JP2008531598A5 - - Google Patents
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- Publication number
- JP2008531598A5 JP2008531598A5 JP2007557223A JP2007557223A JP2008531598A5 JP 2008531598 A5 JP2008531598 A5 JP 2008531598A5 JP 2007557223 A JP2007557223 A JP 2007557223A JP 2007557223 A JP2007557223 A JP 2007557223A JP 2008531598 A5 JP2008531598 A5 JP 2008531598A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- subject
- poloxamer
- cardiomyocytes
- dystrophin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 23
- 229960000502 poloxamer Drugs 0.000 claims 23
- 229920001983 poloxamer Polymers 0.000 claims 23
- 210000004413 cardiac myocyte Anatomy 0.000 claims 12
- 102000001039 Dystrophin Human genes 0.000 claims 8
- 108010069091 Dystrophin Proteins 0.000 claims 8
- 230000002950 deficient Effects 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 230000007423 decrease Effects 0.000 claims 6
- 230000002861 ventricular Effects 0.000 claims 6
- 206010052337 Diastolic dysfunction Diseases 0.000 claims 5
- 210000005003 heart tissue Anatomy 0.000 claims 5
- 230000003834 intracellular effect Effects 0.000 claims 5
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 4
- 239000005557 antagonist Substances 0.000 claims 4
- 239000011575 calcium Substances 0.000 claims 4
- 229910052791 calcium Inorganic materials 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 239000005541 ACE inhibitor Substances 0.000 claims 3
- 229940123413 Angiotensin II antagonist Drugs 0.000 claims 3
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 3
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 3
- 239000002160 alpha blocker Substances 0.000 claims 3
- 229940124308 alpha-adrenoreceptor antagonist Drugs 0.000 claims 3
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims 3
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 3
- 102000012740 beta Adrenergic Receptors Human genes 0.000 claims 3
- 108010079452 beta Adrenergic Receptors Proteins 0.000 claims 3
- 239000000480 calcium channel blocker Substances 0.000 claims 3
- 230000001964 calcium overload Effects 0.000 claims 3
- 230000003205 diastolic effect Effects 0.000 claims 3
- 239000002934 diuretic Substances 0.000 claims 3
- 208000019622 heart disease Diseases 0.000 claims 3
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 3
- 239000004041 inotropic agent Substances 0.000 claims 3
- 239000002171 loop diuretic Substances 0.000 claims 3
- 230000014759 maintenance of location Effects 0.000 claims 3
- 150000002823 nitrates Chemical class 0.000 claims 3
- 239000002571 phosphodiesterase inhibitor Substances 0.000 claims 3
- 239000011591 potassium Substances 0.000 claims 3
- 229910052700 potassium Inorganic materials 0.000 claims 3
- 229940124549 vasodilator Drugs 0.000 claims 3
- 239000003071 vasodilator agent Substances 0.000 claims 3
- 206010007556 Cardiac failure acute Diseases 0.000 claims 2
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 2
- 206010062575 Muscle contracture Diseases 0.000 claims 2
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 claims 2
- 239000000674 adrenergic antagonist Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000030833 cell death Effects 0.000 claims 2
- 208000006111 contracture Diseases 0.000 claims 2
- 230000001882 diuretic effect Effects 0.000 claims 2
- 230000000004 hemodynamic effect Effects 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 230000002107 myocardial effect Effects 0.000 claims 2
- 238000007634 remodeling Methods 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 229940030606 diuretics Drugs 0.000 claims 1
- 210000000663 muscle cell Anatomy 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65657005P | 2005-02-25 | 2005-02-25 | |
| US60/656,570 | 2005-02-25 | ||
| PCT/US2006/006862 WO2006091941A2 (en) | 2005-02-25 | 2006-02-27 | Compositions and methods for treating and preventing cardiomyopathy and heart disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008531598A JP2008531598A (ja) | 2008-08-14 |
| JP2008531598A5 true JP2008531598A5 (https=) | 2009-04-16 |
| JP5042041B2 JP5042041B2 (ja) | 2012-10-03 |
Family
ID=36928113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007557223A Expired - Fee Related JP5042041B2 (ja) | 2005-02-25 | 2006-02-27 | 心筋症及び心臓病を処置及び予防するための組成物及び方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7846426B2 (https=) |
| EP (1) | EP1853280B1 (https=) |
| JP (1) | JP5042041B2 (https=) |
| AT (1) | ATE546147T1 (https=) |
| AU (2) | AU2006216420B2 (https=) |
| CA (1) | CA2599219C (https=) |
| ES (1) | ES2380047T3 (https=) |
| WO (1) | WO2006091941A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2046348B1 (en) * | 2006-08-01 | 2015-07-22 | Phrixus Pharmaceuticals, Incorporated | Use of poloxamer for the prevention and/or treatment of heart failure |
| WO2008124088A2 (en) * | 2007-04-05 | 2008-10-16 | Phrixus Pharmaceuticals, Inc. | Compositions and methods for the treatment of heart failure |
| WO2009070793A1 (en) * | 2007-11-29 | 2009-06-04 | Pluromed, Inc. | Endoscopic mucosal resectioning using purified inverse thermosensitive polymers |
| US8852568B2 (en) | 2007-12-17 | 2014-10-07 | The Regents Of The University Of Michigan | Compositions and methods for treating and preventing skeletal muscle deficiencies |
| US9867547B2 (en) | 2012-11-29 | 2018-01-16 | Siemens Healthcare Gmbh | System and method to calculate cardiac characteristics |
| WO2015050581A1 (en) * | 2013-04-19 | 2015-04-09 | Cedars-Sinai Medical Center | Phosphodiesterase 5a inhibitors for the treatment of muscular dystrophy |
| EP3057598A1 (en) * | 2013-10-16 | 2016-08-24 | Mast Therapeutics, Inc. | Diuretic induced alterations of plasma volume |
| US9757411B2 (en) | 2014-07-07 | 2017-09-12 | Aires Pharmaceuticals, Inc. | Poloxamer therapy for heart failure |
| JP6747748B2 (ja) | 2014-07-07 | 2020-08-26 | ライフラフト バイオサイエンシーズ，インコーポレイテッド | 長期循環物質のないポロクサマー組成物、その産生方法およびその使用 |
| WO2016007542A1 (en) | 2014-07-07 | 2016-01-14 | Mast Therapeutics, Inc. | Poloxamer therapy for heart failure |
| US20220023333A1 (en) * | 2019-05-06 | 2022-01-27 | Elena Valentinovna ARSHINTSEVA | Method for increasing cancer patient's haemoglobin level |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2140408T3 (es) | 1991-03-19 | 2000-03-01 | Cytrx Corp | Copolimeros de polioxipropileno/polioxietileno con actividad biologica mejorada. |
| JPH05178760A (ja) | 1991-06-03 | 1993-07-20 | Alpha Therapeutic Corp | 心筋梗塞治療剤 |
| US5994348A (en) * | 1995-06-07 | 1999-11-30 | Sanofi | Pharmaceutical compositions containing irbesartan |
| US6761824B2 (en) | 2000-08-17 | 2004-07-13 | Reeve Lorraine E | Process for the fractionation of polymers |
| WO2002065834A2 (en) * | 2000-10-24 | 2002-08-29 | Smithkline Beecham Corporation | Novel formulations of carvedilol |
-
2006
- 2006-02-27 CA CA2599219A patent/CA2599219C/en not_active Expired - Lifetime
- 2006-02-27 AT AT06736222T patent/ATE546147T1/de active
- 2006-02-27 JP JP2007557223A patent/JP5042041B2/ja not_active Expired - Fee Related
- 2006-02-27 ES ES06736222T patent/ES2380047T3/es not_active Expired - Lifetime
- 2006-02-27 WO PCT/US2006/006862 patent/WO2006091941A2/en not_active Ceased
- 2006-02-27 EP EP06736222A patent/EP1853280B1/en not_active Expired - Lifetime
- 2006-02-27 AU AU2006216420A patent/AU2006216420B2/en not_active Ceased
- 2006-02-27 US US11/885,304 patent/US7846426B2/en not_active Expired - Lifetime
-
2010
- 2010-08-24 AU AU2010214636A patent/AU2010214636A1/en not_active Abandoned
- 2010-10-29 US US12/915,352 patent/US8580245B2/en not_active Expired - Fee Related
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