JP2008530222A5 - - Google Patents

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Publication number
JP2008530222A5
JP2008530222A5 JP2007556264A JP2007556264A JP2008530222A5 JP 2008530222 A5 JP2008530222 A5 JP 2008530222A5 JP 2007556264 A JP2007556264 A JP 2007556264A JP 2007556264 A JP2007556264 A JP 2007556264A JP 2008530222 A5 JP2008530222 A5 JP 2008530222A5
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JP
Japan
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JP2007556264A
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Japanese (ja)
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JP5063366B2 (ja
JP2008530222A (ja
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Priority claimed from PCT/US2006/005367 external-priority patent/WO2006088972A2/en
Publication of JP2008530222A publication Critical patent/JP2008530222A/ja
Publication of JP2008530222A5 publication Critical patent/JP2008530222A5/ja
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Publication of JP5063366B2 publication Critical patent/JP5063366B2/ja
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JP2007556264A 2005-02-16 2006-02-16 ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用 Expired - Fee Related JP5063366B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65347905P 2005-02-16 2005-02-16
US60/653,479 2005-02-16
PCT/US2006/005367 WO2006088972A2 (en) 2005-02-16 2006-02-16 Use of modulatirs of compounds of tgf-beta superfamily to regulate hepcidin-mediated iron metabolism

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011264338A Division JP5852426B2 (ja) 2005-02-16 2011-12-02 ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用

Publications (3)

Publication Number Publication Date
JP2008530222A JP2008530222A (ja) 2008-08-07
JP2008530222A5 true JP2008530222A5 (enExample) 2008-11-20
JP5063366B2 JP5063366B2 (ja) 2012-10-31

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Family Applications (4)

Application Number Title Priority Date Filing Date
JP2007556264A Expired - Fee Related JP5063366B2 (ja) 2005-02-16 2006-02-16 ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用
JP2011264338A Expired - Fee Related JP5852426B2 (ja) 2005-02-16 2011-12-02 ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用
JP2014111127A Expired - Fee Related JP6073833B2 (ja) 2005-02-16 2014-05-29 ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用
JP2016183644A Expired - Fee Related JP6250764B2 (ja) 2005-02-16 2016-09-21 ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2011264338A Expired - Fee Related JP5852426B2 (ja) 2005-02-16 2011-12-02 ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用
JP2014111127A Expired - Fee Related JP6073833B2 (ja) 2005-02-16 2014-05-29 ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用
JP2016183644A Expired - Fee Related JP6250764B2 (ja) 2005-02-16 2016-09-21 ヘプシジンによる鉄代謝を制御するためのＴＧＦ−βスーパーファミリーの化合物の調節因子の使用

Country Status (7)

Country Link
US (6) US7968091B2 (enExample)
EP (3) EP2954903A1 (enExample)
JP (4) JP5063366B2 (enExample)
CA (1) CA2597925A1 (enExample)
ES (2) ES2547866T3 (enExample)
HK (1) HK1218875A1 (enExample)
WO (1) WO2006088972A2 (enExample)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2390425T3 (es) 2000-12-22 2012-11-12 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Uso de moléculas de orientación repulsivas (RGM) y sus moduladores
CA2448382C (en) * 2001-05-25 2013-02-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of hepcidin as a regulator of iron homeostasis
EP3489257A1 (en) 2004-07-23 2019-05-29 Acceleron Pharma Inc. Actrii receptor polypeptides, methods and compositions
US7968091B2 (en) * 2005-02-16 2011-06-28 The General Hospital Corporation Methods and compositions to regulate iron metabolism
US20070099245A1 (en) * 2005-09-29 2007-05-03 Boris Gorovits Assays for neutralizing antibodies
CN101277974A (zh) 2005-09-30 2008-10-01 阿伯特有限及两合公司 排斥性引导分子(rgm)蛋白质家族的蛋白质的结合结构域及其功能性片段和它们的用途
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
EP2781222B1 (en) 2005-11-23 2017-08-02 Acceleron Pharma, Inc. Activin-actriia antagonists in use for promoting bone growth
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
WO2008076437A2 (en) 2006-12-18 2008-06-26 Acceleron Pharma Inc. Activin-actrii antagonists and uses for increasing red blood cell levels
CA2677007A1 (en) 2007-02-01 2008-08-07 Acceleron Pharma Inc. Activin-actriia antagonists and uses for treating or preventing breast cancer
TW201803890A (zh) 2007-02-02 2018-02-01 艾瑟勒朗法瑪公司 衍生自ＡｃｔＲＩＩＢ的變體與其用途
EP2481415B1 (en) 2007-02-09 2019-09-11 Acceleron Pharma Inc. Pharmaceutical compositions comprising Activin-ActRIIA antagonists
WO2008124768A1 (en) * 2007-04-09 2008-10-16 The General Hospital Corporation Hemojuvelin fusion proteins and uses thereof
JP2010539236A (ja) 2007-09-18 2010-12-16 アクセルロン ファーマ， インコーポレイテッド アクチビン−ＡｃｔＲＩＩａ拮抗薬およびＦＳＨ分泌を低減または阻害するための使用
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
TWI626945B (zh) 2008-08-14 2018-06-21 艾瑟勒朗法瑪公司 使用ｇｄｆ阱以增加紅血球水平
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
EP2349332B1 (en) * 2008-11-13 2019-10-23 The General Hospital Corporation Methods and compositions for regulating iron homeostasis by modulation bmp-6
WO2010059861A1 (en) * 2008-11-20 2010-05-27 University Of Southern California Compositions and methods to modulate hair growth
AU2010204985A1 (en) 2009-01-13 2011-08-04 Acceleron Pharma Inc. Methods for increasing adiponectin
JP5912078B2 (ja) 2009-06-08 2016-04-27 アクセルロン ファーマ， インコーポレイテッド 熱発生性脂肪細胞を増加させるための方法
EP3290439B1 (en) 2009-06-12 2020-09-02 Acceleron Pharma Inc. Truncated actriib-fc fusion proteins
EP3332796A1 (en) 2009-11-17 2018-06-13 Acceleron Pharma Inc. Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy
KR20120118002A (ko) * 2009-12-08 2012-10-25 애보트 게엠베하 운트 콤파니 카게 망막 신경 섬유 층 변성의 치료에 사용하기 위한 ｒｇｍ ａ 단백질에 대한 모노클로날 항체
KR20130132824A (ko) 2010-11-08 2013-12-05 악셀레론 파마 인코포레이티드 Actriia 결합제 및 이의 용도
CN107022032A (zh) * 2011-01-19 2017-08-08 菲卢马克斯制药公司 用于调节铁稳态的组合物及其使用方法
CN104144947B (zh) 2011-12-14 2017-10-27 艾伯维德国有限责任两合公司 用于诊断和治疗铁相关病症的组合物和方法
EP2791175A2 (en) 2011-12-14 2014-10-22 Abbvie Deutschland GmbH & Co. KG Composition and method for the diagnosis and treatment of iron-related disorders
EP3369746A1 (en) 2012-01-27 2018-09-05 AbbVie Deutschland GmbH & Co KG Composition and method for diagnosis and treatment of diseases associated with neurite degeneration
RU2684216C2 (ru) * 2012-11-01 2019-04-04 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Эритроферрон и erfe-полипептиды и способы регуляции метаболизма железа
US10195249B2 (en) 2012-11-02 2019-02-05 Celgene Corporation Activin-ActRII antagonists and uses for treating bone and other disorders
AR093620A1 (es) 2012-12-17 2015-06-10 Lilly Co Eli Anticuerpos bmp-6
EP2976085A1 (en) * 2013-03-21 2016-01-27 INSERM - Institut National de la Santé et de la Recherche Médicale Method and pharmaceutical composition for use in the treatment of chronic liver diseases associated with a low hepcidin expression
JP6518656B2 (ja) * 2013-06-13 2019-05-22 バイオデシー， インコーポレイテッド 標的生体実体を標的にする生化学実体候補をスクリーニングする方法
MA40008A (fr) 2014-06-13 2021-05-05 Acceleron Pharma Inc Antagoniste actrii pour le traitement et la prevention d'un ulcere cutane chez un sujet ayant l'anemie
MA41052A (fr) 2014-10-09 2017-08-15 Celgene Corp Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii
TWI730949B (zh) 2014-12-03 2021-06-21 美商西建公司 活化素-ａｃｔｒｉｉ拮抗劑及治療貧血之用途
UY36449A (es) 2014-12-19 2016-07-29 Novartis Ag Composiciones y métodos para anticuerpos dirigidos a bmp6
EP3237906B8 (en) 2014-12-23 2020-10-28 Bluelight Therapeutics, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
WO2016201077A1 (en) 2015-06-12 2016-12-15 Emory University Growth and survival compositions for cells capable of producing antibodies and methods related thereto
CA2996996A1 (en) 2015-08-31 2017-03-09 National Research Council Of Canada Tgf-.beta.-receptor ectodomain fusion molecules and uses thereof
SG10202005377VA (en) * 2015-10-23 2020-07-29 Vifor Int Ag Novel ferroportin inhibitors
US11458148B2 (en) 2016-02-22 2022-10-04 Brigham Young University Method and compositions for the treatment of anemia through the inhibition of furin
CA3027651A1 (en) 2016-06-15 2017-12-21 Novartis Ag Methods for treating disease using inhibitors of bone morphogenetic protein 6 (bmp6)
JP7231553B2 (ja) 2017-03-02 2023-03-01 ナショナル リサーチ カウンシル オブ カナダ Ｔｇｆ－ｂ－受容体外部ドメイン融合分子及びその使用
US11125757B2 (en) 2017-05-26 2021-09-21 Emory University Methods of culturing and characterizing antibody secreting cells
CA3117695A1 (en) 2018-10-26 2020-04-30 Keros Therapeutics, Inc. Crystal forms of an alk2 inhibitor
JP2022549506A (ja) * 2019-09-27 2022-11-25 ディスク・メディシン・インコーポレイテッド 骨髄線維症および関連状態を処置するための方法
WO2021062171A1 (en) * 2019-09-27 2021-04-01 Disc Medicine, Inc. Methods for treating anemia of chronic disease
WO2021222875A1 (en) 2020-04-30 2021-11-04 Keros Therapeutics, Inc. Methods of using alk2 inhibitors
KR20230012539A (ko) 2020-05-13 2023-01-26 디스크 메디슨, 인크. 골수섬유증을 치료하기 위한 항-헤모주벨린 (hjv) 항체
WO2022098821A1 (en) * 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Methods of treating lymphopenia
WO2022098812A1 (en) 2020-11-04 2022-05-12 Keros Therapeutics, Inc. Methods of treating iron overload

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011912A (en) 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
US5571714A (en) 1988-12-22 1996-11-05 Celtrix Pharmaceuticals, Inc. Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use
DK0414297T3 (da) 1989-08-11 1997-07-07 Genencor Int Effektiv fremstilling af mutantproteaser
US5830847A (en) 1992-10-30 1998-11-03 Hsc Research & Development Limited Partnership Soluble TGF-β-binding endoglin polypeptides and homodimers
JPH09500007A (ja) 1993-04-19 1997-01-07 スチュアート エイ コーフマン 新規化合物生成に関するランダム化学
BR9407947A (pt) 1993-11-02 1996-11-26 Affymax Tech Nv Processo para sintetizar moléculas diversas em uma pluralidade de substratos e uma coleçao molecular etiquetade para realizaçao reaçoes de copulaçao em contas em paralelo para triar uma coleçao molecular etiquetada para detectar a presença de um ou mais diferentes etiquetas e para determinar a sequência de síntese aparelho para reaçoes de copulaçao paralelas em suportes sólidos bloco de alinhamento ótico para uso com um detector ótico sistemas de distribuiçao para distribuir reagentes dispositiv
AU6267098A (en) 1997-02-05 1998-08-25 Regents Of The University Of California, The Morphogenic proteins
EP1396543A3 (en) 1999-07-08 2004-03-31 Research Association for Biotechnology Primers for synthesizing full length cDNA clones and their use
CA2396719A1 (en) 2000-01-31 2001-08-02 Human Genome Sciences, Inc. 22 human secreted proteins
WO2002077006A1 (en) 2001-03-23 2002-10-03 Human Genome Sciences, Inc. Bone morphogenic protein polynucleotides, polypeptides, and antibodies
US6800455B2 (en) 2000-03-31 2004-10-05 Scios Inc. Secreted factors
CN1159063C (zh) 2000-06-21 2004-07-28 中国医学科学院血液学研究所 骨形态发生蛋白（bmp）作为治疗急性再生障碍性贫血药物的应用
ES2390425T3 (es) 2000-12-22 2012-11-12 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Uso de moléculas de orientación repulsivas (RGM) y sus moduladores
CA2448382C (en) * 2001-05-25 2013-02-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of hepcidin as a regulator of iron homeostasis
WO2003000461A1 (fr) 2001-06-21 2003-01-03 Meiyu-Giken Co., Ltd. Procede de polissage de la surface d'extremite de connexion d'un connecteur a fibres optiques, structure optique et structure heterogene coaxiale de couches de materiau, et dispositif de polissage
WO2003004615A2 (en) 2001-07-05 2003-01-16 Incyte Genomics, Inc. Secreted proteins
JP2003135075A (ja) 2001-11-05 2003-05-13 Research Association For Biotechnology 新規な全長ｃＤＮＡ
AU2003234136A1 (en) 2002-04-18 2003-11-03 The General Hospital Corporation Drg11-responsive (dragon) gene family
US7771952B2 (en) 2002-06-26 2010-08-10 Abott Laboratories Modulators and modulation of the interaction between RGM and Neogenin
DE10230381A1 (de) * 2002-07-05 2004-01-22 Institut für Medizintechnologie Magdeburg GmbH, IMTM Verwendung von Inhibitoren der Alanyl-Aminopeptidasen und diese umfassende pharmazeutischen Zubereitungen
GB0217786D0 (en) * 2002-07-31 2002-09-11 Glaxo Group Ltd Compounds
US20070166711A1 (en) 2003-04-15 2007-07-19 Samuels Mark E Juvenile hemochromatosis gene (hfe2a), expression products and uses thereof
US20070184052A1 (en) * 2003-05-09 2007-08-09 Lin Herbert Y Soluble tgf-b type III receptor fusion proteins
US20060063208A1 (en) 2004-08-02 2006-03-23 Woolf Clifford J DRG11-responsive (DRAGON) gene and uses thereof
US7968091B2 (en) * 2005-02-16 2011-06-28 The General Hospital Corporation Methods and compositions to regulate iron metabolism
US7534764B2 (en) 2005-06-29 2009-05-19 The Regents Of The University Of California Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin

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