JP2008534541A5 - - Google Patents

Download PDF

Info

Publication number
JP2008534541A5
JP2008534541A5 JP2008503415A JP2008503415A JP2008534541A5 JP 2008534541 A5 JP2008534541 A5 JP 2008534541A5 JP 2008503415 A JP2008503415 A JP 2008503415A JP 2008503415 A JP2008503415 A JP 2008503415A JP 2008534541 A5 JP2008534541 A5 JP 2008534541A5
Authority
JP
Japan
Prior art keywords
alkyl
aryl
heteroaryl
cycloalkyl
alkenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008503415A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008534541A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2006/002769 external-priority patent/WO2006103038A1/en
Publication of JP2008534541A publication Critical patent/JP2008534541A/ja
Publication of JP2008534541A5 publication Critical patent/JP2008534541A5/ja
Pending legal-status Critical Current

Links

JP2008503415A 2005-03-30 2006-03-27 置換１，２−エチレンジアミン、前記化合物を含む薬物、それらの使用及びそれらの製造方法 Pending JP2008534541A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05006939 2005-03-30
PCT/EP2006/002769 WO2006103038A1 (en) 2005-03-30 2006-03-27 Substituted 1,2-ethylendiamines, medicaments comprising said compound; their use and their method of manufacture

Publications (2)

Publication Number Publication Date
JP2008534541A JP2008534541A (ja) 2008-08-28
JP2008534541A5 true JP2008534541A5 (OSRAM) 2009-05-14

Family

ID=36545049

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008503415A Pending JP2008534541A (ja) 2005-03-30 2006-03-27 置換１，２−エチレンジアミン、前記化合物を含む薬物、それらの使用及びそれらの製造方法

Country Status (7)

Country Link
US (3) US7713961B2 (OSRAM)
EP (1) EP1866034A1 (OSRAM)
JP (1) JP2008534541A (OSRAM)
AR (1) AR056862A1 (OSRAM)
CA (1) CA2603404A1 (OSRAM)
TW (1) TW200716152A (OSRAM)
WO (1) WO2006103038A1 (OSRAM)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006103038A1 (en) * 2005-03-30 2006-10-05 Boehringer Ingelheim International Gmbh Substituted 1,2-ethylendiamines, medicaments comprising said compound; their use and their method of manufacture
CA2617294A1 (en) * 2005-08-03 2007-02-08 Boehringer Ingelheim International Gmbh Substituted ethane-1,2-diamines for the treatment of alzheimer's disease ii
US20100168070A1 (en) * 2005-08-11 2010-07-01 Niklas Heine Compounds for the treatment of alzheimer's disease
CA2618013A1 (en) * 2005-08-11 2007-02-15 Boehringer Ingelheim International Gmbh Beta-secretase inhibitors for use in the treatment of alzheimer's disease
EP1919861A2 (de) * 2005-08-11 2008-05-14 Boehringer Ingelheim International GmbH Verbindungen zur behandlung der alzheimer erkrankung
JP2009504612A (ja) * 2005-08-11 2009-02-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アルツハイマー病の治療用化合物
US8703947B2 (en) 2008-10-10 2014-04-22 Purdue Research Foundation Compounds for treatment of Alzheimer's disease
WO2010059953A1 (en) 2008-11-20 2010-05-27 Purdue Research Foundation Quinazoline inhibitors of bace 1 and methods of using
US8859590B2 (en) 2008-12-05 2014-10-14 Purdue Research Foundation Inhibitors of BACE1 and methods for treating Alzheimer's disease
WO2011044057A1 (en) * 2009-10-05 2011-04-14 Comentis, Inc. Sulfonamido pyrrolidine compounds which inhibit beta-secretase activity and methods of use thereof
WO2014036105A2 (en) * 2012-08-30 2014-03-06 Oklahoma Medical Research Foundation Inhibitors of memapsin 2 cleavage for the treatment of alzheimer's disease
JP2024525160A (ja) 2021-06-18 2024-07-10 アリゴス セラピューティクス インコーポレイテッド Ｐｄ－ｌ１を標的とするための方法及び組成物
TW202328139A (zh) 2021-12-16 2023-07-16 美商艾利格斯醫療公司 用於靶向ｐｄ－ｌ１之方法及組成物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110525A0 (en) 1993-08-09 1994-11-11 Lilly Co Eli Identification and use of protease inhibitors
US7087399B1 (en) 1999-05-13 2006-08-08 Scios, Inc. β-secretase and modulation of β-secretase activity
EP1196609A2 (en) 1999-06-28 2002-04-17 Oklahoma Medical Research Foundation Catalytically active recombinant memapsin and methods of use thereof
MXPA03011399A (es) * 2001-06-08 2004-07-01 Elan Pharm Inc Metodos para tratar la enfermedad de alzheimer.
EP1453516A2 (de) 2001-10-17 2004-09-08 Boehringer Ingelheim Pharma GmbH & Co.KG 5-substituierte 4-amino-2-phenylamino-pyrimdinderivate und ihre verwendung als beta-amyloid modulatoren
CA2472617A1 (en) * 2002-01-04 2003-07-17 Elan Pharmaceuticals, Inc. Substituted amino carboxamides for the treatment of alzheimer's disease
JP2006501282A (ja) * 2002-09-27 2006-01-12 イーラン ファーマスーティカルズ、インコーポレイテッド アルツハイマー病治療のための化合物
ATE443043T1 (de) * 2002-11-12 2009-10-15 Merck & Co Inc Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer
US20050090449A1 (en) 2003-05-13 2005-04-28 Boehringer Ingelheim International Gmbh Novel statine derivatives for the treatment of Alzheimer's disease
AU2004255183A1 (en) * 2003-06-30 2005-01-20 Merck & Co., Inc. N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease
JP2007538024A (ja) 2004-05-19 2007-12-27 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アミロイドベータペプチドのレベル変化に関連する疾患及び状態の治療方法及び新規エノールカルボキサミド化合物
WO2005113582A1 (en) 2004-05-22 2005-12-01 Boehringer Ingelheim International Gmbh Substituted ethane-1,2-diamines for the treatment of alzheimer's disease
WO2006050862A1 (en) 2004-11-10 2006-05-18 Boehringer Ingelheim International Gmbh Statine derivatives for the treatment of alzheimer's disease
WO2006050861A2 (en) 2004-11-10 2006-05-18 Boehringer Ingelheim International Gmbh Statine derivatives for the treatment of alzheimer's disease
WO2006103038A1 (en) * 2005-03-30 2006-10-05 Boehringer Ingelheim International Gmbh Substituted 1,2-ethylendiamines, medicaments comprising said compound; their use and their method of manufacture
CA2617294A1 (en) 2005-08-03 2007-02-08 Boehringer Ingelheim International Gmbh Substituted ethane-1,2-diamines for the treatment of alzheimer's disease ii
JP2009504612A (ja) 2005-08-11 2009-02-05 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング アルツハイマー病の治療用化合物

Similar Documents

Publication Publication Date Title
JP5387997B2 (ja) 血管の収縮または拡張による疾患治療剤
RU2413727C2 (ru) Производные пиразола и их применение в качестве ингибиторов рецепторных тирозинкиназ
RU2370495C2 (ru) Дополнительные гетероциклические соединения и их применение в качестве антагонистов метаботропного глутаматного рецептора
JP2008534541A5 (OSRAM)
RU2008138649A (ru) Применение а1-агонистов аденозина и/или двойных а1/а2в-агонистов аденозина для получения лекарственных средств для лечения заболеваний
CN102497862B (zh) 使用ck2调节剂的组合治疗
RU2007134380A (ru) Антибактериальные производные пиперидина
JP2012521428A5 (OSRAM)
JP2006513265A5 (OSRAM)
HUP0400851A2 (hu) Dihidro-benzo[b][1,4]diazepin-2-on-származékok, mint MGluR2 II antagonisták, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
RU2003102389A (ru) Замещенные производные хиназолина и их применение в качестве ингибиторов
RU2004130488A (ru) Пиримидиновые производные
JP2007531744A5 (OSRAM)
JP2006525226A5 (OSRAM)
CA2514191A1 (en) Compound inhibiting dipeptidyl peptidase iv
RU2481330C2 (ru) Азотсодержащее ароматическое гетероциклическое соединение
JP2012521429A5 (OSRAM)
CA2409741A1 (en) Tnf-.alpha. production inhibitors
JP2007513915A5 (OSRAM)
JP2005526696A5 (OSRAM)
PE20071177A1 (es) Derivados de 3,5-piridina como inhibidores de renina
JP2009541484A (ja) ５ｈｔ６モジュレーターおよびコリンエステラーゼインヒビターを含む組み合わせ
PT1487424E (pt) 4-(4-metilpiperazin-1-ilmetil)-n-[4-metil-3-(4-piridin-3-il)pirimidin-2-il-amino)fenil]-benzamida para o tratamento doenças mediadas por ang ii
JP2007517007A5 (OSRAM)
AU2008222890C1 (en) Methods for treating cognitive disorders using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds