形成性表面に抗浸潤薬を適用することを含む方法を含む。適する抗浸潤薬には、止血性化合物、抗癒着化合物、一時的空間占有性バリア材料、骨形成阻害性化合物またはいずれかそれらの組合せが含まれるが、これに制限されるわけではない。
本発明により、関節形成性人工円板の運動能力を保存する方法であって、人工円板の関節形成性表面に治療的有効量の抗浸潤薬を適用することを含む方法を提供する。関節形成性表面および空間を有する人工円板は、当該技術分野において知られており、本発明の方法は、いずれかこのような関節形成性人工円板に適している。このような関節形成性人工円板の例には、SB Charite Artificial Disk(Johnson and Johnson/Dupey/Acromed)、Acroflex TDR(Johnson and Johnson/Depuy/Acromed)、Spring Disk(Medtronic Sofamer Danek)、Maverick(Medtronic Sofamer Danek)、ProDisc(Synthes)が含まれるが、これに制限されるわけではない。本発明は、いろいろな関節形成性人工円板に関連した運動能力の範囲および関節形成性表面のサイズに特に適している。
Claims (23)
- 関節形成性人工円板の運動能力を保存する方法であって、人工円板の関節形成性表面に抗浸潤薬を適用することを含む方法。
- 抗浸潤薬が、止血性化合物、抗癒着薬、一時的空間占有性バリア材料、骨形成阻害性化合物およびいずれかそれらの組合せから成る群より選択される、請求項1に記載の方法。
- 抗浸潤薬が、ゲル、薄膜、溶液、泡状物、海綿状物または粉末として製剤化されている、請求項2に記載の方法。
- 関節形成性表面への抗浸潤薬の適用が、人工円板の植込物−骨界面の非関節形成性表面における所望の組織成長を妨害しない、請求項1に記載の方法。
- 人工円板の植込物−骨界面の非関節形成性表面に、骨形成性または骨誘導性化合物を適用することを更に含む、請求項1に記載の方法。
- 患者への人工円板の植込み前に、抗浸潤薬を、該円板の関節形成性表面上にコーティングとして適用する、または該表面中に包含させる、請求項1に記載の方法。
- 患者への人工円板の外科的植込みの際に、抗浸潤薬を、該円板の関節形成性表面上およびその周囲に適用する、請求項1に記載の方法。
- 抗浸潤薬が、抗炎症薬、鎮痛薬、麻酔薬、抗微生物薬または抗細菌薬を更に含む、請求項1に記載の方法。
- 抗浸潤薬が、ビオレソルバブル(bioresorbable)である、請求項1に記載の方法。
- 関節形成性人工円板の運動能力を保存する植込物であって、関節形成性表面および非関節形成性表面を有する人工デバイスを含み、ここにおいて、少なくとも一つの非関節形成性表面は、非関節形成性の植込物−骨界面を含み、そしてここにおいて、抗浸潤薬を、関節形成性表面上に塗布している、または関節形成性表面中に包含している植込物。
- 抗浸潤薬が、止血性化合物、抗癒着薬、一時的空間占有性バリア材料、骨形成阻害性化合物およびいずれかそれらの組合せから成る群より選択される、請求項10に記載の植込物。
- 抗浸潤薬が、抗炎症薬、鎮痛薬、麻酔薬、抗微生物薬または抗細菌薬を更に含む、請求項10に記載の植込物。
- 非関節形成性の植込物−骨界面上に塗布されたまたは中に包含された骨形成性または骨誘導性物質を更に含む、請求項10に記載の植込物。
- 関節形成性人工円板を患者に外科的に植込む方法であって、
(a)欠陥が生じた椎間円板を患者から外科的に除去し;
(b)欠陥が生じた椎間円板を除去後に残っている空の椎間腔中に人工円板を植込み;そして
(c)人工円板の関節形成性表面上およびその周囲に抗浸潤薬を適用する
工程を含む方法。 - 抗浸潤薬が、止血性化合物、抗癒着薬、一時的空間占有性バリア材料、骨形成阻害性化合物およびいずれかそれらの組合せから成る群より選択される、請求項14に記載の方法。
- 抗浸潤薬が、ゲル、薄膜、溶液、泡状物、海綿状物または粉末として製剤化されている、請求項14に記載の方法。
- 抗浸潤薬が、抗炎症薬、鎮痛薬、麻酔薬、抗微生物薬または抗細菌薬を更に含む、請求項14に記載の方法。
- 患者への人工円板の植込み前に、抗浸潤薬を、該円板の関節形成性表面上に塗布した、または該表面中に包含させた、請求項14に記載の方法。
- 人工円板の非関節形成性の植込物−骨界面上およびその周囲に、骨形成性または骨誘導性物質を適用する工程を更に含む、請求項14に記載の方法。
- 抗浸潤薬が、ビオレソルバブルである、請求項14に記載の方法。
- 関節形成性人工デバイスの運動能力を保存する方法であって、人工デバイスの関節形成性表面に抗浸潤薬を適用することを含む方法。
- 人工デバイスが、関節置換または修復デバイスである、請求項21に記載の方法。
- 抗浸潤薬が、止血性化合物、抗癒着薬、一時的空間占有性バリア材料、骨形成阻害性化合物およびいずれかそれらの組合せから成る群より選択される、請求項21に記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US11/104,297 US8257438B2 (en) | 2005-04-12 | 2005-04-12 | Methods and devices for preserving motion in an articulating prosthetic disc |
PCT/US2006/013571 WO2006113249A2 (en) | 2005-04-12 | 2006-04-11 | Methods and devices for preserving motion in an articulating prosthetic disc |
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JP2008538315A true JP2008538315A (ja) | 2008-10-23 |
JP2008538315A5 JP2008538315A5 (ja) | 2009-03-19 |
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JP2008507714A Pending JP2008538315A (ja) | 2005-04-12 | 2006-04-11 | 関節形成性人工円板の運動能力を保存する方法およびデバイス |
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US (1) | US8257438B2 (ja) |
EP (1) | EP1874368A2 (ja) |
JP (1) | JP2008538315A (ja) |
AU (1) | AU2006236849B2 (ja) |
CA (1) | CA2604921A1 (ja) |
WO (1) | WO2006113249A2 (ja) |
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US8092541B2 (en) * | 2007-08-03 | 2012-01-10 | Warsaw Orthopedic, Inc. | Method of using an anti-growth matrix as a barrier for cell attachment and osteo-inductive factors |
US9402863B2 (en) * | 2010-03-05 | 2016-08-02 | Endosat Nv | Methods and systems for conditioning in surgery |
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Also Published As
Publication number | Publication date |
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US8257438B2 (en) | 2012-09-04 |
WO2006113249A2 (en) | 2006-10-26 |
EP1874368A2 (en) | 2008-01-09 |
AU2006236849B2 (en) | 2010-04-15 |
WO2006113249A3 (en) | 2007-08-02 |
CA2604921A1 (en) | 2006-10-26 |
AU2006236849A1 (en) | 2006-10-26 |
US20060229728A1 (en) | 2006-10-12 |
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