JP2008533022A5 - - Google Patents

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Publication number
JP2008533022A5
JP2008533022A5 JP2008500871A JP2008500871A JP2008533022A5 JP 2008533022 A5 JP2008533022 A5 JP 2008533022A5 JP 2008500871 A JP2008500871 A JP 2008500871A JP 2008500871 A JP2008500871 A JP 2008500871A JP 2008533022 A5 JP2008533022 A5 JP 2008533022A5
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JP
Japan
Prior art keywords
pharmaceutical composition
composition according
aminopterin
patient
cycle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008500871A
Other languages
English (en)
Japanese (ja)
Other versions
JP5791864B2 (ja
JP2008533022A (ja
Filing date
Publication date
Priority claimed from US11/078,271 external-priority patent/US7312217B2/en
Application filed filed Critical
Publication of JP2008533022A publication Critical patent/JP2008533022A/ja
Publication of JP2008533022A5 publication Critical patent/JP2008533022A5/ja
Application granted granted Critical
Publication of JP5791864B2 publication Critical patent/JP5791864B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2008500871A 2005-03-11 2006-03-08 炎症性疾患に対するアミノプテリン投与形態及び方法 Active JP5791864B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/078,271 2005-03-11
US11/078,271 US7312217B2 (en) 2005-03-11 2005-03-11 Aminopterin dosage forms and methods for inflammatory disorders
PCT/US2006/008233 WO2006098979A2 (en) 2005-03-11 2006-03-08 Aminopterin dosage forms and methods for inflammatory disorders

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013098407A Division JP2013209384A (ja) 2005-03-11 2013-05-08 炎症性疾患に対するアミノプテリン投与形態及び方法

Publications (3)

Publication Number Publication Date
JP2008533022A JP2008533022A (ja) 2008-08-21
JP2008533022A5 true JP2008533022A5 (OSRAM) 2009-07-16
JP5791864B2 JP5791864B2 (ja) 2015-10-07

Family

ID=36971856

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008500871A Active JP5791864B2 (ja) 2005-03-11 2006-03-08 炎症性疾患に対するアミノプテリン投与形態及び方法
JP2013098407A Withdrawn JP2013209384A (ja) 2005-03-11 2013-05-08 炎症性疾患に対するアミノプテリン投与形態及び方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013098407A Withdrawn JP2013209384A (ja) 2005-03-11 2013-05-08 炎症性疾患に対するアミノプテリン投与形態及び方法

Country Status (6)

Country Link
US (5) US7312217B2 (OSRAM)
EP (1) EP1855682B1 (OSRAM)
JP (2) JP5791864B2 (OSRAM)
ES (1) ES2658070T3 (OSRAM)
PL (1) PL1855682T3 (OSRAM)
WO (1) WO2006098979A2 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101098854B (zh) 2004-07-23 2012-12-05 恩多塞特公司 二价连接体及其轭合物
US7312217B2 (en) * 2005-03-11 2007-12-25 Syntrix Biosystems, Inc. Aminopterin dosage forms and methods for inflammatory disorders
WO2008112873A2 (en) 2007-03-14 2008-09-18 Endocyte, Inc. Binding ligand linked drug delivery conjugates of tubulysins
EP3569251A1 (en) 2007-06-25 2019-11-20 Endocyte, Inc. Conjugates containing hydrophilic spacer linkers
US9877965B2 (en) 2007-06-25 2018-01-30 Endocyte, Inc. Vitamin receptor drug delivery conjugates for treating inflammation
EP2384119B1 (en) * 2009-01-24 2015-08-05 Aminopterin LLC Pharmaceutical composition comprising racemic aminopterin
WO2012047525A2 (en) * 2010-09-27 2012-04-12 Endocyte, Inc. Folate conjugates for treating inflammation of the eye
WO2013126797A1 (en) 2012-02-24 2013-08-29 Purdue Research Foundation Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en) 2012-03-29 2014-03-20 Endocyte, Inc. Processes for preparing tubulysin derivatives and conjugates thereof
HK1212618A1 (zh) 2012-10-16 2016-06-17 恩多塞特公司 含有非天然氨基酸的藥物遞送綴合物以及其使用方法
EP3337491A4 (en) * 2015-08-19 2019-04-10 Children's Research Institute, Children's National Medical Center COMPOSITIONS AND METHODS FOR TREATING TRANSPLANT HOST REACTION
CN106046005A (zh) * 2016-08-19 2016-10-26 常州市新鸿医药化工技术有限公司 一种叶酸合成方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2575168A (en) 1948-07-22 1951-11-13 American Cyanamid Co Rodenticide comprising 4-aminopteroylglutamic acid
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3630200A (en) 1969-06-09 1971-12-28 Alza Corp Ocular insert
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4079056A (en) 1975-03-31 1978-03-14 The United States Of America As Represented By The Department Of Health, Education And Welfare Method of making pteridine compounds
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
CH630380A5 (de) 1977-08-12 1982-06-15 Lonza Ag Verfahren zur herstellung von l-methotrexat.
GB8322007D0 (en) 1983-08-16 1983-09-21 Wellcome Found Pharmaceutical delivery system
FR2590255B1 (fr) 1985-11-19 1987-12-24 Rhone Poulenc Sante Procede de preparation de derives de la pteridine
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6673908B1 (en) * 1999-02-22 2004-01-06 Nuvelo, Inc. Tumor necrosis factor receptor 2
AU2001283191A1 (en) * 2000-08-10 2002-02-25 Uab Research Foundation Compositions containing an inhibitor of dihydrofolate reductase and a folate
US20040176381A1 (en) * 2003-03-06 2004-09-09 Walsh Michael J. Methotrexate compliance packaging
US7612071B2 (en) * 2004-03-12 2009-11-03 Syntrix Biosystems, Inc. Compositions and methods employing aminopterin
DE102004016355A1 (de) * 2004-04-02 2005-11-03 Rösner Research GmbH & Co.KG Herstellung und Verwendung des Konjugats Methotrexat-Albumin als Mittel zur Immunosuppression bei GVHD
US7312217B2 (en) * 2005-03-11 2007-12-25 Syntrix Biosystems, Inc. Aminopterin dosage forms and methods for inflammatory disorders
EP2384119B1 (en) * 2009-01-24 2015-08-05 Aminopterin LLC Pharmaceutical composition comprising racemic aminopterin

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