JP2008531070A - 注入可能な眼用レンズのための組成物 - Google Patents
注入可能な眼用レンズのための組成物 Download PDFInfo
- Publication number
- JP2008531070A JP2008531070A JP2007548363A JP2007548363A JP2008531070A JP 2008531070 A JP2008531070 A JP 2008531070A JP 2007548363 A JP2007548363 A JP 2007548363A JP 2007548363 A JP2007548363 A JP 2007548363A JP 2008531070 A JP2008531070 A JP 2008531070A
- Authority
- JP
- Japan
- Prior art keywords
- ophthalmic composition
- injectable ophthalmic
- polysiloxane
- composition according
- functional
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 146
- -1 polysiloxane Polymers 0.000 claims abstract description 147
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 124
- 239000002775 capsule Substances 0.000 claims abstract description 33
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 29
- 239000004971 Cross linker Substances 0.000 claims description 49
- 239000000178 monomer Substances 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 28
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 claims description 27
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 21
- 239000003054 catalyst Substances 0.000 claims description 18
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 229920001187 thermosetting polymer Polymers 0.000 claims description 11
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 11
- 229910052697 platinum Inorganic materials 0.000 claims description 10
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 9
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 125000000524 functional group Chemical group 0.000 claims description 9
- 230000005484 gravity Effects 0.000 claims description 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 9
- 229910052710 silicon Inorganic materials 0.000 claims description 9
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 8
- 229920001577 copolymer Polymers 0.000 claims description 8
- 239000006096 absorbing agent Substances 0.000 claims description 7
- 125000003709 fluoroalkyl group Chemical group 0.000 claims description 7
- 125000000725 trifluoropropyl group Chemical group [H]C([H])(*)C([H])([H])C(F)(F)F 0.000 claims description 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 230000001588 bifunctional effect Effects 0.000 claims description 6
- 235000010290 biphenyl Nutrition 0.000 claims description 6
- 239000004305 biphenyl Substances 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- UOUILILVWRHZSH-UHFFFAOYSA-N dimethyl-tris[(dimethyl-$l^{3}-silanyl)oxy]silyloxysilicon Chemical group C[Si](C)O[Si](O[Si](C)C)(O[Si](C)C)O[Si](C)C UOUILILVWRHZSH-UHFFFAOYSA-N 0.000 claims description 5
- 238000011065 in-situ storage Methods 0.000 claims description 4
- 229920001897 terpolymer Polymers 0.000 claims description 4
- 229910052731 fluorine Inorganic materials 0.000 claims description 3
- 125000001153 fluoro group Chemical group F* 0.000 claims description 3
- 125000003107 substituted aryl group Chemical group 0.000 claims description 3
- FSIJKGMIQTVTNP-UHFFFAOYSA-N bis(ethenyl)-methyl-trimethylsilyloxysilane Chemical compound C[Si](C)(C)O[Si](C)(C=C)C=C FSIJKGMIQTVTNP-UHFFFAOYSA-N 0.000 claims description 2
- 229920001843 polymethylhydrosiloxane Polymers 0.000 claims 2
- 239000006097 ultraviolet radiation absorber Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 description 62
- 239000000463 material Substances 0.000 description 22
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- 201000010041 presbyopia Diseases 0.000 description 7
- 238000001356 surgical procedure Methods 0.000 description 7
- 238000005160 1H NMR spectroscopy Methods 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000004308 accommodation Effects 0.000 description 6
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- 210000001525 retina Anatomy 0.000 description 6
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- 239000010703 silicon Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- VSIKJPJINIDELZ-UHFFFAOYSA-N 2,2,4,4,6,6,8,8-octakis-phenyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane Chemical compound O1[Si](C=2C=CC=CC=2)(C=2C=CC=CC=2)O[Si](C=2C=CC=CC=2)(C=2C=CC=CC=2)O[Si](C=2C=CC=CC=2)(C=2C=CC=CC=2)O[Si]1(C=1C=CC=CC=1)C1=CC=CC=C1 VSIKJPJINIDELZ-UHFFFAOYSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical group C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 4
- 230000002350 accommodative effect Effects 0.000 description 4
- 125000006267 biphenyl group Chemical group 0.000 description 4
- 239000002131 composite material Substances 0.000 description 4
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- IALUUOKJPBOFJL-UHFFFAOYSA-N potassium oxidosilane Chemical compound [K+].[SiH3][O-] IALUUOKJPBOFJL-UHFFFAOYSA-N 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 238000000518 rheometry Methods 0.000 description 4
- 229920005573 silicon-containing polymer Polymers 0.000 description 4
- 210000004127 vitreous body Anatomy 0.000 description 4
- XUPNETROUIFFFS-UHFFFAOYSA-N 2,2-dimethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane Chemical compound C[Si]1(C)O[SiH2]O[SiH2]O[SiH2]O1 XUPNETROUIFFFS-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
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- BITPLIXHRASDQB-UHFFFAOYSA-N ethenyl-[ethenyl(dimethyl)silyl]oxy-dimethylsilane Chemical compound C=C[Si](C)(C)O[Si](C)(C)C=C BITPLIXHRASDQB-UHFFFAOYSA-N 0.000 description 3
- 230000004438 eyesight Effects 0.000 description 3
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- NYMPGSQKHIOWIO-UHFFFAOYSA-N hydroxy(diphenyl)silicon Chemical class C=1C=CC=CC=1[Si](O)C1=CC=CC=C1 NYMPGSQKHIOWIO-UHFFFAOYSA-N 0.000 description 3
- 239000007972 injectable composition Substances 0.000 description 3
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- 238000006116 polymerization reaction Methods 0.000 description 3
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- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- BPMGYFSWCJZSBA-UHFFFAOYSA-N C[SiH](C)O[SiH3] Chemical compound C[SiH](C)O[SiH3] BPMGYFSWCJZSBA-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 229920006397 acrylic thermoplastic Polymers 0.000 description 2
- 238000000149 argon plasma sintering Methods 0.000 description 2
- OCWYEMOEOGEQAN-UHFFFAOYSA-N bumetrizole Chemical compound CC(C)(C)C1=CC(C)=CC(N2N=C3C=C(Cl)C=CC3=N2)=C1O OCWYEMOEOGEQAN-UHFFFAOYSA-N 0.000 description 2
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- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 2
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- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
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- KOMDZQSPRDYARS-UHFFFAOYSA-N cyclopenta-1,3-diene titanium Chemical compound [Ti].C1C=CC=C1.C1C=CC=C1 KOMDZQSPRDYARS-UHFFFAOYSA-N 0.000 description 1
- 238000013461 design Methods 0.000 description 1
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- JZZIHCLFHIXETF-UHFFFAOYSA-N dimethylsilicon Chemical compound C[Si]C JZZIHCLFHIXETF-UHFFFAOYSA-N 0.000 description 1
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- UQEAIHBTYFGYIE-UHFFFAOYSA-N hexamethyldisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)C UQEAIHBTYFGYIE-UHFFFAOYSA-N 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
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- HMMGMWAXVFQUOA-UHFFFAOYSA-N octamethylcyclotetrasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 HMMGMWAXVFQUOA-UHFFFAOYSA-N 0.000 description 1
- 238000005580 one pot reaction Methods 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 1
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- GTWPLTBXXGOHNT-UHFFFAOYSA-N tetrakis(dimethylsilyl) silicate Chemical class C[SiH](C)O[Si](O[SiH](C)C)(O[SiH](C)C)O[SiH](C)C GTWPLTBXXGOHNT-UHFFFAOYSA-N 0.000 description 1
- 238000004073 vulcanization Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/22—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
- C08G77/24—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen halogen-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
- C08G77/44—Block-or graft-polymers containing polysiloxane sequences containing only polysiloxane sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/04—Polysiloxanes
- C08L83/08—Polysiloxanes containing silicon bound to organic groups containing atoms other than carbon, hydrogen and oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/12—Polysiloxanes containing silicon bound to hydrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/04—Polysiloxanes
- C08G77/20—Polysiloxanes containing silicon bound to unsaturated aliphatic groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/70—Siloxanes defined by use of the MDTQ nomenclature
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Eyeglasses (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63805204P | 2004-12-20 | 2004-12-20 | |
| SE0403091A SE0403091D0 (sv) | 2004-12-20 | 2004-12-20 | New composition for injectable ophtalmic lenses |
| PCT/US2005/045985 WO2006069012A2 (en) | 2004-12-20 | 2005-12-15 | Compositions for injectable ophthalmic lenses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008531070A true JP2008531070A (ja) | 2008-08-14 |
| JP2008531070A5 JP2008531070A5 (enExample) | 2009-02-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548363A Pending JP2008531070A (ja) | 2004-12-20 | 2005-12-15 | 注入可能な眼用レンズのための組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20060135477A1 (enExample) |
| EP (2) | EP1827522B1 (enExample) |
| JP (1) | JP2008531070A (enExample) |
| AT (1) | ATE460949T1 (enExample) |
| AU (1) | AU2005319349A1 (enExample) |
| BR (1) | BRPI0519097A2 (enExample) |
| CA (2) | CA2793105C (enExample) |
| DE (1) | DE602005020059D1 (enExample) |
| SE (1) | SE0403091D0 (enExample) |
| WO (1) | WO2006069012A2 (enExample) |
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| JP2014196462A (ja) * | 2013-03-07 | 2014-10-16 | Jsr株式会社 | 硬化性組成物、硬化物および光半導体装置 |
| JP2016512068A (ja) * | 2013-03-14 | 2016-04-25 | アキュフォーカス・インコーポレーテッド | 埋込みマスクを有する眼内レンズを製造するための方法 |
| KR101819810B1 (ko) * | 2013-03-18 | 2018-01-17 | 포라이트 에이에스 | 투명 광학 장치 소자 |
| JP2023501367A (ja) * | 2019-11-07 | 2023-01-18 | レンスゲン、インコーポレイテッド | 眼内レンズデバイスで使用するためのシリコーンオイルターポリマー |
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| US7628810B2 (en) | 2003-05-28 | 2009-12-08 | Acufocus, Inc. | Mask configured to maintain nutrient transport without producing visible diffraction patterns |
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| DE102005005121A1 (de) * | 2005-02-04 | 2006-08-17 | Forschungszentrum Jülich GmbH | Verfahren zur Herstellung eines Elastomers und Elastomer |
| EP2010100B1 (en) | 2006-04-27 | 2018-11-28 | Johnson & Johnson Surgical Vision, Inc. | Materials comprising polysiloxane polymers for enhancement of lens regeneration |
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| US8439974B2 (en) * | 2006-05-03 | 2013-05-14 | Vision Crc Limited | Adjusted index of refraction of ocular replacement material |
| US8216310B2 (en) | 2007-09-28 | 2012-07-10 | Abbott Medical Optics Inc. | Polymer compositions suitable for intraocular lenses and related methods |
| US8232363B2 (en) | 2007-12-21 | 2012-07-31 | Abbott Medical Optics Inc. | Silicone containing polymeric materials |
| US9156949B2 (en) | 2007-12-21 | 2015-10-13 | Abbott Medical Optics Inc. | Silicone containing polymeric materials |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
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| US10004593B2 (en) | 2009-08-13 | 2018-06-26 | Acufocus, Inc. | Intraocular lens with elastic mask |
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| AU2016362384B2 (en) | 2015-12-01 | 2021-10-07 | Lensgen, Inc. | Accommodating intraocular lens device |
| EP3463188B1 (en) | 2016-05-27 | 2023-04-26 | LensGen, Inc. | Lens oil having a narrow molecular weight distribution for intraocular lens devices |
| CN110621261A (zh) * | 2017-03-13 | 2019-12-27 | 凯亚可公司 | 调节性晶状体装置 |
| EP3790508B1 (en) | 2018-05-09 | 2026-04-29 | AcuFocus, Inc. | Intraocular implant with optic |
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| US11707518B2 (en) | 2019-04-28 | 2023-07-25 | Gholam A. Peyman | Method of treating, reducing, or alleviating a medical condition in a patient |
| WO2021257518A1 (en) | 2020-06-15 | 2021-12-23 | Forsight Vision6, Inc. | Fluorosilicone polymers, compositions, and uses thereof |
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- 2005-12-15 US US11/303,287 patent/US20060135477A1/en not_active Abandoned
- 2005-12-15 EP EP05854658A patent/EP1827522B1/en not_active Expired - Lifetime
- 2005-12-15 CA CA2793105A patent/CA2793105C/en not_active Expired - Fee Related
- 2005-12-15 WO PCT/US2005/045985 patent/WO2006069012A2/en not_active Ceased
- 2005-12-15 DE DE602005020059T patent/DE602005020059D1/de not_active Expired - Lifetime
- 2005-12-15 CA CA2589663A patent/CA2589663C/en not_active Expired - Fee Related
- 2005-12-15 AT AT05854658T patent/ATE460949T1/de not_active IP Right Cessation
- 2005-12-15 AU AU2005319349A patent/AU2005319349A1/en not_active Abandoned
- 2005-12-15 BR BRPI0519097-5A patent/BRPI0519097A2/pt not_active Application Discontinuation
- 2005-12-15 EP EP10154834A patent/EP2260879A1/en not_active Withdrawn
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014196462A (ja) * | 2013-03-07 | 2014-10-16 | Jsr株式会社 | 硬化性組成物、硬化物および光半導体装置 |
| JP2016512068A (ja) * | 2013-03-14 | 2016-04-25 | アキュフォーカス・インコーポレーテッド | 埋込みマスクを有する眼内レンズを製造するための方法 |
| KR101819810B1 (ko) * | 2013-03-18 | 2018-01-17 | 포라이트 에이에스 | 투명 광학 장치 소자 |
| US10288777B2 (en) | 2013-03-18 | 2019-05-14 | Polight Asa | Transparent optical device element |
| JP2023501367A (ja) * | 2019-11-07 | 2023-01-18 | レンスゲン、インコーポレイテッド | 眼内レンズデバイスで使用するためのシリコーンオイルターポリマー |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1827522A2 (en) | 2007-09-05 |
| WO2006069012A2 (en) | 2006-06-29 |
| US20060135477A1 (en) | 2006-06-22 |
| BRPI0519097A2 (pt) | 2008-12-23 |
| EP2260879A1 (en) | 2010-12-15 |
| CA2793105A1 (en) | 2006-06-29 |
| ATE460949T1 (de) | 2010-04-15 |
| CA2793105C (en) | 2014-04-29 |
| WO2006069012A3 (en) | 2007-03-01 |
| DE602005020059D1 (de) | 2010-04-29 |
| AU2005319349A1 (en) | 2006-06-29 |
| EP1827522B1 (en) | 2010-03-17 |
| CA2589663C (en) | 2013-07-16 |
| SE0403091D0 (sv) | 2004-12-20 |
| CA2589663A1 (en) | 2006-06-29 |
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