JP2008533186A - 腸炎治療のためのマクロライド類の使用 - Google Patents
腸炎治療のためのマクロライド類の使用 Download PDFInfo
- Publication number
- JP2008533186A JP2008533186A JP2008502380A JP2008502380A JP2008533186A JP 2008533186 A JP2008533186 A JP 2008533186A JP 2008502380 A JP2008502380 A JP 2008502380A JP 2008502380 A JP2008502380 A JP 2008502380A JP 2008533186 A JP2008533186 A JP 2008533186A
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- JP
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- Prior art keywords
- formula
- pharmaceutically acceptable
- treatment
- acceptable salt
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000011282 treatment Methods 0.000 title claims description 19
- 239000003120 macrolide antibiotic agent Substances 0.000 title description 14
- 229940041033 macrolides Drugs 0.000 title description 5
- 208000004232 Enteritis Diseases 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 22
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims abstract description 21
- 150000003839 salts Chemical class 0.000 claims abstract description 16
- 239000003814 drug Substances 0.000 claims abstract description 12
- 206010009944 Colon cancer Diseases 0.000 claims abstract description 7
- 208000029742 colonic neoplasm Diseases 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 6
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- -1 1-oxoethyl Chemical group 0.000 claims description 7
- 206010009900 Colitis ulcerative Diseases 0.000 claims description 7
- 201000006704 Ulcerative Colitis Diseases 0.000 claims description 7
- 230000002265 prevention Effects 0.000 claims description 3
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- 239000001257 hydrogen Substances 0.000 claims description 2
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
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- 206010009887 colitis Diseases 0.000 description 11
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
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- 230000006698 induction Effects 0.000 description 2
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- 238000011552 rat model Methods 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 2
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- 239000007787 solid Substances 0.000 description 2
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- 238000003786 synthesis reaction Methods 0.000 description 2
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
- GWGBNENHEGYJSN-UHFFFAOYSA-N 2,4-dinitrobenzenesulfonic acid;hydrate Chemical compound O.OS(=O)(=O)C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O GWGBNENHEGYJSN-UHFFFAOYSA-N 0.000 description 1
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
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- 206010020565 Hyperaemia Diseases 0.000 description 1
- UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
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- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
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- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
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- 239000002775 capsule Substances 0.000 description 1
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- 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
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- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 description 1
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- 239000000829 suppository Substances 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05102244 | 2005-03-21 | ||
| PCT/EP2006/060709 WO2006100195A1 (en) | 2005-03-21 | 2006-03-14 | Use of macrolides for treating intestinal inflammation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008533186A true JP2008533186A (ja) | 2008-08-21 |
| JP2008533186A5 JP2008533186A5 (https=) | 2008-12-18 |
Family
ID=36649815
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008502380A Pending JP2008533186A (ja) | 2005-03-21 | 2006-03-14 | 腸炎治療のためのマクロライド類の使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20080249034A1 (https=) |
| EP (1) | EP1868619A1 (https=) |
| JP (1) | JP2008533186A (https=) |
| CN (1) | CN101212980A (https=) |
| AU (1) | AU2006226381B2 (https=) |
| BR (1) | BRPI0614009A2 (https=) |
| CA (1) | CA2601640C (https=) |
| EA (1) | EA012309B1 (https=) |
| IT (1) | ITMI20060460A1 (https=) |
| MX (1) | MX2007011544A (https=) |
| WO (1) | WO2006100195A1 (https=) |
| ZA (1) | ZA200708423B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2343748T3 (es) * | 2005-07-06 | 2010-08-09 | Zambon S.P.A. | Formas cristalinas de compuestos macrolidos dotados de una actividad antiinflamatoria. |
| WO2008065636A2 (en) * | 2006-12-01 | 2008-06-05 | University College York - National University Of Ireland, Cork | Treatment of disease by modulating cf5 protein |
| KR20240004268A (ko) * | 2021-02-26 | 2024-01-11 | 팬더릭스 인코포레이티드 | 안정화된 초유 조성물 |
| CN113209084A (zh) * | 2021-05-18 | 2021-08-06 | 南开大学 | 化合物cp0119在制备用于治疗炎性肠病的药物中的应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000512653A (ja) * | 1996-06-18 | 2000-09-26 | アボツト・ラボラトリーズ | 大環状１３員環エリスロマイシンａ及びｂの誘導体 |
| WO2004013153A2 (en) * | 2002-08-01 | 2004-02-12 | Zambon Group S.P.A. | Macrolide compounds endowed with antiinflammatory activity |
| JP2004518670A (ja) * | 2001-01-09 | 2004-06-24 | プリバ デイオニツコ ドルストヴオ | 抗炎症治療の改良された細胞標的指向化用の免疫細胞特異的マクロライド化合物と抗炎症性化合物との複合体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2089219C1 (ru) * | 1994-02-22 | 1997-09-10 | Александра Леонидовна Бурмистрова | Способ лечения неспецифического язвенного колита |
| US6551632B2 (en) * | 1997-04-01 | 2003-04-22 | Thomas Julius Borody | Methods and compositions for treating inflammatory bowel disease |
| IT1306205B1 (it) * | 1999-01-15 | 2001-05-30 | Zambon Spa | Macrolidi ad attivita' antiinfiammatoria. |
| ITMI20040124A1 (it) * | 2004-01-29 | 2004-04-29 | Zambon Spa | Macrolidi ad attivita' antiinfiammatoria |
-
2005
- 2005-03-14 US US11/908,550 patent/US20080249034A1/en not_active Abandoned
-
2006
- 2006-03-14 CA CA2601640A patent/CA2601640C/en not_active Expired - Fee Related
- 2006-03-14 CN CNA2006800126183A patent/CN101212980A/zh active Pending
- 2006-03-14 MX MX2007011544A patent/MX2007011544A/es not_active Application Discontinuation
- 2006-03-14 WO PCT/EP2006/060709 patent/WO2006100195A1/en not_active Ceased
- 2006-03-14 AU AU2006226381A patent/AU2006226381B2/en not_active Ceased
- 2006-03-14 BR BRPI0614009-2A patent/BRPI0614009A2/pt not_active IP Right Cessation
- 2006-03-14 EP EP06725052A patent/EP1868619A1/en not_active Withdrawn
- 2006-03-14 EA EA200702036A patent/EA012309B1/ru not_active IP Right Cessation
- 2006-03-14 JP JP2008502380A patent/JP2008533186A/ja active Pending
- 2006-03-15 IT IT000460A patent/ITMI20060460A1/it unknown
-
2007
- 2007-10-02 ZA ZA200708423A patent/ZA200708423B/xx unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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Also Published As
| Publication number | Publication date |
|---|---|
| EA200702036A1 (ru) | 2008-02-28 |
| AU2006226381A1 (en) | 2006-09-28 |
| CN101212980A (zh) | 2008-07-02 |
| ZA200708423B (en) | 2009-03-25 |
| CA2601640A1 (en) | 2006-09-28 |
| CA2601640C (en) | 2013-10-22 |
| WO2006100195A1 (en) | 2006-09-28 |
| AU2006226381B2 (en) | 2011-09-08 |
| ITMI20060460A1 (it) | 2006-09-22 |
| BRPI0614009A2 (pt) | 2011-03-01 |
| EP1868619A1 (en) | 2007-12-26 |
| MX2007011544A (es) | 2008-03-11 |
| US20080249034A1 (en) | 2008-10-09 |
| EA012309B1 (ru) | 2009-08-28 |
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