JP2008531987A - 酸化ストレス測定デバイスおよび関連の方法 - Google Patents
酸化ストレス測定デバイスおよび関連の方法 Download PDFInfo
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010261944A (ja) * | 2009-04-30 | 2010-11-18 | F Hoffmann La Roche Ag | 光学測定キュベットの汚染物質の検出方法 |
| JP2015531069A (ja) * | 2012-08-20 | 2015-10-29 | コンセジョ スペリオール デ インベスティガショネス シエンティフィカス セ．エセ．イ．セ．Ｃｏｎｓｅｊｏ Ｓｕｐｅｒｉｏｒ Ｄｅ Ｉｎｖｅｓｔｉｇａｃｉｏｎｅｓ Ｃｉｅｎｔｉｆｉｃａｓ Ｃ．Ｓ．Ｉ．Ｃ． | 末梢血の血漿タンパク質構造のラマン、赤外光、またはラマン−赤外光による分析およびそのアルツハイマー病の認知症進行との関係 |
Families Citing this family (7)
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| US20070162992A1 (en) * | 2006-01-09 | 2007-07-12 | Mcgill University | Metabolomic determination in assisted reproductive technology |
| US20090287064A1 (en) * | 2008-05-15 | 2009-11-19 | Medical Interactive Education, Llc | Computer implemented cognitive self test |
| WO2014205426A1 (en) * | 2013-06-21 | 2014-12-24 | Imigene, Inc. | Blood analysis |
| JP6533076B2 (ja) * | 2014-03-26 | 2019-06-19 | アークレイ株式会社 | 還元力の分析方法および還元力の分析試薬 |
| US10542961B2 (en) | 2015-06-15 | 2020-01-28 | The Research Foundation For The State University Of New York | System and method for infrasonic cardiac monitoring |
| US10837926B2 (en) * | 2017-09-01 | 2020-11-17 | Case Western Reserve University | Multi-modal spectroscopic analysis |
| CN115307715B (zh) * | 2022-08-09 | 2025-08-01 | 南昌航空大学 | 一种基于sagnac光纤声传感系统的改进小波去噪方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003083977A (ja) * | 2001-09-12 | 2003-03-19 | Mitsubishi-Tokyo Pharmaceuticals Inc | 酸化ストレスの測定方法 |
| JP2003176277A (ja) * | 2001-12-12 | 2003-06-24 | House Foods Corp | 神経細胞保護物質 |
| JP2003530130A (ja) * | 2000-04-14 | 2003-10-14 | メタボロン インコーポレイテッド | メタボロミクスを使用した薬物発見、疾患の処置、及び診断のための方法 |
| JP2003302396A (ja) * | 2002-12-09 | 2003-10-24 | Nikken Foods Co Ltd | 酸化ストレス評価のための健康指標としての酸化ストレス診断分析図を使用して酸化ストレスを評価する方法 |
| JP2003310621A (ja) * | 2002-04-19 | 2003-11-05 | Nikken Foods Co Ltd | 酸化ストレス特性の診断分析図、これを用いた酸化ストレス特性の診断方法及び機能性食品の評価・開発方法並びに酸化ストレス特性の改善に用いられる機能性食品 |
| JP2005526796A (ja) * | 2002-03-27 | 2005-09-08 | エフ．ホフマン−ラ ロシュ アーゲー | モノアミンオキシダーゼｂの阻害薬としてのフタルイミド誘導体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5712165A (en) * | 1994-08-22 | 1998-01-27 | Beth Israel Hospital Administration | Method and apparatus for detecting hydrocarbon oxidation |
| US7603166B2 (en) * | 1996-09-20 | 2009-10-13 | Board Of Regents University Of Texas System | Method and apparatus for detection of vulnerable atherosclerotic plaque |
| CN1163750C (zh) * | 1998-05-29 | 2004-08-25 | 日研食品株式会社 | 使用氧化压力诊断图作为健康指示剂评价人体内氧化压力并进行控制 |
| US20040121305A1 (en) * | 2002-12-18 | 2004-06-24 | Wiegand Roger Charles | Generation of efficacy, toxicity and disease signatures and methods of use thereof |
| DE102004061064A1 (de) * | 2004-12-18 | 2006-06-29 | Roche Diagnostics Gmbh | Verfahren und Vorrichtung zur spektroskopischen Untersuchung von Körperflüssigkeiten und Gewebeproben hinsichtlich eines erhöhten Alzheimerverdachts |
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2006
- 2006-02-21 EP EP06710410A patent/EP1853894A1/en not_active Withdrawn
- 2006-02-21 JP JP2007555724A patent/JP2008531987A/ja active Pending
- 2006-02-21 CA CA002598529A patent/CA2598529A1/en not_active Abandoned
- 2006-02-21 WO PCT/IB2006/000335 patent/WO2006090228A1/en not_active Ceased
- 2006-02-21 AU AU2006217608A patent/AU2006217608A1/en not_active Abandoned
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003530130A (ja) * | 2000-04-14 | 2003-10-14 | メタボロン インコーポレイテッド | メタボロミクスを使用した薬物発見、疾患の処置、及び診断のための方法 |
| JP2003083977A (ja) * | 2001-09-12 | 2003-03-19 | Mitsubishi-Tokyo Pharmaceuticals Inc | 酸化ストレスの測定方法 |
| JP2003176277A (ja) * | 2001-12-12 | 2003-06-24 | House Foods Corp | 神経細胞保護物質 |
| JP2005526796A (ja) * | 2002-03-27 | 2005-09-08 | エフ．ホフマン−ラ ロシュ アーゲー | モノアミンオキシダーゼｂの阻害薬としてのフタルイミド誘導体 |
| JP2003310621A (ja) * | 2002-04-19 | 2003-11-05 | Nikken Foods Co Ltd | 酸化ストレス特性の診断分析図、これを用いた酸化ストレス特性の診断方法及び機能性食品の評価・開発方法並びに酸化ストレス特性の改善に用いられる機能性食品 |
| JP2003302396A (ja) * | 2002-12-09 | 2003-10-24 | Nikken Foods Co Ltd | 酸化ストレス評価のための健康指標としての酸化ストレス診断分析図を使用して酸化ストレスを評価する方法 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010261944A (ja) * | 2009-04-30 | 2010-11-18 | F Hoffmann La Roche Ag | 光学測定キュベットの汚染物質の検出方法 |
| JP2015531069A (ja) * | 2012-08-20 | 2015-10-29 | コンセジョ スペリオール デ インベスティガショネス シエンティフィカス セ．エセ．イ．セ．Ｃｏｎｓｅｊｏ Ｓｕｐｅｒｉｏｒ Ｄｅ Ｉｎｖｅｓｔｉｇａｃｉｏｎｅｓ Ｃｉｅｎｔｉｆｉｃａｓ Ｃ．Ｓ．Ｉ．Ｃ． | 末梢血の血漿タンパク質構造のラマン、赤外光、またはラマン−赤外光による分析およびそのアルツハイマー病の認知症進行との関係 |
Also Published As
| Publication number | Publication date |
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| CA2598529A1 (en) | 2006-08-31 |
| US20120173154A1 (en) | 2012-07-05 |
| EP1853894A1 (en) | 2007-11-14 |
| AU2006217608A1 (en) | 2006-08-31 |
| US20070054347A1 (en) | 2007-03-08 |
| WO2006090228A1 (en) | 2006-08-31 |
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