JP2008533152A5 - - Google Patents
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- Publication number
- JP2008533152A5 JP2008533152A5 JP2008501950A JP2008501950A JP2008533152A5 JP 2008533152 A5 JP2008533152 A5 JP 2008533152A5 JP 2008501950 A JP2008501950 A JP 2008501950A JP 2008501950 A JP2008501950 A JP 2008501950A JP 2008533152 A5 JP2008533152 A5 JP 2008533152A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- carbon atoms
- nitrogen mustard
- alkynyl
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000004432 carbon atom Chemical group C* 0.000 claims 27
- HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical class ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 claims 18
- 229960004961 mechlorethamine Drugs 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- -1 cyanopropyl group Chemical group 0.000 claims 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 6
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000004946 alkenylalkyl group Chemical group 0.000 claims 3
- 125000005257 alkyl acyl group Chemical group 0.000 claims 3
- 125000002877 alkyl aryl group Chemical group 0.000 claims 3
- 125000005466 alkylenyl group Chemical group 0.000 claims 3
- 239000008365 aqueous carrier Substances 0.000 claims 3
- 239000012736 aqueous medium Substances 0.000 claims 3
- 125000005251 aryl acyl group Chemical group 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000000732 arylene group Chemical group 0.000 claims 3
- 150000001602 bicycloalkyls Chemical group 0.000 claims 3
- 125000000725 trifluoropropyl group Chemical group [H]C([H])(*)C([H])([H])C(F)(F)F 0.000 claims 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 2
- NZJXADCEESMBPW-UHFFFAOYSA-N 1-methylsulfinyldecane Chemical compound CCCCCCCCCCS(C)=O NZJXADCEESMBPW-UHFFFAOYSA-N 0.000 claims 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 125000005038 alkynylalkyl group Chemical group 0.000 claims 2
- 230000001588 bifunctional effect Effects 0.000 claims 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims 2
- 235000011187 glycerol Nutrition 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 229940041616 menthol Drugs 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920001451 polypropylene glycol Polymers 0.000 claims 2
- 239000010453 quartz Substances 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 208000017520 skin disease Diseases 0.000 claims 2
- FDAYLTPAFBGXAB-UHFFFAOYSA-N 2-chloro-n,n-bis(2-chloroethyl)ethanamine Chemical compound ClCCN(CCCl)CCCl FDAYLTPAFBGXAB-UHFFFAOYSA-N 0.000 claims 1
- UQZPGHOJMQTOHB-UHFFFAOYSA-N 2-chloro-n-(2-chloroethyl)-n-ethylethanamine Chemical compound ClCCN(CC)CCCl UQZPGHOJMQTOHB-UHFFFAOYSA-N 0.000 claims 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 1
- 239000004264 Petrolatum Substances 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 229940086555 cyclomethicone Drugs 0.000 claims 1
- 229940008099 dimethicone Drugs 0.000 claims 1
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 1
- 229940124274 edetate disodium Drugs 0.000 claims 1
- 125000005549 heteroarylene group Chemical group 0.000 claims 1
- 229940066842 petrolatum Drugs 0.000 claims 1
- 235000019271 petrolatum Nutrition 0.000 claims 1
- RJXQSIKBGKVNRT-UHFFFAOYSA-N phosphoramide mustard Chemical compound ClCCN(P(O)(=O)N)CCCl RJXQSIKBGKVNRT-UHFFFAOYSA-N 0.000 claims 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66135605P | 2005-03-14 | 2005-03-14 | |
| US60/661,356 | 2005-03-14 | ||
| US75112805P | 2005-12-16 | 2005-12-16 | |
| US60/751,128 | 2005-12-16 | ||
| US11/369,305 | 2006-03-07 | ||
| US11/369,305 US7872050B2 (en) | 2005-03-14 | 2006-03-07 | Stabilized compositions of volatile alkylating agents and methods of using thereof |
| PCT/US2006/009060 WO2006099385A2 (en) | 2005-03-14 | 2006-03-14 | Stabilized compositions of volatile alkylating agents and methods of using thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012253174A Division JP5671514B2 (ja) | 2005-03-14 | 2012-11-19 | 発揮性アルキル化剤の安定化組成物およびその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008533152A JP2008533152A (ja) | 2008-08-21 |
| JP2008533152A5 true JP2008533152A5 (https=) | 2009-05-07 |
| JP5236457B2 JP5236457B2 (ja) | 2013-07-17 |
Family
ID=36971840
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008501950A Expired - Lifetime JP5236457B2 (ja) | 2005-03-14 | 2006-03-14 | 発揮性アルキル化剤の安定化組成物およびその使用方法 |
| JP2012253174A Expired - Lifetime JP5671514B2 (ja) | 2005-03-14 | 2012-11-19 | 発揮性アルキル化剤の安定化組成物およびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012253174A Expired - Lifetime JP5671514B2 (ja) | 2005-03-14 | 2012-11-19 | 発揮性アルキル化剤の安定化組成物およびその使用方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (7) | US7872050B2 (https=) |
| EP (1) | EP1858864B1 (https=) |
| JP (2) | JP5236457B2 (https=) |
| KR (1) | KR101168252B1 (https=) |
| CN (1) | CN101175735B (https=) |
| AU (1) | AU2006223076B2 (https=) |
| CA (1) | CA2600468C (https=) |
| CY (2) | CY1113305T1 (https=) |
| DK (1) | DK1858864T3 (https=) |
| ES (1) | ES2388744T3 (https=) |
| FR (1) | FR17C1029I2 (https=) |
| HU (1) | HUS1700033I1 (https=) |
| LT (1) | LTC1858864I2 (https=) |
| LU (1) | LUC00033I2 (https=) |
| NZ (3) | NZ599001A (https=) |
| PL (1) | PL1858864T3 (https=) |
| PT (1) | PT1858864E (https=) |
| SI (1) | SI1858864T1 (https=) |
| WO (1) | WO2006099385A2 (https=) |
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| LT3494960T (lt) * | 2008-03-27 | 2021-02-25 | Helsinn Healthcare Sa | Stabilizuotos alkilinimo agentų kompozicijos ir jų naudojimo būdai |
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| US8703778B2 (en) | 2008-09-26 | 2014-04-22 | Intellikine Llc | Heterocyclic kinase inhibitors |
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| US20070287719A1 (en) | 2005-03-11 | 2007-12-13 | Pfizer Inc | Salts, Prodrugs and Formulations of 1-[5-(4-Amino-7-Isopropyl-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonyl)-2-Methoxy-Phenyl]-3-(2,4-Dichloro-Phenyl)-Urea |
| US20120157545A1 (en) | 2005-03-14 | 2012-06-21 | Robert Alonso | Methods for treating skin disorders with topical nitrogen mustard compositions |
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| US20060281720A1 (en) * | 2005-06-08 | 2006-12-14 | Loria Roger M | 5-Androstenediol As An Inhibitor of Gliomas |
| LT3494960T (lt) | 2008-03-27 | 2021-02-25 | Helsinn Healthcare Sa | Stabilizuotos alkilinimo agentų kompozicijos ir jų naudojimo būdai |
| WO2013009800A2 (en) | 2011-07-11 | 2013-01-17 | Ceptaris Therapeutics, Inc. | Compositions of alkylating agents and methods of treating skin disorders therewith |
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2006
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- 2006-03-14 CA CA2600468A patent/CA2600468C/en not_active Expired - Lifetime
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- 2006-03-14 ES ES06738150T patent/ES2388744T3/es not_active Expired - Lifetime
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- 2006-03-14 AU AU2006223076A patent/AU2006223076B2/en active Active
- 2006-03-14 DK DK06738150.9T patent/DK1858864T3/da active
- 2006-03-14 SI SI200631397T patent/SI1858864T1/sl unknown
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- 2006-03-14 WO PCT/US2006/009060 patent/WO2006099385A2/en not_active Ceased
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2010
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